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Volumn 21, Issue 1, 2013, Pages 21-28

Activation of autophagy pathway suppresses the expression of iNOS, IL6 and cell death of LPS-stimulated microglia cells

Author keywords

Autophagy; IL6; iNOS; LPS; Microglia

Indexed keywords

ANTIBODY; AUTOPHAGY PROTEIN 5; BETA INTERFERON; GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE ASSOCIATED PROTEIN LIGHT CHAIN 3 ANTIBODY; MICROTUBULE ASSOCIATED PROTEIN LIGHT CHAIN 3 TYPE II; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; RAPAMYCIN; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; WORTMANNIN;

EID: 84873404266     PISSN: 19769148     EISSN: 20054483     Source Type: Journal    
DOI: 10.4062/biomolther.2012.089     Document Type: Article
Times cited : (79)

References (49)
  • 3
    • 53549096775 scopus 로고    scopus 로고
    • Decreased neuronal autophagy in HIV dementia: A mechanism of indirect neurotoxicity
    • Alirezaei, M., Kiosses, W. B. and Fox, H. S. (2008) Decreased neuronal autophagy in HIV dementia: a mechanism of indirect neurotoxicity. Autophagy 4, 963-966.
    • (2008) Autophagy , vol.4 , pp. 963-966
    • Alirezaei, M.1    Kiosses, W.B.2    Fox, H.S.3
  • 4
    • 63549151154 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced interleukin-6 production is controlled by glycogen synthase kinase-3 and STAT3 in the brain
    • Beurel, E. and Jope, R. S. (2009) Lipopolysaccharide-induced interleukin-6 production is controlled by glycogen synthase kinase-3 and STAT3 in the brain. J. Neuroinflammation 6, 9.
    • (2009) J. Neuroinflammation , vol.6 , pp. 9
    • Beurel, E.1    Jope, R.S.2
  • 5
    • 14044263586 scopus 로고    scopus 로고
    • Cutting edge: Microbial products elicit formation of dendritic cell aggresome-like induced structures in macrophages
    • Canadien, V., Tan, T., Zilber, R., Szeto, J., Perrin, A. J. and Brumell, J. H. (2005) Cutting edge: microbial products elicit formation of dendritic cell aggresome-like induced structures in macrophages. J. Immunol. 174, 2471-2475.
    • (2005) J. Immunol , vol.174 , pp. 2471-2475
    • Canadien, V.1    Tan, T.2    Zilber, R.3    Szeto, J.4    Perrin, A.J.5    Brumell, J.H.6
  • 6
    • 79951565767 scopus 로고    scopus 로고
    • Associations of gene sequence variation and serum levels of C-reactive protein and interleukin-6 with Alzheimer's disease and dementia
    • Eriksson, U. K., Pedersen, N. L., Reynolds, C. A., Hong, M. G., Prince, J. A., Gatz, M., Dickman, P. W. and Bennet, A. M. (2011) Associations of gene sequence variation and serum levels of C-reactive protein and interleukin-6 with Alzheimer's disease and dementia. J. Alzheimers Dis. 23, 361-369.
    • (2011) J. Alzheimers Dis , vol.23 , pp. 361-369
    • Eriksson, U.K.1    Pedersen, N.L.2    Reynolds, C.A.3    Hong, M.G.4    Prince, J.A.5    Gatz, M.6    Dickman, P.W.7    Bennet, A.M.8
  • 7
    • 79952139698 scopus 로고    scopus 로고
    • Nrf2- mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation
    • Fujita, K., Maeda, D., Xiao, Q. and Srinivasula, S. M. (2011) Nrf2- mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation. Proc. Natl. Acad. Sci. USA 108, 1427-1432.
    • (2011) Proc. Natl. Acad. Sci. , vol.108 , pp. 1427-1432
    • Fujita, K.1    Maeda, D.2    Xiao, Q.3    Srinivasula, S.M.4
  • 8
    • 0029076362 scopus 로고
    • Microglia: Intrinsic immuneffector cell of the brain
    • Gehrmann, J., Matsumoto, Y. and Kreutzberg, G. W. (1995) Microglia: intrinsic immuneffector cell of the brain. Brain Res. Rev. 20, 269-287.
    • (1995) Brain Res. Rev , vol.20 , pp. 269-287
    • Gehrmann, J.1    Matsumoto, Y.2    Kreutzberg, G.W.3
  • 9
    • 0028922422 scopus 로고
    • Nitric oxide: Pathophysiological mechanisms
    • Gross, S. S. and Wolin, M. S. (1995) Nitric oxide: pathophysiological mechanisms. Annu. Rev. Physiol. 57, 737-769.
    • (1995) Annu. Rev. Physiol , vol.57 , pp. 737-769
    • Gross, S.S.1    Wolin, M.S.2
  • 11
    • 0036849018 scopus 로고    scopus 로고
    • Microglia as a source and target of cytokines
    • Hanisch, U. K. (2002) Microglia as a source and target of cytokines. Glia 40, 140-155.
    • (2002) Glia , vol.40 , pp. 140-155
    • Hanisch, U.K.1
  • 13
    • 0030664096 scopus 로고    scopus 로고
    • Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene
    • Iadecola, C., Zhang, F., Casey, R., Nagayama, M. and Ross, M. E. (1997) Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene. J. Neurosci. 17, 9157-9164.
    • (1997) J. Neurosci , vol.17 , pp. 9157-9164
    • Iadecola, C.1    Zhang, F.2    Casey, R.3    Nagayama, M.4    Ross, M.E.5
  • 16
    • 34248165446 scopus 로고    scopus 로고
    • NO-induced downregulation of HSP10 and HSP60 expression in the postischemic brain
    • Kim, S. W. and Lee, J. K. (2007) NO-induced downregulation of HSP10 and HSP60 expression in the postischemic brain. J. Neurosci. Res. 85, 1252-1259.
    • (2007) J. Neurosci. Res , vol.85 , pp. 1252-1259
    • Kim, S.W.1    Lee, J.K.2
  • 17
    • 84863078686 scopus 로고    scopus 로고
    • Autophagy suppresses interleukin-1β (IL-1β) signaling by activation of p62 degradation via lysosomal and proteasomal pathways
    • Lee, J., Kim, H. R., Quinley, C., Kim, J., Gonzalez-Navajas, J., Xavier, R. and Raz, E. (2012) Autophagy suppresses interleukin-1β (IL-1β) signaling by activation of p62 degradation via lysosomal and proteasomal pathways. J. Biol. Chem. 287, 4033-4040.
    • (2012) J. Biol. Chem , vol.287 , pp. 4033-4040
    • Lee, J.1    Kim, H.R.2    Quinley, C.3    Kim, J.4    Gonzalez-Navajas, J.5    Xavier, R.6    Raz, E.7
  • 19
    • 1442358797 scopus 로고    scopus 로고
    • Dendritic cell aggresomelike induced structures are dedicated areas for ubiquitination and storage of newly synthesized defective proteins
    • Lelouard, H., Ferrand, V., Marguet, D., Bania, J., Camosseto, V., David, A., Gatti, E. and Pierre, P. (2004) Dendritic cell aggresomelike induced structures are dedicated areas for ubiquitination and storage of newly synthesized defective proteins. J. Cell Biol. 164, 667-675.
    • (2004) J. Cell Biol , vol.164 , pp. 667-675
    • Lelouard, H.1    Ferrand, V.2    Marguet, D.3    Bania, J.4    Camosseto, V.5    David, A.6    Gatti, E.7    Pierre, P.8
  • 20
    • 0037046536 scopus 로고    scopus 로고
    • Transient aggregation of ubiquitinated proteins during dendritic cell maturation
    • Lelouard, H., Gatti E., Cappello, F., Gresser, O., Camosseto, V. and Pierre P. (2002) Transient aggregation of ubiquitinated proteins during dendritic cell maturation. Nature 417, 177-182.
    • (2002) Nature , vol.417 , pp. 177-182
    • Lelouard, H.1    Gatti, E.2    Cappello, F.3    Gresser, O.4    Camosseto, V.5    Pierre, P.6
  • 21
    • 1842583789 scopus 로고    scopus 로고
    • Development by self-digestion: Molecular mechanisms and biological functions of autophagy
    • Levine, B. and Klionsky, D. J. (2004) Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev. Cell 6, 463-477.
    • (2004) Dev. Cell , vol.6 , pp. 463-477
    • Levine, B.1    Klionsky, D.J.2
  • 22
    • 43049179999 scopus 로고    scopus 로고
    • LPS/TLR4 signal transduction pathway
    • Lu, Y. C., Yeh, W. C. and Ohashi, P. S. (2008) LPS/TLR4 signal transduction pathway. Cytokine 42, 145-151.
    • (2008) Cytokine , vol.42 , pp. 145-151
    • Lu, Y.C.1    Yeh, W.C.2    Ohashi, P.S.3
  • 23
    • 0029934759 scopus 로고    scopus 로고
    • Morphine-induced conformational changes in human monocytes, granulocytes, and endothelial cells and in invertebrate immunocytes and microglia are mediated by nitric oxide
    • Magazine, H. I., Liu, Y., Bilfinger, T. V., Fricchione, G. L. and Stefano, G. B. (1996) Morphine-induced conformational changes in human monocytes, granulocytes, and endothelial cells and in invertebrate immunocytes and microglia are mediated by nitric oxide. J. Immunol. 156, 4845-4850.
    • (1996) J. Immunol , vol.156 , pp. 4845-4850
    • Magazine, H.I.1    Liu, Y.2    Bilfinger, T.V.3    Fricchione, G.L.4    Stefano, G.B.5
  • 24
    • 0026514073 scopus 로고
    • Microglial and astroglial reactions to inflammatory lesions of experimental autoimmune encephalomyelitis in the rat central nervous system
    • Matsumoto, Y., Ohmori, K. and Fujiwara, M. (1992) Microglial and astroglial reactions to inflammatory lesions of experimental autoimmune encephalomyelitis in the rat central nervous system. J. Neuroimmunol. 37, 23-33.
    • (1992) J. Neuroimmunol , vol.37 , pp. 23-33
    • Matsumoto, Y.1    Ohmori, K.2    Fujiwara, M.3
  • 25
    • 33845482913 scopus 로고    scopus 로고
    • Characterization of LPS and interferongamma triggered activation-induced cell death in N9 and primary microglial cells: Induction of the mitochondrial gateway by nitric oxide
    • Mayo, L. and Stein, R. (2007) Characterization of LPS and interferongamma triggered activation-induced cell death in N9 and primary microglial cells: induction of the mitochondrial gateway by nitric oxide. Cell Death Differ. 14, 183-186.
    • (2007) Cell Death Differ , vol.14 , pp. 183-186
    • Mayo, L.1    Stein, R.2
  • 26
    • 0023789193 scopus 로고
    • Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
    • McGeer, P. L., Itagaki, S., Boyes, B. E. and McGeer, E. G. (1988) Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 38, 1285-1291.
    • (1988) Neurology , vol.38 , pp. 1285-1291
    • McGeer, P.L.1    Itagaki, S.2    Boyes, B.E.3    McGeer, E.G.4
  • 29
    • 79955969705 scopus 로고    scopus 로고
    • Autophagy failure in Alzheimer's disease--locating the primary defect
    • Nixon, R. A. and Yang, D. S. (2011) Autophagy failure in Alzheimer's disease--locating the primary defect. Neurobiol. Dis. 43, 38-45.
    • (2011) Neurobiol. Dis , vol.43 , pp. 38-45
    • Nixon, R.A.1    Yang, D.S.2
  • 30
    • 77950858637 scopus 로고    scopus 로고
    • Microglia in neurodegenerative disease
    • Perry, V. H., Nicoll, J. A. and Holmes, C. (2010) Microglia in neurodegenerative disease. Nat. Rev. Neurol. 6, 193-201.
    • (2010) Nat. Rev. Neurol , vol.6 , pp. 193-201
    • Perry, V.H.1    Nicoll, J.A.2    Holmes, C.3
  • 31
    • 0028304387 scopus 로고
    • Multiple sclerosis: Immune system molecule expression in the central nervous system
    • Raine, C. S. (1994) Multiple sclerosis: immune system molecule expression in the central nervous system. J. Neuropathol. Exp. Neurol. 53, 328-337.
    • (1994) J. Neuropathol. Exp. Neurol , vol.53 , pp. 328-337
    • Raine, C.S.1
  • 33
    • 84857700077 scopus 로고    scopus 로고
    • Cell death pathways and autophagy in the central nervous system and its involvement in neurodegeneration, immunity and central nervous system infection: To die or not to die--that is the question
    • Rosello, A., Warnes, G. and Meier, U. C. (2012) Cell death pathways and autophagy in the central nervous system and its involvement in neurodegeneration, immunity and central nervous system infection: to die or not to die--that is the question. Clin. Exp. Immunol. 168, 52-57.
    • (2012) Clin. Exp. Immunol , vol.168 , pp. 52-57
    • Rosello, A.1    Warnes, G.2    Meier, U.C.3
  • 35
    • 49749096430 scopus 로고    scopus 로고
    • Small molecule enhancers of autophagy for neurodegenerative diseases
    • Sarkar, S. and Rubinsztein, D. C. (2008) Small molecule enhancers of autophagy for neurodegenerative diseases. Mol. Biosyst. 4, 895-901.
    • (2008) Mol. Biosyst , vol.4 , pp. 895-901
    • Sarkar, S.1    Rubinsztein, D.C.2
  • 36
    • 33947690200 scopus 로고    scopus 로고
    • Long-term cognitive impairment, neuronal loss and reduced cortical cholinergic innervation after recovery from sepsis in a rodent model
    • Semmler, A., Frisch, C., Debeir, T., Ramanathan, M., Okulla, T., Klockgether, T. and Heneka, M. T. (2007) Long-term cognitive impairment, neuronal loss and reduced cortical cholinergic innervation after recovery from sepsis in a rodent model. Exp. Neurol. 204, 733-740.
    • (2007) Exp. Neurol , vol.204 , pp. 733-740
    • Semmler, A.1    Frisch, C.2    Debeir, T.3    Ramanathan, M.4    Okulla, T.5    Klockgether, T.6    Heneka, M.T.7
  • 37
    • 57749100267 scopus 로고    scopus 로고
    • MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages
    • Shi, C. S. and Kehrl, J. H. (2008) MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages. J. Biol. Chem. 283, 33175-33182.
    • (2008) J. Biol. Chem , vol.283 , pp. 33175-33182
    • Shi, C.S.1    Kehrl, J.H.2
  • 38
    • 78649650469 scopus 로고    scopus 로고
    • Kdo2-lipid A, a TLR4-specific agonist, induces de novo sphingolipid biosynthesis in RAW264.7 macrophages, which is essential for induction of autophagy
    • Sims, K., Haynes, C. A., Kelly, S., Allegood, J. C., Wang, E., Momin, A., Leipelt, M., Reichart, D., Glass, C. K., Sullards, M. C. and Merrill, A. H. Jr. (2010) Kdo2-lipid A, a TLR4-specific agonist, induces de novo sphingolipid biosynthesis in RAW264.7 macrophages, which is essential for induction of autophagy. J. Biol. Chem. 285, 38568-38579.
    • (2010) J. Biol. Chem , vol.285 , pp. 38568-38579
    • Sims, K.1    Haynes, C.A.2    Kelly, S.3    Allegood, J.C.4    Wang, E.5    Momin, A.6    Leipelt, M.7    Reichart, D.8    Glass, C.K.9    Sullards, M.C.10    Merrill Jr., A.H.11
  • 39
    • 33748506089 scopus 로고    scopus 로고
    • Human IRGM induces autophagy to eliminate intracellular mycobacteria
    • Singh, S. B., Davis, A. S., Taylor, G. A. and Deretic, V. (2006) Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science 313, 1438-1441.
    • (2006) Science , vol.313 , pp. 1438-1441
    • Singh, S.B.1    Davis, A.S.2    Taylor, G.A.3    Deretic, V.4
  • 40
    • 84155162481 scopus 로고    scopus 로고
    • Role of proinflammatory cytokines released from microglia in neurodegenerative diseases
    • Smith, J. A., Das, A., Ray, S. K. and Banik, N. L. (2012) Role of proinflammatory cytokines released from microglia in neurodegenerative diseases. Brain Res. Bull. 87, 10-20.
    • (2012) Brain Res. Bull , vol.87 , pp. 10-20
    • Smith, J.A.1    Das, A.2    Ray, S.K.3    Banik, N.L.4
  • 41
    • 0026553710 scopus 로고
    • Detection of interleukin-6 and alpha 2-macroglobulin im- munoreactivity in cortex and hippocampus of Alzheimer's disease patients
    • Strauss, S., Bauer, J., Ganter, U., Jonas, U., Berger, M. and Volk, B. (1992) Detection of interleukin-6 and alpha 2-macroglobulin im- munoreactivity in cortex and hippocampus of Alzheimer's disease patients. Lab. Invest. 66, 223-230.
    • (1992) Lab. Invest , vol.66 , pp. 223-230
    • Strauss, S.1    Bauer, J.2    Ganter, U.3    Jonas, U.4    Berger, M.5    Volk, B.6
  • 43
    • 65249108735 scopus 로고    scopus 로고
    • Autophagy genes in immunity
    • Virgin, H. W. and Levine, B. (2009) Autophagy genes in immunity. Nat. Immunol. 10, 461-470.
    • (2009) Nat. Immunol , vol.10 , pp. 461-470
    • Virgin, H.W.1    Levine, B.2
  • 44
    • 0036522967 scopus 로고    scopus 로고
    • Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease
    • Wu, D. C., Jackson-Lewis, V., Vila, M., Tieu, K., Teismann, P., Vadseth, C., Choi, D. K., Ischiropoulos, H. and Przedborski, S. (2002) Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease. J. Neurosci. 22, 1763-1771.
    • (2002) J. Neurosci , vol.22 , pp. 1763-1771
    • Wu, D.C.1    Jackson-Lewis, V.2    Vila, M.3    Tieu, K.4    Teismann, P.5    Vadseth, C.6    Choi, D.K.7    Ischiropoulos, H.8    Przedborski, S.9
  • 45
    • 34447643958 scopus 로고    scopus 로고
    • Toll-like receptor 4 is a sensor for au tophagy associated with innate immunity
    • Xu, Y., Jagannath, C., Liu, X. D., Sharafkhaneh, A., Kolodziejska, K. E. and Eissa, N. T. (2007) Toll-like receptor 4 is a sensor for au tophagy associated with innate immunity. Immunity 27, 135-144.
    • (2007) Immunity , vol.27 , pp. 135-144
    • Xu, Y.1    Jagannath, C.2    Liu, X.D.3    Sharafkhaneh, A.4    Kolodziejska, K.E.5    Eissa, N.T.6
  • 46
    • 26444558061 scopus 로고    scopus 로고
    • Inhibition of the cerebral ischemic injury by ethyl pyruvate with a wide therapeutic window
    • Yu, Y. M., Kim, J. B., Lee, K. W., Kim, S. Y., Han, P. L. and Lee, J. K. (2005) Inhibition of the cerebral ischemic injury by ethyl pyruvate with a wide therapeutic window. Stroke 36, 2238-2243.
    • (2005) Stroke , vol.36 , pp. 2238-2243
    • Yu, Y.M.1    Kim, J.B.2    Lee, K.W.3    Kim, S.Y.4    Han, P.L.5    Lee, J.K.6
  • 47
    • 84863259013 scopus 로고    scopus 로고
    • Autophagy plays an essential role in the clearance of Pseudomonas aeruginosa by alveolar macrophages
    • Yuan, K., Huang, C., Fox, J., Laturnus, D., Carlson, E., Zhang, B., Yin, Q., Gao, H. and Wu, M. (2012) Autophagy plays an essential role in the clearance of Pseudomonas aeruginosa by alveolar macrophages. J. Cell Sci. 125, 507-515.
    • (2012) J. Cell Sci , vol.125 , pp. 507-515
    • Yuan, K.1    Huang, C.2    Fox, J.3    Laturnus, D.4    Carlson, E.5    Zhang, B.6    Yin, Q.7    Gao, H.8    Wu, M.9
  • 48
    • 0029670958 scopus 로고    scopus 로고
    • Aminoguanidine ameliorates and L-arginine worsens brain damage from intraluminal middle cerebral artery occlusion
    • Zhang, F., Casey, R. M., Ross, M. E. and Iadecola, C. (1996) Aminoguanidine ameliorates and L-arginine worsens brain damage from intraluminal middle cerebral artery occlusion. Stroke 27, 317-323.
    • (1996) Stroke , vol.27 , pp. 317-323
    • Zhang, F.1    Casey, R.M.2    Ross, M.E.3    Iadecola, C.4
  • 49
    • 78650510609 scopus 로고    scopus 로고
    • MTOR: From growth signal integration to cancer, diabetes and ageing
    • Zoncu, R., Efeyan, A. and Sabatini, D. M. (2011) mTOR: from growth signal integration to cancer, diabetes and ageing. Nature Rev. Mol. Cell Biol. 12, 21-35.
    • (2011) Nature Rev. Mol. Cell Biol , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3


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