Pharmacophore development and application toward the identification of novel, small-molecule autotaxin inhibitors

Journal of Medicinal Chemistry

Volumn 53, Issue 8, 2010, Pages 3095-3105

  North, E Jeffrey ^a,b   Howard, Angela L ^a,b   Wanjala, Irene W ^a,b   Pham, Truc Chi T ^a   Baker, Daniel L ^a   Parrill, Abby L ^a,b  

^a University of Memphis   (United States)

^b UNIVERSITY OF MEMPHIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOTAXIN; AUTOTAXIN INHIBITOR; LYSOPHOSPHOLIPASE; NSC 12859; NSC 75779; NSC 75913; NSC 8680; NSC 9616; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CANCER GROWTH; CARDIOVASCULAR DISEASE; CHEMICAL REACTION; CONCENTRATION RESPONSE; DATA BASE; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVITY; IC 50; INHIBITION KINETICS; OBESITY; PHARMACOPHORE; PROTEIN FUNCTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REACTION ANALYSIS;

DATABASES, FACTUAL; ENZYME INHIBITORS; HUMANS; ISOENZYMES; MODELS, MOLECULAR; MULTIENZYME COMPLEXES; PHOSPHODIESTERASE I; PYROPHOSPHATASES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; STEREOISOMERISM; SULFONIC ACIDS;

EID: 77951128594     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm901718z     Document Type: Article

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