2′,4′-dihydroxy-6′-methoxy-3′,5′- dimethylchalcone protects the impaired insulin secretion induced by glucotoxicity in pancreatic β-cells

Journal of Agricultural and Food Chemistry

Volumn 62, Issue 7, 2014, Pages 1602-1608

  Hu, Ying Chun ^a,b   Hao, Dong Ming ^c   Zhou, Lu Xian ^b   Zhang, Zhe ^b   Huang, Nan ^b   Hoptroff, Michael ^b   Lu, Yan Hua ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Unilever R and D   (China)

^c Tianjin Union Medicine Centre   (China)

Author keywords

2 ,4 dihydroxy 6 methoxy 3 ,5 dimethylchalcone; glucotoxicity; insulin secretion; oxidative stress; PDX 1

Indexed keywords

GLUCOSE; MOBILE SECURITY; NITRIC OXIDE; OXIDATIVE STRESS; PHYSIOLOGY;

DOSE-DEPENDENT MANNER; GLUCOSE-STIMULATED INSULIN SECRETIONS; GLUCOTOXICITY; INSULIN SECRETION; METHOXY; PANCREATIC BETA CELLS; PANCREATIC ISLET; PDX-1;

INSULIN;

MYRTACEAE;

2',4' DIHYDROXY 6' METHOXY 3',5' DIMETHYLCHALCONE; 2',4'-DIHYDROXY-6'-METHOXY-3',5'-DIMETHYLCHALCONE; CHALCONE DERIVATIVE; GLUCOSE; GLUCOSE TRANSPORTER 2; HOMEODOMAIN PROTEIN; INSULIN; PANCREATIC AND DUODENAL HOMEOBOX 1 PROTEIN; PLANT EXTRACT; PROTECTIVE AGENT; TRANSACTIVATOR PROTEIN;

ANIMAL; ARTICLE; CHEMISTRY; DRUG EFFECT; GENE EXPRESSION; GENETICS; METABOLISM; MYRTACEAE; PANCREAS ISLET BETA CELL; RAT; SECRETION (PROCESS); TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CHALCONES; GENE EXPRESSION; GLUCOSE; GLUCOSE TRANSPORTER TYPE 2; HOMEODOMAIN PROTEINS; INSULIN; INSULIN-SECRETING CELLS; MYRTACEAE; PLANT EXTRACTS; PROTECTIVE AGENTS; RATS; TRANS-ACTIVATORS;

EID: 84894417375     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf405365d     Document Type: Article

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