메뉴 건너뛰기




Volumn 163, Issue 2, 2014, Pages 151-159

Sex differences and steroid modulation of cardiac iron in a mouse model of iron overload

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTANOLONE; CHOLESTEROL; ESTROGEN; HEMOJUVELIN; IRON; TESTOSTERONE;

EID: 84895077084     PISSN: 19315244     EISSN: 18781810     Source Type: Journal    
DOI: 10.1016/j.trsl.2013.08.004     Document Type: Article
Times cited : (8)

References (49)
  • 1
    • 0041672570 scopus 로고    scopus 로고
    • Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation
    • T. Ganz Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation Blood 102 2003 783 788
    • (2003) Blood , vol.102 , pp. 783-788
    • Ganz, T.1
  • 2
    • 47649126246 scopus 로고    scopus 로고
    • Forging a field: The golden age of iron biology
    • N.C. Andrews Forging a field: the golden age of iron biology Blood 112 2008 219 230
    • (2008) Blood , vol.112 , pp. 219-230
    • Andrews, N.C.1
  • 3
    • 0037460697 scopus 로고    scopus 로고
    • Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis
    • K.R. Bridle, D.M. Frazer, and S.J. Wilkins et al. Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis Lancet 361 2003 669 673
    • (2003) Lancet , vol.361 , pp. 669-673
    • Bridle, K.R.1    Frazer, D.M.2    Wilkins, S.J.3
  • 4
    • 33646370235 scopus 로고    scopus 로고
    • Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
    • J.L. Babitt, F.W. Huang, and D.M. Wrighting et al. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression Nat Genet 38 2006 531 539
    • (2006) Nat Genet , vol.38 , pp. 531-539
    • Babitt, J.L.1    Huang, F.W.2    Wrighting, D.M.3
  • 5
    • 34447137331 scopus 로고    scopus 로고
    • Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance
    • J.L. Babitt, F.W. Huang, Y. Xia, Y. Sidis, N.C. Andrews, and H.Y. Lin Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance J Clin Invest 117 2007 1933 1939
    • (2007) J Clin Invest , vol.117 , pp. 1933-1939
    • Babitt, J.L.1    Huang, F.W.2    Xia, Y.3    Sidis, Y.4    Andrews, N.C.5    Lin, H.Y.6
  • 6
    • 34250865977 scopus 로고    scopus 로고
    • The molecular mechanism of hepcidin-mediated ferroportin down-regulation
    • I. De Domenico, D.M. Ward, and C. Langelier et al. The molecular mechanism of hepcidin-mediated ferroportin down-regulation Mol Biol Cell 18 2007 2569 2578
    • (2007) Mol Biol Cell , vol.18 , pp. 2569-2578
    • De Domenico, I.1    Ward, D.M.2    Langelier, C.3
  • 7
    • 0037184526 scopus 로고    scopus 로고
    • Mechanisms of cellular iron acquisition: Another iron in the fire
    • J. Kaplan Mechanisms of cellular iron acquisition: another iron in the fire Cell 111 2002 603 606
    • (2002) Cell , vol.111 , pp. 603-606
    • Kaplan, J.1
  • 8
    • 78649445085 scopus 로고    scopus 로고
    • Altered hepatic BMP signaling pathway in human HFE hemochromatosis
    • G. Bolondi, C. Garuti, and E. Corradini et al. Altered hepatic BMP signaling pathway in human HFE hemochromatosis Blood Cell Mol Dis 45 2010 308 312
    • (2010) Blood Cell Mol Dis , vol.45 , pp. 308-312
    • Bolondi, G.1    Garuti, C.2    Corradini, E.3
  • 9
    • 9144252017 scopus 로고    scopus 로고
    • Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis
    • G. Papanikolaou, M.E. Samuels, and E.H. Ludwig et al. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis Nat Genet 36 2004 77 82
    • (2004) Nat Genet , vol.36 , pp. 77-82
    • Papanikolaou, G.1    Samuels, M.E.2    Ludwig, E.H.3
  • 10
    • 33144456592 scopus 로고    scopus 로고
    • Hemochromatosis: Genetics and pathophysiology
    • E. Beutler Hemochromatosis: genetics and pathophysiology Annu Rev Med 57 2006 331 347
    • (2006) Annu Rev Med , vol.57 , pp. 331-347
    • Beutler, E.1
  • 11
    • 80052655782 scopus 로고    scopus 로고
    • The molecular pathogenesis of hereditary hemochromatosis
    • J.L. Babitt, and H.Y. Lin The molecular pathogenesis of hereditary hemochromatosis Semin Liver Dis 31 2011 280 292
    • (2011) Semin Liver Dis , vol.31 , pp. 280-292
    • Babitt, J.L.1    Lin, H.Y.2
  • 12
    • 73949098890 scopus 로고    scopus 로고
    • Pathophysiology of transfusional iron overload: Contrasting patterns in thalassemia major and sickle cell disease
    • J.B. Porter Pathophysiology of transfusional iron overload: contrasting patterns in thalassemia major and sickle cell disease Hemoglobin 33 2009 S37 S45
    • (2009) Hemoglobin , vol.33
    • Porter, J.B.1
  • 13
    • 0029843953 scopus 로고    scopus 로고
    • Thalassemia: A global public health problem
    • D.J. Weatherall, and J.B. Clegg Thalassemia: a global public health problem Nat Med 2 1996 847 849
    • (1996) Nat Med , vol.2 , pp. 847-849
    • Weatherall, D.J.1    Clegg, J.B.2
  • 14
    • 0141461407 scopus 로고    scopus 로고
    • L-type Ca(2+) channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy
    • G.Y. Oudit, H. Sun, and M.G. Trivieri et al. L-type Ca(2+) channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy Nat Med 9 2003 1187 1194
    • (2003) Nat Med , vol.9 , pp. 1187-1194
    • Oudit, G.Y.1    Sun, H.2    Trivieri, M.G.3
  • 16
    • 84877978900 scopus 로고    scopus 로고
    • ZIP14 and DMT1 in the liver, pancreas, and heart are differentially regulated by iron deficiency and overload: Implications for tissue iron uptake in iron-related disorders
    • H. Nam, C.Y. Wang, and L. Zhang et al. ZIP14 and DMT1 in the liver, pancreas, and heart are differentially regulated by iron deficiency and overload: implications for tissue iron uptake in iron-related disorders Haematologica 98 2013 1049 1057
    • (2013) Haematologica , vol.98 , pp. 1049-1057
    • Nam, H.1    Wang, C.Y.2    Zhang, L.3
  • 17
    • 1542284114 scopus 로고    scopus 로고
    • The thalassemias: The role of molecular genetics in an evolving global health problem
    • D. Weatherall The thalassemias: the role of molecular genetics in an evolving global health problem Am J Hum Genet 74 2004 385 392
    • (2004) Am J Hum Genet , vol.74 , pp. 385-392
    • Weatherall, D.1
  • 18
    • 44949259826 scopus 로고    scopus 로고
    • Onset of cardiac iron loading in pediatric patients with thalassemia major
    • J.C. Wood, R. Origa, A. Agus, G. Matta, T.D. Coates, and R. Galanello Onset of cardiac iron loading in pediatric patients with thalassemia major Haematologica 93 2008 917 920
    • (2008) Haematologica , vol.93 , pp. 917-920
    • Wood, J.C.1    Origa, R.2    Agus, A.3    Matta, G.4    Coates, T.D.5    Galanello, R.6
  • 19
    • 77953779950 scopus 로고    scopus 로고
    • The effect of deferasirox on cardiac iron in thalassemia major: Impact of total body iron stores
    • J.C. Wood, B.P. Kang, and A. Thompson et al. The effect of deferasirox on cardiac iron in thalassemia major: impact of total body iron stores Blood 116 2010 537 543
    • (2010) Blood , vol.116 , pp. 537-543
    • Wood, J.C.1    Kang, B.P.2    Thompson, A.3
  • 20
    • 20844460608 scopus 로고    scopus 로고
    • Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine
    • C. Borgna-Pignatti, S. Rugolotto, and P. De Stefano et al. Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine Haematologica 89 2004 1187 1193
    • (2004) Haematologica , vol.89 , pp. 1187-1193
    • Borgna-Pignatti, C.1    Rugolotto, S.2    De Stefano, P.3
  • 21
    • 0032496881 scopus 로고    scopus 로고
    • Hereditary hemochromatosis: Gene discovery and its implications for population-based screening
    • W. Burke, E. Thomson, and M.J. Khoury et al. Hereditary hemochromatosis: gene discovery and its implications for population-based screening JAMA 280 1998 172 178
    • (1998) JAMA , vol.280 , pp. 172-178
    • Burke, W.1    Thomson, E.2    Khoury, M.J.3
  • 22
    • 0000104755 scopus 로고
    • Organizing action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig
    • C.H. Phoenix, R.W. Goy, A.A. Gerall, and W.C. Young Organizing action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig Endocrinology 65 1959 369 382
    • (1959) Endocrinology , vol.65 , pp. 369-382
    • Phoenix, C.H.1    Goy, R.W.2    Gerall, A.A.3    Young, W.C.4
  • 23
    • 70350500140 scopus 로고    scopus 로고
    • New tricks by an old dogma: Mechanisms of the organizational/activational hypothesis of steroid-mediated sexual differentiation of brain and behavior
    • M.M. McCarthy, C.L. Wright, and J.M. Schwarz New tricks by an old dogma: mechanisms of the organizational/activational hypothesis of steroid-mediated sexual differentiation of brain and behavior Horm Behav 55 2009 655 665
    • (2009) Horm Behav , vol.55 , pp. 655-665
    • McCarthy, M.M.1    Wright, C.L.2    Schwarz, J.M.3
  • 24
    • 79251500676 scopus 로고    scopus 로고
    • Interdependence of cardiac iron and calcium in a murine model of iron overload
    • M. Otto-Duessel, C. Brewer, and J.C. Wood Interdependence of cardiac iron and calcium in a murine model of iron overload Transl Res 157 2011 92 99
    • (2011) Transl Res , vol.157 , pp. 92-99
    • Otto-Duessel, M.1    Brewer, C.2    Wood, J.C.3
  • 25
    • 56149116825 scopus 로고    scopus 로고
    • Safety and efficacy of combined chelation therapy with deferasirox and deferoxamine in a gerbil model of iron overload
    • M. Otto-Duessel, C. Brewer, I. Gonzalez, H. Nick, and J.C. Wood Safety and efficacy of combined chelation therapy with deferasirox and deferoxamine in a gerbil model of iron overload Acta Haematol 120 2008 123 128
    • (2008) Acta Haematol , vol.120 , pp. 123-128
    • Otto-Duessel, M.1    Brewer, C.2    Gonzalez, I.3    Nick, H.4    Wood, J.C.5
  • 27
    • 19244386891 scopus 로고    scopus 로고
    • Masculine sexual behavior is disrupted in male and female mice lacking a functional estrogen receptor alpha gene
    • S.R. Wersinger, K. Sannen, C. Villalba, D.B. Lubahn, E.F. Rissman, and G.J. De Vries Masculine sexual behavior is disrupted in male and female mice lacking a functional estrogen receptor alpha gene Horm Behav 32 1997 176 183
    • (1997) Horm Behav , vol.32 , pp. 176-183
    • Wersinger, S.R.1    Sannen, K.2    Villalba, C.3    Lubahn, D.B.4    Rissman, E.F.5    De Vries, G.J.6
  • 28
    • 77952547832 scopus 로고    scopus 로고
    • Sex differences in motor behavior in the MPTP mouse model of Parkinson's disease
    • E. Antzoulatos, M.W. Jakowec, G.M. Petzinger, and R.I. Wood Sex differences in motor behavior in the MPTP mouse model of Parkinson's disease Pharmacol Biochem Behav 95 2010 466 472
    • (2010) Pharmacol Biochem Behav , vol.95 , pp. 466-472
    • Antzoulatos, E.1    Jakowec, M.W.2    Petzinger, G.M.3    Wood, R.I.4
  • 29
    • 0034974563 scopus 로고    scopus 로고
    • Coumestrol antagonizes neuroendocrine actions of estrogen via the estrogen receptor alpha
    • D.A. Jacob, J.L. Temple, H.B. Patisaul, L.J. Young, and E.F. Rissman Coumestrol antagonizes neuroendocrine actions of estrogen via the estrogen receptor alpha Exp Biol Med 226 2001 301 306
    • (2001) Exp Biol Med , vol.226 , pp. 301-306
    • Jacob, D.A.1    Temple, J.L.2    Patisaul, H.B.3    Young, L.J.4    Rissman, E.F.5
  • 30
    • 0017412466 scopus 로고
    • The effects of castration and Silastic implants of testosterone on intermale aggression in the mouse
    • M.S. Barkley, and B.D. Goldman The effects of castration and Silastic implants of testosterone on intermale aggression in the mouse Horm Behav 9 1977 32 48
    • (1977) Horm Behav , vol.9 , pp. 32-48
    • Barkley, M.S.1    Goldman, B.D.2
  • 31
    • 77952747961 scopus 로고    scopus 로고
    • The role of hepatocyte hemojuvelin in regulation of bone morphogenic protein-6 and hepcidin expression in vivo
    • A.S. Zhang, J. Gao, D.D. Koeberi, and C.A. Enns The role of hepatocyte hemojuvelin in regulation of bone morphogenic protein-6 and hepcidin expression in vivo J Biol Chem 285 2010 16416 16423
    • (2010) J Biol Chem , vol.285 , pp. 16416-16423
    • Zhang, A.S.1    Gao, J.2    Koeberi, D.D.3    Enns, C.A.4
  • 32
    • 5144227606 scopus 로고    scopus 로고
    • Responsive transporter genes within the murine intestinal-pancreatic axis form a basis of zinc homeostasis
    • J.P. Liuzzi, J.A. Bobo, L.A. Lichten, D.A. Samuelson, and R.J. Cousins Responsive transporter genes within the murine intestinal-pancreatic axis form a basis of zinc homeostasis Proc Natl Acad Sci U S A 101 2004 14355 14360
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 14355-14360
    • Liuzzi, J.P.1    Bobo, J.A.2    Lichten, L.A.3    Samuelson, D.A.4    Cousins, R.J.5
  • 33
    • 0036999353 scopus 로고    scopus 로고
    • Castration reduces mRNA levels for calcium regulatory proteins in rat heart
    • K.L. Golden, J.D. Marsh, and Y. Jiang Castration reduces mRNA levels for calcium regulatory proteins in rat heart Endocrine 19 2002 339 344
    • (2002) Endocrine , vol.19 , pp. 339-344
    • Golden, K.L.1    Marsh, J.D.2    Jiang, Y.3
  • 34
    • 25644457531 scopus 로고    scopus 로고
    • Subtype switching of T-type Ca 2+ channels from Cav3.2 to Cav3.1 during differentiation of embryonic stem cells to cardiac cell lineage
    • E. Mizuta, J. Miake, and S. Yano et al. Subtype switching of T-type Ca 2+ channels from Cav3.2 to Cav3.1 during differentiation of embryonic stem cells to cardiac cell lineage Circ J 69 2005 1284 1289
    • (2005) Circ J , vol.69 , pp. 1284-1289
    • Mizuta, E.1    Miake, J.2    Yano, S.3
  • 35
    • 68949220321 scopus 로고    scopus 로고
    • ER stress controls iron metabolism through induction of hepcidin
    • C. Vecchi, G. Montosi, and K. Zhang et al. ER stress controls iron metabolism through induction of hepcidin Science 325 2009 877 880
    • (2009) Science , vol.325 , pp. 877-880
    • Vecchi, C.1    Montosi, G.2    Zhang, K.3
  • 36
    • 34248557899 scopus 로고    scopus 로고
    • Effect of phlebotomy on hepcidin expression in hemojuvelin-mutant mice
    • J. Krijt, V. Niederkofler, and R. Salie et al. Effect of phlebotomy on hepcidin expression in hemojuvelin-mutant mice Blood Cells Mol Dis 39 2007 92 95
    • (2007) Blood Cells Mol Dis , vol.39 , pp. 92-95
    • Krijt, J.1    Niederkofler, V.2    Salie, R.3
  • 37
    • 50949102412 scopus 로고    scopus 로고
    • Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network
    • M.U. Muckenthaler, B. Galy, and M.W. Hentze Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network Annu Rev Nutr 28 2008 197 213
    • (2008) Annu Rev Nutr , vol.28 , pp. 197-213
    • Muckenthaler, M.U.1    Galy, B.2    Hentze, M.W.3
  • 38
    • 17844404538 scopus 로고    scopus 로고
    • Increased PKA activity and its influence on isoprenaline-stimulated L-type Ca2+ channels in the heart from ovariectomized rats
    • K.W. Kam, G.M. Kravtsov, J. Liu, and T.M. Wong Increased PKA activity and its influence on isoprenaline-stimulated L-type Ca2+ channels in the heart from ovariectomized rats Br J Pharmacol 144 2005 972 981
    • (2005) Br J Pharmacol , vol.144 , pp. 972-981
    • Kam, K.W.1    Kravtsov, G.M.2    Liu, J.3    Wong, T.M.4
  • 39
    • 0030818832 scopus 로고    scopus 로고
    • Increased expression of the cardiac L-type calcium channel in estrogen receptor-deficient mice
    • B.D. Johnson, W. Zheng, K.S. Korach, T. Scheuer, W.A. Catterall, and G.M. Rubanyi Increased expression of the cardiac L-type calcium channel in estrogen receptor-deficient mice J Gen Physiol 110 1997 135 140
    • (1997) J Gen Physiol , vol.110 , pp. 135-140
    • Johnson, B.D.1    Zheng, W.2    Korach, K.S.3    Scheuer, T.4    Catterall, W.A.5    Rubanyi, G.M.6
  • 40
    • 84860745045 scopus 로고    scopus 로고
    • Non-genomic vasorelaxant effects of 17β-estradiol and progesterone in rat aorta are mediated by L-type Ca2+ current inhibition
    • E. Cairrão, E. Alvarez, J.M. Carvas, A.J. Santos-Silva, and I. Verde Non-genomic vasorelaxant effects of 17β-estradiol and progesterone in rat aorta are mediated by L-type Ca2+ current inhibition Acta Pharmacol Sin 33 2012 615 624
    • (2012) Acta Pharmacol Sin , vol.33 , pp. 615-624
    • Cairrão, E.1    Alvarez, E.2    Carvas, J.M.3    Santos-Silva, A.J.4    Verde, I.5
  • 41
    • 58149458142 scopus 로고    scopus 로고
    • High nontransferrin bound iron levels and heart disease in thalassemia major
    • A. Piga, F. Longo, and L. Duca et al. High nontransferrin bound iron levels and heart disease in thalassemia major Am J Hematol 84 2009 29 33
    • (2009) Am J Hematol , vol.84 , pp. 29-33
    • Piga, A.1    Longo, F.2    Duca, L.3
  • 42
    • 10744226568 scopus 로고    scopus 로고
    • Strain and gender modulate hepatic hepcidin 1 and 2 mRNA expression in mice
    • B. Courselaud, M.B. Troadec, and S. Fruchon et al. Strain and gender modulate hepatic hepcidin 1 and 2 mRNA expression in mice Blood Cell Mol Dis 32 2004 283 289
    • (2004) Blood Cell Mol Dis , vol.32 , pp. 283-289
    • Courselaud, B.1    Troadec, M.B.2    Fruchon, S.3
  • 43
    • 2442681406 scopus 로고    scopus 로고
    • Different expression pattern of hepcidin genes in the liver and pancreas of C57BL/6N and DBA/2N mice
    • J. Krijt, R. Cmejla, V. Sýkora, M. Vokurka, D. Vyoral, and E. Necas Different expression pattern of hepcidin genes in the liver and pancreas of C57BL/6N and DBA/2N mice J Hepatol 40 2004 891 896
    • (2004) J Hepatol , vol.40 , pp. 891-896
    • Krijt, J.1    Cmejla, R.2    Sýkora, V.3    Vokurka, M.4    Vyoral, D.5    Necas, E.6
  • 44
    • 0242457714 scopus 로고    scopus 로고
    • Sources of estrogen and their importance
    • E.R. Simpson Sources of estrogen and their importance J Steroid Biochem Mol Biol 86 2003 225 230
    • (2003) J Steroid Biochem Mol Biol , vol.86 , pp. 225-230
    • Simpson, E.R.1
  • 45
    • 82355190860 scopus 로고    scopus 로고
    • Aromatase deficiency confers paradoxical postischemic cardioprotection
    • J.R. Bell, K.M. Mellor, and A.C. Wollermann et al. Aromatase deficiency confers paradoxical postischemic cardioprotection Endocrinology 152 2011 4937 4947
    • (2011) Endocrinology , vol.152 , pp. 4937-4947
    • Bell, J.R.1    Mellor, K.M.2    Wollermann, A.C.3
  • 46
    • 0031906093 scopus 로고    scopus 로고
    • Expression of oestrogen receptor alpha and beta in rat heart: Role of local oestrogen synthesis
    • C. Grohe, S. Kahlert, K. Lobbert, and H. Vetter Expression of oestrogen receptor alpha and beta in rat heart: role of local oestrogen synthesis J Endocrinol 156 1998 R1 R7
    • (1998) J Endocrinol , vol.156
    • Grohe, C.1    Kahlert, S.2    Lobbert, K.3    Vetter, H.4
  • 47
    • 84862736353 scopus 로고    scopus 로고
    • 17β-Estradiol inhibits iron hormone hepcidin through an estrogen responsive element half-site
    • Q. Yang, J. Jian, S. Katz, S.B. Abramson, and X. Huang 17β-Estradiol inhibits iron hormone hepcidin through an estrogen responsive element half-site Endocrinology 153 2012 3170 3178
    • (2012) Endocrinology , vol.153 , pp. 3170-3178
    • Yang, Q.1    Jian, J.2    Katz, S.3    Abramson, S.B.4    Huang, X.5
  • 48
    • 84868193427 scopus 로고    scopus 로고
    • Estrogen regulates iron homeostasis through governing hepatic hepcidin expression via an estrogen response element
    • Y. Hou, S. Zhang, and L. Wang et al. Estrogen regulates iron homeostasis through governing hepatic hepcidin expression via an estrogen response element Gene 511 2012 398 403
    • (2012) Gene , vol.511 , pp. 398-403
    • Hou, Y.1    Zhang, S.2    Wang, L.3
  • 49
    • 84863827034 scopus 로고    scopus 로고
    • Estrogen regulates hepcidin expression via GPR30-BMP6-dependent signaling in hepatocytes
    • Y. Ikeda, S. Tajima, and Y. Izawa-Ishizawa et al. Estrogen regulates hepcidin expression via GPR30-BMP6-dependent signaling in hepatocytes PLoS One 7 2012 e40465
    • (2012) PLoS One , vol.7 , pp. 40465
    • Ikeda, Y.1    Tajima, S.2    Izawa-Ishizawa, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.