Bixin and norbixin have opposite effects on glycemia, lipidemia, and oxidative stress in streptozotocin-induced diabetic rats

International Journal of Endocrinology

Volumn 2014, Issue , 2014, Pages

  Roehrs, Miguel ^a   Figueiredo, Cassieli Gehlen ^a   Zanchi, Mariane Magalhães ^a   Bochi, Guilherme Vargas ^a   Moresco, Rafael Noal ^a   Quatrin, Andréia ^a   Somacal, Sabrina ^a   Conte, Lisiane ^a   Emanuelli, Tatiana ^a  

^a FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

BIXIN; CAROTENOID; CATALASE; CHOLESTEROL; FRUCTOSAMINE; GLUCOSE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; ISOPHANE INSULIN; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; NITRIC OXIDE; NORBIXIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; STREPTOZOCIN; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BIXA ORELLANA; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETES MELLITUS; DRUG DOSE COMPARISON; DRUG STRUCTURE; DYSLIPIDEMIA; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; LIPID BLOOD LEVEL; LIPOPHILICITY; MALE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; TREATMENT DURATION; TREATMENT OUTCOME; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 84895085752     PISSN: 16878337     EISSN: 16878345     Source Type: Journal    
DOI: 10.1155/2014/839095     Document Type: Article

References (52)

1. International Diabetes Federation,. 2012, http://www.idf.org/
2. Shen S.-C., Cheng F.-C., Wu N.-J., Effect of guava (psidium guajava linn.) leaf soluble solids on glucose metabolism in type 2 diabetic rats. Phytotherapy Research 2008 22 11 1458 1464 2-s2.0-57349176526 10.1002/ptr.2476
3. Kesavulu M. M., Girl R., Kameswara Rao B., Apparao C. H., Lipid peroxidation and antioxidant enzyme levels in type 2 diabetics with microvascular complications. Diabetes and Metabolism 2000 26 5 387 392 2-s2.0-0033675481
4. Ahmed N., Alloxan diabetes-induced oxidative stress and impairment of oxidative defense system in rat brain: neuroprotective effects of cichorium intybus. International Journal of Diabetes and Metabolism 2009 17 3 105 109 2-s2.0-76149111926
5. Ceriello A., Postprandial hyperglycemia and diabetes complications: Is it time to treat? Diabetes 2005 54 1 1 7 2-s2.0-12144251636 10.2337/diabetes.54.1. 1
6. Jenkins A. J., Lyons T. J., Zheng D., Otvos J. D., Lackland D. T., McGee D., Garvey W. T., Klein R. L., Serum lipoproteins in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Intervention and Complications cohort: associations with gender and glycemia. Diabetes Care 2003 26 3 810 818 2-s2.0-0042905925 10.2337/diacare.26.3.810
7. Ahmad F. K., He Z., King G. L., Molecular targets of diabetic cardiovascular complications. Current Drug Targets 2005 6 4 487 494 2-s2.0-21444454887 10.2174/1389450054021990
8. Brownlee M., Biochemistry and molecular cell biology of diabetic complications. Nature 2001 414 6865 813 820 2-s2.0-0035856980 10.1038/414813a
9. Basta G., Schmidt A. M., De Caterina R., Advanced glycation end products and vascular inflammation: implications for accelerated atherosclerosis in diabetes. Cardiovascular Research 2004 63 4 582 592 2-s2.0-4043058031 10.1016/j.cardiores.2004.05.001
10. Pandey K. B., Rizvi S. I., Plant polyphenols as dietary antioxidants in human health and disease. Oxidative Medicine and Cellular Longevity 2009 2 5 270 278 2-s2.0-77953474824 10.4161/oxim.2.5.9498
11. Schmatz R., Perreira L. B., Stefanello N., Mazzanti C., Spanevello R., Gutierres J., Bagatini M., Martins C. C., Abdalla F. H., Daci Da Silva Serres J., Zanini D., Vieira J. M., Cardoso A. M., Schetinger M. R., Morsch V. M., Effects of resveratrol on biomarkers of oxidative stress and on the activity of delta aminolevulinic acid dehydratase in liver and kidney of streptozotocin-induced diabetic rats. Biochimie 2012 94 2 374 383 2-s2.0-84855848324 10.1016/j.biochi.2011.08.005
12. Ashraf R., Khan R. A., Ashraf I., Garlic (Allium sativum) supplementation with standard antidiabetic agent provides better diabetic control in type 2 diabetes patients. Pakistan Journal of Pharmaceutical Sciences 2011 24 4 565 570 2-s2.0-80053460952
13. Preston H. D., Rickard M. D., Extraction and chemistry of annatto. Food Chemistry 1980 5 1 47 56 2-s2.0-0002791585
14. Mercadante A. Z., Steck A., Pfander H., Three minor carotenoids from annatto (Bixa orellana) seeds. Phytochemistry 1999 52 1 135 139 2-s2.0-0032793559 10.1016/S0031-9422(98)00761-4
15. Chisté R. C., Mercadante A. Z., Gomes A., Fernandes E., Lima J. L. F. D. C., Bragagnolo N., In vitro scavenging capacity of annatto seed extracts against reactive oxygen and nitrogen species. Food Chemistry 2011 127 2 419 426 2-s2.0-79952311468 10.1016/j.foodchem.2010.12.139
16. Russell K. R. M., Morrison E. Y. S. A., Ragoobirsingh D., The effect of annatto on insulin binding properties in the dog. Phytotherapy Research 2005 19 5 433 436 2-s2.0-24644499992 10.1002/ptr.1650
17. Russel K. R. M., Karen R. M., Morrison E. Y., West M. E., The hypoglycaemic effect of annatto (Bixa orellana). West Indian Medical Journal 1991 40 4 24 27
18. Fernandes A. C. S., Almeida C. A., Albano F., Laranja G. A. T., Felzenszwalb I., Lage C. L. S., De Sa C. C. N. F., Moura A. S., Kovary K., Norbixin ingestion did not induce any detectable DNA breakage in liver and kidney but caused a considerable impairment in plasma glucose levels of rats and mice. Journal of Nutritional Biochemistry 2002 13 7 411 420 2-s2.0-0036307869 10.1016/S0955-2863(02)00177-8
19. Goto T., Takahashi N., Hirai S., Kawada T., Bixin activates PPAR α and improves obesity-induced abnormalities of carbohydrate and lipid metabolism in mice. Journal of Agricultural and Food Chemistry 2012 60 48 11952 11958
20. Takahashi N., Goto T., Taimatsu A., Egawa K., Katoh S., Kusudo T., Sakamoto T., Ohyane C., Lee J.-Y., Kim Y.-I., Uemura T., Hirai S., Kawada T., Bixin regulates mRNA expression involved in adipogenesis and enhances insulin sensitivity in 3T3-L1 adipocytes through PPAR γ activation. Biochemical and Biophysical Research Communications 2009 390 4 1372 1376 2-s2.0-70450257641 10.1016/j.bbrc.2009.10.162
21. Szkudelski T., Kandulska K., Okulicz M., Alloxan in vivo does not only exert deleterious effects on pancreatic B cells. Physiological Research 1998 47 5 343 346 2-s2.0-0031774996
22. Friedewald W. T., Levy R. I., Fredrickson D. S., Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry 1972 18 6 499 502 2-s2.0-0015348189
23. Tatsch E., Bochi G. V., Pereira R. D. S., Kober H., Agertt V. A., Anraku de Campos M. M., Gomes P., Duarte M. M. M. F., Moresco R. N., A simple and inexpensive automated technique for measurement of serum nitrite/nitrate. Clinical Biochemistry 2011 44 4 348 350 2-s2.0-79651469467 10.1016/j. clinbiochem.2010.12.011
24. Witko-Sarsat V., Friedlander M., Capeillère-Blandin C., Nguyen-Khoa T., Nguyen A. T., Zingraff J., Jungers P., Descamps-Latscha B., Advanced oxidation protein products as a novel marker of oxidative stress in uremia. Kidney International 1996 49 5 1304 1313 2-s2.0-0029948839
25. Paglia D. E., Valentine W. N., Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. The Journal of Laboratory and Clinical Medicine 1967 70 1 158 169 2-s2.0-0014108436
26. Aebi H., Catalase in vitro. Methods in Enzymology 1984 105 121 126 2-s2.0-0021318441 10.1016/S0076-6879(84)05016-3
27. Misra H. P., Fridovich I., The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. The Journal of Biological Chemistry 1972 247 10 3170 3175 2-s2.0-0015523099
28. Holmgren A., Bjornstedt M., Thioredoxin and thioredoxin reductase. Methods in Enzymology 1995 252 199 208 2-s2.0-0029187491 10.1016/0076-6879(95) 52023-6
29. Carlberg I., Mannervik B., Inhibition of glutathione reductase by interaction of 2,4,6-trinitrobenzenesulfonate with the active-site dithiol. FEBS Letters 1979 98 2 263 266 2-s2.0-0018790599
30. Lenzen S., The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia 2008 51 2 216 226 2-s2.0-37549029242 10.1007/s00125-007- 0886-7
31. Begum N., Draznin B., Effect of streptozotocin-induced diabetes on GLUT-4 phosphorylation in rat adipocytes. The Journal of Clinical Investigation 1992 90 4 1254 1262 2-s2.0-0026450839
32. Ohkawara E., Nohara Y., Kanno Y., Suzuki H., Matsumoto G., Kinoshita T., Watanabe M., Fructosamine assay using albumin extracted from serum. Biological and Pharmaceutical Bulletin 2002 25 9 1121 1124 2-s2.0-0036728999 10.1248/bpb.25.1121
33. Takahashi N., Goto T., Taimatsu A., Egawa K., Katoh S., Kusudo T., Sakamoto T., Ohyane C., Lee J.-Y., Kim Y.-I., Uemura T., Hirai S., Kawada T., Bixin regulates mRNA expression involved in adipogenesis and enhances insulin sensitivity in 3T3-L1 adipocytes through PPAR γ activation. Biochemical and Biophysical Research Communications 2009 390 4 1372 1376 2-s2.0-70450257641 10.1016/j.bbrc.2009.10.162
34. Rocchi S., Picard F., Vamecq J., Gelman L., Potier N., Zeyer D., Dubuquoy L., Bac P., Champy M.-F., Plunket K. D., Leesnitzer L. M., Blanchard S. G., Desreumaux P., Moras D., Renaud J.-P., Auwerx J., A unique PPAR γ ligand with potent insulin-sensitizing yet weak adipogenic activity. Molecular Cell 2001 8 4 737 747 2-s2.0-2642557181 10.1016/S1097-2765(01)00353-7
35. Cheng J.-T., Huang C.-C., Liu I.-M., Tzeng T.-F., Chih J. C., Novel mechanism for plasma glucose-lowering action of metformin in streptozotocin-induced diabetic rats. Diabetes 2006 55 3 819 825 2-s2.0-33644767124
36. de Paula H., Pedrosa M. L., Júnior J. V. R., Haraguchi F. K., dos Santos R. C., Silva M. E., Effect of an aqueous extract of annatto (Bixa orellana) seeds on lipid profile and biochemical markers of renal and hepatic function in hipercholesterolemic rats. Brazilian Archives of Biology and Technology 2009 52 6 1373 1378 2-s2.0-77953262893 10.1590/S1516- 89132009000600008
37. Lefebvre P., Chinetti G., Fruchart J.-C., Staels B., Sorting out the roles of PPAR α in energy metabolism and vascular homeostasis. The Journal of Clinical Investigation 2006 116 3 571 580 2-s2.0-33644652183 10.1172/JCI27989
38. Takahashi N., Kang M.-S., Kuroyanagi K., Goto T., Hirai S., Ohyama K., Lee J.-Y., Yu R., Yano M., Sasaki T., Murakami S., Kawada T., Auraptene, a citrus fruit compound, regulates gene expression as a PPAR α agonist in HepG2 hepatocytes. BioFactors 2008 33 1 25 32 2-s2.0-65449152857 10.1002/biof.5520330103
39. Kawada T., Goto T., Takahashi N., Hirai S., Various Terpenoids derived from herbal and dietary plants function as PPAR modulators and regulate carbohydrate and lipid metabolism. PPAR Research 2010 48 39 58 2-s2.0-77954568426 10.1155/2010/483958
40. Evans R. M., Barish G. D., Wang Y.-X., PPARs and the complex journey to obesity. Nature Medicine 2004 10 4 355 361 2-s2.0-1942518840 10.1038/nm1025
41. Maritim A. C., Sanders R. A., Watkins J. B. III, Diabetes, oxidative stress, and antioxidants: a review. Journal of Biochemical and Molecular Toxicology 2003 17 1 24 38 2-s2.0-0037253073 10.1002/jbt.10058
42. Giacco F., Brownlee M., Oxidative stress and diabetic complications. Circulation Research 2010 107 9 1058 1070 2-s2.0-78349297565 10.1161/CIRCRESAHA.110.223545
43. Mandrup-Poulsen T., Bendtzen K., Nielsen H., Bendixen G., Nerup J., Cytokines cause functional and structural damage to isolated islets of Langerhans. Allergy 1985 40 6 424 429 2-s2.0-0022234371
44. Corbett J. A., McDaniel M. L., Does nitric oxide mediate autoimmune destruction of β -cells? Possible therapeutic interventions in IDDM. Diabetes 1992 41 8 897 903 2-s2.0-0026683354
45. Gelisgen R., Genc H., Kayali R., Oncul M., Benian A., Guralp O., Uludag S., Cakatay U., Albayrak M., Uzun H., Protein oxidation markers in women with and without gestational diabetes mellitus: a possible relation with paraoxonase activity. Diabetes Research and Clinical Practice 2011 94 3 404 409 2-s2.0-82955187341 10.1016/j.diabres.2011.08.001
46. Halliwell B., Gutterdige J. M. C., Free Radicals in Biology and Medicine 1999 Oxford, UK Oxford University Press
47. Ceriello A., New insights on oxidative stress and diabetic complications may lead to a "causal" antioxidant therapy. Diabetes Care 2003 26 5 1589 1596 2-s2.0-0042093769 10.2337/diacare.26.5.1589
48. Pinho R. A., Andrades M. E., Oliveira M. R., Pirola A. C., Zago M. S., Silveira P. C. L., Dal-Pizzol F., Moreira J. C. F., Imbalance in SOD/CAT activities in rat skeletal muscles submitted to treadmill training exercise. Cell Biology International 2006 30 10 848 853 2-s2.0-33750000823 10.1016/j.cellbi.2006.03.011
49. Ren J., Chung S. H., Anti-inflammatory effect of α -linolenic acid and its mode of action through the inhibition of nitric oxide production and inducible nitric oxide synthase gene expression via NF- B and mitogen-activated protein kinase pathways. Journal of Agricultural and Food Chemistry 2007 55 13 5073 5080 2-s2.0-34447343605 10.1021/jf0702693
50. Jnior J. V. R., Arajo G. R., Pádua B. D. C., De Brito Magalhães C. L., Chaves M. M., Pedrosa M. L., Silva M. E., Costa D. C., Annatto extract and β -carotene enhances antioxidant status and regulate gene expression in neutrophils of diabetic rats. Free Radical Research 2012 46 3 329 338 2-s2.0-84857307663 10.3109/10715762.2012.656100
51. Bautista A. R. P. L., Moreira E. L. T., Batista M. S., Miranda M. S., Gomes I. C. S., Subacute toxicity assessment of annatto in rat. Food and Chemical Toxicology 2004 42 4 625 629 2-s2.0-1542346444 10.1016/j.fct.2003.11. 007
52. Bailey C. J., Path M. R. C., Turner R. C., Metformin. The New England Journal of Medicine 1996 334 9 574 579 2-s2.0-0030605388