Targeting the hydrophobic pocket of autotaxin with virtual screening of inhibitors identifies a common aromatic sulfonamide structural motif

FEBS Journal

Volumn 281, Issue 4, 2014, Pages 1017-1028

  Fells, James I ^a   Lee, Sue Chin ^a   Norman, Derek D ^a   Tsukahara, Ryoko ^a   Kirby, Jason R ^b   Nelson, Sandra ^b   Seibel, William ^b   Papoian, Ruben ^b   Patil, Renukadevi ^c   Miller, Duane D ^c   Parrill, Abby L ^d   Pham, Truc Chi ^d   Baker, Daniel L ^d   Bittman, Robert ^e   Tigyi, Gabor ^a  

^a UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CINCINNATI   (United States)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^d University of Memphis   (United States)

^e CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

autotaxin; enzymology; inhibitors; virtual screening

Indexed keywords

ALKYLGLYCEROPHOSPHOETHANOLAMINE PHOSPHODIESTERASE; PHOSPHODIESTERASE; SULFONAMIDE;

CHEMICAL PHENOMENA; CHEMICAL STRUCTURE; CHEMISTRY; STRUCTURE ACTIVITY RELATION;

HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MOLECULAR STRUCTURE; PHOSPHORIC DIESTER HYDROLASES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 84894277134     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12674     Document Type: Article

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