Masculine sexual behavior is disrupted in male and female mice lacking a functional estrogen receptor α gene

Hormones and Behavior

Volumn 32, Issue 3, 1997, Pages 176-183

  Wersinger, Scott R ^a   Sannen, Koen ^b   Villalba, Constanza ^b   Lubahn, Dennis B ^c   Rissman, Emilie F ^a   De Vries, Geert J ^b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF MASSACHUSETTS   (United States)

^c UNIVERSITY OF MISSOURI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; TESTOSTERONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; FEMALE; GENOTYPE; GONADECTOMY; HORMONE RECEPTOR INTERACTION; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; LATENT PERIOD; MALE; MASCULINITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR GENE; RECEPTOR UPREGULATION; SEXUAL BEHAVIOR;

EID: 19244386891     PISSN: 0018506X     EISSN: None     Source Type: Journal    
DOI: 10.1006/hbeh.1997.1419     Document Type: Article

References (35)

1. Baum M. J., Vreeburg J. T. M. Copulation in castrated male rats following combined treatment with estradiol and dihydrotestosterone. Science. 182:1973;283-285.
2. Baum M. J., Sodersten P., Vreeburg J. T. Mounting and receptive behavior in the ovariectomized female rat: Influence of estradiol, dihydrotestosterone, and genital anesthetization. Horm. Behav. 5:1974;175-190.
3. Baum M. J., Carroll R. S., Cherry J. A. and Tobet S. A. Steroidal control of behavioral, neuroendocrine, and brain sexual differentiation: Studies in a carnivore, the ferret. J. Neuroendocrinol. 2:1990;401-418.
4. Baum M. J., Everitt B. J. Increased expression ofc-fos. Neuroscience. 50:1992;627-646.
5. Baum M. J., Brown J. J. G., Kica E., Rubin B. S., Johnson R. S., Papaioannou V. E. Effect of a null mutation of thec-fos. Biol. Reprod. 50:1994;1040-1048.
6. Breedlove M. E., Arnold A. P. Sexually dimorphic motor nucleus in the rat lumbar spinal cord: Response to adult hormone manipulation, absence in androgen-insensitive rats. Brain Res. 225:1981;297-307.
7. Burgess L. H., Handa R. J. Hormonal regulation of androgen receptor mRNA in the brain and anterior pituitary gland of the male rat. Br. Res. Mol. Br. Res. 19:1993;31-38.
8. Christensen L. W., Clemens L. G. Intrahypothalamic implants of testosterone or estradiol and resumption of masculine sexual behavior in long-term castrated male rats. Endocrinology. 95:1974;984-990.
9. Christensen L. W., Clemens L. G. Blockade of testosterone-induced mounting behavior in the male rat with intracranial applications of the aromatization inhibitor, androst-1,4,6-triene-3,17-dione. Endocrinology. 97:1975;1545-1551.
10. Davidson J. M. Effects of estrogen on the sexual behavior of male rats. Endocrinology. 84:1969;1365-1372.
11. Davis P. G., Barfield R. J. Activation of masculine sexual behavior by intracranial estradiol benzoate implants in male rats. Neuroendocrinology. 28:1979;217-227.
12. Eddy E. M., Washburn T. F., Bunch D. O., Goulding E. H., Gladen B. C., Lubahn D. B., Korach K. S. Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility. Endocrinology. 137:1996;4796-4805.
13. Edwards D. A., Burge K. G. Early androgen treatment and male and female sexual behavior in mice. Horm. Behav. 2:1971;49-58.
14. Friend K. E., Ang L. W., Shupnik M. A. Estrogen regulates the expression of several different estrogen receptor mRNA isoforms in rat pituitary. Proc. Natl. Acad. Sci. USA. 92:1995;4367-4371.
15. Green S., Walter P., Kumar V., Krust A., Bornert J. M., Argos P., Chambon P. Human oestrogen receptor cDNA: Sequence, expression and homology to v-erb-A. Nature. 320:1986;134-139.
16. Handa R. J., Roselli C. E., Horton L., Resko J. A. The quantitative distribution of cytosolic androgen receptors in microdissected areas of the male rat brain: Effects of estrogen treatment. Endocrinology. 121:1987;233-240.
17. Kuiper G. G. J. M., Enmark E., Pelto-Huikko M., Nilsson S., Gustafsson J. A. Cloning of a novel estrogen receptor expressed in rat prostate and ovary. Proc. Natl. Acad. Sci. USA. 93:1996;5925-5930.
18. Li X., Schwartz P. E., Rissman E. F. Distribution of estrogen receptor β-like immunoreactivity in rat forebrain. Neuroendocrinology. 66:1997;63-67.
19. Lubahn D. B., Moyer J. S., Golding T. S., Couse J. F., Korach K. S., Smithies O. Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Proc. Natl. Acad. Sci. USA. 90:1993;11162-11166.
20. Manning A., McGill T. E. Neonatal androgen and sexual behavior in female house mice. Horm. Behav. 5:1974;19-31.
21. Meisel R. L., Sachs B. D. The physiology of male sexual behavior. The Physiology of Reproduction. 1994;Raven Press, New York. p. 3-105.
22. Mooradian A. D., Morely J. E., Korenman S. G. Biological actions of androgens. Endocrine Rev. 8:1987;1-28.
23. Mosselman S., Polman J., Dijkema R. ERβ: Identification and characterization of a novel human estrogen receptor. FEBS. 392:1996;49-53.
24. Ogawa S., Lubahn D. B., Korach K. S., Pfaff D. W. Behavioral effects of estrogen receptor gene disruption in male mice. Proc. Natl. Acad. Sci. USA. 1997;1476-1481.
25. Ramirez V. D. Characterization of membrane action of steroids. Neuroreports. 1:1992;35-41.
26. Rines J. P., vom Saal F. S. Fetal effects on sexual behavior and aggression in young and old female mice treated with estrogen testosterone. Horm. Behav. 18:1984;117-129.
27. Rissman E. F., Wersinger S. R., Taylor J. A., Lubahn D. B. Estrogen receptor function as revealed by knockout studies: Neuroendocrine and behavioral aspects. Horm. Behav. 31:1997;232-243.
28. Simerly R. B., Chang C., Muramatsu M., Swanson L. W. Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: An in situ hybridization study. J. Comp. Neurol. 294:1990;76-95.
29. Skipper J. K., Young L. J., Bergeron J. M., Tetzlaff M. T., Osborn C. T., Crews D. Identification of an isoform of the estrogen receptor messenger RNA lacking exon four and present in the brain. Proc. Natl. Acad. Sci. USA. 90:1993;7172-7175.
30. Vagell M. E., McGinnis M. Y. The role of aromatization in the restoration of male rat reproductive behavior. J. Neuroendocrinol. 9:1997;415-421.
31. Vale J. R., Ray D., Vale C. A. The interaction of genotype and exogenous neonatal androgen and estrogen: Sex behavior in female mice. Dev. Psychobiology. 7:1973;483-488.
32. vom Saal F. S., Bronson F. H. Sexual characteristics of adult female mice are correlated with their blood testosterone levels during prenatal development. Science. 208:1980;597-599.
33. Wood R. I., Newman S. W. Mating activates androgen receptor-containing neurons in chemosensory pathways of the male Syrian hamster brain. Brain Res. 614:1993;65-77.
34. Wood R. I., Newman S. W. Androgen and estrogen receptors coexist within individual neurons in the brain of the Syrian hamster. Neuroendocrinology. 62:1995;487-497.
35. Wood R. I., Brabec R. K., Swann J. M., Newman S. W. Androgen and estrogen concentrating neurons in chemosensory pathways of the male Syrian hamster brain. Brain Res. 596:1992;89-98.