메뉴 건너뛰기




Volumn 4, Issue SEP, 2013, Pages

Immunosuppressive MDSCS induced by TLR signaling during infection and role in resolution of inflammation

Author keywords

Bacteria; Inflammation; LPS; Lung; MDSC; Pneumonia; Resolution; TLR

Indexed keywords

CD11B ANTIGEN; GLYCOPROTEIN P 15095; INTERLEUKIN 10; JANUS KINASE; LIPOPOLYSACCHARIDE; MYELOID DIFFERENTIATION FACTOR 88; STAT PROTEIN; TOLL LIKE RECEPTOR;

EID: 84891528390     PISSN: None     EISSN: 22352988     Source Type: Journal    
DOI: 10.3389/fcimb.2013.00052     Document Type: Short Survey
Times cited : (84)

References (76)
  • 1
    • 0037394676 scopus 로고    scopus 로고
    • Neutrophils and acute lung injury
    • doi: 10.1097/01.CCM.0000057843.47705.E8
    • Abraham, E. (2003). Neutrophils and acute lung injury. Crit. Care Med. 31, S195-S199. doi: 10.1097/01.CCM.0000057843.47705.E8
    • (2003) Crit. Care Med. , vol.31
    • Abraham, E.1
  • 2
    • 77958166370 scopus 로고    scopus 로고
    • 4/MyD88-induced CD11b+Gr-1 int F4/80+ non-migratory myeloid cells suppress Th2 effector function in the lung
    • doi: 10.1038/mi.2010.41
    • 4/MyD88-induced CD11b+Gr-1 int F4/80+ non-migratory myeloid cells suppress Th2 effector function in the lung. Mucosal Immunol. 3, 578-593. doi: 10.1038/mi.2010.41
    • (2010) Mucosal Immunol , vol.3 , pp. 578-593
    • Arora, M.1    Poe, S.L.2    Oriss, T.B.3    Krishnamoorthy, N.4    Yarlagadda, M.5    Wenzel6
  • 4
    • 38849133044 scopus 로고    scopus 로고
    • A calculated response: control of inflammation by the innate immune system
    • doi: 10.1172/JCI34431
    • Barton, G. M. (2008). A calculated response: control of inflammation by the innate immune system. J. Clin. Invest. 118, 413-420. doi: 10.1172/JCI34431
    • (2008) J. Clin. Invest. , vol.118 , pp. 413-420
    • Barton, G.M.1
  • 5
    • 0032825194 scopus 로고    scopus 로고
    • Influence of cefodizime on pulmonary inflammatory response to heat-killed Klebsiella pneumoniae in mice
    • Bergeron, Y., Deslauriers, A. M., Ouellet, N., Gauthier, M. C., and Bergeron, M. G. (1999). Influence of cefodizime on pulmonary inflammatory response to heat-killed Klebsiella pneumoniae in mice. Antimicrob. Agents Chemother. 43, 2291-2294.
    • (1999) Antimicrob. Agents Chemother. , vol.43 , pp. 2291-2294
    • Bergeron, Y.1    Deslauriers, A.M.2    Ouellet, N.3    Gauthier, M.C.4    Bergeron, M.G.5
  • 6
    • 0037044792 scopus 로고    scopus 로고
    • Granulocyte/macrophage-colony-stimulating factor (GM-CSF) regulates lung innate immunity to lipopolysaccharide through Akt/Erk activation of NFkappa B and AP-1 in vivo
    • doi: 10.1074/jbc.M207840200
    • Bozinovski, S., Jones, J. E., Vlahos, R., Hamilton, J. A., and Anderson, G. P. (2002). Granulocyte/macrophage-colony-stimulating factor (GM-CSF) regulates lung innate immunity to lipopolysaccharide through Akt/Erk activation of NFkappa B and AP-1 in vivo. J. Biol. Chem. 277, 42808-42814. doi: 10.1074/jbc.M207840200
    • (2002) J. Biol. Chem. , vol.277 , pp. 42808-42814
    • Bozinovski, S.1    Jones, J.E.2    Vlahos, R.3    Hamilton, J.A.4    Anderson, G.P.5
  • 7
    • 0031004806 scopus 로고    scopus 로고
    • Alveolar macrophages are required for protective pulmonary defenses in murine Klebsiella pneumonia: elimination of alveolar macrophages increases neutrophil recruitment but decreases bacterial clearance and survival
    • Broug-Holub, E., Toews, G. B., van Iwaarden, J. F., Strieter, R. M., Kunkel, S. L., Paine, R. 3rd., et al. (1997). Alveolar macrophages are required for protective pulmonary defenses in murine Klebsiella pneumonia: elimination of alveolar macrophages increases neutrophil recruitment but decreases bacterial clearance and survival. Infect. Immun. 65, 1139-1146.
    • (1997) Infect. Immun. , vol.65 , pp. 1139-1146
    • Broug-Holub, E.1    Toews, G.B.2    van Iwaarden, J.F.3    Strieter, R.M.4    Kunkel, S.L.5    Paine III, R.6
  • 8
    • 67149115417 scopus 로고    scopus 로고
    • Inflammation enhances myeloid-derived suppressor cell cross-talk by signaling through Toll-like receptor 4
    • doi: 10.1189/jlb.0708446
    • Bunt, S. K., Clements, V. K., Hanson, E. M., Sinha, P., and Ostrand-Rosenberg, S. (2009). Inflammation enhances myeloid-derived suppressor cell cross-talk by signaling through Toll-like receptor 4. J. Leukoc. Biol. 85, 996-1004. doi: 10.1189/jlb.0708446
    • (2009) J. Leukoc. Biol. , vol.85 , pp. 996-1004
    • Bunt, S.K.1    Clements, V.K.2    Hanson, E.M.3    Sinha, P.4    Ostrand-Rosenberg, S.5
  • 9
    • 76649097628 scopus 로고    scopus 로고
    • Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells
    • doi: 10.1172/JCI40483
    • Chalmin, F., Ladoire, S., Mignot, G., Vincent, J., Bruchard, M., Remy-Martin, J. P., et al. (2010). Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells. J. Clin. Invest. 120, 457-471. doi: 10.1172/JCI40483
    • (2010) J. Clin. Invest. , vol.120 , pp. 457-471
    • Chalmin, F.1    Ladoire, S.2    Mignot, G.3    Vincent, J.4    Bruchard, M.5    Remy-Martin, J.P.6
  • 10
    • 65249089826 scopus 로고    scopus 로고
    • Lipocalin 2 is required for pulmonary host defense against Klebsiella infection
    • doi: 10.4049/jimmunol.0803282
    • Chan, Y. R., Liu, J. S., Pociask, D. A., Zheng, M., Mietzner, T. A., Berger, T., et al. (2009). Lipocalin 2 is required for pulmonary host defense against Klebsiella infection. J. Immunol. 182, 4947-4956. doi: 10.4049/jimmunol.0803282
    • (2009) J. Immunol. , vol.182 , pp. 4947-4956
    • Chan, Y.R.1    Liu, J.S.2    Pociask, D.A.3    Zheng, M.4    Mietzner, T.A.5    Berger, T.6
  • 11
    • 23944437926 scopus 로고    scopus 로고
    • Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL-10 expression
    • doi: 10.1182/blood-2005-02-0494
    • Chauveau, C., Remy, S., Royer, P. J., Hill, M., Tanguy-Royer, S., Hubert, F. X., et al. (2005). Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL-10 expression. Blood 106, 1694-1702. doi: 10.1182/blood-2005-02-0494
    • (2005) Blood , vol.106 , pp. 1694-1702
    • Chauveau, C.1    Remy, S.2    Royer, P.J.3    Hill, M.4    Tanguy-Royer, S.5    Hubert, F.X.6
  • 12
    • 53349099219 scopus 로고    scopus 로고
    • Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein
    • doi: 10.1084/jem.20080132
    • Cheng, P., Corzo, C. A., Luetteke, N., Yu, B., Nagaraj, S., Bui, M. M., et al. (2008). Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein. J. Exp. Med. 205, 2235-2249. doi: 10.1084/jem.20080132
    • (2008) J. Exp. Med. , vol.205 , pp. 2235-2249
    • Cheng, P.1    Corzo, C.A.2    Luetteke, N.3    Yu, B.4    Nagaraj, S.5    Bui, M.M.6
  • 13
    • 78650756969 scopus 로고    scopus 로고
    • Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function
    • doi: 10.1016/j.it.2010.10.002
    • Condamine, T., and Gabrilovich, D. I. (2011). Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function. Trends Immunol. 32, 19-25. doi: 10.1016/j.it.2010.10.002
    • (2011) Trends Immunol , vol.32 , pp. 19-25
    • Condamine, T.1    Gabrilovich, D.I.2
  • 14
    • 60549100505 scopus 로고    scopus 로고
    • Neutrophil recruitment to the lungs during bacterial pneumonia
    • doi: 10.1128/IAI.00832-08
    • Craig, A., Mai, J., Cai, S., and Jeyaseelan, S. (2009). Neutrophil recruitment to the lungs during bacterial pneumonia. Infect. Immun. 77, 568-575. doi: 10.1128/IAI.00832-08
    • (2009) Infect. Immun. , vol.77 , pp. 568-575
    • Craig, A.1    Mai, J.2    Cai, S.3    Jeyaseelan, S.4
  • 15
    • 70349687102 scopus 로고    scopus 로고
    • CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury
    • doi: 10.1172/JCI36498
    • D'Alessio, F. R., Tsushima, K., Aggarwal, N. R., West, E. E., Willett, M. H., Britos, M. F., et al. (2009). CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury. J. Clin. Invest. 119, 2898-2913. doi: 10.1172/JCI36498
    • (2009) J. Clin. Invest. , vol.119 , pp. 2898-2913
    • D'Alessio, F.R.1    Tsushima, K.2    Aggarwal, N.R.3    West, E.E.4    Willett, M.H.5    Britos, M.F.6
  • 16
    • 24944569742 scopus 로고    scopus 로고
    • Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues
    • doi: 10.1038/ni1238
    • Debes, G. F., Arnold, C. N., Young, A. J., Krautwald, S., Lipp, M., Hay, J. B., et al. (2005). Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues. Nat. Immunol. 6, 889-894. doi: 10.1038/ni1238
    • (2005) Nat. Immunol. , vol.6 , pp. 889-894
    • Debes, G.F.1    Arnold, C.N.2    Young, A.J.3    Krautwald, S.4    Lipp, M.5    Hay, J.B.6
  • 17
    • 34250359119 scopus 로고    scopus 로고
    • MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis
    • doi: 10.1084/jem.20062602
    • Delano, M. J., Scumpia, P. O., Weinstein, J. S., Coco, D., Nagaraj, S., Kelly-Scumpia, K. M., et al. (2007). MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis. J. Exp. Med. 204, 1463-1474. doi: 10.1084/jem.20062602
    • (2007) J. Exp. Med. , vol.204 , pp. 1463-1474
    • Delano, M.J.1    Scumpia, P.O.2    Weinstein, J.S.3    Coco, D.4    Nagaraj, S.5    Kelly-Scumpia, K.M.6
  • 18
    • 27844559733 scopus 로고    scopus 로고
    • Exposure to endotoxins during sensitization prevents further endotoxin-induced exacerbation of airway inflammation in a mouse model of allergic asthma
    • doi: 10.1159/000088867
    • Delayre-Orthez, C., Becker, J., de Blay, F., Frossard, N., and Pons, F. (2005). Exposure to endotoxins during sensitization prevents further endotoxin-induced exacerbation of airway inflammation in a mouse model of allergic asthma. Int. Arch. Allergy Immunol. 138, 298-304. doi: 10.1159/000088867
    • (2005) Int. Arch. Allergy Immunol. , vol.138 , pp. 298-304
    • Delayre-Orthez, C.1    Becker, J.2    de Blay, F.3    Frossard, N.4    Pons, F.5
  • 19
    • 57449088879 scopus 로고    scopus 로고
    • Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans
    • doi: 10.1172/JCI36264
    • De Santo, C., Salio, M., Masri, S. H., Lee, L. Y., Dong, T., Speak, A. O., et al. (2008). Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans. J. Clin. Invest. 118, 4036-4048. doi: 10.1172/JCI36264
    • (2008) J. Clin. Invest. , vol.118 , pp. 4036-4048
    • De Santo, C.1    Salio, M.2    Masri, S.H.3    Lee, L.Y.4    Dong, T.5    Speak, A.O.6
  • 20
    • 69149103835 scopus 로고    scopus 로고
    • Endotoxin-induced myeloid-derived suppressor cells inhibit alloimmune responses via heme oxygenase-1
    • doi: 10.1111/j.1600-6143.2009.02757.x
    • De Wilde, V., Van Rompaey, N., Hill, M., Lebrun, J. F., Lemaitre, P., Lhomme, F., et al. (2009). Endotoxin-induced myeloid-derived suppressor cells inhibit alloimmune responses via heme oxygenase-1. Am. J. Transplant. 9, 2034-2047. doi: 10.1111/j.1600-6143.2009.02757.x
    • (2009) Am. J. Transplant. , vol.9 , pp. 2034-2047
    • De Wilde, V.1    Van Rompaey, N.2    Hill, M.3    Lebrun, J.F.4    Lemaitre, P.5    Lhomme, F.6
  • 21
    • 0037121946 scopus 로고    scopus 로고
    • Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen
    • doi: 10.1084/jem.20021340
    • Eisenbarth, S. C., Piggott, D. A., Huleatt, J. W., Visintin, I., Herrick, C. A., and Bottomly, K. (2002). Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J. Exp. Med. 196, 1645-1651. doi: 10.1084/jem.20021340
    • (2002) J. Exp. Med. , vol.196 , pp. 1645-1651
    • Eisenbarth, S.C.1    Piggott, D.A.2    Huleatt, J.W.3    Visintin, I.4    Herrick, C.A.5    Bottomly, K.6
  • 22
    • 84856706929 scopus 로고    scopus 로고
    • Phenotype, function and clinical implications of myeloid-derived suppressor cells in cancer patients
    • doi: 10.1007/s00262-011-1161-9
    • Filipazzi, P., Huber, V., and Rivoltini, L. (2012). Phenotype, function and clinical implications of myeloid-derived suppressor cells in cancer patients. Cancer Immunol. Immunother. 61, 255-263. doi: 10.1007/s00262-011-1161-9
    • (2012) Cancer Immunol. Immunother. , vol.61 , pp. 255-263
    • Filipazzi, P.1    Huber, V.2    Rivoltini, L.3
  • 23
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • doi: 10.1038/nri2506
    • Gabrilovich, D. I., and Nagaraj, S. (2009). Myeloid-derived suppressor cells as regulators of the immune system. Nat. Rev. Immunol. 9, 162-174. doi: 10.1038/nri2506
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 24
    • 84858785703 scopus 로고    scopus 로고
    • Coordinated regulation of myeloid cells by tumours
    • doi: 10.1038/nri3175
    • Gabrilovich, D. I., Ostrand-Rosenberg, S., and Bronte, V. (2012). Coordinated regulation of myeloid cells by tumours. Nat. Rev. Immunol. 12, 253-268. doi: 10.1038/nri3175
    • (2012) Nat. Rev. Immunol. , vol.12 , pp. 253-268
    • Gabrilovich, D.I.1    Ostrand-Rosenberg, S.2    Bronte, V.3
  • 25
    • 49749084305 scopus 로고    scopus 로고
    • Lipopolysaccharides modulate allergen-specific immune regulation in a murine model of mucosal tolerance induction
    • doi: 10.1159/000128583
    • Gerhold, K., Avagyan, A., Reichert, E., Blumchen, K., Wahn, U., and Hamelmann, E. (2008). Lipopolysaccharides modulate allergen-specific immune regulation in a murine model of mucosal tolerance induction. Int. Arch. Allergy Immunol. 147, 25-34. doi: 10.1159/000128583
    • (2008) Int. Arch. Allergy Immunol. , vol.147 , pp. 25-34
    • Gerhold, K.1    Avagyan, A.2    Reichert, E.3    Blumchen, K.4    Wahn, U.5    Hamelmann, E.6
  • 27
    • 70350536358 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cell activation by combined LPS and IFN-gamma treatment impairs DC development
    • doi: 10.1002/eji.200939486
    • Greifenberg, V., Ribechini, E., Rossner, S., and Lutz, M. B. (2009). Myeloid-derived suppressor cell activation by combined LPS and IFN-gamma treatment impairs DC development. Eur. J. Immunol. 39, 2865-2876. doi: 10.1002/eji.200939486
    • (2009) Eur. J. Immunol. , vol.39 , pp. 2865-2876
    • Greifenberg, V.1    Ribechini, E.2    Rossner, S.3    Lutz, M.B.4
  • 28
    • 84863213361 scopus 로고    scopus 로고
    • Anticancer TLR agonists on the ropes
    • doi: 10.1038/nrd3775
    • Guha, M. (2012). Anticancer TLR agonists on the ropes. Nat. Rev. Drug Discov. 11, 503-505. doi: 10.1038/nrd3775
    • (2012) Nat. Rev. Drug Discov. , vol.11 , pp. 503-505
    • Guha, M.1
  • 29
    • 78049268109 scopus 로고    scopus 로고
    • Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival
    • doi: 10.1073/pnas.1003457107
    • Hand, T. W., Cui, W., Jung, Y. W., Sefik, E., Joshi, N. S., Chandele, A., et al. (2010). Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival. Proc. Natl. Acad. Sci. U.S.A. 107, 16601-16606. doi: 10.1073/pnas.1003457107
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 16601-16606
    • Hand, T.W.1    Cui, W.2    Jung, Y.W.3    Sefik, E.4    Joshi, N.S.5    Chandele, A.6
  • 30
    • 0034885547 scopus 로고    scopus 로고
    • CD4(+) T cell effectors can become memory cells with high efficiency and without further division
    • doi: 10.1038/90643
    • Hu, H., Huston, G., Duso, D., Lepak, N., Roman, E., and Swain, S. L. (2001). CD4(+) T cell effectors can become memory cells with high efficiency and without further division. Nat. Immunol. 2, 705-710. doi: 10.1038/90643
    • (2001) Nat. Immunol. , vol.2 , pp. 705-710
    • Hu, H.1    Huston, G.2    Duso, D.3    Lepak, N.4    Roman, E.5    Swain, S.L.6
  • 31
    • 31544446571 scopus 로고    scopus 로고
    • Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host
    • doi: 10.1158/0008-5472.CAN-05-1299
    • Huang, B., Pan, P. Y., Li, Q., Sato, A. I., Levy, D. E., Bromberg, J., et al. (2006). Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host. Cancer Res. 66, 1123-1131. doi: 10.1158/0008-5472.CAN-05-1299
    • (2006) Cancer Res , vol.66 , pp. 1123-1131
    • Huang, B.1    Pan, P.Y.2    Li, Q.3    Sato, A.I.4    Levy, D.E.5    Bromberg, J.6
  • 32
    • 84878756188 scopus 로고    scopus 로고
    • Role of tissue protection in lethal respiratory viral-bacterial coinfection
    • doi: 10.1126/science.1233632
    • Jamieson, A. M., Pasman, L., Yu, S., Gamradt, P., Homer, R. J., Decker, T., et al. (2013). Role of tissue protection in lethal respiratory viral-bacterial coinfection. Science 34, 1230-1234. doi: 10.1126/science.1233632
    • (2013) Science , vol.34 , pp. 1230-1234
    • Jamieson, A.M.1    Pasman, L.2    Yu, S.3    Gamradt, P.4    Homer, R.J.5    Decker, T.6
  • 33
    • 80053092279 scopus 로고    scopus 로고
    • Increased MDSC accumulation and Th2 biased response to influenza A virus infection in the absence of TLR7 in mice
    • doi: 10.1371/journal.pone.0025242
    • Jeisy-Scott, V., Davis, W. G., Patel, J. R., Bowzard, J. B., Shieh, W. J., and Zaki, S. R. (2011). Increased MDSC accumulation and Th2 biased response to influenza A virus infection in the absence of TLR7 in mice. PLoS ONE 6:e25242. doi: 10.1371/journal.pone.0025242
    • (2011) PLoS ONE , vol.6
    • Jeisy-Scott, V.1    Davis, W.G.2    Patel, J.R.3    Bowzard, J.B.4    Shieh, W.J.5    Zaki, S.R.6
  • 34
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
    • doi: 10.1038/ni.1863
    • Kawai, T., and Akira, S. (2010). The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat. Immunol. 11, 373-384. doi: 10.1038/ni.1863
    • (2010) Nat. Immunol. , vol.11 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 35
    • 84865298775 scopus 로고    scopus 로고
    • Dissecting negative regulation of Toll-like receptor signaling
    • doi: 10.1016/j.it.2012.05.002
    • Kondo, T., Kawai, T., and Akira, S. (2012). Dissecting negative regulation of Toll-like receptor signaling. Trends Immunol. 33, 449-458. doi: 10.1016/j.it.2012.05.002
    • (2012) Trends Immunol , vol.33 , pp. 449-458
    • Kondo, T.1    Kawai, T.2    Akira, S.3
  • 36
    • 0035109852 scopus 로고    scopus 로고
    • Neutrophil activation and acute lung injury
    • doi: 10.1097/00075198-200102000-00001
    • Lee, W. L., and Downey, G. P. (2001). Neutrophil activation and acute lung injury. Curr. Opin. Crit. Care 7, 1-7. doi: 10.1097/00075198-200102000-00001
    • (2001) Curr. Opin. Crit. Care , vol.7 , pp. 1-7
    • Lee, W.L.1    Downey, G.P.2
  • 37
    • 0030595339 scopus 로고    scopus 로고
    • The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    • doi: 10.1016/S0092-8674(00)80172-5
    • Lemaitre, B., Nicolas, E., Michaut, L., Reichhart, J. M., and Hoffmann, J. A. (1996). The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86, 973-983. doi: 10.1016/S0092-8674(00)80172-5
    • (1996) Cell , vol.86 , pp. 973-983
    • Lemaitre, B.1    Nicolas, E.2    Michaut, L.3    Reichhart, J.M.4    Hoffmann, J.A.5
  • 38
    • 20644450804 scopus 로고    scopus 로고
    • Negative regulation of toll-like receptor-mediated immune responses
    • doi: 10.1038/nri1630
    • Liew, F. Y., Xu, D., Brint, E. K., and O'Neill, L. A. (2005). Negative regulation of toll-like receptor-mediated immune responses. Nat. Rev. Immunol. 5, 446-458. doi: 10.1038/nri1630
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 446-458
    • Liew, F.Y.1    Xu, D.2    Brint, E.K.3    O'Neill, L.A.4
  • 39
    • 77954514970 scopus 로고    scopus 로고
    • Treatment failure of a TLR-7 agonist occurs due to self-regulation of acute inflammation and can be overcome by IL-10 blockade
    • doi: 10.4049/jimmunol.0902997
    • Lu, H., Wagner, W. M., Gad, E., Yang, Y., Duan, H., Amon, L. M., et al. (2010). Treatment failure of a TLR-7 agonist occurs due to self-regulation of acute inflammation and can be overcome by IL-10 blockade. J. Immunol. 184, 5360-5367. doi: 10.4049/jimmunol.0902997
    • (2010) J. Immunol. , vol.184 , pp. 5360-5367
    • Lu, H.1    Wagner, W.M.2    Gad, E.3    Yang, Y.4    Duan, H.5    Amon, L.M.6
  • 40
    • 77949888327 scopus 로고    scopus 로고
    • Mycobacterium bovis bacillus Calmette-Guerin vaccination mobilizes innate myeloid-derived suppressor cells restraining in vivo T cell priming via IL-1R-dependent nitric oxide production
    • doi: 10.4049/jimmunol.0903348
    • Martino, A., Badell, E., Abadie, V., Balloy, V., Chignard, M., Mistou, M. Y., et al. (2010). Mycobacterium bovis bacillus Calmette-Guerin vaccination mobilizes innate myeloid-derived suppressor cells restraining in vivo T cell priming via IL-1R-dependent nitric oxide production. J. Immunol. 184, 2038-2047. doi: 10.4049/jimmunol.0903348
    • (2010) J. Immunol. , vol.184 , pp. 2038-2047
    • Martino, A.1    Badell, E.2    Abadie, V.3    Balloy, V.4    Chignard, M.5    Mistou, M.Y.6
  • 41
    • 36248957063 scopus 로고    scopus 로고
    • Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues
    • doi: 10.1016/j.cell.2007.09.047
    • Massberg, S., Schaerli, P., Knezevic-Maramica, I., Kollnberger, M., Tubo, N., Moseman, E. A., et al. (2007). Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. Cell 131, 994-1008. doi: 10.1016/j.cell.2007.09.047
    • (2007) Cell , vol.131 , pp. 994-1008
    • Massberg, S.1    Schaerli, P.2    Knezevic-Maramica, I.3    Kollnberger, M.4    Tubo, N.5    Moseman, E.A.6
  • 42
    • 0030831210 scopus 로고    scopus 로고
    • A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    • doi: 10.1038/41131
    • Medzhitov, R., Preston-Hurlburt, P., and Janeway, C. A. Jr. (1997). A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388, 394-397. doi: 10.1038/41131
    • (1997) Nature , vol.388 , pp. 394-397
    • Medzhitov, R.1    Preston-Hurlburt, P.2    Janeway Jr., C.A.3
  • 43
    • 33644836257 scopus 로고    scopus 로고
    • Lung infection-a public health priority
    • doi: 10.1371/journal.pmed.0030076
    • Mizgerd, J. P. (2006). Lung infection-a public health priority. PLoS Med. 3:e76. doi: 10.1371/journal.pmed.0030076
    • (2006) PLoS Med , vol.3
    • Mizgerd, J.P.1
  • 44
    • 39049085847 scopus 로고    scopus 로고
    • Acute lower respiratory tract infection
    • doi: 10.1056/NEJMra074111
    • Mizgerd, J. P. (2008). Acute lower respiratory tract infection. N. Engl. J. Med. 358, 716-727. doi: 10.1056/NEJMra074111
    • (2008) N. Engl. J. Med. , vol.358 , pp. 716-727
    • Mizgerd, J.P.1
  • 45
    • 33744978765 scopus 로고    scopus 로고
    • Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment
    • doi: 10.1016/j.immuni.2006.04.008
    • Nagai, Y., Garrett, K. P., Ohta, S., Bahrun, U., Kouro, T., Akira, S., et al. (2006). Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment. Immunity 24, 801-812. doi: 10.1016/j.immuni.2006.04.008
    • (2006) Immunity , vol.24 , pp. 801-812
    • Nagai, Y.1    Garrett, K.P.2    Ohta, S.3    Bahrun, U.4    Kouro, T.5    Akira, S.6
  • 46
    • 84879637291 scopus 로고    scopus 로고
    • Reciprocal Relationship between Myeloid-Derived Suppressor Cells and T Cells
    • doi: 10.4049/jimmunol.1300654
    • Nagaraj, S., Youn, J. I., and Gabrilovich, D. I. (2013). Reciprocal Relationship between Myeloid-Derived Suppressor Cells and T Cells. J. Immunol. 191, 17-23. doi: 10.4049/jimmunol.1300654
    • (2013) J. Immunol. , vol.191 , pp. 17-23
    • Nagaraj, S.1    Youn, J.I.2    Gabrilovich, D.I.3
  • 47
    • 0347364683 scopus 로고    scopus 로고
    • Hyperactivation of STAT3 is involved in abnormal differentiation of dendritic cells in cancer
    • Nefedova, Y., Huang, M., Kusmartsev, S., Bhattacharya, R., Cheng, P., Salup, R., et al. (2004). Hyperactivation of STAT3 is involved in abnormal differentiation of dendritic cells in cancer. J. Immunol. 172, 464-474.
    • (2004) J. Immunol. , vol.172 , pp. 464-474
    • Nefedova, Y.1    Huang, M.2    Kusmartsev, S.3    Bhattacharya, R.4    Cheng, P.5    Salup, R.6
  • 48
    • 0037453976 scopus 로고    scopus 로고
    • Antibiotic resistance among gram-negative bacilli in US intensive care units: implications for fluoroquinolone use
    • doi: 10.1001/jama.289.7.885
    • Neuhauser, M. M., Weinstein, R. A., Rydman, R., Danziger, L. H., Karam, G., and Quinn, J. P. (2003). Antibiotic resistance among gram-negative bacilli in US intensive care units: implications for fluoroquinolone use. JAMA 289, 885-888. doi: 10.1001/jama.289.7.885
    • (2003) JAMA , vol.289 , pp. 885-888
    • Neuhauser, M.M.1    Weinstein, R.A.2    Rydman, R.3    Danziger, L.H.4    Karam, G.5    Quinn, J.P.6
  • 49
    • 11844254526 scopus 로고    scopus 로고
    • Dynamics of dendritic cell phenotype and interactions with CD4+ T cells in airway inflammation and tolerance
    • Oriss, T. B., Ostroukhova, M., Seguin-Devaux, C., Dixon-McCarthy, B., Stolz, D. B., Watkins, S. C., et al. (2005). Dynamics of dendritic cell phenotype and interactions with CD4+ T cells in airway inflammation and tolerance. J. Immunol. 174, 854-863.
    • (2005) J. Immunol. , vol.174 , pp. 854-863
    • Oriss, T.B.1    Ostroukhova, M.2    Seguin-Devaux, C.3    Dixon-McCarthy, B.4    Stolz, D.B.5    Watkins, S.C.6
  • 50
    • 84877315077 scopus 로고    scopus 로고
    • Resolution of infllammation:an integrated view
    • doi: 10.1002/emmm.201202382
    • Ortega-Gomez, A., Perretti, M., and Soehnlein, O. (2013). Resolution of infllammation:an integrated view. EMBO Mol. Med. 5, 661-674. doi: 10.1002/emmm.201202382
    • (2013) EMBO Mol. Med. , vol.5 , pp. 661-674
    • Ortega-Gomez, A.1    Perretti, M.2    Soehnlein, O.3
  • 51
    • 65249138393 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells: linking inflammation and cancer
    • doi: 10.4049/jimmunol.0802740
    • Ostrand-Rosenberg, S., and Sinha, P. (2009). Myeloid-derived suppressor cells: linking inflammation and cancer. J. Immunol. 182, 4499-4506. doi: 10.4049/jimmunol.0802740
    • (2009) J. Immunol. , vol.182 , pp. 4499-4506
    • Ostrand-Rosenberg, S.1    Sinha, P.2
  • 52
    • 77951258918 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cell heterogeneity and subset definition
    • doi: 10.1016/j.coi.2010.01.021
    • Peranzoni, E., Zilio, S., Marigo, I., Dolcetti, L., Zanovello, P., Mandruzzato, S., et al. (2010). Myeloid-derived suppressor cell heterogeneity and subset definition. Curr. Opin. Immunol. 22, 238-244. doi: 10.1016/j.coi.2010.01.021
    • (2010) Curr. Opin. Immunol. , vol.22 , pp. 238-244
    • Peranzoni, E.1    Zilio, S.2    Marigo, I.3    Dolcetti, L.4    Zanovello, P.5    Mandruzzato, S.6
  • 53
    • 82555193654 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells help protective immunity to Leishmania major infection despite suppressed T cell responses
    • doi: 10.1189/jlb.1110608
    • Pereira, W. F., Ribeiro-Gomes, F. L., Guillermo, L. V., Vellozo, N. S., Montalvao, F., and Dosreis, G. A. (2011). Myeloid-derived suppressor cells help protective immunity to Leishmania major infection despite suppressed T cell responses. J. Leukoc. Biol. 90, 1191-1197. doi: 10.1189/jlb.1110608
    • (2011) J. Leukoc. Biol. , vol.90 , pp. 1191-1197
    • Pereira, W.F.1    Ribeiro-Gomes, F.L.2    Guillermo, L.V.3    Vellozo, N.S.4    Montalvao, F.5    Dosreis, G.A.6
  • 54
    • 84874062334 scopus 로고    scopus 로고
    • STAT1-regulated lung MDSC-like cells produce IL-10 and efferocytose apoptotic neutrophils with relevance in resolution of bacterial pneumonia
    • doi: 10.1038/mi.2012.62
    • Poe, S. L., Arora, M., Oriss, T. B., Yarlagadda, M., Isse, K., Khare, A., et al. (2013). STAT1-regulated lung MDSC-like cells produce IL-10 and efferocytose apoptotic neutrophils with relevance in resolution of bacterial pneumonia. Mucosal Immunol. 6, 189-199. doi: 10.1038/mi.2012.62
    • (2013) Mucosal Immunol , vol.6 , pp. 189-199
    • Poe, S.L.1    Arora, M.2    Oriss, T.B.3    Yarlagadda, M.4    Isse, K.5    Khare, A.6
  • 55
    • 0032509295 scopus 로고    scopus 로고
    • Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene
    • doi: 10.1126/science.282.5396.2085
    • Poltorak, A., He, X., Smirnova, I., Liu, M. Y., Van Huffel, C., Du, X., et al. (1998). Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282, 2085-2088. doi: 10.1126/science.282.5396.2085
    • (1998) Science , vol.282 , pp. 2085-2088
    • Poltorak, A.1    He, X.2    Smirnova, I.3    Liu, M.Y.4    Van Huffel, C.5    Du, X.6
  • 56
    • 0345561540 scopus 로고    scopus 로고
    • Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)
    • doi: 10.1084/jem.189.4.615
    • Qureshi, S. T., Lariviere, L., Leveque, G., Clermont, S., Moore, K. J., Gros, P., et al. (1999). Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4). J. Exp. Med. 189, 615-625. doi: 10.1084/jem.189.4.615
    • (1999) J. Exp. Med. , vol.189 , pp. 615-625
    • Qureshi, S.T.1    Lariviere, L.2    Leveque, G.3    Clermont, S.4    Moore, K.J.5    Gros, P.6
  • 57
    • 4344584558 scopus 로고    scopus 로고
    • Heme oxygenase 1 expression induced by IL-10 requires STAT-3 and phosphoinositol-3 kinase and is inhibited by lipopolysaccharide
    • doi: 10.1189/jlb.0104046
    • Ricchetti, G. A., Williams, L. M., and Foxwell, B. M. (2004). Heme oxygenase 1 expression induced by IL-10 requires STAT-3 and phosphoinositol-3 kinase and is inhibited by lipopolysaccharide. J. Leukoc. Biol. 76, 719-726. doi: 10.1189/jlb.0104046
    • (2004) J. Leukoc. Biol. , vol.76 , pp. 719-726
    • Ricchetti, G.A.1    Williams, L.M.2    Foxwell, B.M.3
  • 58
    • 84875189381 scopus 로고    scopus 로고
    • Molecular pathways: toll-like receptors in the tumor microenvironment-poor prognosis or new therapeutic opportunity
    • doi: 10.1158/1078-0432.CCR-12-0408
    • Ridnour, L. A., Cheng, R. Y., Switzer, C. H., Heinecke, J. L., Ambs, S., Glynn, S., et al. (2013). Molecular pathways: toll-like receptors in the tumor microenvironment-poor prognosis or new therapeutic opportunity. Clin. Cancer Res. 19, 1340-1346. doi: 10.1158/1078-0432.CCR-12-0408
    • (2013) Clin. Cancer Res. , vol.19 , pp. 1340-1346
    • Ridnour, L.A.1    Cheng, R.Y.2    Switzer, C.H.3    Heinecke, J.L.4    Ambs, S.5    Glynn, S.6
  • 59
    • 84872738010 scopus 로고    scopus 로고
    • Flagellin induces myeloid-derived suppressor cells:implications for cystic fibrosis infection in cystic fibrosis lung disease
    • doi: 10.4049/jimmunol.1202144
    • Rieber, N., Brand, A., Hector, A., Graepler-Mainka, U., Ost, M., Schafer, I., et al. (2012). Flagellin induces myeloid-derived suppressor cells:implications for cystic fibrosis infection in cystic fibrosis lung disease. J. Immunol. 190, 1276-1284. doi: 10.4049/jimmunol.1202144
    • (2012) J. Immunol. , vol.190 , pp. 1276-1284
    • Rieber, N.1    Brand, A.2    Hector, A.3    Graepler-Mainka, U.4    Ost, M.5    Schafer, I.6
  • 60
    • 52949118458 scopus 로고    scopus 로고
    • Harmful molecular mechanisms in sepsis
    • doi: 10.1038/nri2402
    • Rittirsch, D., Flierl, M. A., and Ward, P. A. (2008). Harmful molecular mechanisms in sepsis. Nat. Rev. Immunol. 8, 776-787. doi: 10.1038/nri2402
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 776-787
    • Rittirsch, D.1    Flierl, M.A.2    Ward, P.A.3
  • 61
    • 0038448226 scopus 로고    scopus 로고
    • Bacterial lipopolysaccharide signaling through Toll-like receptor 4 suppresses asthma-like responses via nitric oxide synthase 2 activity
    • Rodriguez, D., Keller, A. C., Faquim-Mauro, E. L., de Macedo, M. S., Cunha, F. Q., Lefort, J., et al. (2003). Bacterial lipopolysaccharide signaling through Toll-like receptor 4 suppresses asthma-like responses via nitric oxide synthase 2 activity. J. Immunol. 171, 1001-1008.
    • (2003) J. Immunol. , vol.171 , pp. 1001-1008
    • Rodriguez, D.1    Keller, A.C.2    Faquim-Mauro, E.L.3    de Macedo, M.S.4    Cunha, F.Q.5    Lefort, J.6
  • 62
    • 25844501447 scopus 로고    scopus 로고
    • Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma
    • doi: 10.1084/jem.20050715
    • Rodriguez, P. C., Hernandez, C. P., Quiceno, D., Dubinett, S. M., Zabaleta, J., Ochoa, J. B., et al. (2005). Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma. J. Exp. Med. 202, 931-939. doi: 10.1084/jem.20050715
    • (2005) J. Exp. Med. , vol.202 , pp. 931-939
    • Rodriguez, P.C.1    Hernandez, C.P.2    Quiceno, D.3    Dubinett, S.M.4    Zabaleta, J.5    Ochoa, J.B.6
  • 63
    • 0142250019 scopus 로고    scopus 로고
    • Lipopolysaccharide or whole bacteria block the conversion of inflammatory monocytes into dendritic cells in vivo
    • doi: 10.1084/jem.20030335
    • Rotta, G., Edwards, E. W., Sangaletti, S., Bennett, C., Ronzoni, S., Colombo, M. P., et al. (2003). Lipopolysaccharide or whole bacteria block the conversion of inflammatory monocytes into dendritic cells in vivo. J. Exp. Med. 198, 1253-1263. doi: 10.1084/jem.20030335
    • (2003) J. Exp. Med. , vol.198 , pp. 1253-1263
    • Rotta, G.1    Edwards, E.W.2    Sangaletti, S.3    Bennett, C.4    Ronzoni, S.5    Colombo, M.P.6
  • 64
    • 77954399377 scopus 로고    scopus 로고
    • Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function
    • doi: 10.1084/jem.20091474
    • Sander, L. E., Sackett, S. D., Dierssen, U., Beraza, N., Linke, R. P., and Muller, M. (2010). Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function. J. Exp. Med. 207, 1453-1464. doi: 10.1084/jem.20091474
    • (2010) J. Exp. Med. , vol.207 , pp. 1453-1464
    • Sander, L.E.1    Sackett, S.D.2    Dierssen, U.3    Beraza, N.4    Linke, R.P.5    Muller, M.6
  • 65
    • 48549085973 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells
    • doi: 10.1158/0008-5472.CAN-07-6621
    • Serafini, P., Mgebroff, S., Noonan, K., and Borrello, I. (2008). Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells. Cancer Res. 68, 5439-5449. doi: 10.1158/0008-5472.CAN-07-6621
    • (2008) Cancer Res , vol.68 , pp. 5439-5449
    • Serafini, P.1    Mgebroff, S.2    Noonan, K.3    Borrello, I.4
  • 66
    • 77952865796 scopus 로고    scopus 로고
    • Phagocyte partnership during the onset and resolution of inflammation
    • doi: 10.1038/nri2779
    • Soehnlein, O., and Lindbom, L. (2010). Phagocyte partnership during the onset and resolution of inflammation. Nat. Rev. Immunol. 10, 427-439. doi: 10.1038/nri2779
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 427-439
    • Soehnlein, O.1    Lindbom, L.2
  • 67
    • 75149123468 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine
    • doi: 10.1158/0008-5472.CAN-09-2587
    • Srivastava, M. K., Sinha, P., Clements, V. K., Rodriguez, P., and Ostrand-Rosenberg, S. (2010). Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine. Cancer Res. 70, 68-77. doi: 10.1158/0008-5472.CAN-09-2587
    • (2010) Cancer Res , vol.70 , pp. 68-77
    • Srivastava, M.K.1    Sinha, P.2    Clements, V.K.3    Rodriguez, P.4    Ostrand-Rosenberg, S.5
  • 68
    • 42449106990 scopus 로고    scopus 로고
    • Pulmonary defense mechanisms against pneumonia and sepsis
    • doi: 10.1097/MCP.0b013e3282f76457
    • Tsai, K. S., and Grayson, M. H. (2008). Pulmonary defense mechanisms against pneumonia and sepsis. Curr. Opin. Pulm. Med. 14, 260-265. doi: 10.1097/MCP.0b013e3282f76457
    • (2008) Curr. Opin. Pulm. Med. , vol.14 , pp. 260-265
    • Tsai, K.S.1    Grayson, M.H.2
  • 69
    • 79952113538 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells in parasitic infections
    • doi: 10.1002/eji.201040911
    • Van Ginderachter, J. A., Beschin, A., De Baetselier, P., and Raes, G. (2010). Myeloid-derived suppressor cells in parasitic infections. Eur. J. Immunol. 40, 2976-2985. doi: 10.1002/eji.201040911
    • (2010) Eur. J. Immunol. , vol.40 , pp. 2976-2985
    • Van Ginderachter, J.A.1    Beschin, A.2    De Baetselier, P.3    Raes, G.4
  • 70
    • 0034604129 scopus 로고    scopus 로고
    • The acute respiratory distress syndrome
    • doi: 10.1056/NEJM200005043421806
    • Ware, L. B., and Matthay, M. A. (2000). The acute respiratory distress syndrome. N. Engl. J. Med. 342, 1334-1349. doi: 10.1056/NEJM200005043421806
    • (2000) N. Engl. J. Med. , vol.342 , pp. 1334-1349
    • Ware, L.B.1    Matthay, M.A.2
  • 71
    • 79953679923 scopus 로고    scopus 로고
    • Host defense during Klebsiella pneumonia relies on hematopoietic expressed TLR4 and TLR2
    • doi: 10.1183/09031936.00076510
    • Wieland, C. W., van Lieshout, M. H., Hoogendijk, A. J., and van der Poll, T. (2011). Host defense during Klebsiella pneumonia relies on hematopoietic expressed TLR4 and TLR2. Eur. Respir. J. 37, 848-857. doi: 10.1183/09031936.00076510
    • (2011) Eur. Respir. J. , vol.37 , pp. 848-857
    • Wieland, C.W.1    van Lieshout, M.H.2    Hoogendijk, A.J.3    van der Poll, T.4
  • 72
    • 41349093966 scopus 로고    scopus 로고
    • IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival
    • doi: 10.1182/blood-2007-06-096297
    • Wofford, J. A., Wieman, H. L., Jacobs, S. R., Zhao, Y., and Rathmell, J. C. (2008). IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival. Blood 111, 2101-2111. doi: 10.1182/blood-2007-06-096297
    • (2008) Blood , vol.111 , pp. 2101-2111
    • Wofford, J.A.1    Wieman, H.L.2    Jacobs, S.R.3    Zhao, Y.4    Rathmell, J.C.5
  • 73
    • 37349100945 scopus 로고    scopus 로고
    • Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis
    • doi: 10.1016/j.ccr.2007.12.004
    • Yang, L., Huang, J., Ren, X., Gorska, A. E., Chytil, A., Aakre, M., et al. (2008). Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. Cancer Cell 13, 23-35. doi: 10.1016/j.ccr.2007.12.004
    • (2008) Cancer Cell , vol.13 , pp. 23-35
    • Yang, L.1    Huang, J.2    Ren, X.3    Gorska, A.E.4    Chytil, A.5    Aakre, M.6
  • 74
    • 0030764961 scopus 로고    scopus 로고
    • Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene
    • doi: 10.1074/jbc.272.34.21597
    • Zhang, D. H., Cohn, L., Ray, P., Bottomly, K., and Ray, A. (1997). Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene. J. Biol. Chem. 272, 21597-21603. doi: 10.1074/jbc.272.34.21597
    • (1997) J. Biol. Chem. , vol.272 , pp. 21597-21603
    • Zhang, D.H.1    Cohn, L.2    Ray, P.3    Bottomly, K.4    Ray, A.5
  • 75
    • 0030810155 scopus 로고    scopus 로고
    • The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
    • doi: 10.1016/S0092-8674(00)80240-8
    • Zheng, W., and Flavell, R. A. (1997). The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89, 587-596. doi: 10.1016/S0092-8674(00)80240-8
    • (1997) Cell , vol.89 , pp. 587-596
    • Zheng, W.1    Flavell, R.A.2
  • 76
    • 0344064893 scopus 로고    scopus 로고
    • Stat5 activation plays a critical role in Th2 differentiation
    • doi: 10.1016/S1074-7613(03)00292-9
    • Zhu, J., Cote-Sierra, J., Guo, L., and Paul, W. E. (2003). Stat5 activation plays a critical role in Th2 differentiation. Immunity 19, 739-748. doi: 10.1016/S1074-7613(03)00292-9
    • (2003) Immunity , vol.19 , pp. 739-748
    • Zhu, J.1    Cote-Sierra, J.2    Guo, L.3    Paul, W.E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.