Differential upregulation in DRG neurons of an α2δ-1 splice variant with a lower affinity for gabapentin after peripheral sensory nerve injury

Pain

Volumn 155, Issue 3, 2014, Pages 522-533

  Lana, Beatrice ^a   Schlick, Bettina ^a   Martin, Stuart ^a   Pratt, Wendy S ^a   Page, Karen M ^a   Goncalves, Leonor ^a   Rahman, Wahida ^a   Dickenson, Anthony H ^a   Bauer, Claudia S ^a   Dolphin, Annette C ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Calcium channel; Gabapentin; Neuropathic pain; Splice variant

Indexed keywords

ALPHA2DELTA SPLICE VARIANT PROTEIN; GABAPENTIN; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CALCIUM CURRENT; CONTROLLED STUDY; DENSITY GRADIENT CENTRIFUGATION; DRUG PROTEIN BINDING; MALE; NONHUMAN; NONMYELINATED NERVE; NUCLEOTIDE SEQUENCE; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SUBUNIT; RAT; SENSORY NERVE; SPINAL GANGLION; SPINAL NERVE LIGATION INJURY; UPREGULATION;

ALPHA2DELTA (Α(2)Δ); CALCIUM CHANNEL; GABAPENTIN; NEUROPATHIC PAIN; SPLICE VARIANT;

AMINES; ANIMALS; CALCIUM CHANNELS; CYCLOHEXANECARBOXYLIC ACIDS; GAMMA-AMINOBUTYRIC ACID; GANGLIA, SPINAL; MALE; PERIPHERAL NERVE INJURIES; PROTEIN BINDING; PROTEIN ISOFORMS; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; UP-REGULATION;

EID: 84894287803     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1016/j.pain.2013.12.001     Document Type: Article

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