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Volumn 8, Issue 22, 2009, Pages 3695-3701

ATX-LPA receptor axis in inflammation and cancer

Author keywords

ATX; Breast cancer; Cytokines; G protein coupled receptor; Inflammation; LPA; Target therapy

Indexed keywords

AUTOTAXIN; ESTROGEN RECEPTOR; LPATHOMAB; LYSOPHOSPHATIDIC ACID RECEPTOR; MONOCLONAL ANTIBODY; PROTEIN TYROSINE KINASE; SPHINGOMAB; TRASTUZUMAB; UNCLASSIFIED DRUG;

EID: 70449769732     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.8.22.9937     Document Type: Review
Times cited : (96)

References (116)
  • 1
    • 0029077406 scopus 로고
    • A family of phospholipid autacoids: Occurrence, metabolism and bioactions
    • Tokumura A. A family of phospholipid autacoids: occurrence, metabolism and bioactions, Prog. Lipid Res 1995; 34:151-184
    • (1995) Prog. Lipid Res , vol.34 , pp. 151-184
    • Tokumura, A.1
  • 2
    • 0029836932 scopus 로고    scopus 로고
    • Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex
    • Hecht JH, Weiner JA, Post SR, Chun J. Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. J Biol Chem 1996; 135:1071-1083 (Pubitemid 26403779)
    • (1996) Journal of Cell Biology , vol.135 , Issue.4 , pp. 1071-1083
    • Hecht, J.H.1    Weiner, J.A.2    Post, S.R.3    Chun, J.4
  • 3
    • 0032478615 scopus 로고    scopus 로고
    • Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid
    • An S, Bleu T, Hallmark OG, Goetzl EJ. Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid. J Biol Chem 1998; 273:7906-7910
    • (1998) J Biol Chem , vol.273 , pp. 7906-7910
    • An, S.1    Bleu, T.2    Hallmark, O.G.3    Goetzl, E.J.4
  • 5
    • 0038152846 scopus 로고    scopus 로고
    • 9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family
    • 9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. J Biol Chem 2003; 278:25600-25606
    • (2003) J Biol Chem , vol.278 , pp. 25600-25606
    • Noguchi, K.1    Ishii, S.2    Shimizu, T.3
  • 10
    • 44149111549 scopus 로고    scopus 로고
    • Identification of the orphan GPCR, P2Y10 receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor
    • Murakami M, Shiraishi A, Tabata K, Fujita N. Identification of the orphan GPCR, P2Y10 receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor. Biochem Biophys Res Commun 2008; 371:707-712
    • (2008) Biochem Biophys Res Commun , vol.371 , pp. 707-712
    • Murakami, M.1    Shiraishi, A.2    Tabata, K.3    Fujita, N.4
  • 11
    • 33750456153 scopus 로고    scopus 로고
    • Targeting sphingosine-1-phosphate for cancer therapy
    • Sabbadini RA. Targeting sphingosine-1-phosphate for cancer therapy. Br J Cancer 2006; 95:1131-1135
    • (2006) Br J Cancer , vol.95 , pp. 1131-1135
    • Sabbadini, R.A.1
  • 12
    • 0030976523 scopus 로고    scopus 로고
    • Elevated levels and altered fatty acid composition of plasma lysophosphatidylcholine(lysoPC) in ovarian cancer patients
    • DOI 10.1002/(SICI)1097-0215(19970328)71:1<31::AID-IJC7>3.0.CO;2-4
    • Okita M, Gaudette DC, Mills GB, Holub BJ. Elevated levels and altered fatty acid composition of plasma lysophosphatidylcholine (lysoPC) in ovarian cancer patients. Int J Cancer 1997; 71:31-34 (Pubitemid 27158406)
    • (1997) International Journal of Cancer , vol.71 , Issue.1 , pp. 31-34
    • Okita, M.1    Gaudette, D.C.2    Mills, G.B.3    Holub, B.J.4
  • 13
    • 1542359873 scopus 로고    scopus 로고
    • Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production
    • Umezu-Goto M, Kishi Y, Taira A, Hama K, Dohmae N, Takio K, et al. Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. J Biol Chem 2002; 158:227-233
    • (2002) J Biol Chem , vol.158 , pp. 227-233
    • Umezu-Goto, M.1    Kishi, Y.2    Taira, A.3    Hama, K.4    Dohmae, N.5    Takio, K.6
  • 16
    • 0042887042 scopus 로고    scopus 로고
    • The emerging role of lysophosphatidic acid in cancer
    • DOI 10.1038/nrc1143
    • Mills GB, Moolenaar WH. The emerging role of lysophosphatidic acid in cancer. Nature reviews 2003; 3:582-591 (Pubitemid 37328830)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.8 , pp. 582-591
    • Mills, G.B.1    Moolenaar, W.H.2
  • 17
    • 0345735940 scopus 로고    scopus 로고
    • Rho-Dependent Contractile Responses in the Neuronal Growth Cone Are Independent of Classical Peripheral Retrograde Actin Flow
    • DOI 10.1016/S0896-6273(03)00754-2
    • Zhang XF, Schaefer AW, Burnette DT, Schoonderwoert VT, Forscher P. Rho-dependent contractile responses in the neuronal growth cone are independent of classical peripheral retrograde actin flow. Neuron 2003; 40:931-944 (Pubitemid 37522051)
    • (2003) Neuron , vol.40 , Issue.5 , pp. 931-944
    • Zhang, X.-F.1    Schaefer, A.W.2    Burnette, D.T.3    Schoonderwoert, V.T.4    Forscher, P.5
  • 21
    • 65249173527 scopus 로고    scopus 로고
    • The absence of LPA2 attenuates tumor formation in an experimental model of colitis-associated cancer
    • Lin S, Wang D, Iyer S, Ghaleb AM, Shim H, Yang VW, et al. The absence of LPA2 attenuates tumor formation in an experimental model of colitis-associated cancer. Gastroenterology 2009; 136:1711-1720
    • (2009) Gastroenterology , vol.136 , pp. 1711-1720
    • Lin, S.1    Wang, D.2    Iyer, S.3    Ghaleb, A.M.4    Shim, H.5    Yang, V.W.6
  • 22
    • 48949119466 scopus 로고    scopus 로고
    • Inflammation and breast cancer: Metalloproteinases as common effectors of inflammation and extracellular matrix breakdown in breast cancer
    • Hojilla CV, Wood GA, Khokha R. Inflammation and breast cancer: metalloproteinases as common effectors of inflammation and extracellular matrix breakdown in breast cancer. Breast Cancer Res 2008; 10:205.
    • (2008) Breast Cancer Res , vol.10 , pp. 205
    • Hojilla, C.V.1    Wood, G.A.2    Khokha, R.3
  • 23
    • 19344365408 scopus 로고    scopus 로고
    • De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent
    • de Visser KE, Korets LV, Coussens LM. De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent. Cancer Cell 2005; 7:411-423
    • (2005) Cancer Cell , vol.7 , pp. 411-423
    • De Visser, K.E.1    Korets, L.V.2    Coussens, L.M.3
  • 24
    • 0347123433 scopus 로고    scopus 로고
    • Tumour-educated macrophages promote tumour progression and metastasis
    • Pollard JW. Tumour-educated macrophages promote tumour progression and metastasis. Nature reviews 2004; 4:71-78
    • (2004) Nature Reviews , vol.4 , pp. 71-78
    • Pollard, J.W.1
  • 26
    • 33745857293 scopus 로고    scopus 로고
    • Regulation of lysophosphatidic acid-induced epidermal growth factor receptor transactivation and interleukin-8 secretion in human bronchial epithelial cells by protein kinase Cδ, lyn kinase, and matrix metalloproteinases
    • DOI 10.1074/jbc.M511224200
    • Zhao Y, He D, Saatian B, Watkins T, Spannhake EW, Pyne NJ, et al. Regulation of lysophosphatidic acid-induced epidermal growth factor receptor transactivation and interleukin-8 secretion in human bronchial epithelial cells by protein kinase Cδ, Lyn kinase and matrix metalloproteinases. J Biol Chem 2006; 281:19501-19511 (Pubitemid 44035454)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.28 , pp. 19501-19511
    • Zhao, Y.1    He, D.2    Saatian, B.3    Watkins, T.4    Spannhake, E.W.5    Pyne, N.J.6    Natarajan, V.7
  • 27
    • 31644436887 scopus 로고    scopus 로고
    • Transcriptional regulation of lysophosphatidic acid-induced interleukin-8 expression and secretion by p38 MAPK and JNK in human bronchial epithelial cells
    • DOI 10.1042/BJ20050791
    • Saatian B, Zhao Y, He D, Georas SN, Watkins T, Spannhake EW, et al. Transcriptional regulation of lysophosphatidic acid-induced interleukin-8 expression and secretion by p38 MAPK and JNK in human bronchial epithelial cells. Biochem J 2006; 393:657-668 (Pubitemid 43168213)
    • (2006) Biochemical Journal , vol.393 , Issue.3 , pp. 657-668
    • Saatian, B.1    Zhao, Y.2    He, D.3    Georas, S.N.4    Watkins, T.5    Spannhake, E.W.6    Natarajan, V.7
  • 30
    • 65649132676 scopus 로고    scopus 로고
    • Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion and metastases
    • Liu S, Umezu-Goto M, Murph M, Lu Y, Liu W, Zhang W, et al. Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion and metastases. Cancer Cell 2009; 15:539-550
    • (2009) Cancer Cell , vol.15 , pp. 539-550
    • Liu, S.1    Umezu-Goto, M.2    Murph, M.3    Lu, Y.4    Liu, W.5    Zhang, W.6
  • 31
    • 56749151299 scopus 로고    scopus 로고
    • Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells
    • Yu S, Murph MM, Lu Y, Liu S, Hall HS, Liu J, et al. Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells. J Natl Cancer Inst 2008; 100:1630-1642
    • (2008) J Natl Cancer Inst , vol.100 , pp. 1630-1642
    • Yu, S.1    Murph, M.M.2    Lu, Y.3    Liu, S.4    Hall, H.S.5    Liu, J.6
  • 33
    • 11144285387 scopus 로고    scopus 로고
    • ERK-MAP-kinases differentially regulate expression of IL-23 p19 compared with p40 and IFNbeta in Theiler's virus-infected RAW264.7 cells
    • Petro TM. ERK-MAP-kinases differentially regulate expression of IL-23 p19 compared with p40 and IFNbeta in Theiler's virus-infected RAW264.7 cells. Immunol Lett 2005; 97:47-53.
    • (2005) Immunol Lett , vol.97 , pp. 47-53
    • Petro, T.M.1
  • 34
    • 0037119464 scopus 로고    scopus 로고
    • p38 MAPK-mediated transcriptional activation of inducible nitric-oxide synthase in glial cells. Roles of nuclear factors, nuclear factor kappaB, cAMP response element-binding protein, CCAAT/enhancer-binding protein-beta, and activating transcription factor-2
    • Bhat NR, Feinstein DL, Shen O, Bhat AN. p38 MAPK-mediated transcriptional activation of inducible nitric-oxide synthase in glial cells. Roles of nuclear factors, nuclear factor kappaB, cAMP response element-binding protein, CCAAT/enhancer-binding protein-beta, and activating transcription factor-2. J Biol Chem 2002; 277:29584-29592
    • (2002) J Biol Chem , vol.277 , pp. 29584-29592
    • Bhat, N.R.1    Feinstein, D.L.2    Shen, O.3    Bhat, A.N.4
  • 35
    • 34848836414 scopus 로고    scopus 로고
    • Interleukin-17 stimulates C-reactive protein expression in hepatocytes and smooth muscle cells via p38 MAPK and ERK1/2-dependent NF-kappaB and C/EBPbeta activation
    • DOI 10.1074/jbc.M703250200
    • Patel DN, King CA, Bailey SR, Holt JW, Venkatachalam K, Agrawal A, et al. Interleukin-17 stimulates C-reactive protein expression in hepatocytes and smooth muscle cells via p38 MAPK and ERK1/2-dependent NFkappaB and C/EBPbeta activation. J Biol Chem 2007; 282:27229-27238 (Pubitemid 47501976)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.37 , pp. 27229-27238
    • Patel, D.N.1    King, C.A.2    Bailey, S.R.3    Holt, J.W.4    Venkatachalam, K.5    Agrawal, A.6    Valente, A.J.7    Chandrasekar, B.8
  • 37
    • 34250004968 scopus 로고    scopus 로고
    • Lysophosphatidic acid induces prostate cancer PC3 cell migration via activation of LPA (1), p42 and p38alpha
    • Hao F, Tan M, Xu X, Han J, Miller DD, Tigyi G, et al. Lysophosphatidic acid induces prostate cancer PC3 cell migration via activation of LPA (1), p42 and p38alpha. Biochim Biophys Acta 2007; 1771:883-892
    • (2007) Biochim Biophys Acta , vol.1771 , pp. 883-892
    • Hao, F.1    Tan, M.2    Xu, X.3    Han, J.4    Miller, D.D.5    Tigyi, G.6
  • 38
    • 64249109680 scopus 로고    scopus 로고
    • Role of acylglycerol kinase in LPA-induced IL-8 secretion and transactivation of epidermal growth factor-receptor in human bronchial epithelial cells
    • Kalari S, Zhao Y, Spannhake EW, Berdyshev EV, Natarajan V. Role of acylglycerol kinase in LPA-induced IL-8 secretion and transactivation of epidermal growth factor-receptor in human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol 2009; 296:328-336
    • (2009) Am J Physiol Lung Cell Mol Physiol , vol.296 , pp. 328-336
    • Kalari, S.1    Zhao, Y.2    Spannhake, E.W.3    Berdyshev, E.V.4    Natarajan, V.5
  • 39
    • 33845907698 scopus 로고    scopus 로고
    • 2 adrenergic receptor activation stimulates pro-inflammatory cytokine production in macrophages via PKA- And NF-kappaB-independent mechanisms
    • DOI 10.1016/j.cellsig.2006.06.007, PII S0898656806001537
    • Tan KS, Nackley AG, Satterfield K, Maixner W, Diatchenkol L, Flood PM. Beta2 adrenergic receptor activation stimulates pro-inflammatory cytokine production in macrophages via PKA- and NFkappaB-independent mechanisms. Cell Signal 2007; 19:251-260 (Pubitemid 46017083)
    • (2007) Cellular Signalling , vol.19 , Issue.2 , pp. 251-260
    • Tan, K.S.1    Nackley, A.G.2    Satterfield, K.3    Maixner, W.4    Diatchenko, L.5    Flood, P.M.6
  • 40
    • 34250017968 scopus 로고    scopus 로고
    • An atomic model of the interferon-beta enhanceosome
    • Panne D, Maniatis T, Harrison SC. An atomic model of the interferon-beta enhanceosome. Cells 2007; 129:1111-1123
    • (2007) Cells , vol.129 , pp. 1111-1123
    • Panne, D.1    Maniatis, T.2    Harrison, S.C.3
  • 41
    • 17644394616 scopus 로고    scopus 로고
    • Smoldering and polarized inflammation in the initiation and promotion of malignant disease
    • DOI 10.1016/j.ccr.2005.02.013
    • Balkwill F, Charles KA, Mantovani A. Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell 2005; 7:211-217 (Pubitemid 40568680)
    • (2005) Cancer Cell , vol.7 , Issue.3 , pp. 211-217
    • Balkwill, F.1    Charles, K.A.2    Mantovani, A.3
  • 44
    • 34548785120 scopus 로고    scopus 로고
    • Activation of the signal transducers and activators of the transcription 3 pathway in alveolar epithelial cells induces inflammation and adenocarcinomas in mouse lung
    • DOI 10.1158/0008-5472.CAN-07-0647
    • Li Y, Du H, Qin Y, Roberts J, Cummings OW, Yan C. Activation of the signal transducers and activators of the transcription 3 pathway in alveolar epithelial cells induces inflammation and adenocarcinomas in mouse lung. Cancer Res 2007; 67:8494-8503 (Pubitemid 47437423)
    • (2007) Cancer Research , vol.67 , Issue.18 , pp. 8494-8503
    • Li, Y.1    Du, H.2    Qin, Y.3    Roberts, J.4    Cummings, O.W.5    Yan, C.6
  • 46
    • 0030683639 scopus 로고    scopus 로고
    • Signal characteristics of G protein-transactivated EGF receptor
    • Daub H, Wallasch C, Lankenau A, Herrlich A, Ullrich A. Signal characteristics of G protein-transactivated EGF receptor. EMBO J 1997; 16:7032-7044 (Pubitemid 27520803)
    • (1997) EMBO Journal , vol.16 , Issue.23 , pp. 7032-7044
    • Daub, H.1    Wallasch, C.2    Lankenau, A.3    Herrlich, A.4    Ullrich, A.5
  • 47
    • 33645986145 scopus 로고    scopus 로고
    • Lysophosphatidic acid-induced effects in human colon carcinoma DLD1 cells are partially dependent on transactivation of epidermal growth factor receptor
    • Mori K, Kitayama J, Shida D, Yamashita H, Watanabe T, Nagawa H. Lysophosphatidic acid-induced effects in human colon carcinoma DLD1 cells are partially dependent on transactivation of epidermal growth factor receptor. J Surg Res 2006; 132:56-61.
    • (2006) J Surg Res , vol.132 , pp. 56-61
    • Mori, K.1    Kitayama, J.2    Shida, D.3    Yamashita, H.4    Watanabe, T.5    Nagawa, H.6
  • 48
    • 25444458568 scopus 로고    scopus 로고
    • Mechanisms of extracellularly regulated kinases 1/2 activation in adrenal glomerulosa cells by lysophosphatidic acid and epidermal growth factor
    • Shah BH, Baukal AJ, Shah FB, Catt KJ. Mechanisms of extracellularly regulated kinases 1/2 activation in adrenal glomerulosa cells by lysophosphatidic acid and epidermal growth factor. Mol Endocrinol 2005; 19:2535-2548
    • (2005) Mol Endocrinol , vol.19 , pp. 2535-2548
    • Shah, B.H.1    Baukal, A.J.2    Shah, F.B.3    Catt, K.J.4
  • 50
    • 0141925648 scopus 로고    scopus 로고
    • Involvement of phospholipase D2 in lysophosphatidate-induced transactivation of platelet-derived growth factor receptor-beta in human bronchial epithelial cells
    • DOI 10.1074/jbc.M302896200
    • Wang L, Cummings R, Zhao Y, Kazlauskas A, Sham JK, Morris A, et al. Involvement of phospholipase D2 in lysophosphatidate-induced transactivation of platelet-derived growth factor receptor-beta in human bronchial epithelial cells. J Biol Chem 2003; 278:39931-39940 (Pubitemid 37248557)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.41 , pp. 39931-39940
    • Wang, L.1    Cummings, R.2    Zhao, Y.3    Kazlauskas, A.4    Sham, J.K.S.5    Morris, A.6    Georas, S.7    Brindley, D.N.8    Natarajan, V.9
  • 51
    • 0028564863 scopus 로고
    • Scatter factor and the c-met receptor: A paradigm for mesenchymal/epithelial interaction
    • Rosen EM, Nigam SK, Goldberg ID. Scatter factor and the c-met receptor: a paradigm for mesenchymal/epithelial interaction. J Biol Chem 1994; 127:1783-1787
    • (1994) J Biol Chem , vol.127 , pp. 1783-1787
    • Rosen, E.M.1    Nigam, S.K.2    Goldberg, I.D.3
  • 52
    • 0027742111 scopus 로고
    • Hepatocyte growth factor/scatter factor and its receptor, the c-met proto-oncogene product
    • DOI 10.1016/0304-419X(93)90015-5
    • Rubin JS, Bottaro DP, Aaronson SA. Hepatocyte growth factor/scatter factor and its receptor, the c-met proto-oncogene product. Biochim Biophys Acta 1993; 1155:357-371 (Pubitemid 24012300)
    • (1993) Biochimica et Biophysica Acta - Reviews on Cancer , vol.1155 , Issue.3 , pp. 357-371
    • Rubin, J.S.1    Bottaro, D.P.2    Aaronson, S.A.3
  • 54
    • 33745221886 scopus 로고    scopus 로고
    • Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid
    • DOI 10.1074/jbc.M601803200
    • Kishi Y, Okudaira S, Tanaka M, Hama K, Shida D, Kitayama J, et al. Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid. J Biol Chem 2006; 281:17492-17500 (Pubitemid 43909557)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.25 , pp. 17492-17500
    • Kishi, Y.1    Okudaira, S.2    Tanaka, M.3    Hama, K.4    Shida, D.5    Kitayama, J.6    Yamori, T.7    Aoki, J.8    Fujimaki, T.9    Arai, H.10
  • 55
    • 51249116856 scopus 로고    scopus 로고
    • Serum autotaxin measurement in haematological makignancies: A promising marker for follicular lymphoma
    • Masuda A, Nakamura K, Izutsu K, Igarashi K, Ohkawa R, Jona M, et al. Serum autotaxin measurement in haematological makignancies: a promising marker for follicular lymphoma. Br J Haematol 2008; 143:60-70.
    • (2008) Br J Haematol , vol.143 , pp. 60-70
    • Masuda, A.1    Nakamura, K.2    Izutsu, K.3    Igarashi, K.4    Ohkawa, R.5    Jona, M.6
  • 56
    • 33645525087 scopus 로고    scopus 로고
    • Lysophosphatidic acid is constitutively produced by human peritoneal mesothelial cells and enhances adhesion, migration and invasion of ovarian cancer cells
    • Ren J, Xiao YJ, Singh LS, Zhao X, Zhao Z, Feng L, et al. Lysophosphatidic acid is constitutively produced by human peritoneal mesothelial cells and enhances adhesion, migration and invasion of ovarian cancer cells. Cancer Res 2006; 66:3006-3014
    • (2006) Cancer Res , vol.66 , pp. 3006-3014
    • Ren, J.1    Xiao, Y.J.2    Singh, L.S.3    Zhao, X.4    Zhao, Z.5    Feng, L.6
  • 57
    • 0042704741 scopus 로고    scopus 로고
    • A novel laminin-induced LPA autocrine loop in the migration of ovarian cancer cells
    • Sengupta S, Xiao YJ, Xu Y. A novel laminin-induced LPA autocrine loop in the migration of ovarian cancer cells. FASEB J 2003; 17:1570-1572
    • (2003) FASEB J , vol.17 , pp. 1570-1572
    • Sengupta, S.1    Xiao, Y.J.2    Xu, Y.3
  • 60
    • 50249090428 scopus 로고    scopus 로고
    • Sharpening the edges of understanding the structure/function of the LPA1 receptor: Expression in cancer and mechanisms of regulation
    • Murph MM, Nguyen GH, Radhakrishna H, Mills GB. Sharpening the edges of understanding the structure/function of the LPA1 receptor: expression in cancer and mechanisms of regulation. Biochim Biophys Acta 2008; 1781:547-557
    • (2008) Biochim Biophys Acta , vol.1781 , pp. 547-557
    • Murph, M.M.1    Nguyen, G.H.2    Radhakrishna, H.3    Mills, G.B.4
  • 61
    • 0025011698 scopus 로고
    • Ascitic fluid from human ovarian cancer patients contains growth factors necessary for intraperitoneal growth of human ovarian adenocarcinoma cells
    • Mills GB, May C, Hill M, Campbell S, Shaw P, Marks A. Ascitic fluid from human ovarian cancer patients contains growth factors necessary for intraperitoneal growth of human ovarian adenocarcinoma cells. J Clin Invest 1990; 86:851-855 (Pubitemid 20327375)
    • (1990) Journal of Clinical Investigation , vol.86 , Issue.3 , pp. 851-855
    • Bills, G.B.1    May, C.2    Hill, M.3    Campbell, S.4    Shaw, P.5    Marks, A.6
  • 62
    • 67649440886 scopus 로고    scopus 로고
    • The biology of ovarian cancer: New opportunities for translation
    • Bast RC Jr, Hennessy B, Mills GB. The biology of ovarian cancer: new opportunities for translation. Nature reviews 2009; 9:415-428
    • (2009) Nature Reviews , vol.9 , pp. 415-428
    • Bast Jr., R.C.1    Hennessy, B.2    Mills, G.B.3
  • 64
    • 65949112275 scopus 로고    scopus 로고
    • Lysophosphatidic acid-induced transcriptional profile represents serous epithelial ovarian carcinoma and worsened prognosis
    • Murph MM, Liu W, Yu S, Lu Y, Hall H, Hennessy BT, et al. Lysophosphatidic acid-induced transcriptional profile represents serous epithelial ovarian carcinoma and worsened prognosis. PLoS One 2009; 4:5583.
    • (2009) PLoS One , vol.4 , pp. 5583
    • Murph, M.M.1    Liu, W.2    Yu, S.3    Lu, Y.4    Hall, H.5    Hennessy, B.T.6
  • 66
    • 1842536852 scopus 로고    scopus 로고
    • Microarray analysis identifies Autotaxin, a tumour cell motility and angiogenic factor with lysophospholipase D activity, as a specific target of cell transformation by v-Jun
    • DOI 10.1038/sj.onc.1207377
    • Black EJ, Clair T, Delrow J, Neiman P, Gillespie DA. Microarray analysis identifies autotaxin, a tumour cell motility and angiogenic factor with lysophospholipase D activity, as a specific target of cell transformation by v-Jun. Oncogene 2004; 23:2357-2366 (Pubitemid 38496791)
    • (2004) Oncogene , vol.23 , Issue.13 , pp. 2357-2366
    • Black, E.J.1    Clair, T.2    Delrow, J.3    Neiman, P.4    Gillespie, D.A.F.5
  • 67
    • 29244477512 scopus 로고    scopus 로고
    • The candidate tumor suppressor CST6 alters the gene expression profile of human breast carcinoma cells: Down-regulation of the potent mitogenic, motogenic, and angiogenic factor autotaxin
    • DOI 10.1016/j.bbrc.2005.11.171, PII S0006291X05027038
    • Song J, Jie C, Polk P, Shridhar R, Clair T, Zhang J, et al. The candidate tumor suppressor CST6 alters the gene expression profile of human breast carcinoma cells: downregulation of the potent mitogenic, motogenic and angiogenic factor autotaxin. Biochem Biophys Res Commun 2006; 340:175-182 (Pubitemid 41827662)
    • (2006) Biochemical and Biophysical Research Communications , vol.340 , Issue.1 , pp. 175-182
    • Song, J.1    Jie, C.2    Polk, P.3    Shridhar, R.4    Clair, T.5    Zhang, J.6    Yin, L.7    Keppler, D.8
  • 69
    • 11844301025 scopus 로고    scopus 로고
    • Overexpression of lysophosphatidic acid receptor-2 in human invasive ductal carcinoma
    • Kitayama J, Shida D, Sako A, Ishikawa M, Hama K, Aoki J, et al. Overexpression of lysophosphatidic acid receptor-2 in human invasive ductal carcinoma. Breast Cancer Res 2004; 6:640-646
    • (2004) Breast Cancer Res , vol.6 , pp. 640-646
    • Kitayama, J.1    Shida, D.2    Sako, A.3    Ishikawa, M.4    Hama, K.5    Aoki, J.6
  • 70
    • 37549041384 scopus 로고    scopus 로고
    • Nm23-H1 suppresses metastasis by inhibiting expression of the lysophosphatidic acid receptor EDG2
    • Horak CE, Mendoza A, Vega-Valle E, Albaugh M, Graff-Cherry C, McDermott WG, et al. Nm23-H1 suppresses metastasis by inhibiting expression of the lysophosphatidic acid receptor EDG2. Cancer Res 2007; 67:11751-11759
    • (2007) Cancer Res , vol.67 , pp. 11751-11759
    • Horak, C.E.1    Mendoza, A.2    Vega-Valle, E.3    Albaugh, M.4    Graff-Cherry, C.5    McDermott, W.G.6
  • 72
    • 0024428410 scopus 로고
    • Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins
    • DOI 10.1016/0092-8674(89)90868-4
    • van Corven EJ, Groenink A, Jalink K, Eichholtz T, Moolenaar WH. Lysophosphatidate-induced cell proliferation: identification and dissection of signaling pathways mediated by G proteins. Cell 1989; 59:45-54. (Pubitemid 19248557)
    • (1989) Cell , vol.59 , Issue.1 , pp. 45-54
    • Van Corven, E.J.1    Groenink, A.2    Jalink, K.3    Eichholtz, T.4    Moolenaar, W.H.5
  • 73
    • 0027583540 scopus 로고
    • Lysophosphatidic acid induces neuronal shape changes via a novel, receptor-mediated signaling pathway: Similarity to thrombin action
    • Jalink K, Eichholtz T, Postma FR, van Corven EJ, Moolenaar WH. Lysophosphatidic acid induces neuronal shape changes via a novel, receptor-mediated signaling pathway: similarity to thrombin action. Cell Growth Differ 1993; 4:247-255
    • (1993) Cell Growth Differ , vol.4 , pp. 247-255
    • Jalink, K.1    Eichholtz, T.2    Postma, F.R.3    Van Corven, E.J.4    Moolenaar, W.H.5
  • 74
    • 0028091046 scopus 로고
    • Protein tyrosine phosphorylation induced by lysophosphatidic acid in rat- 1 fibroblasts. Evidence that phosphorylation of map kinase is mediated by the G(i)-p21(ras) pathway
    • Hordijk PL, Verlaan I, van Corven EJ, Moolenaar WH. Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. Evidence that phosphorylation of map kinase is mediated by the Gi-p21ras pathway. J Biol Chem 1994; 269:645-651 (Pubitemid 24026708)
    • (1994) Journal of Biological Chemistry , vol.269 , Issue.1 , pp. 645-651
    • Hordijk, P.L.1    Verlaan, I.2    Van Corven, E.J.3    Moolenaar, W.H.4
  • 75
    • 0027496730 scopus 로고
    • ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells
    • Kumagai N, Morii N, Fujisawa K, Nemoto Y, Narumiya S. ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells. J Biol Chem 1993; 268:24535-24538
    • (1993) J Biol Chem , vol.268 , pp. 24535-24538
    • Kumagai, N.1    Morii, N.2    Fujisawa, K.3    Nemoto, Y.4    Narumiya, S.5
  • 81
    • 0035952741 scopus 로고    scopus 로고
    • Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists
    • DOI 10.1038/sj.onc.1204187
    • Kranenburg O, Moolenaar WH. Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists. Oncogene 2001; 20:1540-1546 (Pubitemid 32336841)
    • (2001) Oncogene , vol.20 , Issue.13 REV. ISS. 1 , pp. 1540-1546
    • Kranenburg, O.1    Moolenaar, W.H.2
  • 82
    • 0347520943 scopus 로고    scopus 로고
    • Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiam1
    • Van Leeuwen FN, Olivo C, Grivell S, Giepmans BN, Collard JG, Moolenaar WH. Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiam1. J Biol Chem2003; 278:400-406
    • (2003) J Biol Chem , vol.278 , pp. 400-406
    • Van Leeuwen, F.N.1    Olivo, C.2    Grivell, S.3    Giepmans, B.N.4    Collard, J.G.5    Moolenaar, W.H.6
  • 86
    • 34247269026 scopus 로고    scopus 로고
    • Genetic determinants of cancer metastasis
    • Nguyen DX, Massague J. Genetic determinants of cancer metastasis. Nat Rev Genet 2007; 8:341-352
    • (2007) Nat Rev Genet , vol.8 , pp. 341-352
    • Nguyen, D.X.1    Massague, J.2
  • 88
    • 57349178989 scopus 로고    scopus 로고
    • Analysis of lysophosphatidic acid (LPA) receptor and LPA-induced endometrial prostaglandin-endoperoxide synthase 2 expression in the porcine uterus
    • Seo H, Kim M, Choi Y, Lee CK, Ka H. Analysis of lysophosphatidic acid (LPA) receptor and LPA-induced endometrial prostaglandin-endoperoxide synthase 2 expression in the porcine uterus. Endocrinology 2008; 149:6166-6175
    • (2008) Endocrinology , vol.149 , pp. 6166-6175
    • Seo, H.1    Kim, M.2    Choi, Y.3    Lee, C.K.4    Ka, H.5
  • 92
    • 5344266925 scopus 로고    scopus 로고
    • Lysophosphatidic acid production and action: Validated targets in cancer?
    • Umezu-Goto M, Tanyi J, Lahad J, Liu S, Yu S, Lapushin R, et al. Lysophosphatidic acid production and action: validated targets in cancer? J Cell Biochem 2004; 92:1115-1140
    • (2004) J Cell Biochem , vol.92 , pp. 1115-1140
    • Umezu-Goto, M.1    Tanyi, J.2    Lahad, J.3    Liu, S.4    Yu, S.5    Lapushin, R.6
  • 95
    • 35448989224 scopus 로고    scopus 로고
    • Targeting the lipids LPA and S1P and their signalling pathways to inhibit tumour progression
    • DOI 10.1017/S1462399407000476, PII S1462399407000476
    • Murph M, Mills GB. Targeting the lipids LPA and S1P and their signalling pathways to inhibit tumour progression. Expert Rev Mol Med 2007; 9:1-18. (Pubitemid 47617558)
    • (2007) Expert Reviews in Molecular Medicine , vol.9 , Issue.28 , pp. 1-18
    • Murph, M.1    Mills, G.B.2
  • 98
    • 0035206909 scopus 로고    scopus 로고
    • Activity of 2-substituted lysophosphatidic acid (LPA) analogs at LPA receptors: Discovery of a LPA1/LPA3 receptor antagonist
    • Heise CE, Santos WL, Schreihofer AM, Heasley BH, Mukhin YV, Macdonald TL, et al. Activity of 2-substituted lysophosphatidic acid (LPA) analogs at LPA receptors: discovery of a LPA1/LPA3 receptor antagonist. Mol Pharmacol 2001; 60:1173-1180
    • (2001) Mol Pharmacol , vol.60 , pp. 1173-1180
    • Heise, C.E.1    Santos, W.L.2    Schreihofer, A.M.3    Heasley, B.H.4    Mukhin, Y.V.5    Macdonald, T.L.6
  • 100
    • 32144439188 scopus 로고    scopus 로고
    • FGFR4 GLY388 isotype suppresses motility of MDA-MB-231 breast cancer cells by EDG-2 gene repression
    • DOI 10.1016/j.cellsig.2005.07.002, PII S0898656805001750
    • Stadler CR, Knyazev P, Bange J, Ullrich A. FGFR4 GLY388 isotype suppresses motility of MDA-MB- 231 breast cancer cells by EDG-2 gene repression. Cell Signal 2006; 18:783-794 (Pubitemid 43208932)
    • (2006) Cellular Signalling , vol.18 , Issue.6 , pp. 783-794
    • Stadler, C.R.1    Knyazev, P.2    Bange, J.3    Ullrich, A.4
  • 101
    • 33645047391 scopus 로고    scopus 로고
    • Lysophosphatidic acid is a major regulator of growth-regulated oncogene alpha in ovarian cancer
    • Lee Z, Swaby RF, Liang Y, Yu S, Liu S, Lu KH, et al. Lysophosphatidic acid is a major regulator of growth-regulated oncogene alpha in ovarian cancer. Cancer Res 2006; 66:2740-2748
    • (2006) Cancer Res , vol.66 , pp. 2740-2748
    • Lee, Z.1    Swaby, R.F.2    Liang, Y.3    Yu, S.4    Liu, S.5    Lu, K.H.6
  • 102
    • 35448975763 scopus 로고    scopus 로고
    • α-Substituted phosphonate analogues of lysophosphatidic acid (LPA) selectively inhibit production and action of LPA
    • Jiang G, Xu Y, Fujiwara Y, Tsukahara T, Tsukahara R, Gajewiak J, et al. α-Substituted phosphonate analogues of lysophosphatidic acid (LPA) selectively inhibit production and action of LPA. ChemMedChem 2007; 2:679-690
    • (2007) ChemMedChem , vol.2 , pp. 679-690
    • Jiang, G.1    Xu, Y.2    Fujiwara, Y.3    Tsukahara, T.4    Tsukahara, R.5    Gajewiak, J.6
  • 104
    • 0024320404 scopus 로고
    • Darmstoff analogues 3. Actions of choline esters of acetal phosphatidic acids on visceral smooth muscle
    • Marx MH, Wiley RA, Satchell DG, Maguire MH. Darmstoff analogues 3. Actions of choline esters of acetal phosphatidic acids on visceral smooth muscle. J Med Chem 1989; 32:1319-1322
    • (1989) J Med Chem , vol.32 , pp. 1319-1322
    • Marx, M.H.1    Wiley, R.A.2    Satchell, D.G.3    Maguire, M.H.4
  • 107
    • 49949098676 scopus 로고    scopus 로고
    • Two pathways for lysophosphatidic acid production
    • Aoki J, Inoue A, Okudaira S. Two pathways for lysophosphatidic acid production. Biochim Biophys Acta 2008; 1781:513-518
    • (2008) Biochim Biophys Acta , vol.1781 , pp. 513-518
    • Aoki, J.1    Inoue, A.2    Okudaira, S.3
  • 108
  • 109
    • 33747593309 scopus 로고    scopus 로고
    • Phosphonothioate and fluoromethylene phosphonate analogues of cyclic phosphatidic acid: Novel antagonists of lysophosphatidic acid receptors
    • DOI 10.1021/jm060351+
    • Xu Y, Jiang G, Tsukahara R, Fujiwara Y, Tigyi G, Prestwich GD. Phosphonothioate and fluoromethylene phosphonate analogues of cyclic phosphatidic acid: Novel antagonists of lysophosphatidic acid receptors. J Med Chem 2006; 49:5309-5315 (Pubitemid 44262034)
    • (2006) Journal of Medicinal Chemistry , vol.49 , Issue.17 , pp. 5309-5315
    • Xu, Y.1    Jiang, G.2    Tsukahara, R.3    Fujiwara, Y.4    Tigyi, G.5    Prestwich, G.D.6
  • 116
    • 55749092457 scopus 로고    scopus 로고
    • Identification of small-molecule inhibitors of autotaxin that inhibit melanoma cell migration and invasion
    • Saunders LP, Ouellette A, Bandle R, Chang WC, Zhou H, Misra RN, et al. Identification of small-molecule inhibitors of autotaxin that inhibit melanoma cell migration and invasion. Mol Cancer Ther 2008; 7:3352-3362
    • (2008) Mol Cancer Ther , vol.7 , pp. 3352-3362
    • Saunders, L.P.1    Ouellette, A.2    Bandle, R.3    Chang, W.C.4    Zhou, H.5    Misra, R.N.6


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