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Volumn 53, Issue 1, 2014, Pages 269-275

The flavonoid luteolin induces nitric oxide production and arterial relaxation

Author keywords

eNOS; Luteolin; NO; Vasorelaxation, endothelial cells

Indexed keywords

ANIMALS; AORTA; ARGININE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; HUMANS; LUTEOLIN; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHENYLEPHRINE; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; VASODILATION;

EID: 84895077320     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-013-0525-7     Document Type: Article
Times cited : (68)

References (44)
  • 2
    • 0022592152 scopus 로고
    • Depression of contractile responses in rat aorta by spontaneously released endothelium-derived relaxing factor
    • 1:CAS:528:DyaL28XktF2gt7c%3D
    • Martin W, Furchgott RF, Villani GM, Jothianandan D (1986) Depression of contractile responses in rat aorta by spontaneously released endothelium-derived relaxing factor. J Pharmacol Exp Ther 237:529-538
    • (1986) J Pharmacol Exp Ther , vol.237 , pp. 529-538
    • Martin, W.1    Furchgott, R.F.2    Villani, G.M.3    Jothianandan, D.4
  • 3
    • 41349096436 scopus 로고    scopus 로고
    • Nitric oxide, tetrahydrobiopterin, oxidative stress, and endothelial dysfunction in hypertension
    • 1:CAS:528:DC%2BD1cXjvFyqu78%3D 10.1089/ars.2007.1989
    • Schulz E, Jansen T, Wenzel P, Daiber A, Munzel T (2008) Nitric oxide, tetrahydrobiopterin, oxidative stress, and endothelial dysfunction in hypertension. Antioxid Redox Signal 10:1115-1126
    • (2008) Antioxid Redox Signal , vol.10 , pp. 1115-1126
    • Schulz, E.1    Jansen, T.2    Wenzel, P.3    Daiber, A.4    Munzel, T.5
  • 4
    • 0033402792 scopus 로고    scopus 로고
    • Ageing and the cardiovascular system
    • 1:STN:280:DC%2BD3c7hvFyktw%3D%3D 10.1007/s003910050138
    • Ribera-Casado JM (1999) Ageing and the cardiovascular system. Z Gerontol Geriatr 32:412-419
    • (1999) Z Gerontol Geriatr , vol.32 , pp. 412-419
    • Ribera-Casado, J.M.1
  • 5
    • 0034851475 scopus 로고    scopus 로고
    • Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants
    • 1:CAS:528:DC%2BD3MXjtlGgt70%3D 10.1021/jf000892m
    • Miean KH, Mohamed S (2001) Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants. J Agric Food Chem 49:3106-3112
    • (2001) J Agric Food Chem , vol.49 , pp. 3106-3112
    • Miean, K.H.1    Mohamed, S.2
  • 6
    • 0036400016 scopus 로고    scopus 로고
    • Dietary flavonoids: Bioavailability, metabolic effects, and safety
    • 1:CAS:528:DC%2BD38XmtF2ht7o%3D 10.1146/annurev.nutr.22.111401.144957
    • Ross JA, Kasum CM (2002) Dietary flavonoids: bioavailability, metabolic effects, and safety. Annu Rev Nutr 22:19-34
    • (2002) Annu Rev Nutr , vol.22 , pp. 19-34
    • Ross, J.A.1    Kasum, C.M.2
  • 8
    • 0036711591 scopus 로고    scopus 로고
    • Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase i
    • 1:CAS:528:DC%2BD38XnvFGlur4%3D 10.1042/BJ20020098
    • Chowdhury AR, Sharma S, Mandal S, Goswami A, Mukhopadhyay S, Majumder HK (2002) Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I. Biochem J 366:653-661
    • (2002) Biochem J , vol.366 , pp. 653-661
    • Chowdhury, A.R.1    Sharma, S.2    Mandal, S.3    Goswami, A.4    Mukhopadhyay, S.5    Majumder, H.K.6
  • 9
    • 0042286578 scopus 로고    scopus 로고
    • Inhibitory effects of luteolin isolated from Ixeris sonchifolia Hance on the proliferation of HepG2 human hepatocellular carcinoma cells
    • 1:CAS:528:DC%2BD3sXitlCqsr0%3D 10.1007/BF02976662
    • Yee SB, Lee JH, Chung HY, Im KS, Bae SJ, Choi JS, Kim ND (2003) Inhibitory effects of luteolin isolated from Ixeris sonchifolia Hance on the proliferation of HepG2 human hepatocellular carcinoma cells. Arch Pharmacal Res 26:151-156
    • (2003) Arch Pharmacal Res , vol.26 , pp. 151-156
    • Yee, S.B.1    Lee, J.H.2    Chung, H.Y.3    Im, K.S.4    Bae, S.J.5    Choi, J.S.6    Kim, N.D.7
  • 10
    • 60149091041 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of novel luteolin derivatives as antibacterial agents
    • 10.1016/j.ejmech.2008.01.013
    • Lv PC, Li HQ, Xue JY, Shi L, Zhu HL (2008) Synthesis and biological evaluation of novel luteolin derivatives as antibacterial agents. Eur J Med Chem 44:908-914
    • (2008) Eur J Med Chem , vol.44 , pp. 908-914
    • Lv, P.C.1    Li, H.Q.2    Xue, J.Y.3    Shi, L.4    Zhu, H.L.5
  • 11
    • 0034492864 scopus 로고    scopus 로고
    • Metabolic fate of luteolin and its functional activity at focal site
    • 1:CAS:528:DC%2BD3MXhsFegu70%3D 10.1002/biof.5520120129
    • Shimoi K, Saka N, Kaji K, Nozawa R, Kinae N (2000) Metabolic fate of luteolin and its functional activity at focal site. BioFactors (Oxford, England) 12:181-186
    • (2000) BioFactors (Oxford, England) , vol.12 , pp. 181-186
    • Shimoi, K.1    Saka, N.2    Kaji, K.3    Nozawa, R.4    Kinae, N.5
  • 12
    • 0035193217 scopus 로고    scopus 로고
    • Luteolin inhibits an endotoxin-stimulated phosphorylation cascade and proinflammatory cytokine production in macrophages
    • 1:CAS:528:DC%2BD3MXosVeg
    • Xagorari A, Papapetropoulos A, Mauromatis A, Economou M, Fotsis T, Roussos C (2001) Luteolin inhibits an endotoxin-stimulated phosphorylation cascade and proinflammatory cytokine production in macrophages. J Pharmacol Exp Ther 296:181-187
    • (2001) J Pharmacol Exp Ther , vol.296 , pp. 181-187
    • Xagorari, A.1    Papapetropoulos, A.2    Mauromatis, A.3    Economou, M.4    Fotsis, T.5    Roussos, C.6
  • 13
    • 8444250342 scopus 로고    scopus 로고
    • Determination of free radical scavenging activity of quercetin, rutin, luteolin and apigenin in H2O2-treated human ML cells K562
    • 1:CAS:528:DC%2BD2MXhtlKqurg%3D
    • Horvathova K, Novotny L, Tothova D, Vachalkova A (2004) Determination of free radical scavenging activity of quercetin, rutin, luteolin and apigenin in H2O2-treated human ML cells K562. Neoplasma 51:395-399
    • (2004) Neoplasma , vol.51 , pp. 395-399
    • Horvathova, K.1    Novotny, L.2    Tothova, D.3    Vachalkova, A.4
  • 14
    • 57149103144 scopus 로고    scopus 로고
    • Anti-oxidant, anti-inflammatory and anti-allergic activities of luteolin
    • 1:CAS:528:DC%2BD1MXit1Ol 10.1055/s-0028-1088314
    • Seelinger G, Merfort I, Schempp CM (2008) Anti-oxidant, anti-inflammatory and anti-allergic activities of luteolin. Planta Med 74:1667-1677
    • (2008) Planta Med , vol.74 , pp. 1667-1677
    • Seelinger, G.1    Merfort, I.2    Schempp, C.M.3
  • 15
    • 0034068157 scopus 로고    scopus 로고
    • Efficacy of Artichoke dry extract in patients with hyperlipoproteinemia
    • 1:CAS:528:DC%2BD3cXisFOmtL8%3D
    • Englisch W, Beckers C, Unkauf M, Ruepp M, Zinserling V (2000) Efficacy of Artichoke dry extract in patients with hyperlipoproteinemia. Arzneimittelforschung 50:260-265
    • (2000) Arzneimittelforschung , vol.50 , pp. 260-265
    • Englisch, W.1    Beckers, C.2    Unkauf, M.3    Ruepp, M.4    Zinserling, V.5
  • 16
    • 0036748245 scopus 로고    scopus 로고
    • Prevention of taurolithocholate-induced hepatic bile canalicular distortions by HPLC-characterized extracts of artichoke (Cynara scolymus) leaves
    • 1:CAS:528:DC%2BD38XotVGnsro%3D 10.1055/s-2002-34417
    • Gebhardt R (2002) Prevention of taurolithocholate-induced hepatic bile canalicular distortions by HPLC-characterized extracts of artichoke (Cynara scolymus) leaves. Planta Med 68:776-779
    • (2002) Planta Med , vol.68 , pp. 776-779
    • Gebhardt, R.1
  • 17
    • 0036836936 scopus 로고    scopus 로고
    • Protective properties of artichoke (Cynara scolymus) against oxidative stress induced in cultured endothelial cells and monocytes
    • 10.1016/S0024-3205(02)02136-7
    • Zapolska-Downar D, Zapolski-Downar A, Naruszewicz M, Siennicka A, Krasnodebska B, Koldziej B (2002) Protective properties of artichoke (Cynara scolymus) against oxidative stress induced in cultured endothelial cells and monocytes. Life Sci 71:2808-2897
    • (2002) Life Sci , vol.71 , pp. 2808-2897
    • Zapolska-Downar, D.1    Zapolski-Downar, A.2    Naruszewicz, M.3    Siennicka, A.4    Krasnodebska, B.5    Koldziej, B.6
  • 18
    • 4243063942 scopus 로고    scopus 로고
    • Flavonoids from artichoke (Cynara scolymus L.) up-regulate endothelial-type nitric-oxide synthase gene expression in human endothelial cells
    • 1:CAS:528:DC%2BD2cXnt1eqt7k%3D 10.1124/jpet.104.066639
    • Li H, Xia N, Brausch I, Yao Y, Forstermann U (2004) Flavonoids from artichoke (Cynara scolymus L.) up-regulate endothelial-type nitric-oxide synthase gene expression in human endothelial cells. J Pharmacol Exp Ther 310:926-932
    • (2004) J Pharmacol Exp Ther , vol.310 , pp. 926-932
    • Li, H.1    Xia, N.2    Brausch, I.3    Yao, Y.4    Forstermann, U.5
  • 19
    • 30544440831 scopus 로고    scopus 로고
    • Wild artichoke prevents the age-associated loss of vasomotor function
    • 1:CAS:528:DC%2BD2MXht1Omt77O 10.1021/jf052499s
    • Rossoni G, Grande S, Galli C, Visioli F (2005) Wild artichoke prevents the age-associated loss of vasomotor function. J Agric Food Chem 53:10291-10296
    • (2005) J Agric Food Chem , vol.53 , pp. 10291-10296
    • Rossoni, G.1    Grande, S.2    Galli, C.3    Visioli, F.4
  • 20
    • 20544442520 scopus 로고    scopus 로고
    • Mechanisms of relaxant action of luteolin in isolated guinea pig trachea
    • 1:CAS:528:DC%2BD2MXlsFemtbg%3D 10.1055/s-2005-864133
    • Ko WC, Shih CM, Leu IJ, Chen TT, Chang JP (2005) Mechanisms of relaxant action of luteolin in isolated guinea pig trachea. Planta Med 71:406-411
    • (2005) Planta Med , vol.71 , pp. 406-411
    • Ko, W.C.1    Shih, C.M.2    Leu, I.J.3    Chen, T.T.4    Chang, J.P.5
  • 21
    • 27744553563 scopus 로고    scopus 로고
    • The comparison of the relaxant effects of two methoxylated flavones in rat aortic rings
    • 1:CAS:528:DC%2BD2MXhtFyksbvF 10.1016/j.vph.2005.07.002
    • Uydes-Dogan BS, Takir S, Ozdemir O, Kolak U, Topcu G, Ulubelen A (2005) The comparison of the relaxant effects of two methoxylated flavones in rat aortic rings. Vascul Pharmacol 43:220-226
    • (2005) Vascul Pharmacol , vol.43 , pp. 220-226
    • Uydes-Dogan, B.S.1    Takir, S.2    Ozdemir, O.3    Kolak, U.4    Topcu, G.5    Ulubelen, A.6
  • 23
    • 33845574406 scopus 로고    scopus 로고
    • Fat intake modifies vascular responsiveness and receptor expression of vasoconstrictors: Implications for diet-induced obesity
    • 1:CAS:528:DC%2BD2sXpvVyk 10.1016/j.cardiores.2006.11.019
    • Mundy AL, Haas E, Bhattacharya I, Widmer CC, Kretz M, Hofmann-Lehmann R, Minotti R, Barton M (2007) Fat intake modifies vascular responsiveness and receptor expression of vasoconstrictors: implications for diet-induced obesity. Cardiovasc Res 73:368-375
    • (2007) Cardiovasc Res , vol.73 , pp. 368-375
    • Mundy, A.L.1    Haas, E.2    Bhattacharya, I.3    Widmer, C.C.4    Kretz, M.5    Hofmann-Lehmann, R.6    Minotti, R.7    Barton, M.8
  • 24
    • 14244263906 scopus 로고    scopus 로고
    • Genistein activates the 3′,5′-cyclic adenosine monophosphate signaling pathway in vascular endothelial cells and protects endothelial barrier function
    • 1:CAS:528:DC%2BD2MXitleht7w%3D 10.1210/en.2004-1221
    • Liu D, Jiang H, Grange RW (2005) Genistein activates the 3′,5′-cyclic adenosine monophosphate signaling pathway in vascular endothelial cells and protects endothelial barrier function. Endocrinology 146:1312-1320
    • (2005) Endocrinology , vol.146 , pp. 1312-1320
    • Liu, D.1    Jiang, H.2    Grange, R.W.3
  • 25
    • 34347224378 scopus 로고    scopus 로고
    • Dehydroepiandrosterone protects vascular endothelial cells against apoptosis through a Galphai protein-dependent activation of phosphatidylinositol 3-kinase/Akt and regulation of antiapoptotic Bcl-2 expression
    • 1:CAS:528:DC%2BD2sXntVOgurw%3D 10.1210/en.2006-1378
    • Liu D, Si H, Reynolds KA, Zhen W, Jia Z, Dillon JS (2007) Dehydroepiandrosterone protects vascular endothelial cells against apoptosis through a Galphai protein-dependent activation of phosphatidylinositol 3-kinase/Akt and regulation of antiapoptotic Bcl-2 expression. Endocrinology 148:3068-3076
    • (2007) Endocrinology , vol.148 , pp. 3068-3076
    • Liu, D.1    Si, H.2    Reynolds, K.A.3    Zhen, W.4    Jia, Z.5    Dillon, J.S.6
  • 26
    • 0348107405 scopus 로고    scopus 로고
    • Proinsulin C-peptide increases nitric oxide production by enhancing mitogen-activated protein-kinase-dependent transcription of endothelial nitric oxide synthase in aortic endothelial cells of Wistar rats
    • 1:CAS:528:DC%2BD3sXpsVGitb8%3D 10.1007/s00125-003-1232-3
    • Kitamura T, Kimura K, Makondo K, Furuya DT, Suzuki M, Yoshida T, Saito M (2003) Proinsulin C-peptide increases nitric oxide production by enhancing mitogen-activated protein-kinase-dependent transcription of endothelial nitric oxide synthase in aortic endothelial cells of Wistar rats. Diabetologia 46:1698-1705
    • (2003) Diabetologia , vol.46 , pp. 1698-1705
    • Kitamura, T.1    Kimura, K.2    Makondo, K.3    Furuya, D.T.4    Suzuki, M.5    Yoshida, T.6    Saito, M.7
  • 27
    • 9444257630 scopus 로고    scopus 로고
    • Genistein acutely stimulates nitric oxide synthesis in vascular endothelial cells by a cyclic adenosine 5′-monophosphate-dependent mechanism
    • 1:CAS:528:DC%2BD2cXhtVaqu73J 10.1210/en.2004-0102
    • Liu D, Homan LL, Dillon JS (2004) Genistein acutely stimulates nitric oxide synthesis in vascular endothelial cells by a cyclic adenosine 5′-monophosphate-dependent mechanism. Endocrinology 145:5532-5539
    • (2004) Endocrinology , vol.145 , pp. 5532-5539
    • Liu, D.1    Homan, L.L.2    Dillon, J.S.3
  • 29
    • 0021591097 scopus 로고
    • Potassium-induced contraction in smooth muscle
    • 1:CAS:528:DyaL2MXktlGitbs%3D 10.1540/jsmr1965.20.427
    • Karaki H, Urakawa N, Kutsky P (1984) Potassium-induced contraction in smooth muscle. Nihon Heikatsukin Gakkai Zasshi 20:427-444
    • (1984) Nihon Heikatsukin Gakkai Zasshi , vol.20 , pp. 427-444
    • Karaki, H.1    Urakawa, N.2    Kutsky, P.3
  • 30
    • 0017413556 scopus 로고
    • Renin-angiotensin system: Biochemistry and mechanisms of action
    • 1:CAS:528:DyaE2sXhvVKgtLs%3D
    • Peach MJ (1977) Renin-angiotensin system: biochemistry and mechanisms of action. Physiol Rev 57:313-370
    • (1977) Physiol Rev , vol.57 , pp. 313-370
    • Peach, M.J.1
  • 31
    • 0024249484 scopus 로고
    • Calcium and abnormal reactivity of vascular smooth muscle in hypertension
    • 1:CAS:528:DyaL1MXhtFantb4%3D 10.1016/0143-4160(88)90007-3
    • Sharma RV, Bhalla RC (1988) Calcium and abnormal reactivity of vascular smooth muscle in hypertension. Cell Calcium 9:267-274
    • (1988) Cell Calcium , vol.9 , pp. 267-274
    • Sharma, R.V.1    Bhalla, R.C.2
  • 33
    • 0033793227 scopus 로고    scopus 로고
    • Calcium channel blockers reduce blood pressure in part by inhibiting vascular smooth muscle carbonic anhydrase i
    • 1:CAS:528:DC%2BD3cXosVSnsrg%3D 10.1023/A:1007893207279
    • Puscas L, Gilau L, Coltau M, Pasca R, Domuta G, Baican M, Hecht A (2000) Calcium channel blockers reduce blood pressure in part by inhibiting vascular smooth muscle carbonic anhydrase I. Cardiovasc Drugs Ther 14:523-528
    • (2000) Cardiovasc Drugs Ther , vol.14 , pp. 523-528
    • Puscas, L.1    Gilau, L.2    Coltau, M.3    Pasca, R.4    Domuta, G.5    Baican, M.6    Hecht, A.7
  • 34
    • 0033898257 scopus 로고    scopus 로고
    • Molecular mechanism of cGMP-mediated smooth muscle relaxation
    • 1:CAS:528:DC%2BD3cXlsl2ls7s%3D 10.1002/1097-4652(200009)184:3<409: AID-JCP16>3.0.CO;2-K
    • Carvajal JA, Germain AM, Huidobro-Toro JP, Weiner CP (2000) Molecular mechanism of cGMP-mediated smooth muscle relaxation. J Cell Physiol 184:409-420
    • (2000) J Cell Physiol , vol.184 , pp. 409-420
    • Carvajal, J.A.1    Germain, A.M.2    Huidobro-Toro, J.P.3    Weiner, C.P.4
  • 35
    • 14644414763 scopus 로고    scopus 로고
    • 2+-sensitivity and cGMP-independent effects of NO in vascular smooth muscle
    • 10.1016/j.niox.2005.01.002
    • 2+-sensitivity and cGMP-independent effects of NO in vascular smooth muscle. Nitric Oxide 12:105-113
    • (2005) Nitric Oxide , vol.12 , pp. 105-113
    • Lehen'Kyi, V.V.1    Zelensky, S.N.2    Stefanov, A.V.3
  • 36
    • 0026500077 scopus 로고
    • Activation of phospholipase C by the alpha subunits of the Gq and G11 proteins in transfected Cos-7 cells
    • 1:CAS:528:DyaK38XhtVeitbg%3D
    • Wu DQ, Lee CH, Rhee SG, Simon MI (1992) Activation of phospholipase C by the alpha subunits of the Gq and G11 proteins in transfected Cos-7 cells. J Biol Chem 267:1811-1817
    • (1992) J Biol Chem , vol.267 , pp. 1811-1817
    • Wu, D.Q.1    Lee, C.H.2    Rhee, S.G.3    Simon, M.I.4
  • 37
    • 0042346242 scopus 로고    scopus 로고
    • 2+)-independent protein kinase C activity is required for alpha1-adrenergic-receptor-mediated regulation of ribosomal protein S6 kinases in adult cardiomyocytes
    • 1:CAS:528:DC%2BD3sXmsFGrtbo%3D 10.1042/BJ20030454
    • 2+)-independent protein kinase C activity is required for alpha1-adrenergic-receptor-mediated regulation of ribosomal protein S6 kinases in adult cardiomyocytes. Biochem J 373:603-611
    • (2003) Biochem J , vol.373 , pp. 603-611
    • Wang, L.1    Rolfe, M.2    Proud, C.G.3
  • 38
    • 70350074624 scopus 로고    scopus 로고
    • Vasodilator efficacy of nitric oxide depends on mechanisms of intracellular calcium mobilization in mouse aortic smooth muscle cells
    • 10.1111/j.1476-5381.2009.00396.x
    • Van Hove CE, Van der Donckt C, Herman AG, Bult H, Fransen P (2009) Vasodilator efficacy of nitric oxide depends on mechanisms of intracellular calcium mobilization in mouse aortic smooth muscle cells. Br J Pharmacol 158:920-930
    • (2009) Br J Pharmacol , vol.158 , pp. 920-930
    • Van Hove, C.E.1    Van Der Donckt, C.2    Herman, A.G.3    Bult, H.4    Fransen, P.5
  • 39
    • 34047130348 scopus 로고    scopus 로고
    • Structure-activity relationships of flavonoids for vascular relaxation in porcine coronary artery
    • 1:CAS:528:DC%2BD2sXjvFeitb8%3D 10.1016/j.phytochem.2007.02.013
    • Xu YC, Leung SW, Yeung DK, Hu LH, Chen GH, Che CM, Man RY (2007) Structure-activity relationships of flavonoids for vascular relaxation in porcine coronary artery. Phytochemistry 68:1179-1188
    • (2007) Phytochemistry , vol.68 , pp. 1179-1188
    • Xu, Y.C.1    Leung, S.W.2    Yeung, D.K.3    Hu, L.H.4    Chen, G.H.5    Che, C.M.6    Man, R.Y.7
  • 40
    • 38949143319 scopus 로고    scopus 로고
    • Genistein, a soy phytoestrogen, upregulates the expression of human endothelial nitric oxide synthase and lowers blood pressure in spontaneously hypertensive rats
    • 1:CAS:528:DC%2BD1cXht1yntb4%3D
    • Si H, Liu D (2008) Genistein, a soy phytoestrogen, upregulates the expression of human endothelial nitric oxide synthase and lowers blood pressure in spontaneously hypertensive rats. J Nutr 138:297-304
    • (2008) J Nutr , vol.138 , pp. 297-304
    • Si, H.1    Liu, D.2
  • 41
    • 80053928927 scopus 로고    scopus 로고
    • Direct evidence that (-)-epicatechin increases nitric oxide levels in human endothelial cells
    • 1:CAS:528:DC%2BC3MXht1eisbbI 10.1007/s00394-011-0172-9
    • Brossette T, Hundsdorfer C, Kroncke KD, Sies H, Stahl W (2011) Direct evidence that (-)-epicatechin increases nitric oxide levels in human endothelial cells. Eur J Nutr 50:595-599
    • (2011) Eur J Nutr , vol.50 , pp. 595-599
    • Brossette, T.1    Hundsdorfer, C.2    Kroncke, K.D.3    Sies, H.4    Stahl, W.5
  • 42
    • 77952951185 scopus 로고    scopus 로고
    • (-)-epicatechin activation of endothelial cell endothelial nitric oxide synthase, nitric oxide, and related signaling pathways
    • 1:CAS:528:DC%2BC3cXmt1alur4%3D 10.1161/HYPERTENSIONAHA.109.147892
    • Ramirez-Sanchez I, Maya L, Ceballos G, Villarreal F (2010) (-)-epicatechin activation of endothelial cell endothelial nitric oxide synthase, nitric oxide, and related signaling pathways. Hypertension 55:1398-1405
    • (2010) Hypertension , vol.55 , pp. 1398-1405
    • Ramirez-Sanchez, I.1    Maya, L.2    Ceballos, G.3    Villarreal, F.4
  • 43
    • 0031738302 scopus 로고    scopus 로고
    • Intestinal absorption of luteolin and luteolin 7-O-beta-glucoside in rats and humans
    • 1:CAS:528:DyaK1cXnsFynsbk%3D 10.1016/S0014-5793(98)01304-0
    • Shimoi K, Okada H, Furugori M, Goda T, Takase S, Suzuki M, Hara Y, Yamamoto H, Kinae N (1998) Intestinal absorption of luteolin and luteolin 7-O-beta-glucoside in rats and humans. FEBS Lett 438:220-224
    • (1998) FEBS Lett , vol.438 , pp. 220-224
    • Shimoi, K.1    Okada, H.2    Furugori, M.3    Goda, T.4    Takase, S.5    Suzuki, M.6    Hara, Y.7    Yamamoto, H.8    Kinae, N.9
  • 44
    • 79960763581 scopus 로고    scopus 로고
    • Activation of NAD(P)H:quinone oxidoreductase ameliorates spontaneous hypertension in an animal model via modulation of eNOS activity
    • 10.1093/cvr/cvr110
    • Kim YH, Hwang JH, Noh JR, Gang GT, Kim do H, Son HY, Kwak TH, Shong M, Lee IK, Lee CH (2010) Activation of NAD(P)H:quinone oxidoreductase ameliorates spontaneous hypertension in an animal model via modulation of eNOS activity. Cardiovasc Res 91:519-527
    • (2010) Cardiovasc Res , vol.91 , pp. 519-527
    • Kim, Y.H.1    Hwang, J.H.2    Noh, J.R.3    Gang, G.T.4    Kim Do, H.5    Son, H.Y.6    Kwak, T.H.7    Shong, M.8    Lee, I.K.9    Lee, C.H.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.