β-Mangostin induces p53-dependent G2/M cell cycle arrest and apoptosis through ROS mediated mitochondrial pathway and NfkB suppression in MCF-7 cells

Journal of Functional Foods

Volumn 6, Issue 1, 2014, Pages 290-304

  Syam, Suvitha ^a,b   Bustamam, Ahmad ^a   Abdullah, Rasedee ^a   Sukari, Mohamed Aspollah ^a   Hashim, Najihah Mohd ^b   Ghaderian, Mostafa ^b   Rahmani, Mawardi ^a   Mohan, Syam ^c   Abdelwahab, Siddig Ibrahim ^c   Ali, Hapipah Mohd ^b  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^b UNIVERSITY OF MALAYA   (Malaysia)

^c JAZAN UNIVERSITY   (Saudi Arabia)

Author keywords

Mangostin; Apoptosis; Bax Bcl 2; Cratoxylum arborescens; NF kB; P53

Indexed keywords

EID: 84895067902     PISSN: 17564646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jff.2013.10.018     Document Type: Article

References (50)

1. Althaus F.R., Kleczowska H.E., Malanga M., Müntener C.R., Pleschke J.M., Ebner M., Auer B. Poly ADP-ribosylation: A DNA break signal mechanism. Molecular and Cellular Biochemistry 1999, 193:5-11.
2. Ando T., Kawabe T., Ohara H., Ducommun B., Itoh M., Okamoto T. Involvement of the interaction between p21 and proliferating cell nuclear antigen for the maintenance of G2/M arrest after DNA damage. Journal of Biological Chemistry 2001, 276:42971-42977.
3. Bennett G.J., Lee H.-H. Xanthones from guttiferae. Phytochemistry 1989, 28:967-998.
4. Bulavin D.V., Higashimoto Y., Popoff I.J., Gaarde W.A., Basrur V., Potapova O., Appella E., Fornace A.J. Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase. Nature 2001, 411:102-107.
5. Bumrungpert A., Kalpravidh R.W., Suksamrarn S., Chaivisuthangkura A., Chitchumroonchokchai C., Failla M.L. Bioaccessibility, biotransformation, and transport of α-mangostin from Garcinia mangostana (Mangosteen) using simulated digestion and Caco-2 human intestinal cells. Molecular Nutrition & Food Research 2009, 53:S54-S61.
6. Cai J., Yang J., Jones D. Mitochondrial control of apoptosis: The role of cytochrome c. Biochimica et Biophysica Acta (BBA)-Bioenergetics 1998, 1366:139-149.
7. Coultas L., Terzano S., Thomas T., Voss A., Reid K., Stanley E.G., Scott C.L., Bouillet P., Bartlett P., Ham J. Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis. Journal of Cell Science 2007, 120:2044-2052.
8. Daniel P.T., Koert U., Schuppan J. Apoptolidin: Induction of apoptosis by a natural product. Angewandte Chemie International Edition 2006, 45:872-893.
9. Desagher S., Martinou J.-C. Mitochondria as the central control point of apoptosis. Trends in Cell Biology 2000, 10:369-377.
10. Elmore S. Apoptosis: A review of programmed cell death. Toxicologic Pathology 2007, 35:495-516.
11. Ferlay J., Shin H.R., Bray F., Forman D., Mathers C., Parkin D.M. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. International Journal of Cancer 2010, 127:2893-2917.
12. Garrido C., Schmitt E., Candé C., Vahsen N., Parcellier A., Kroemer G. HSP27 and HSP70: Potentially oncogenic apoptosis inhibitors. Cell Cycle 2003, 2:578-583.
13. Gross A., McDonnell J.M., Korsmeyer S.J. BCL-2 family members and the mitochondria in apoptosis. Genes & Development 1999, 13:1899-1911.
14. Gutierrez-Orozco F., Failla M.L. Biological activities and bioavailability of Mangosteen xanthones: A critical review of the current evidence. Nutrients 2013, 5:3163-3183.
15. Ham Y.-M., Yoon W.-J., Park S.-Y., Song G.-P., Jung Y.-H., Jeon Y.-J., Kang S.-M., Kim K.-N. Quercitrin protects against oxidative stress-induced injury in lung fibroblast cells via up-regulation of Bcl-xL. Journal of Functional Foods 2012, 4:253-262.
16. Hartwell L.H., Kastan M.B. Cell cycle control and cancer. Science 1994, 266:1821-1828.
17. Hengartner M.O. The biochemistry of apoptosis. Nature 2000, 407:770-776.
18. Hung S.-H., Shen K.-H., Wu C.-H., Liu C.-L., Shih Y.-W. α-Mangostin suppresses PC-3 human prostate carcinoma cell metastasis by inhibiting matrix metalloproteinase-2/9 and urokinase-plasminogen expression through the JNK signaling pathway. Journal of Agricultural and Food Chemistry 2009, 57:1291-1298.
19. Isa N.M., Abdul A.B., Abdelwahab S.I., Abdullah R., Sukari M.A., Kamalidehghan B., Hadi A.H.A., Mohan S. Boesenbergin A, a chalcone from Boesenbergia rotunda induces apoptosis via mitochondrial dysregulation and cytochrome c release in A549 cells in vitro: Involvement of HSP70 and Bcl2/Bax signalling pathways. Journal of Functional Foods 2012, 5:87-97.
20. Jia N., Xiong Y.L., Kong B., Liu Q., Xia X. Radical scavenging activity of black currant (Ribes nigrum L.) extract and its inhibitory effect on gastric cancer cell proliferation via induction of apoptosis. Journal of Functional Foods 2012, 4:382-390.
21. Kaomongkolgit R., Chaisomboon N., Pavasant P. Apoptotic effect of alpha-mangostin on head and neck squamous carcinoma cells. Archives of Oral Biology 2011, 56:483-490.
22. Kintzios S.E., Barberaki M.G. Plants that fight cancer 2004, CRC Press.
23. Kroemer G. Mitochondrial control of apoptosis: An introduction. Biochemical and Biophysical Research Communications 2003, 304:433-435.
24. Lee A.C.-L., Hsiao W.-C., Wright D.E., Chong S.Y., Leow S.K., Ho C.-T., Kao C.-F., Lo Y.-C. Induction of GADD45α expression contributes to the anti-proliferative effects of polymethoxyflavones on colorectal cancer cells. Journal of Functional Foods 2013, 5:616-624.
25. Lee Y.B., Ko K.C., Shi M.D., Liao Y.C., Chiang T.A., Wu P.F., Shih Y.X., Shih Y.W. α Mangostin, a novel dietary Xanthone, suppresses TPA-mediated MMP-2 and MMP-9 expressions through the ERK signaling pathway in MCF-7 human breast adenocarcinoma cells. Journal of Food Science 2010, 75:H13-H23.
26. Li X., Lewis M.T., Huang J., Gutierrez C., Osborne C.K., Wu M.-F., Hilsenbeck S.G., Pavlick A., Zhang X., Chamness G.C. Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy. Journal of the National Cancer Institute 2008, 100:672-679.
27. Li H., Zhu H., Xu C.-J., Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 1998, 94:491-501.
28. Liang Y., Yan C., Schor N.F. Apoptosis in the absence of caspase 3. Oncogene 2001, 20:6570-6578.
29. Lin M.-T., Chang C.-C., Chen S.-T., Chang H.-L., Su J.-L., Chau Y.-P., Kuo M.-L. Cyr61 expression confers resistance to apoptosis in breast cancer MCF-7 cells by a mechanism of NF-κB-dependent XIAP up-regulation. Journal of Biological Chemistry 2004, 279:24015-24023.
30. Lowe S.W., Lin A.W. Apoptosis in cancer. Carcinogenesis 2000, 21:485-495.
31. Matsumoto K., Akao Y., Kobayashi E., Ohguchi K., Ito T., Tanaka T., Iinuma M., Nozawa Y. Induction of apoptosis by xanthones from Mangosteen in human leukemia cell lines. Journal of Natural Products 2003, 66:1124-1127.
32. Matsumoto K., Akao Y., Ohguchi K., Ito T., Tanaka T., Iinuma M., Nozawa Y. Xanthones induce cell-cycle arrest and apoptosis in human colon cancer DLD-1 cells. Bioorganic & Medicinal Chemistry 2005, 13:6064-6069.
33. McCurrach M.E., Connor T.M., Knudson C.M., Korsmeyer S.J., Lowe S.W. Bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis. Proceedings of the National Academy of Sciences 1997, 94:2345-2349.
34. Mohan S., Abdelwahab S.I., Kamalidehghan B., Syam S., May K.S., Harmal N.S.M., Shafifiyaz N., Hadi A.H.A., Hashim N.M., Rahmani M. Involvement of NF-κB and Bcl2/Bax signaling pathways in the apoptosis of MCF7 cells induced by a Xanthone compound Pyranocycloartobiloxanthone A. Phytomedicine 2012, 19:1007-1015.
35. Mohan S., Bustamam A., Ibrahim S., Al-Zubairi A.S., Aspollah M., Abdullah R., Elhassan M.M. In vitro ultramorphological assessment of apoptosis on CEMss induced by linoleic acid-rich fraction from typhonium flagelliforme tuber. Evidence-Based Complementary and Alternative Medicine 2011, 2011.
36. Nabandith V., Suzui M., Morioka T., Kaneshiro T., Kinjo T., Matsumoto K., Akao Y., Iinuma M., Yoshimi N. inhibitory effects of crude alpha-mangostin, a Xanthone derivative, on two different categories of colon preneoplastic lesions induced by 1,2-dimethylhydrazine in the rat. Asian Pacific Journal of Cancer Prevention 2004, 5:433-438.
37. Nelson W.G., Kastan M.B. DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways. Molecular and Cellular Biology 1994, 14:1815-1823.
38. Pedro M., Cerqueira F., Sousa M.E., Nascimento M.S.J., Pinto M. Xanthones as inhibitors of growth of human cancer cell lines and their effects on the proliferation of human lymphocytes in vitro. Bioorganic & Medicinal Chemistry 2002, 10:3725-3730.
39. Sampath P.D., Vijayaragavan K. Ameliorative prospective of alpha-mangostin, a xanthone derivative from Garcinia mangostana against β-adrenergic cathecolamine-induced myocardial toxicity and anomalous cardiac TNF-α and COX-2 expressions in rats. Experimental and Toxicologic Pathology 2008, 60:357-364.
40. Sato A., Fujiwara H., Oku H., Ishiguro K., Ohizumi Y. α-Mangostin induces Ca 2+-ATPase-dependent apoptosis via mitochondrial pathway in PC12 cells. Journal of Pharmacological Sciences 2004, 95:33-40.
41. Saxena N., Hartman M., Bhoo-Pathy N., Lim J.N., Aw T.-C., Iau P., Taib N.A., Lee S.-C., Yip C.-H., Verkooijen H.M. Breast cancer in South East asia: Comparison of presentation and outcome between a middle income and a high income country. World Journal of Surgery 2012, 36:2838-2846.
42. Shibata M.-A., Iinuma M., Morimoto J., Kurose H., Akamatsu K., Okuno Y., Akao Y., Otsuki Y. α-Mangostin extracted from the pericarp of the mangosteen (Garcinia mangostana Linn) reduces tumor growth and lymph node metastasis in an immunocompetent xenograft model of metastatic mammary cancer carrying a p53 mutation. BMC Medicine 2011, 9:69.
43. Sim W., Ee G., Lim C., Sukari M. Cratoxylum glaucum and Cratoxylum arborescens (Guttiferae)-two potential source of antioxidant agents. Asian Journal of Chemistry 2011, 23:569-572.
44. Simstein R., Burow M., Parker A., Weldon C., Beckman B. Apoptosis, chemoresistance, and breast cancer: Insights from the MCF-7 cell model system. Experimental Biology and Medicine 2003, 228:995-1003.
45. Singh B., Bhat T.K., Singh B. Potential therapeutic applications of some antinutritional plant secondary metabolites. Journal of Agricultural and Food Chemistry 2003, 51:5579-5597.
46. Taher M., Susanti D., Rezali M.F., Zohri F.S.A., Ichwan S.J.A., Alkhamaiseh S.I., Ahmad F. Apoptosis, antimicrobial and antioxidant activities of phytochemicals from Garcinia malaccensis Hk. f. Asian Pacific Journal of Tropical Medicine 2012, 5:136-141.
47. Walsh J.G., Cullen S.P., Sheridan C., Lüthi A.U., Gerner C., Martin S.J. Executioner caspase-3 and caspase-7 are functionally distinct proteases. Proceedings of the National Academy of Sciences 2008, 105:12815-12819.
48. Yang H.-L., Chen C.-S., Chang W.-H., Lu F.-J., Lai Y.-C., Chen C.-C., Hseu T.-H., Kuo C.-T., Hseu Y.-C. Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by Antrodia camphorata. Cancer Letters 2006, 231:215-227.
49. Yeung F., Hoberg J.E., Ramsey C.S., Keller M.D., Jones D.R., Frye R.A., Mayo M.W. Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase. The EMBO Journal 2004, 23:2369-2380.
50. Zamzami N., Kroemer G. Apoptosis: Mitochondrial membrane permeabilisation - the (w)hole story?. Current Biology 2003, 13:R71-R73.