Induction of apoptosis in K562 human leukemia cells by 2′,4′- dihydroxy-6′-methoxy-3′,5′-dimethylchalcone

Leukemia Research

Volumn 29, Issue 8, 2005, Pages 887-892

  Ye, Chun Lin ^a   Qian, Feng ^a   Wei, Dong Zhi ^a   Lu, Yan Hua ^a   Liu, Jian Wen ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Apoptosis; Bcl 2 Bax; Cleistocalyx operculatus; Flavonoids; K562

Indexed keywords

2,4 DIHYDROXY 6 METHOXY 3,5 DIMETHYLCHALCONE; 4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; CHALCONE DERIVATIVE; CLEISTOCALYX OPERCULATUS EXTRACT; DNA; PLANT EXTRACT; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL STRAIN K 562; CHROMATIN CONDENSATION; CLEISTOCALYX OPERCULATUS; CONTROLLED STUDY; CYTOTOXICITY; DIPLOIDY; DNA CONTENT; DOWN REGULATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; INCUBATION TIME; LEUKEMIA; MEDICINAL PLANT; PRIORITY JOURNAL; PROTEIN EXPRESSION; STAINING; WESTERN BLOTTING;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL LINE, TUMOR; CELL NUCLEUS; CELL SURVIVAL; CHALCONE; CHALCONES; COLONY-FORMING UNITS ASSAY; DIPLOIDY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; K562 CELLS; LEUKEMIA, ERYTHROBLASTIC, ACUTE; MOLECULAR STRUCTURE; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 20544458556     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2005.01.006     Document Type: Article

References (36)

1. M. Abdulla, and P. Gruber Role of diet modification in cancer prevention Biofactors 12 2000 45 51
2. A. Mori, C. Nishino, N. Enoki, and S. Tawata Cytotoxicity of plant flavonoids against Hela cells Phytochemistry 27 1988 1017 1020
3. T. Hirano, K. Oka, and M. Akiba Antiproliferative effects of synthetic and naturally occurring flavonoids on tumor cells of the human breast carcinoma cell ZR-75-1 Res Commun Chem Pathol Pharmacol 64 1989 69 78
4. Y.M. Lin, F.C. Chen, and K.H. Lee Hinokiflavone, a cytotoxicity of the related biflavonoids Planta Med 55 1989 166 168
5. M. Cushman, and D. Nagarathnam Cytotoxicities of some flavonoid analogues J Nat Prod 54 1991 1556 1660
6. C.C. Yit, and N.P. Das Cytotoxic effect of butein on human colon adenocarcinoma cell proliferation Cancer Lett 82 1994 65 72
7. Y. Satomi Inhibitory effects of 3-methyl-3-hydroxychalcone on proliferation of human malignant tumor cells and on skin carcinogenesis Int J Cancer 55 1993 506 514
8. L.W. Wattenberg, J.B. Coccia, and A.R. Galhaith Inhibition of carcinogen-induced pulmonary and mammary carcinogenesis by chalcone administered after carcinogen exposure Cancer Lett 83 1994 165 169
9. Edwards ML, Stemerick DM, Sunkara SP. Chalcone derivatives useful in controlling growth of tumor tissue and their preparation. European Patent Application EP 288,794 (1988).
10. A.Y.H. Woo, M.M.Y. Waye, H.S. Kwan, M.C.Y. Chan, C.F. Chau, and C.H.K. Cheng Inhibition of ATPases by Cleistocalyx operculatus a possible mechanism for the cardiotonic actiond of the herb Vascul Pharmacol 38 2002 163 168
11. C.L. Ye, Y.H. Lu, and D.Z. Wei Flavonoids from Cleistocalyx operculatus Phytochemistry 65 2004 445 447
12. T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays J Immunol Methods 65 1983 55 63
13. J.D. Liu, S.H. Chen, C.L. Lin, S.H. Tsai, and Y.C. Liang Inhibition of melanoma growth and metastasis by combination with (-)-epigallocatechin-3- gallate and dacarbazine in mice J Cell Biochem 83 2001 631 642
14. Y.L. Niu, S.L. Cao, Y.Y. Jiang, W. Du, and Y.F. Zhao Apoptosis of K562 cell induced by N-phosphoryl dipeptide methyl ester Chin J Cancer 21 2002 823 827
15. M.M. Bradford A rapid and sensitive method for the quantitation of microgrm quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72 1976 248 254
16. R.J. Anto, K. Sukumara, G. Kuttan, M.N.A. Rao, V. Subbaraju, and R. Kuttan Anticancer and antioxidant of synthetic chalcones and related compounds Cancer Lett 97 1995 33 37
17. V.S. Parmar, N.K. Sharma, M. Husain, A.C. Watterson, J. Kumar, and L.A. Samuelson Synthesis, characterization and in vitro anti-invasive activity screening of polyphenolic and heterocyclic compounds Bioorg Med Chem 11 2003 913 929
18. J.C. Le Bail, C. Pouget, C. Fagnere, J.P. Basly, A.J. Chulia, and G. Habrioux Chalcones are potent inhibitors of aromatase and 17β- hydroxysteroid dehydrogenase activities Life Sci 68 2001 751 761
19. G. Saydam, H. Aydin, F. Sahin, O. Kucukoglu, E. Ericiyas, and E. Terzioglu Cytotoxic and inhibitory effects of 4′,4′-dihydroxy chalcone (RVC-588) on proliferation of human leukemic HL-60 cells Leuk Res 27 2003 57 64
20. N. Nam, Y. Kim, Y. You, D. Hong, H. Kim, and B. Ahn Cytotoxic 2′,4′-dihydroxychalcones with unexpected antiangiogenic activity Eur J Med Chem 38 2003 179 187
21. L. Cipák, P. Rauko, E. Miadoková, I. Cipáková , and L. Novotný Effects of flavonoids on cisplatin-induced apoptosis of HL-60 and L1210 leukemia cells Leuk Res 27 2003 65 72
22. J.L. Liesveld, C.N. Abboud, C.H. Lu, C. McNair, A. Menon, and A. Smith Flavonoid effects on normal and leukemic cells Leuk Res 27 2003 517 527
23. L. Cipák, L. Novotný, I. Cipáková, and P. Rauko Differential modulation of cisplatin and doxorubicin efficacies in leukemia cells by flavonoids Nutr Res 23 2003 1045 1057
24. S. Kajimoto, N. Takanashi, T. Kajimoto, M. Xu, J.D. Cao, and Y. Masuda Sophoranone, extracted from a traditional Chinese medicine Shan Dou Gen, induces apoptosis in human leukemia U937 cells via formation of reactive oxygen species and opening of mitochondrial permeability transition pores Int J Cancer 99 2002 879 890
25. 2+-dependent endonuclease Biochem Pharmacol 63 2002 225 236
26. W. Gorczyca, J. Gong, B. Ardelt, F. Trafanos, and Z. Darzynkiewicz The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents Cancer Res 53 1993 3186 3192
27. M.J.J. Mccabe, and S. Orrenius Genistein induces apoptosis in immature human thymocytes by inhibiting topoisomerase-II Biochem Biophys Res Commun 194 1993 944 950
28. G. Bergamaschi, Rosti v, M. Danova, L. Ponchio, C. Lucotti, and M. Cazzola Inhibition of tyrosine phosphorylation induce apoptosis in human leukemia cells Leukemia 7 1993 2012 2018
29. S.M. Kuo Antiproliferative potency of structurally distinct dietary flavonoid on human colon cancer cells Cancer Lett 110 1996 41 48
30. Y.Q. Wei, X. Zhao, Y. Kariya, H. Rukata, K. Teshigawara, and A. Uchida Induction of apoptosis by quercetin: Involvement of heat shock protein Cancer Res 54 1994 4952 4957
31. B. Csokay, N. Prajda, G. Weber, and E. Olah Molecular mechanisms in the antiproliferative action of quercetin Life Sci 60 1997 2157 2163
32. F.L. Chan, Z.Y. Choi, Chan PSF, and Y. Huang Induction of apoptosis in prostate cancer cell lines by a flavonoid, baicalin Cancer Lett 160 2000 218 219
33. K. Iwashita, M. Kobori, K. Yamaki, and T. Tsushida Falvonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells Biosci Biotechnol Biochem 64 2000 1813 1820
34. M. Kobori, K. Iwashita, H. Shinmoto, and T. Tsushida Phloretin-induced apoptosis in B16 melanoma 4A5 cells and HL-60 human leukemia cells Biosci Biotechnol Biochem 63 1999 719 725
35. D.M. Hockembery, Z.N. Oltvai, X.M. Yin, C.L. Milliman, and S. Korsmeyer Bcl-2 functions in a qutioxidant pathway to prevent apoptosis Cell 75 1993 241 251
36. Z.N. Oltral, C.L. Millman, and S.J. korsmeyer Bcl-2 heterodimerizes in vivo with a conserved homolog Bax that accelerates programmed cell death Cell 74 1993 609 619