-
2
-
-
0035896581
-
A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
-
Pigeon C., Ilyin G., Courselaud B., et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J. Biol. Chem. 2001, 276:7811-7819.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 7811-7819
-
-
Pigeon, C.1
Ilyin, G.2
Courselaud, B.3
-
3
-
-
10844258104
-
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
-
Nemeth E., Tuttle M.S., Powelson J., et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004, 306:2090-2093.
-
(2004)
Science
, vol.306
, pp. 2090-2093
-
-
Nemeth, E.1
Tuttle, M.S.2
Powelson, J.3
-
5
-
-
0036910425
-
Two major Smad pathways in TGF-beta superfamily signalling
-
Miyazawa K., Shinozaki M., Hara T., Furuya T., Miyazono K. Two major Smad pathways in TGF-beta superfamily signalling. Genes Cells 2002, 7:1191-1204.
-
(2002)
Genes Cells
, vol.7
, pp. 1191-1204
-
-
Miyazawa, K.1
Shinozaki, M.2
Hara, T.3
Furuya, T.4
Miyazono, K.5
-
6
-
-
77950979752
-
SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression
-
Mleczko-Sanecka K., Casanovas G., Ragab A., et al. SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression. Blood 2010, 115:2657-2665.
-
(2010)
Blood
, vol.115
, pp. 2657-2665
-
-
Mleczko-Sanecka, K.1
Casanovas, G.2
Ragab, A.3
-
7
-
-
33646370235
-
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
-
Babitt J.L., Huang F.W., Wrighting D.M., et al. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat. Genet. 2006, 38:531-539.
-
(2006)
Nat. Genet.
, vol.38
, pp. 531-539
-
-
Babitt, J.L.1
Huang, F.W.2
Wrighting, D.M.3
-
8
-
-
9144252017
-
Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis
-
Papanikolaou G., Samuels M.E., Ludwig E.H., et al. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat. Genet. 2004, 36:77-82.
-
(2004)
Nat. Genet.
, vol.36
, pp. 77-82
-
-
Papanikolaou, G.1
Samuels, M.E.2
Ludwig, E.H.3
-
9
-
-
37249010753
-
Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
-
Yu P.B., Hong C.C., Sachidanandan C., et al. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat. Chem. Biol. 2008, 4:33-41.
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 33-41
-
-
Yu, P.B.1
Hong, C.C.2
Sachidanandan, C.3
-
10
-
-
33644876815
-
A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression
-
Wang R.H., Li C., Xu X., et al. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab. 2005, 2:399-409.
-
(2005)
Cell Metab.
, vol.2
, pp. 399-409
-
-
Wang, R.H.1
Li, C.2
Xu, X.3
-
11
-
-
34447137331
-
Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance
-
Babitt J.L., Huang F.W., Xia Y., et al. Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. J. Clin. Invest. 2007, 117:1933-1939.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 1933-1939
-
-
Babitt, J.L.1
Huang, F.W.2
Xia, Y.3
-
12
-
-
63449103712
-
BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism
-
Andriopoulos B., Corradini E., Xia Y., et al. BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nat. Genet. 2009, 41:482-487.
-
(2009)
Nat. Genet.
, vol.41
, pp. 482-487
-
-
Andriopoulos, B.1
Corradini, E.2
Xia, Y.3
-
13
-
-
63449122819
-
Lack of the bone morphogenetic protein BMP6 induces massive iron overload
-
Meynard D., Kautz L., Darnaud V., et al. Lack of the bone morphogenetic protein BMP6 induces massive iron overload. Nat. Genet. 2009, 41:478-481.
-
(2009)
Nat. Genet.
, vol.41
, pp. 478-481
-
-
Meynard, D.1
Kautz, L.2
Darnaud, V.3
-
14
-
-
51649096725
-
Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver
-
Kautz L., Meynard D., Monnier A., et al. Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver. Blood 2008, 112:1503-1509.
-
(2008)
Blood
, vol.112
, pp. 1503-1509
-
-
Kautz, L.1
Meynard, D.2
Monnier, A.3
-
15
-
-
9344224529
-
A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
-
Feder J.N., Gnirke A., Thomas W., et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat. Genet. 1996, 13:399-408.
-
(1996)
Nat. Genet.
, vol.13
, pp. 399-408
-
-
Feder, J.N.1
Gnirke, A.2
Thomas, W.3
-
16
-
-
0034022636
-
The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22
-
Camaschella C., Roetto A., Cali A., et al. The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22. Nat. Genet. 2000, 25:14-15.
-
(2000)
Nat. Genet.
, vol.25
, pp. 14-15
-
-
Camaschella, C.1
Roetto, A.2
Cali, A.3
-
17
-
-
0034930197
-
A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis
-
Njajou O.T., Vaessen N., Joosse M., et al. A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis. Nat. Genet. 2001, 28:213-214.
-
(2001)
Nat. Genet.
, vol.28
, pp. 213-214
-
-
Njajou, O.T.1
Vaessen, N.2
Joosse, M.3
-
18
-
-
20244388240
-
Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis
-
Roetto A., Papanikolaou G., Politou M., et al. Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat. Genet. 2003, 33:21-22.
-
(2003)
Nat. Genet.
, vol.33
, pp. 21-22
-
-
Roetto, A.1
Papanikolaou, G.2
Politou, M.3
-
19
-
-
0030923653
-
Global prevalence of putative haemochromatosis mutations
-
Merryweather-Clarke A.T., Pointon J.J., Shearman J.D., Robson K.J. Global prevalence of putative haemochromatosis mutations. J. Med. Genet. 1997, 34:275-278.
-
(1997)
J. Med. Genet.
, vol.34
, pp. 275-278
-
-
Merryweather-Clarke, A.T.1
Pointon, J.J.2
Shearman, J.D.3
Robson, K.J.4
-
20
-
-
77955508573
-
Hereditary hemochromatosis: pathogenesis, diagnosis and treatment
-
Pietrangelo A. Hereditary hemochromatosis: pathogenesis, diagnosis and treatment. Gastroenterology 2010.
-
(2010)
Gastroenterology
-
-
Pietrangelo, A.1
-
21
-
-
0037460697
-
Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis
-
Bridle K.R., Frazer D.M., Wilkins S.J., et al. Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis. Lancet 2003, 361:669-673.
-
(2003)
Lancet
, vol.361
, pp. 669-673
-
-
Bridle, K.R.1
Frazer, D.M.2
Wilkins, S.J.3
-
22
-
-
0037564038
-
Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron
-
Gehrke S.G., Kulaksiz H., Herrmann T., et al. Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron. Blood 2003, 102:371-376.
-
(2003)
Blood
, vol.102
, pp. 371-376
-
-
Gehrke, S.G.1
Kulaksiz, H.2
Herrmann, T.3
-
23
-
-
13544250486
-
Hepcidin is decreased in TFR2 hemochromatosis
-
Nemeth E., Roetto A., Garozzo G., Ganz T., Camaschella C. Hepcidin is decreased in TFR2 hemochromatosis. Blood 2005, 105:1803-1806.
-
(2005)
Blood
, vol.105
, pp. 1803-1806
-
-
Nemeth, E.1
Roetto, A.2
Garozzo, G.3
Ganz, T.4
Camaschella, C.5
-
24
-
-
33745755350
-
The effects of erythropoietic activity and iron burden on hepcidin expression in patients with thalassemia major
-
Kattamis A., Papassotiriou I., Palaiologou D., et al. The effects of erythropoietic activity and iron burden on hepcidin expression in patients with thalassemia major. Haematologica 2006, 91:809-812.
-
(2006)
Haematologica
, vol.91
, pp. 809-812
-
-
Kattamis, A.1
Papassotiriou, I.2
Palaiologou, D.3
-
25
-
-
70349494083
-
Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis
-
Corradini E., Garuti C., Montosi G., et al. Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis. Gastroenterology 2009, 137:1489-1497.
-
(2009)
Gastroenterology
, vol.137
, pp. 1489-1497
-
-
Corradini, E.1
Garuti, C.2
Montosi, G.3
-
26
-
-
70350494274
-
BMP/Smad signaling is not enhanced in Hfe-deficient mice despite increased Bmp6 expression
-
Kautz L., Meynard D., Besson-Fournier C., et al. BMP/Smad signaling is not enhanced in Hfe-deficient mice despite increased Bmp6 expression. Blood 2009, 114:2515-2520.
-
(2009)
Blood
, vol.114
, pp. 2515-2520
-
-
Kautz, L.1
Meynard, D.2
Besson-Fournier, C.3
-
27
-
-
23644460325
-
A mouse model of juvenile hemochromatosis
-
Huang F.W., Pinkus J.L., Pinkus G.S., Fleming M.D., Andrews N.C. A mouse model of juvenile hemochromatosis. J. Clin. Invest. 2005, 115:2187-2191.
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 2187-2191
-
-
Huang, F.W.1
Pinkus, J.L.2
Pinkus, G.S.3
Fleming, M.D.4
Andrews, N.C.5
-
28
-
-
23644444316
-
Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload
-
Niederkofler V., Salie R., Arber S. Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload. J. Clin. Invest. 2005, 115:2180-2186.
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 2180-2186
-
-
Niederkofler, V.1
Salie, R.2
Arber, S.3
-
29
-
-
0002413872
-
Tissue iron stores
-
Churchill Livingstone, New York, NY, J.D. Cook (Ed.)
-
Torrance J.D., Bothwell T.H. Tissue iron stores. Methods in Hematology 1980, 104. Churchill Livingstone, New York, NY. J.D. Cook (Ed.).
-
(1980)
Methods in Hematology
, pp. 104
-
-
Torrance, J.D.1
Bothwell, T.H.2
-
30
-
-
24344462594
-
Iron stores modulate hepatic hepcidin expression by an HFE-independent pathway
-
Gehrke S.G., Herrmann T., Kulaksiz H., et al. Iron stores modulate hepatic hepcidin expression by an HFE-independent pathway. Digestion 2005, 72:25-32.
-
(2005)
Digestion
, vol.72
, pp. 25-32
-
-
Gehrke, S.G.1
Herrmann, T.2
Kulaksiz, H.3
-
31
-
-
77957964766
-
Defective bone morphogenic protein signaling underlies hepcidin deficiency in HFE hereditary hemochromatosis
-
Ryan J.D., Ryan E., Fabre A., Lawless M.W., Crowe J. Defective bone morphogenic protein signaling underlies hepcidin deficiency in HFE hereditary hemochromatosis. Hepatology 2010.
-
(2010)
Hepatology
-
-
Ryan, J.D.1
Ryan, E.2
Fabre, A.3
Lawless, M.W.4
Crowe, J.5
-
32
-
-
10744231157
-
Induction and regulation of Smad7 in the gastric mucosa of patients with Helicobacter pylori infection
-
Monteleone G., Del Vecchio Blanco G., Palmieri G., et al. Induction and regulation of Smad7 in the gastric mucosa of patients with Helicobacter pylori infection. Gastroenterology 2004, 126:674-682.
-
(2004)
Gastroenterology
, vol.126
, pp. 674-682
-
-
Monteleone, G.1
Del Vecchio Blanco, G.2
Palmieri, G.3
-
33
-
-
78049463632
-
BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice
-
Corradini E., Schmidt P.J., Meynard D., et al. BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice. Gastroenterology 2010.
-
(2010)
Gastroenterology
-
-
Corradini, E.1
Schmidt, P.J.2
Meynard, D.3
|