Migfilin and filamin as regulators of integrin activation in endothelial cells and neutrophils

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Das, Mitali ^a   Ithychanda, Sujay Subbayya ^a   Qin, Jun ^a   Plow, Edward F ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2BBETA3 INTEGRIN; BETA1 INTEGRIN; BETA2 INTEGRIN; BETA3 INTEGRIN; FILAMIN; INTEGRIN; MIGFILIN; UNCLASSIFIED DRUG; ACTIN BINDING PROTEIN; BETA INTEGRIN; CELL ADHESION MOLECULE; CONTRACTILE PROTEIN; CYTOSKELETON PROTEIN; FBLIM1 PROTEIN, HUMAN; FILAMINS;

ARTICLE; CELL MIGRATION; CELL SPREADING; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; NEUTROPHIL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; CELL ADHESION; FLOW CYTOMETRY; METABOLISM; VASCULAR ENDOTHELIUM;

CELL ADHESION; CELL ADHESION MOLECULES; CONTRACTILE PROTEINS; CYTOSKELETAL PROTEINS; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FLOW CYTOMETRY; HUMANS; INTEGRIN BETA CHAINS; INTEGRINS; MICROFILAMENT PROTEINS; NEUTROPHILS;

EID: 80054774358     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026355     Document Type: Article

References (56)

1. Kiema T, Lad Y, Jiang P, Oxley CL, Baldassarre M, et al. (2006) The molecular basis of filamin binding to integrins and competition with talin. Mol Cell 21: 337-347.
2. Takala H, Nurminen E, Nurmi SM, Aatonen M, Strandin T, et al. (2008) Beta2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding. Blood 112: 1853-1862 blood-2007-12-127795 [pii]; doi:10.1182/blood-2007-12-127795.
3. Lad Y, Jiang P, Ruskamo S, Harburger DS, Ylanne J, et al. (2008) Structural basis of the migfilin-filamin interaction and competition with integrin beta tails. J Biol Chem 283: 35154-35163.
4. Ithychanda SS, Das M, Ma YQ, Ding K, Wang X, et al. (2009) Migfilin, a molecular switch in regulation of integrin activation. J Biol Chem 284: 4713-4722 M807719200 [pii]; doi:10.1074/jbc.M807719200.
5. Ithychanda SS, Hsu D, Li H, Yan L, Liu DD, et al. (2009) Identification and characterization of multiple similar ligand-binding repeats in filamin: implication on filamin-mediated receptor clustering and cross-talk. J Biol Chem 284: 35113-35121 M109.060954 [pii];doi:10.1074/jbc.M109.060954.
6. Calderwood DA, Huttenlocher A, Kiosses WB, Rose DM, Woodside DG, et al. (2001) Increased filamin binding to beta-integrin cytoplasmic domains inhibits cell migration. Nat Cell Biol 3: 1060-1068 ncb1201-1060 [pii] doi:10.1038/ncb1201-1060.
7. Wegener KL, Partridge AW, Han J, Pickford AR, Liddington RC, et al. (2007) Structural basis of integrin activation by talin. Cell 128: 171-182.
8. Nieves B, Jones CW, Ward R, Ohta Y, Reverte CG, et al. (2010) The NPIY motif in the integrin beta1 tail dictates the requirement for talin-1 in outside-in signaling. J Cell Sci 123: 1216-1226 jcs.056549 [pii]; doi:10.1242/jcs.056549.
9. Tu Y, Wu S, Shi X, Chen K, Wu C, (2003) Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation. Cell 113: 37-47.
10. Takafuta T, Saeki M, Fujimoto TT, Fujimura K, Shapiro SS, (2003) A new member of the LIM protein family binds to filamin B and localizes at stress fibers. J Biol Chem 278: 12175-12181 M209339200 [pii] doi:10.1074/jbc.M209339200.
11. Zhang Y, Tu Y, Gkretsi V, Wu C, (2006) Migfilin interacts with vasodilator-stimulated phosphoprotein (VASP) and regulates VASP localization to cell-matrix adhesions and migration. J Biol Chem 281: 12397-12407 M512107200 [pii]; doi:10.1074/jbc.M512107200.
12. Zhao J, Zhang Y, Ithychanda SS, Tu Y, Chen K, et al. (2009) Migfilin interacts with Src and contributes to cell-matrix adhesion-mediated survival signaling. J Biol Chem 284: 34308-34320 M109.045021 [pii]; doi:10.1074/jbc.M109.045021.
13. Akazawa H, Kudoh S, Mochizuki N, Takekoshi N, Takano H, et al. (2004) A novel LIM protein Cal promotes cardiac differentiation by association with CSX/NKX2-5. J Cell Biol 164: 395-405 jcb.200309159 [pii] doi:10.1083/jcb.200309159.
14. Harburger DS, Bouaouina M, Calderwood DA, (2009) Kindlin-1 and-2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects. J Biol Chem 284: 11485-11497 M809233200 [pii]; doi:10.1074/jbc.M809233200.
15. Ma YQ, Qin J, Wu C, Plow EF, (2008) Kindlin-2 (Mig-2): a co-activator of beta3 integrins. J Cell Biol 181: 439-446.
16. Woods VL Jr, Oh EH, Mason D, McMillan R, (1984) Autoantibodies against the platelet glycoprotein IIb/IIIa complex in patients with chronic ITP. Blood 63: 368-375.
17. Cunningham CC, Gorlin JB, Kwiatkowski DJ, Hartwig JH, Janmey PA, et al. (1992) Actin-binding protein requirement for cortical stability and efficient locomotion. Science 255: 325-327.
18. Collins SJ, Gallo RC, Gallagher RE, (1977) Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture. Nature 270: 347-349.
19. Collins SJ, Ruscetti FW, Gallagher RE, Gallo RC, (1978) Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds. Proc Natl Acad Sci U S A 75: 2458-2462.
20. Huberman E, Callaham MF, (1979) Induction of terminal differentiation in human promyelocytic leukemia cells by tumor-promoting agents. Proc Natl Acad Sci U S A 76: 1293-1297.
21. Scarpati EM, DiCorleto PE, (1996) Identification of a thrombin response element in the human platelet-derived growth factor B-chain (c-sis) promoter. J Biol Chem 271: 3025-3032.
22. Pluskota E, Soloviev DA, Szpak D, Weber C, Plow EF, (2008) Neutrophil apoptosis: selective regulation by different ligands of integrin alphaMbeta2. J Immunol 181: 3609-3619.
23. Bandyopadhyay S, Ashraf MZ, Daher P, Howe PH, DiCorleto PE, (2007) HOXA9 participates in the transcriptional activation of E-selectin in endothelial cells. Mol Cell Biol 27: 4207-4216 MCB.00052-07 [pii]; doi:10.1128/MCB.00052-07.
24. Zandy NL, Playford M, Pendergast AM, (2007) Abl tyrosine kinases regulate cell-cell adhesion through Rho GTPases. Proc Natl Acad Sci U S A 104: 17686-17691 0703077104 [pii]; doi:10.1073/pnas.0703077104.
25. Carrigan SO, Pink DB, Stadnyk AW, (2007) Neutrophil transepithelial migration in response to the chemoattractant fMLP but not C5a is phospholipase D-dependent and related to the use of CD11b/CD18. J Leukoc Biol 82: 1575-1584 jlb.0806528 [pii]; doi:10.1189/jlb.0806528.
26. Eades-Perner AM, Thompson J, van der Putten H, Zimmermann W, (1998) Mice transgenic for the human CGM6 gene express its product, the granulocyte marker CD66b, exclusively in granulocytes. Blood 91: 663-672.
27. Diamond MS, Springer TA, (1993) A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen. J Cell Biol 120: 545-556.
28. Hogg N, Dransfield I, (1989) Regulated expression of Mg2+ binding epitope on leukocyte integrin alpha subunits. EMBO J 8 (12): 3759-3765.
29. Hickstein DD, Smith A, Fisher W, Beatty PG, Schwartz BR, et al. (1987) Expression of leukocyte adherence-related glycoproteins during differentiation of HL-60 promyelocytic leukemia cells. J Immunol 138: 513-519.
30. Brackman D, Lund-Johansen F, Aarskog D, (1995) Expression of cell surface antigens during the differentiation of HL-60 cells induced by 1,25-dihydroxyvitamin D3, retinoic acid and DMSO. Leuk Res 19: 57-64 014521269400061E [pii].
31. Oxvig C, Lu C, Springer TA, (1999) Conformational changes in tertiary structure near the ligand binding site of an integrin I domain. Proc Natl Acad Sci USA 96: 2215-2220.
32. Futaki S, Suzuki T, Ohashi W, Yagami T, Tanaka S, et al. (2001) Arginine-rich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery. J Biol Chem 276: 5836-5840.
33. David T, Ohlmann P, Eckly A, Moog S, Cazenave JP, et al. (2006) Inhibition of adhesive and signaling functions of the platelet GPIb-V-IX complex by a cell penetrating GPIbalpha peptide. J Thromb Haemost 4: 2645-2655.
34. Ithychanda SS, Das M, Ma YQ, Ding K, Wang X, et al. (2009) Migfilin, a molecular switch in regulation of integrin activation. J Biol Chem 284: 4713-4722 M807719200 [pii]; doi:10.1074/jbc.M807719200.
35. Borregaard N, Kjeldsen L, Sengelov H, Diamond MS, Springer TA, et al. (1994) Changes in subcellular localization and surface expression of L-selectin, alkaline phosphatase, and Mac-1 in human neutrophils during stimulation with inflammatory mediators. J Leukoc Biol 56: 80-87.
36. Ithychanda SS, Qin J, (2011) Evidence for multisite ligand binding and stretching of filamin by integrin and migfilin. Biochemistry 50: 4229-4231 doi:10.1021/bi2003229.
37. Arnaout MA, Todd RF III, Dana N, Melamed J, Schlossman SF, et al. (1983) Inhibition of phagocytosis of complement C3- or immunoglobuoin G coated particles and of C3bi binding by monoclonal antibodies to a monocyte-granulocyte membrane glycoprotein (Mol). J Clin Invest 72: 171-179.
38. Beller DE, Springer TA, Schreiber RD, (1982) Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor. J Exp Med 156: 1000-1010.
39. Wright SD, Rao PE, Van Voorhis WC, Craigmyle LS, Iida K, et al. (1983) Identification of the C3bi receptor of human monocytes and macrophages by using monoclonal antibodies. Proc Natl Acad Sci USA 80: 5699-5703.
40. Tadokoro S, Shattil SJ, Eto K, Tai V, Liddington RC, et al. (2003) Talin binding to integrin β tails: a final common step in integrin activation. Science 302: 103-106.
41. Malinin NL, Plow EF, Byzova TV, (2010) Kindlins in FERM adhesion. Blood 115: 4011-4017.
42. Lai-Cheong JE, Ussar S, Arita K, Hart IR, McGrath JA, (2008) Colocalization of kindlin-1, kindlin-2, and migfilin at keratinocyte focal adhesion and relevance to the pathophysiology of Kindler syndrome. J Invest Dermatol 128: 2156-2165.
43. Hato T, Pampori N, Shattil SJ, (1998) Complementary roles for receptor clustering and conformational change in the adhesive and signaling functions of integrin αIIbβ3. J Cell Biol 141: 1685-1695.
44. Bunch TA, (2010) Integrin alphaIIbbeta3 activation in Chinese hamster ovary cells and platelets increases clustering rather than affinity. J Biol Chem 285: 1841-1849 M109.057349 [pii]; doi:10.1074/jbc.M109.057349.
45. Moik DV, Janbandhu VC, Fässler R, (2011) Loss of migfilin expression has no overt consequences on murine development and homeostasis. J Cell Sci 124: 414-421 jcs.075960 [pii]; doi:10.1242/jcs.075960.
46. Feng Y, Zhao H, Luderer HF, Epple H, Faccio R, et al. (2007) The LIM protein, Limd1, regulates AP-1 activation through an interaction with Traf6 to influence osteoclast development. J Biol Chem 282: 39-48 M607399200 [pii]; doi:10.1074/jbc.M607399200.
47. Hoffman LM, Nix DA, Benson B, Boot-Hanford R, Gustafsson E, et al. (2003) Targeted disruption of the murine zyxin gene. Mol Cell Biol 23: 70-79.
48. Pratt SJ, Epple H, Ward M, Feng Y, Braga VM, et al. (2005) The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration. J Cell Biol 168: 813-824 jcb.200406083 [pii]; doi:10.1083/jcb.200406083.
49. Malinin NL, Zhang L, Choi J, Ciocea A, Razorenova O, et al. (2009) A point mutation in kindlin-3 ablates activation of three integrin subfamilies in humans. Nature Med 15: 313-318.
50. Petrich BG, Marchese P, Ruggeri ZM, Spiess S, Weichert RA, et al. (2007) Talin is required for integrin-mediated platelet function in hemostasis and thrombosis. J Exp Med 204: 3103-3111.
51. Siegel DH, Ashton GH, Penagos HG, Lee JV, Feiler HS, et al. (2003) Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome. Am J Hum Genet 73: 174-187.
52. Montanez E, Ussar S, Schifferer M, Bosl M, Zent R, et al. (2008) Kindlin-2 controls bidirectional signaling of integrins. Genes Dev 22: 1325-1330.
53. Moser M, Nieswandt B, Ussar S, Pozgajova M, Fässler R, (2008) Kindlin-3 is essential for integrin activation and platelet aggregation. Nat Med 14: 325-330.
54. Feng Y, Longmore GD, (2005) The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex. Mol Cell Biol 25: 4010-4022 25/10/4010 [pii]; doi:10.1128/MCB.25.10.4010-4022.2005.
55. Sharp TV, Al-Attar A, Foxler DE, Ding L, de A Vallim TQ, Zhang Y, et al. (2008) The chromosome 3p21.3-encoded gene, LIMD1, is a critical tumor suppressor involved in human lung cancer development. Proc Natl Acad Sci U S A 105: 19932-19937 0805003105 [pii]; doi:10.1073/pnas.0805003105.
56. Schiller HB, Friedel CC, Boulegue C, Fässler R, (2011) Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins. EMBO Rep 12: 259-266 embor20115 [pii]; doi:10.1038/embor.2011.5.