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Volumn 138, Issue 2, 2008, Pages 297-304

Genistein, a soy phytoestrogen, upregulates the expression of human endothelial nitric oxide synthase and lowers blood pressure in spontaneously hypertensive rats

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; ESTROGEN; GENISTEIN; NITRIC OXIDE; PHYTOESTROGEN; PROTEIN TYROSINE KINASE;

EID: 38949143319     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/138.2.297     Document Type: Article
Times cited : (122)

References (66)
  • 1
    • 0141687200 scopus 로고    scopus 로고
    • Blood pressure, arterial function, structure, and aging: The role of hormonal replacement therapy in postmenopausal women
    • Scuteri A, Ferrucci L. Blood pressure, arterial function, structure, and aging: the role of hormonal replacement therapy in postmenopausal women. J Clin Hypertens (Greenwich). 2003;5:219-25.
    • (2003) J Clin Hypertens (Greenwich) , vol.5 , pp. 219-225
    • Scuteri, A.1    Ferrucci, L.2
  • 5
    • 13444310823 scopus 로고    scopus 로고
    • Phytoestrogens as cardioprotective agents
    • Park D, Huang T, Frishman WH. Phytoestrogens as cardioprotective agents. Cardiol Rev. 2005;13:13-7.
    • (2005) Cardiol Rev , vol.13 , pp. 13-17
    • Park, D.1    Huang, T.2    Frishman, W.H.3
  • 6
    • 0034996015 scopus 로고    scopus 로고
    • Differential effects of flavonoids on 3T3-L1 adipogenesis and lipolysis
    • Harmon AW, Harp JB. Differential effects of flavonoids on 3T3-L1 adipogenesis and lipolysis. Am J Physiol Cell Physiol. 2001;280:c807-13.
    • (2001) Am J Physiol Cell Physiol , vol.280
    • Harmon, A.W.1    Harp, J.B.2
  • 7
    • 11844264895 scopus 로고    scopus 로고
    • Hepatic gene expression profiles are altered by genistein supplementation in mice with diet-induced obesity
    • Kim S, Sohn I, Lee YS, Lee YS. Hepatic gene expression profiles are altered by genistein supplementation in mice with diet-induced obesity. J Nutr. 2005;135:33-41.
    • (2005) J Nutr , vol.135 , pp. 33-41
    • Kim, S.1    Sohn, I.2    Lee, Y.S.3    Lee, Y.S.4
  • 8
    • 0042785118 scopus 로고    scopus 로고
    • Dietary phytoestrogens and their effect on bone: Evidence from in vitro and in vivo, human observational, and dietary intervention studies
    • Setchell KD, Lydeking-Olsen E. Dietary phytoestrogens and their effect on bone: evidence from in vitro and in vivo, human observational, and dietary intervention studies. Am J Clin Nutr. 2003;78:S593-609.
    • (2003) Am J Clin Nutr , vol.78
    • Setchell, K.D.1    Lydeking-Olsen, E.2
  • 9
    • 0035066409 scopus 로고    scopus 로고
    • Usual dietary isoflavone intake is associated with cardiovascular disease risk factors in postmenopausal women
    • Goodman-Gruen D, Kritz-Silverstein D. Usual dietary isoflavone intake is associated with cardiovascular disease risk factors in postmenopausal women. J Nutr. 2001;131:1202-6.
    • (2001) J Nutr , vol.131 , pp. 1202-1206
    • Goodman-Gruen, D.1    Kritz-Silverstein, D.2
  • 11
    • 0031772711 scopus 로고    scopus 로고
    • Effects of soy isoflavones on atherosclerosis: Potential mechanisms
    • Anthony MS, Clarkson TB, Williams JK. Effects of soy isoflavones on atherosclerosis: potential mechanisms. Am J Clin Nutr. 1998;68:S1390-3.
    • (1998) Am J Clin Nutr , vol.68
    • Anthony, M.S.1    Clarkson, T.B.2    Williams, J.K.3
  • 13
    • 0035145693 scopus 로고    scopus 로고
    • Soy isoflavones improve plasma lipids in normocholesterolemic and mildly hypercholesterolemic postmenopausal women
    • Wangen KE, Duncan AM, Xu X, Kurzer MS. Soy isoflavones improve plasma lipids in normocholesterolemic and mildly hypercholesterolemic postmenopausal women. Am J Clin Nutr. 2001;73:225-31.
    • (2001) Am J Clin Nutr , vol.73 , pp. 225-231
    • Wangen, K.E.1    Duncan, A.M.2    Xu, X.3    Kurzer, M.S.4
  • 14
    • 0035895323 scopus 로고    scopus 로고
    • The phytoestrogen genistein produces acute nitric oxide-dependent dilation of human forearm vasculature with similar potency to 17ss-estradiol
    • Walker HA, Dean TS, Sanders TA, Jackson G, Ritter JM, Chowienczyk PJ. The phytoestrogen genistein produces acute nitric oxide-dependent dilation of human forearm vasculature with similar potency to 17ss-estradiol. Circulation. 2001;103:258-62.
    • (2001) Circulation , vol.103 , pp. 258-262
    • Walker, H.A.1    Dean, T.S.2    Sanders, T.A.3    Jackson, G.4    Ritter, J.M.5    Chowienczyk, P.J.6
  • 17
    • 0030061704 scopus 로고    scopus 로고
    • Soybean isoflavones improve cardiovascular risk factors without affecting the reproductive system of peripubertal rhesus monkeys
    • Anthony MS, Clarkson TB, Hughes CL Jr, Morgan TM, Burke GL. Soybean isoflavones improve cardiovascular risk factors without affecting the reproductive system of peripubertal rhesus monkeys. J Nutr. 1996;126:43-50.
    • (1996) J Nutr , vol.126 , pp. 43-50
    • Anthony, M.S.1    Clarkson, T.B.2    Hughes Jr, C.L.3    Morgan, T.M.4    Burke, G.L.5
  • 18
    • 0037159604 scopus 로고    scopus 로고
    • Genistein, an isoflavone included in soy, inhibits thrombotic vessel occlusion in the mouse femoral artery and in vitro platelet aggregation
    • Kondo K, Suzuki Y, Ikeda Y, Umemura K. Genistein, an isoflavone included in soy, inhibits thrombotic vessel occlusion in the mouse femoral artery and in vitro platelet aggregation. Eur J Pharmacol. 2002;455:53-7.
    • (2002) Eur J Pharmacol , vol.455 , pp. 53-57
    • Kondo, K.1    Suzuki, Y.2    Ikeda, Y.3    Umemura, K.4
  • 19
    • 33745078959 scopus 로고    scopus 로고
    • Phytoestrogens and cardiovascular disease
    • Cassidy A, Hooper L. Phytoestrogens and cardiovascular disease. J Br Menopause Soc. 2006;12:49-56.
    • (2006) J Br Menopause Soc , vol.12 , pp. 49-56
    • Cassidy, A.1    Hooper, L.2
  • 22
    • 0035947563 scopus 로고    scopus 로고
    • Estrogen receptor beta-selective transcriptional activity and recruitment of coregulators by phytoestrogens
    • An J, Tzagarakis-Foster C, Scharschmidt TC, Lomri N, Leitman DC. Estrogen receptor beta-selective transcriptional activity and recruitment of coregulators by phytoestrogens. J Biol Chem. 2001;276:17808-14.
    • (2001) J Biol Chem , vol.276 , pp. 17808-17814
    • An, J.1    Tzagarakis-Foster, C.2    Scharschmidt, T.C.3    Lomri, N.4    Leitman, D.C.5
  • 25
    • 34948849676 scopus 로고    scopus 로고
    • Genistein restores caveolin-1 and AT-1 receptor expression and vascular function in large vessels of ovariectomized hypertensive rats
    • Vera R, Jimenez R, Lodi F, Sanchez M, Galisteo M, Zarzuelo A, Perez-Vizcaino F, Duarte J. Genistein restores caveolin-1 and AT-1 receptor expression and vascular function in large vessels of ovariectomized hypertensive rats. Menopause. 2007;14:933-40.
    • (2007) Menopause , vol.14 , pp. 933-940
    • Vera, R.1    Jimenez, R.2    Lodi, F.3    Sanchez, M.4    Galisteo, M.5    Zarzuelo, A.6    Perez-Vizcaino, F.7    Duarte, J.8
  • 27
    • 0034998916 scopus 로고    scopus 로고
    • Phytoestrogens restore nitric oxide-mediated relaxation in isolated pulmonary arteries from chronically hypoxic rats
    • Karamsetty MR, Klinger JR, Hill NS. Phytoestrogens restore nitric oxide-mediated relaxation in isolated pulmonary arteries from chronically hypoxic rats. J Pharmacol Exp Ther. 2001;297:968-74.
    • (2001) J Pharmacol Exp Ther , vol.297 , pp. 968-974
    • Karamsetty, M.R.1    Klinger, J.R.2    Hill, N.S.3
  • 28
    • 0030843573 scopus 로고    scopus 로고
    • Estrogen upregulates endothelial nitric oxide synthase gene expression in fetal pulmonary artery endothelium
    • MacRitchie AN, Jun SS, Chen Z, German Z, Yuhanna IS, Sherman TS, Shaul PW. Estrogen upregulates endothelial nitric oxide synthase gene expression in fetal pulmonary artery endothelium. Circ Res. 1997;81:355-62.
    • (1997) Circ Res , vol.81 , pp. 355-362
    • MacRitchie, A.N.1    Jun, S.S.2    Chen, Z.3    German, Z.4    Yuhanna, I.S.5    Sherman, T.S.6    Shaul, P.W.7
  • 29
    • 0032589745 scopus 로고    scopus 로고
    • Estrogen receptor alpha mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen
    • Chen Z, Yuhanna IS, Galcheva-Gargova Z, Karas RH, Mendelsohn ME, Shaul PW. Estrogen receptor alpha mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen. J Clin Invest. 1999;103:401-6.
    • (1999) J Clin Invest , vol.103 , pp. 401-406
    • Chen, Z.1    Yuhanna, I.S.2    Galcheva-Gargova, Z.3    Karas, R.H.4    Mendelsohn, M.E.5    Shaul, P.W.6
  • 30
    • 9444257630 scopus 로고    scopus 로고
    • Genistein acutely stimulates nitric oxide synthesis in vascular endothelial cells by a cyclic adenosine 5′-monophosphate-dependent mechanism
    • Liu D, Homan LL, Dillon JS. Genistein acutely stimulates nitric oxide synthesis in vascular endothelial cells by a cyclic adenosine 5′-monophosphate-dependent mechanism. Endocrinology. 2004;145:5532-9.
    • (2004) Endocrinology , vol.145 , pp. 5532-5539
    • Liu, D.1    Homan, L.L.2    Dillon, J.S.3
  • 31
    • 14244263906 scopus 로고    scopus 로고
    • Genistein activates the 3′,5′- cyclic adenosine monophosphate signaling pathway in vascular endothelial cells and protects endothelial barrier function
    • Liu D, Jiang H, Grange RW. Genistein activates the 3′,5′- cyclic adenosine monophosphate signaling pathway in vascular endothelial cells and protects endothelial barrier function. Endocrinology. 2005;146:1312-20.
    • (2005) Endocrinology , vol.146 , pp. 1312-1320
    • Liu, D.1    Jiang, H.2    Grange, R.W.3
  • 32
    • 26444582257 scopus 로고    scopus 로고
    • Dietary soy isoflavone induced increases in antioxidant and eNOS gene expression lead to improved endothelial function and reduced blood pressure in vivo
    • Mahn K, Borras C, Knock GA, Taylor P, Khan IY, Sugden D, Poston L, Ward JP, Sharpe RM, et al. Dietary soy isoflavone induced increases in antioxidant and eNOS gene expression lead to improved endothelial function and reduced blood pressure in vivo. FASEB J. 2005;19:1755-7.
    • (2005) FASEB J , vol.19 , pp. 1755-1757
    • Mahn, K.1    Borras, C.2    Knock, G.A.3    Taylor, P.4    Khan, I.Y.5    Sugden, D.6    Poston, L.7    Ward, J.P.8    Sharpe, R.M.9
  • 33
    • 33846990867 scopus 로고    scopus 로고
    • Chronic administration of genistein improves endothelial dysfunction in spontaneously hypertensive rats: Involvement of eNOS, caveolin and calmodulin expression and NADPH oxidase activity
    • Vera R, Sanchez M, Galisteo M, Villar IC, Jimenez R, Zarzuelo A, Perez-Vizcaino F, Duarte J. Chronic administration of genistein improves endothelial dysfunction in spontaneously hypertensive rats: involvement of eNOS, caveolin and calmodulin expression and NADPH oxidase activity. Clin Sci (Lond). 2007;112:183-91.
    • (2007) Clin Sci (Lond) , vol.112 , pp. 183-191
    • Vera, R.1    Sanchez, M.2    Galisteo, M.3    Villar, I.C.4    Jimenez, R.5    Zarzuelo, A.6    Perez-Vizcaino, F.7    Duarte, J.8
  • 34
    • 14644435162 scopus 로고    scopus 로고
    • The soy isoflavone genistein induces a late but sustained activation of the endothelial nitric oxide-synthase system in vitro
    • Rathel TR, Leikert JF, Vollmar AM, Dirsch VM. The soy isoflavone genistein induces a late but sustained activation of the endothelial nitric oxide-synthase system in vitro. Br J Pharmacol. 2005;144:394-9.
    • (2005) Br J Pharmacol , vol.144 , pp. 394-399
    • Rathel, T.R.1    Leikert, J.F.2    Vollmar, A.M.3    Dirsch, V.M.4
  • 35
    • 0000096792 scopus 로고
    • Second Report of the Ad Hoc Committee on Standards for Nutritional Studies
    • John GB. Second Report of the Ad Hoc Committee on Standards for Nutritional Studies. J Nutr. 1980;110:1726.
    • (1980) J Nutr , vol.110 , pp. 1726
    • John, G.B.1
  • 36
    • 0035812477 scopus 로고    scopus 로고
    • Quantitative analysis of the principle soy isoflavones genistein, daidzein and glycitein, and their primary conjugated metabolites in human plasma and urine using reversed-phase high-performance liquid chromatography with ultraviolet detection
    • Thomas BF, Zeisel SH, Busby MG, Hill JM, Mitchell RA, Scheffler NM, Brown SS, Bloeden LT, Dix KJ, et al. Quantitative analysis of the principle soy isoflavones genistein, daidzein and glycitein, and their primary conjugated metabolites in human plasma and urine using reversed-phase high-performance liquid chromatography with ultraviolet detection. J Chromatogr B Biomed Sci Appl. 2001;760:191-205.
    • (2001) J Chromatogr B Biomed Sci Appl , vol.760 , pp. 191-205
    • Thomas, B.F.1    Zeisel, S.H.2    Busby, M.G.3    Hill, J.M.4    Mitchell, R.A.5    Scheffler, N.M.6    Brown, S.S.7    Bloeden, L.T.8    Dix, K.J.9
  • 38
    • 0037126012 scopus 로고    scopus 로고
    • Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells
    • Venugopal SK, Devaraj S, Yuhanna I, Shaul P, Jialal I. Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells. Circulation. 2002;106:1439-41.
    • (2002) Circulation , vol.106 , pp. 1439-1441
    • Venugopal, S.K.1    Devaraj, S.2    Yuhanna, I.3    Shaul, P.4    Jialal, I.5
  • 39
    • 25844501410 scopus 로고    scopus 로고
    • Diagnosis of cat scratch disease with Bartonella henselae infection in formalin-fixed paraffin-embedded tissues by two different PCR assays
    • Qian X, Jin L, Hayden RT, Macon WR, Lloyd RV. Diagnosis of cat scratch disease with Bartonella henselae infection in formalin-fixed paraffin-embedded tissues by two different PCR assays. Diagn Mol Pathol. 2005;14:146-51.
    • (2005) Diagn Mol Pathol , vol.14 , pp. 146-151
    • Qian, X.1    Jin, L.2    Hayden, R.T.3    Macon, W.R.4    Lloyd, R.V.5
  • 40
    • 34347224378 scopus 로고    scopus 로고
    • Dehydroepiandrosterone protects vascular endothelial cells against apoptosis through a Galphai protein-dependent activation of phosphatidylinositol 3-kinase/Akt and regulation of antiapoptotic Bcl-2 expression
    • Liu D, Si H, Reynolds KA, Zhen W, Jia Z, Dillon JS. Dehydroepiandrosterone protects vascular endothelial cells against apoptosis through a Galphai protein-dependent activation of phosphatidylinositol 3-kinase/Akt and regulation of antiapoptotic Bcl-2 expression. Endocrinology. 2007;148:3068-76.
    • (2007) Endocrinology , vol.148 , pp. 3068-3076
    • Liu, D.1    Si, H.2    Reynolds, K.A.3    Zhen, W.4    Jia, Z.5    Dillon, J.S.6
  • 41
    • 0031741785 scopus 로고    scopus 로고
    • Mechanisms of action of the soy isoflavone genistein: Emerging role for its effects via transforming growth factor beta signaling pathways
    • Kim H, Peterson TG, Barnes S. Mechanisms of action of the soy isoflavone genistein: emerging role for its effects via transforming growth factor beta signaling pathways. Am J Clin Nutr. 1998;68:S1418-25.
    • (1998) Am J Clin Nutr , vol.68
    • Kim, H.1    Peterson, T.G.2    Barnes, S.3
  • 43
    • 0029146781 scopus 로고
    • Bioavailability of soybean isoflavones depends upon gut microflora in women
    • Xu X, Harris KS, Wang HJ, Murphy PA, Hendrich S. Bioavailability of soybean isoflavones depends upon gut microflora in women. J Nutr. 1995;125:2307-15.
    • (1995) J Nutr , vol.125 , pp. 2307-2315
    • Xu, X.1    Harris, K.S.2    Wang, H.J.3    Murphy, P.A.4    Hendrich, S.5
  • 44
    • 0036854547 scopus 로고    scopus 로고
    • Chronic administration of a tyrosine kinase inhibitor restores functional and morphological changes of the basilar artery during chronic hypertension
    • Kitayama J, Kitazono T, Ooboshi H, Ago T, Ohgami T, Fujishima M, Ibayashi S. Chronic administration of a tyrosine kinase inhibitor restores functional and morphological changes of the basilar artery during chronic hypertension. J Hypertens. 2002;20:2205-11.
    • (2002) J Hypertens , vol.20 , pp. 2205-2211
    • Kitayama, J.1    Kitazono, T.2    Ooboshi, H.3    Ago, T.4    Ohgami, T.5    Fujishima, M.6    Ibayashi, S.7
  • 45
    • 0031886546 scopus 로고    scopus 로고
    • Alterations of nitric oxide synthase expression with aging and hypertension in rats
    • Chou TC, Yen MH, Li CY, Ding YA. Alterations of nitric oxide synthase expression with aging and hypertension in rats. Hypertension. 1998;31:643-8.
    • (1998) Hypertension , vol.31 , pp. 643-648
    • Chou, T.C.1    Yen, M.H.2    Li, C.Y.3    Ding, Y.A.4
  • 46
    • 0035678978 scopus 로고    scopus 로고
    • Pulse pressure, endothelium function, and arterial stiffness in spontaneously hypertensive rats
    • Safar M, Chamiot-Clerc P, Dagher G, Renaud JF. Pulse pressure, endothelium function, and arterial stiffness in spontaneously hypertensive rats. Hypertension. 2001;38:1416-21.
    • (2001) Hypertension , vol.38 , pp. 1416-1421
    • Safar, M.1    Chamiot-Clerc, P.2    Dagher, G.3    Renaud, J.F.4
  • 47
    • 13144269618 scopus 로고    scopus 로고
    • Assay of antioxidant and antiinflammatory activity of nitric oxide in vivo
    • Higuchi H, Granger DN, Saito H, Kurose I. Assay of antioxidant and antiinflammatory activity of nitric oxide in vivo. Methods Enzymol. 1999;301:424-36.
    • (1999) Methods Enzymol , vol.301 , pp. 424-436
    • Higuchi, H.1    Granger, D.N.2    Saito, H.3    Kurose, I.4
  • 48
    • 2542532203 scopus 로고    scopus 로고
    • Antiatherogenic effects of endothelium-derived relaxing factor (nitric oxide)
    • Iturry-Yamamoto G, Alves AA, Picon PD. Antiatherogenic effects of endothelium-derived relaxing factor (nitric oxide). Arq Bras Cardiol. 1997;69:349-57.
    • (1997) Arq Bras Cardiol , vol.69 , pp. 349-357
    • Iturry-Yamamoto, G.1    Alves, A.A.2    Picon, P.D.3
  • 50
    • 33745032835 scopus 로고    scopus 로고
    • Role of ERK1/2 in the anti-apoptotic and cardioprotective effects of nitric oxide after myocardial ischemia and reperfusion
    • Li DY, Tao L, Liu H, Christopher TA, Lopez BL, Ma XL. Role of ERK1/2 in the anti-apoptotic and cardioprotective effects of nitric oxide after myocardial ischemia and reperfusion. Apoptosis. 2006;11:923-30.
    • (2006) Apoptosis , vol.11 , pp. 923-930
    • Li, D.Y.1    Tao, L.2    Liu, H.3    Christopher, T.A.4    Lopez, B.L.5    Ma, X.L.6
  • 51
    • 0036269245 scopus 로고    scopus 로고
    • The effect of the phytoestrogen genistein on plasma nitric oxide concentrations, endothelin-1 levels and endothelium dependent vasodilation in postmenopausal women
    • Squadrito F, Altavilla D, Morabito N, Crisafulli A, D'Anna R, Corrado F, Ruggeri P, Campo GM, Calapai G, et al. The effect of the phytoestrogen genistein on plasma nitric oxide concentrations, endothelin-1 levels and endothelium dependent vasodilation in postmenopausal women. Atherosclerosis. 2002;163:339-47.
    • (2002) Atherosclerosis , vol.163 , pp. 339-347
    • Squadrito, F.1    Altavilla, D.2    Morabito, N.3    Crisafulli, A.4    D'Anna, R.5    Corrado, F.6    Ruggeri, P.7    Campo, G.M.8    Calapai, G.9
  • 53
    • 0034807834 scopus 로고    scopus 로고
    • Genome and hormones: An integrated approach to gender differences in physiology
    • Sieck GC. Genome and hormones: an integrated approach to gender differences in physiology. J Appl Physiol. 2001;91:1485-6.
    • (2001) J Appl Physiol , vol.91 , pp. 1485-1486
    • Sieck, G.C.1
  • 54
    • 0036798936 scopus 로고    scopus 로고
    • Estrogen modulation of endothelial nitric oxide synthase
    • Chambliss KL, Shaul PW. Estrogen modulation of endothelial nitric oxide synthase. Endocr Rev. 2002;23:665-86.
    • (2002) Endocr Rev , vol.23 , pp. 665-686
    • Chambliss, K.L.1    Shaul, P.W.2
  • 55
    • 23944461848 scopus 로고    scopus 로고
    • Soy isoflavones improve endothelial function in spontaneously hypertensive rats in an estrogen-independent manner: Role of nitricoxide synthase, superoxide, and cyclooxygenase metabolites
    • Vera R, Galisteo M, Villar IC, Sanchez M, Zarzuelo A, Perez-Vizcaino F, Duarte J. Soy isoflavones improve endothelial function in spontaneously hypertensive rats in an estrogen-independent manner: role of nitricoxide synthase, superoxide, and cyclooxygenase metabolites. J Pharmacol Exp Ther. 2005;314:1300-9.
    • (2005) J Pharmacol Exp Ther , vol.314 , pp. 1300-1309
    • Vera, R.1    Galisteo, M.2    Villar, I.C.3    Sanchez, M.4    Zarzuelo, A.5    Perez-Vizcaino, F.6    Duarte, J.7
  • 57
    • 0344198493 scopus 로고    scopus 로고
    • Estrogen-related receptor alpha 1 up-regulates endothelial nitric oxide synthase expression
    • Sumi D, Ignarro LJ. Estrogen-related receptor alpha 1 up-regulates endothelial nitric oxide synthase expression. Proc Natl Acad Sci USA. 2003;100:14451-6.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 14451-14456
    • Sumi, D.1    Ignarro, L.J.2
  • 58
    • 0034730663 scopus 로고    scopus 로고
    • Bradykinin-regulated interactions of the mitogen-activated protein kinase pathway with the endothelial nitric-oxide synthase
    • Bernier SG, Haldar S, Michel T. Bradykinin-regulated interactions of the mitogen-activated protein kinase pathway with the endothelial nitric-oxide synthase. J Biol Chem. 2000;275:30707-15.
    • (2000) J Biol Chem , vol.275 , pp. 30707-30715
    • Bernier, S.G.1    Haldar, S.2    Michel, T.3
  • 59
    • 0035853775 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate and activation of endothelial nitric-oxide synthase. Differential regulation of Akt and MAP kinase pathways by EDG and bradykinin receptors in vascular endothelial cells
    • Igarashi J, Bernier SG, Michel T. Sphingosine 1-phosphate and activation of endothelial nitric-oxide synthase. Differential regulation of Akt and MAP kinase pathways by EDG and bradykinin receptors in vascular endothelial cells. J Biol Chem. 2001;276:12420-6.
    • (2001) J Biol Chem , vol.276 , pp. 12420-12426
    • Igarashi, J.1    Bernier, S.G.2    Michel, T.3
  • 61
    • 0141831989 scopus 로고    scopus 로고
    • Transcriptional stimulation of the eNOS gene by the stable prostacyclin analogue beraprost is mediated through cAMP-responsive element in vascular endothelial cells: Close link between PGI2 signal and NO pathways
    • Niwano K, Arai M, Tomaru K, Uchiyama T, Ohyama Y, Kurabayashi M. Transcriptional stimulation of the eNOS gene by the stable prostacyclin analogue beraprost is mediated through cAMP-responsive element in vascular endothelial cells: close link between PGI2 signal and NO pathways. Circ Res. 2003;93:523-30.
    • (2003) Circ Res , vol.93 , pp. 523-530
    • Niwano, K.1    Arai, M.2    Tomaru, K.3    Uchiyama, T.4    Ohyama, Y.5    Kurabayashi, M.6
  • 62
    • 0019859301 scopus 로고
    • Similarities of genetic (spontaneous) hypertension
    • Trippodo NC, Frohlich ED. Similarities of genetic (spontaneous) hypertension. Man and rat. Circ Res. 1981;48:309-19.
    • (1981) Man and rat. Circ Res , vol.48 , pp. 309-319
    • Trippodo, N.C.1    Frohlich, E.D.2
  • 63
    • 0038293353 scopus 로고    scopus 로고
    • Insulin signalling pathways in aorta and muscle from two animal models of insulin resistance: The obese middle-aged and the spontaneously hypertensive rats
    • Zecchin HG, Bezerra RM, Carvalheira JB, Carvalho-Filho MA, Metze K, Franchini KG, Saad MJ. Insulin signalling pathways in aorta and muscle from two animal models of insulin resistance: the obese middle-aged and the spontaneously hypertensive rats. Diabetologia. 2003;46:479-91.
    • (2003) Diabetologia , vol.46 , pp. 479-491
    • Zecchin, H.G.1    Bezerra, R.M.2    Carvalheira, J.B.3    Carvalho-Filho, M.A.4    Metze, K.5    Franchini, K.G.6    Saad, M.J.7
  • 64
    • 33746675046 scopus 로고    scopus 로고
    • Phytoestrogen genistein supplementation increases eNOS and decreases caveolin-1 expression in ovariectomized rat hearts
    • Tang YB, Wang QL, Zhu BY, Huang HL, Liao DF. Phytoestrogen genistein supplementation increases eNOS and decreases caveolin-1 expression in ovariectomized rat hearts. Sheng Li Xue Bao. 2005;57:373-8.
    • (2005) Sheng Li Xue Bao , vol.57 , pp. 373-378
    • Tang, Y.B.1    Wang, Q.L.2    Zhu, B.Y.3    Huang, H.L.4    Liao, D.F.5
  • 65
    • 0035073833 scopus 로고    scopus 로고
    • Genistein, daidzein and glycitein inhibit growth and DNA synthesis of aortic smooth muscle cells from stroke-prone spontaneously hypertensive rats
    • Pan W, Ikeda K, Takebe M, Yamori Y. Genistein, daidzein and glycitein inhibit growth and DNA synthesis of aortic smooth muscle cells from stroke-prone spontaneously hypertensive rats. J Nutr. 2001;131:1154-8.
    • (2001) J Nutr , vol.131 , pp. 1154-1158
    • Pan, W.1    Ikeda, K.2    Takebe, M.3    Yamori, Y.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.