Autotaxin and LPA receptor signaling in cancer

Cancer and Metastasis Reviews

Volumn 30, Issue 3-4, 2011, Pages 557-565

  Houben, Anna J S ^a   Moolenaar, Wouter H ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

Autotaxin; Cancer; G protein coupled receptor; Lysophosphatidic acid

Indexed keywords

AUTOTAXIN; FINGOLIMOD; LYSOPHOSPHATIDIC ACID RECEPTOR;

BLADDER CANCER; CELL SURFACE; EMBRYO DEVELOPMENT; GENETIC MODEL; HUMAN; IN VITRO STUDY; NEOPLASM; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CELL MEMBRANE; EMBRYONIC DEVELOPMENT; ENZYME INHIBITORS; HUMANS; LYSOPHOSPHOLIPIDS; NEOPLASMS; PHOSPHORIC DIESTER HYDROLASES; RECEPTORS, LYSOPHOSPHATIDIC ACID; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

EID: 83855160838     PISSN: 01677659     EISSN: 15737233     Source Type: Journal    
DOI: 10.1007/s10555-011-9319-7     Document Type: Review

References (78)

1. JW Choi DR Herr K Noguchi YC Yung CW Lee T Mutoh ME Lin ST Teo KE Park AN Mosley J Chun 2010 LPA receptors: subtypes and biological actions Annual Review of Pharmacology and Toxicology 50 157 186 20055701 10.1146/annurev.pharmtox. 010909.105753 1:CAS:528:DC%2BC3cXisVelur8%3D
2. WH Moolenaar LA van Meeteren BN Giepmans 2004 The ins and outs of lysophosphatidic acid signaling Bioessays 26 870 881 15273989 10.1002/bies.20081 1:CAS:528:DC%2BD2cXnt1CqtLg%3D
3. A Tokumura E Majima Y Kariya K Tominaga K Kogure K Yasuda K Fukuzawa 2002 Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase Journal of Biological Chemistry 277 39436 39442 12176993 10.1074/jbc.M205623200 1:CAS:528:DC%2BD38XnvVeit7k%3D
4. M Umezu-Goto Y Kishi A Taira K Hama N Dohmae K Takio T Yamori GB Mills K Inoue J Aoki H Arai 2002 Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production The Journal of Cell Biology 158 227 233 12119361 10.1083/jcb.200204026 1:CAS:528: DC%2BD38Xls1Shsrg%3D
5. ML Stracke HC Krutzsch EJ Unsworth A Arestad V Cioce E Schiffmann LA Liotta 1992 Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein Journal of Biological Chemistry 267 2524 2529 1733949 1:CAS:528:DyaK3sXhsVCmu7w%3D
6. J Chun T Hla KR Lynch S Spiegel WH Moolenaar 2010 International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature Pharmacological Reviews 62 579 587 21079037 10.1124/pr.110.003111 1:CAS:528:DC%2BC3MXktlek
7. GB Mills WH Moolenaar 2003 The emerging role of LPA in cancer Nature Reviews Cancer 3 582 591 12894246 10.1038/nrc1143 1:CAS:528:DC%2BD3sXlvV2iu7w%3D
8. EJ van Corven PL Hordijk RH Medema JL Bos WH Moolenaar 1993 Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts Proceedings of the National Academy of Sciences of the United States of America 90 1257 1261 7679495 10.1073/pnas.90.4.1257
9. O Kranenburg WH Moolenaar 2001 Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists Oncogene 20 1540 1546 11313900 10.1038/sj.onc.1204187 1:CAS:528:DC%2BD3MXivValsbk%3D
10. J Guillermet-Guibert K Bjorklof A Salpekar C Gonella F Ramadani A Bilancio S Meek AJ Smith K Okkenhaug B Vanhaesebroeck 2008 The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma Proceedings of the National Academy of Sciences of the United States of America 105 8292 8297 18544649 10.1073/pnas.0707761105 1:CAS:528:DC%2BD1cXnvVyrsr8%3D
11. O Kranenburg M Poland FP van Horck D Drechsel A Hall WH Moolenaar 1999 Activation of RhoA by lysophosphatidic acid and Galpha12/13 subunits in neuronal cells: induction of neurite retraction Molecular Biology of the Cell 10 1851 1857 10359601 1:CAS:528:DyaK1MXjvVamt78%3D
12. JC Stam F Michiels RA van der Kammen WH Moolenaar JG Collard 1998 Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling EMBO Journal 17 4066 4074 9670021 10.1093/emboj/17.14.4066 1:CAS:528:DyaK1cXltFygtLg%3D
13. FN van Leeuwen C Olivo S Grivell BN Giepmans JG Collard WH Moolenaar 2003 Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiam1 Journal of Biological Chemistry 278 400 406 12393875 10.1074/jbc.M210151200
14. EJ van Corven A Groenink K Jalink T Eichholtz WH Moolenaar 1989 Lysophosphatidate-induced cell proliferation: identification and dissection of signaling pathways mediated by G proteins Cell 59 45 54 2551506 10.1016/0092-8674(89)90868-4
15. K Jalink EJ van Corven WH Moolenaar 1990 Lysophosphatidic acid, but not phosphatidic acid, is a potent Ca2(+)-mobilizing stimulus for fibroblasts. Evidence for an extracellular site of action Journal of Biological Chemistry 265 12232 12239 2373690 1:CAS:528:DyaK3cXkvFGhs7Y%3D
16. C Stortelers R Kerkhoven WH Moolenaar 2008 Multiple actions of lysophosphatidic acid on fibroblasts revealed by transcriptional profiling BMC Genomics 9 387 18702810 10.1186/1471-2164-9-387
17. K Harper D Arsenault S Boulay-Jean A Lauzier F Lucien CM Dubois 2010 Autotaxin promotes cancer invasion via the lysophosphatidic acid receptor 4: participation of the cyclic AMP/EPAC/Rac1 signaling pathway in invadopodia formation Cancer Research 70 4634 4643 20484039 10.1158/0008-5472.CAN-09-3813 1:CAS:528:DC%2BC3cXmslWgtLY%3D
18. Z Lee CT Cheng H Zhang MA Subler J Wu A Mukherjee JJ Windle CK Chen X Fang 2008 Role of LPA4/p2y9/GPR23 in negative regulation of cell motility Molecular Biology of the Cell 19 5435 5445 18843048 10.1091/mbc.E08-03-0316 1:CAS:528:DC%2BD1cXhsVynu77K
19. C Stefan S Jansen M Bollen 2005 NPP-type ectophosphodiesterases: unity in diversity Trends in Biochemical Sciences 30 542 550 16125936 10.1016/j.tibs.2005.08.005 1:CAS:528:DC%2BD2MXhtVKjsL7L
20. LA van Meeteren WH Moolenaar 2007 Regulation and biological activities of the autotaxin-LPA axis Progress in Lipid Research 46 145 160 17459484 10.1016/j.plipres.2007.02.001
21. H Kanda R Newton R Klein Y Morita MD Gunn SD Rosen 2008 Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs Nature Immunology 9 415 423 18327261 10.1038/ni1573 1:CAS:528:DC%2BD1cXjtlGms7c%3D
22. R Dusaulcy C Rancoule S Gres E Wanecq A Colom C Guigne LA van Meeteren WH Moolenaar P Valet JS Saulnier-Blache 2011 Adipose-specific disruption of autotaxin enhances nutritional fattening and reduces plasma lysophosphatidic acid Journal of Lipid Research 52 6 1247 1255 21421848 10.1194/jlr.M014985 1:CAS:528:DC%2BC3MXmslOitL8%3D
23. LA van Meeteren P Ruurs E Christodoulou JW Goding H Takakusa K Kikuchi A Perrakis T Nagano WH Moolenaar 2005 Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate Journal of Biological Chemistry 280 21155 21161 15769751 10.1074/jbc.M413183200
24. H Nishimasu S Okudaira K Hama E Mihara N Dohmae A Inoue R Ishitani J Takagi J Aoki O Nureki 2011 Crystal structure of autotaxin and insight into GPCR activation by lipid mediators Nature Structural and Molecular Biology 18 205 212 21240269 10.1038/nsmb.1998 1:CAS:528:DC%2BC3MXmsFGgsQ%3D%3D
25. J Hausmann S Kamtekar E Christodoulou JE Day T Wu Z Fulkerson HM Albers LA van Meeteren AJ Houben L van Zeijl S Jansen M Andries T Hall LE Pegg TE Benson M Kasiem K Harlos CW Kooi SS Smyth H Ovaa M Bollen AJ Morris WH Moolenaar A Perrakis 2011 Structural basis of substrate discrimination and integrin binding by autotaxin Nature Structural and Molecular Biology 18 198 204 21240271 10.1038/nsmb.1980 1:CAS:528:DC%2BC3MXmsFCmsA%3D%3D
26. Z Pamuklar L Federico S Liu M Umezu-Goto A Dong M Panchatcharam Z Fulkerson E Berdyshev V Natarajan X Fang LA van Meeteren WH Moolenaar GB Mills AJ Morris SS Smyth 2009 Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis Journal of Biological Chemistry 284 7385 7394 19139100 10.1074/jbc.M807820200 1:CAS:528:DC%2BD1MXislWqtr4%3D
27. LA van Meeteren P Ruurs C Stortelers P Bouwman MA van Rooijen JP Pradere TR Pettit MJ Wakelam JS Saulnier-Blache CL Mummery WH Moolenaar J Jonkers 2006 Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development Molecular and Cellular Biology 26 5015 5022 16782887 10.1128/MCB.02419-05
28. M Tanaka S Okudaira Y Kishi R Ohkawa S Iseki M Ota S Noji Y Yatomi J Aoki H Arai 2006 Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid Journal of Biological Chemistry 281 25822 25830 16829511 10.1074/jbc.M605142200 1:CAS:528:DC%2BD28XoslKltLc%3D
29. S Fotopoulou N Oikonomou E Grigorieva I Nikitopoulou T Paparountas A Thanassopoulou Z Zhao Y Xu DL Kontoyiannis E Remboutsika V Aidinis 2010 ATX expression and LPA signalling are vital for the development of the nervous system Dev Biol 339 451 464 20079728 10.1016/j.ydbio.2010.01.007 1:CAS:528:DC%2BC3cXis1aisrY%3D
30. S Koike K Keino-Masu M Masu 2010 Deficiency of autotaxin/ lysophospholipase D results in head cavity formation in mouse embryos through the LPA receptor-Rho-ROCK pathway Biochemical and Biophysical Research Communications 400 66 71 20692235 10.1016/j.bbrc.2010.08.008 1:CAS:528:DC%2BC3cXhtFGju7vN
31. E Matas-Rico B Garcia-Diaz P Llebrez-Zayas D Lopez-Barroso L Santin C Pedraza A Smith-Fernandez P Fernandez-Llebrez T Tellez M Redondo J Chun FR De Fonseca G Estivill-Torrus 2008 Deletion of lysophosphatidic acid receptor LPA1 reduces neurogenesis in the mouse dentate gyrus Molecular and Cellular Neuroscience 39 342 355 18708146 10.1016/j.mcn.2008.07.014 1:CAS:528: DC%2BD1cXht1Klt7nO
32. I Gennero S Laurencin-Dalicieux F Conte-Auriol F Briand-Mesange D Laurencin J Rue N Beton N Malet M Mus A Tokumura P Bourin L Vico G Brunel RO Oreffo J Chun JP Salles 2011 Absence of the lysophosphatidic acid receptor LPA1 results in abnormal bone development and decreased bone mass Bone 49 3 395 403 21569876 10.1016/j.bone.2011.04.018 1:CAS:528:DC%2BC3MXptlymtL4%3D
33. X Ye K Hama JJ Contos B Anliker A Inoue MK Skinner H Suzuki T Amano G Kennedy H Arai J Aoki J Chun 2005 LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing Nature 435 104 108 15875025 10.1038/nature03505 1:CAS:528:DC%2BD2MXjvVKnur8%3D
34. H Sumida K Noguchi Y Kihara M Abe K Yanagida F Hamano S Sato K Tamaki Y Morishita MR Kano C Iwata K Miyazono K Sakimura T Shimizu S Ishii 2010 LPA4 regulates blood and lymphatic vessel formation during mouse embryogenesis Blood 116 5060 5070 20713964 10.1182/blood-2010-03-272443 1:CAS:528:DC%2BC3cXhs1SlsrnN
35. JJ Contos I Ishii N Fukushima MA Kingsbury X Ye S Kawamura JH Brown J Chun 2002 Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to lpa(2) Molecular and Cellular Biology 22 6921 6929 12215548 10.1128/MCB.22.19.6921-6929.2002 1:CAS:528: DC%2BD38XntFant7w%3D
36. H Kawagoe ML Stracke H Nakamura K Sano 1997 Expression and transcriptional regulation of the PD-Ialpha/autotaxin gene in neuroblastoma Cancer Research 57 2516 2521 9192834 1:CAS:528:DyaK2sXjvFKiurw%3D
37. G Zhang Z Zhao S Xu L Ni X Wang 1999 Expression of autotaxin mRNA in human hepatocellular carcinoma Chinese Medical Journal 112 330 332 11593532 1:CAS:528:DyaK1MXjtFOksbg%3D
38. SY Yang J Lee CG Park S Kim S Hong HC Chung SK Min JW Han HW Lee HY Lee 2002 Expression of autotaxin (NPP-2) is closely linked to invasiveness of breast cancer cells Clinical & Experimental Metastasis 19 603 608 10.1023/A:1020950420196 1:CAS:528:DC%2BD38Xotlektr8%3D
39. MJ Stassar G Devitt M Brosius L Rinnab J Prang T Schradin J Simon S Petersen A Kopp-Schneider M Zoller 2001 Identification of human renal cell carcinoma associated genes by suppression subtractive hybridization British Journal of Cancer 85 1372 1382 11720477 10.1054/bjoc.2001.2074 1:CAS:528:DC%2BD38XhsVemuw%3D%3D
40. DB Hoelzinger L Mariani J Weis T Woyke TJ Berens WS McDonough A Sloan SW Coons ME Berens 2005 Gene expression profile of glioblastoma multiforme invasive phenotype points to new therapeutic targets Neoplasia 7 7 16 15720813 10.1593/neo.04535 1:CAS:528:DC%2BD2MXit1Gnsb8%3D
41. Y Yang L Mou N Liu MS Tsao 1999 Autotaxin expression in non-small-cell lung cancer American Journal of Respiratory Cell and Molecular Biology 21 216 222 10423404
42. KR Baumforth JR Flavell GM Reynolds G Davies TR Pettit W Wei S Morgan T Stankovic Y Kishi H Arai M Nowakova G Pratt J Aoki MJ Wakelam LS Young PG Murray 2005 Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin lymphoma cells Blood 106 2138 2146 15933052 10.1182/blood-2005-02-0471 1:CAS:528:DC%2BD2MXhtVWksLvK
43. A Masuda K Nakamura K Izutsu K Igarashi R Ohkawa M Jona K Higashi H Yokota S Okudaira T Kishimoto T Watanabe Y Koike H Ikeda Y Kozai M Kurokawa J Aoki Y Yatomi 2008 Serum autotaxin measurement in haematological malignancies: a promising marker for follicular lymphoma British Journal of Haematology 143 60 70 18710386 10.1111/j.1365-2141.2008.07325.x 1:CAS:528:DC%2BD1cXht1ClsL%2FN
44. A Kehlen N Englert A Seifert T Klonisch H Dralle J Langner C Hoang-Vu 2004 Expression, regulation and function of autotaxin in thyroid carcinomas International Journal of Cancer 109 833 838 10.1002/ijc.20022 1:CAS:528:DC%2BD2cXjt1ensrk%3D
45. SW Nam T Clair YS Kim A McMarlin E Schiffmann LA Liotta ML Stracke 2001 Autotaxin (NPP-2), a metastasis-enhancing motogen, is an angiogenic factor Cancer Research 61 6938 6944 11559573 1:CAS:528:DC%2BD3MXntFait74%3D
46. EJ Black T Clair J Delrow P Neiman DA Gillespie 2004 Microarray analysis identifies autotaxin, a tumour cell motility and angiogenic factor with lysophospholipase D activity, as a specific target of cell transformation by v-Jun Oncogene 23 2357 2366 14691447 10.1038/sj.onc.1207377 1:CAS:528: DC%2BD2cXisVGks7c%3D
47. B Zirn B Samans S Wittmann T Pietsch I Leuschner N Graf M Gessler 2006 Target genes of the WNT/beta-catenin pathway in Wilms tumors Genes, Chromosomes & Cancer 45 565 574 10.1002/gcc.20319 1:CAS:528:DC%2BD28XktlCruro%3D
48. DA Tice W Szeto I Soloviev B Rubinfeld SE Fong DL Dugger J Winer PM Williams D Wieand V Smith RH Schwall D Pennica P Polakis 2002 Synergistic induction of tumor antigens by Wnt-1 signaling and retinoic acid revealed by gene expression profiling Journal of Biological Chemistry 277 14329 14335 11832495 10.1074/jbc.M200334200 1:CAS:528:DC%2BD38XjsFWnurc%3D
49. J Dufner-Beattie RS Lemons A Thorburn 2001 Retinoic acid-induced expression of autotaxin in N-myc-amplified neuroblastoma cells Molecular Carcinogenesis 30 181 189 11346880 10.1002/mc.1028 1:CAS:528: DC%2BD3MXjsVajtLg%3D
50. B Zirn B Samans C Spangenberg N Graf M Eilers M Gessler 2005 All-trans retinoic acid treatment of Wilms tumor cells reverses expression of genes associated with high risk and relapse in vivo Oncogene 24 5246 5251 15897880 10.1038/sj.onc.1208725 1:CAS:528:DC%2BD2MXmvFemtr4%3D
51. M Chen KL O'Connor 2005 Integrin alpha6beta4 promotes expression of autotaxin/ENPP2 autocrine motility factor in breast carcinoma cells Oncogene 24 5125 5130 15897878 10.1038/sj.onc.1208729 1:CAS:528:DC%2BD2MXmsFKqsrg%3D
52. SW Nam T Clair CK Campo HY Lee LA Liotta ML Stracke 2000 Autotaxin (ATX), a potent tumor motogen, augments invasive and metastatic potential of ras-transformed cells Oncogene 19 241 247 10645002 10.1038/sj.onc.1203263 1:CAS:528:DC%2BD3cXhtVSitLg%3D
53. A Boucharaba CM Serre S Gres JS Saulnier-Blache JC Bordet J Guglielmi P Clezardin O Peyruchaud 2004 Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer The Journal of Clinical Investigation 114 1714 1725 15599396 1:CAS:528:DC%2BD2cXhtFaiur7M
54. A Boucharaba CM Serre J Guglielmi JC Bordet P Clezardin O Peyruchaud 2006 The type 1 lysophosphatidic acid receptor is a target for therapy in bone metastases Proceedings of the National Academy of Sciences of the United States of America 103 9643 9648 16769891 10.1073/pnas.0600979103 1:CAS:528: DC%2BD28XmsVOnsb0%3D
55. M David E Wannecq F Descotes S Jansen B Deux J Ribeiro CM Serre S Gres N Bendriss-Vermare M Bollen S Saez J Aoki JS Saulnier-Blache P Clezardin O Peyruchaud 2010 Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts PLoS One 5 e9741 20305819 10.1371/journal.pone.0009741
56. S Yu MM Murph Y Lu S Liu HS Hall J Liu C Stephens X Fang GB Mills 2008 Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells Journal of the National Cancer Institute 100 1630 1642 19001604 10.1093/jnci/djn378 1:CAS:528:DC%2BD1cXhsVWmsbjO
57. P Taghavi E Verhoeven JJ Jacobs JP Lambooij C Stortelers E Tanger WH Moolenaar M van Lohuizen 2008 In vitro genetic screen identifies a cooperative role for LPA signaling and c-Myc in cell transformation Oncogene 27 6806 6816 18762810 10.1038/onc.2008.294 1:CAS:528:DC%2BD1cXhtl2gsb7N
58. S Liu M Umezu-Goto M Murph Y Lu W Liu F Zhang S Yu LC Stephens X Cui G Murrow K Coombes W Muller MC Hung CM Perou AV Lee X Fang GB Mills 2009 Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases Cancer Cell 15 539 550 19477432 10.1016/j.ccr.2009.03.027 1:CAS:528:DC%2BD1MXntlegtbk%3D
59. S Lin D Wang S Iyer AM Ghaleb H Shim VW Yang J Chun CC Yun 2009 The absence of LPA2 attenuates tumor formation in an experimental model of colitis-associated cancer Gastroenterology 136 1711 1720 19328876 10.1053/j.gastro.2009.01.002 1:CAS:528:DC%2BD1MXmtFajsr4%3D
60. Min mutation in the intestine American Journal of Physiology. Gastrointestinal and Liver Physiology 299 G1128 G1138 20724530 10.1152/ajpgi.00321.2010 1:CAS:528:DC%2BC3cXhsFSnsr%2FM
61. Y Nakai H Ikeda K Nakamura Y Kume M Fujishiro N Sasahira K Hirano H Isayama M Tada T Kawabe Y Komatsu M Omata J Aoki K Koike Y Yatomi 2011 Specific increase in serum autotaxin activity in patients with pancreatic cancer Clinical Biochemistry 44 8-9 576 581 21439952 10.1016/j.clinbiochem.2011.03.128 1:CAS:528:DC%2BC3MXmtFClsLo%3D
62. Y Lu W Lemon PY Liu Y Yi C Morrison P Yang Z Sun J Szoke WL Gerald M Watson R Govindan M You 2006 A gene expression signature predicts survival of patients with stage I non-small cell lung cancer PLoS Medicine 3 e467 17194181 10.1371/journal.pmed.0030467
63. S Lee J Jeong T Majewski SE Scherer MS Kim T Tuziak KS Tang K Baggerly, et al. 2007 Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia Proceedings of the National Academy of Sciences of the United States of America 104 13732 13737 17702869 10.1073/pnas.0701771104 1:CAS:528:DC%2BD2sXpvVOjsbk%3D
64. SM Pasternack I von Kugelgen KA Aboud YA Lee F Ruschendorf K Voss AM Hillmer GJ Molderings, et al. 2008 G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth Nature Genetics 40 329 334 18297070 10.1038/ng.84 1:CAS:528:DC%2BD1cXisVKhtrg%3D
65. K Yanagida K Masago H Nakanishi Y Kihara F Hamano Y Tajima R Taguchi T Shimizu S Ishii 2009 Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6 Journal of Biological Chemistry 284 26 17731 17741 19386608 10.1074/jbc.M808506200 1:CAS:528:DC%2BD1MXnsVWksLk%3D
66. MH Kaplan DI Smith RS Sundick 1993 Identification of a G protein coupled receptor induced in activated T cells Journal of Immunology 151 628 636 1:CAS:528:DyaK3sXmsVOqsrs%3D
67. T Majewski S Lee J Jeong DS Yoon A Kram MS Kim T Tuziak J Bondaruk, et al. 2008 Understanding the development of human bladder cancer by using a whole-organ genomic mapping strategy Laboratory Investigation 88 694 721 18458673 10.1038/labinvest.2008.27 1:CAS:528:DC%2BD1cXnsFKqtb4%3D
68. H Song SJ Ramus D Shadforth L Quaye SK Kjaer RA Dicioccio AM Dunning E Hogdall C Hogdall AS Whittemore V McGuire F Lesueur DF Easton IJ Jacobs BA Ponder SA Gayther PD Pharoah 2006 Common variants in RB1 gene and risk of invasive ovarian cancer Cancer Research 66 10220 10226 17047088 10.1158/0008-5472.CAN-06-2222 1:CAS:528:DC%2BD28XhtVyiurzP
69. A Kazantseva A Goltsov R Zinchenko AP Grigorenko AV Abrukova YK Moliaka AG Kirillov Z Guo S Lyle EK Ginter EI Rogaev 2006 Human hair growth deficiency is linked to a genetic defect in the phospholipase gene LIPH Science 314 982 985 17095700 10.1126/science.1133276 1:CAS:528:DC%2BD28XhtFyqtLnJ
70. JM Crawford 2008 The origins of bladder cancer Laboratory Investigation 88 686 693 18475256 10.1038/labinvest.2008.48 1:CAS:528:DC%2BD1cXnsFKqu78%3D
71. DL Baker Y Fujiwara KR Pigg R Tsukahara S Kobayashi H Murofushi A Uchiyama K Murakami-Murofushi E Koh RW Bandle HS Byun R Bittman D Fan M Murph GB Mills G Tigyi 2006 Carba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasis Journal of Biological Chemistry 281 22786 22793 16782709 10.1074/jbc.M512486200 1:CAS:528:DC%2BD28XnvVWjsLo%3D
72. GG Durgam T Virag MD Walker R Tsukahara S Yasuda K Liliom LA van Meeteren WH Moolenaar N Wilke W Siess G Tigyi DD Miller 2005 Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin Journal of Medicinal Chemistry 48 4919 4930 16033271 10.1021/jm049609r 1:CAS:528:DC%2BD2MXltlGhtbo%3D
73. H Zhang X Xu J Gajewiak R Tsukahara Y Fujiwara J Liu JI Fells D Perygin AL Parrill G Tigyi GD Prestwich 2009 Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo Cancer Research 69 5441 5449 19509223 10.1158/0008-5472.CAN-09-0302 1:CAS:528:DC%2BD1MXnvFajsrg%3D
74. LA van Meeteren V Brinkmann JS Saulnier-Blache KR Lynch WH Moolenaar 2008 Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D Cancer Letters 266 203 208 18378389 10.1016/j.canlet.2008.02.052
75. R Gupte R Patil J Liu Y Wang SC Lee Y Fujiwara J Fells AL Bolen K Emmons-Thompson CR Yates A Siddam N Panupinthu TC Pham DL Baker AL Parrill GB Mills G Tigyi DD Miller 2011 Benzyl and naphthalene methylphosphonic acid inhibitors of autotaxin with anti-invasive and anti-metastatic activity ChemMedChem 6 922 935 21465666 10.1002/cmdc.201000425 1:CAS:528: DC%2BC3MXkvFGis74%3D
76. HM Albers A Dong LA van Meeteren DA Egan M Sunkara EW van Tilburg K Schuurman O van Tellingen AJ Morris SS Smyth WH Moolenaar H Ovaa 2010 Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation Proceedings of the National Academy of Sciences of the United States of America 107 7257 7262 20360563 10.1073/pnas.1001529107 1:CAS:528: DC%2BC3cXlsFWhsr0%3D
77. HM Albers LA van Meeteren DA Egan EW van Tilburg WH Moolenaar H Ovaa 2010 Discovery and optimization of boronic acid based inhibitors of autotaxin Journal of Medicinal Chemistry 53 4958 4967 20536182 10.1021/jm1005012 1:CAS:528:DC%2BC3cXnt1Cmsr8%3D
78. J Gierse A Thorarensen K Beltey E Bradshaw-Pierce L Cortes-Burgos T Hall A Johnston M Murphy O Nemirovskiy S Ogawa L Pegg M Pelc M Prinsen M Schnute J Wendling S Wene R Weinberg A Wittwer B Zweifel J Masferrer 2010 A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation Journal of Pharmacology and Experimental Therapeutics 334 310 317 20392816 10.1124/jpet.110.165845 1:CAS:528:DC%2BC3cXos1Klur8%3D