Cell line profiling to improve monoclonal antibody production

Biotechnology and Bioengineering

Volumn 111, Issue 4, 2014, Pages 748-760

  Kang, Sohye ^a   Ren, Da ^a   Xiao, Gang ^a   Daris, Kristi ^a   Buck, Lynette ^a   Enyenihi, Atim A ^b   Zubarev, Roman ^b,c   Bondarenko, Pavel V ^a   Deshpande, Rohini ^a  

^a AMGEN INC   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

^c SCIENCE FOR LIFE LABORATORY   (Sweden)

Author keywords

Chinese hamster ovary cells; Monoclonal antibody production; Productivity; Proteomics; Systems biology; Transcriptomics

Indexed keywords

CELL CULTURE; CHAINS; MOLECULAR BIOLOGY; MONOCLONAL ANTIBODIES; PRINCIPAL COMPONENT ANALYSIS; RECOMBINANT PROTEINS;

CHINESE HAMSTER OVARY CELLS; MONOCLONAL ANTIBODY PRODUCTION; PROTEOMICS; SYSTEMS BIOLOGY; TRANSCRIPTOMICS;

PRODUCTIVITY;

2 AMINO 3 PHOSPHONOPROPIONIC ACID; ACETYL COENZYME A ACYLTRANSFERASE; ACETYL COENZYME A ACYLTRANSFERASE 2; ADAPTOR PROTEIN; ADAPTOR PROTEIN AP2B2; ADAPTOR PROTEIN AP3D1; CHAPERONIN CONTAINING TCP1; CHAPERONIN CONTAINING TCP1 SUBUNIT ALPHA; CHAPERONIN CONTAINING TCP1 SUBUNIT DELTA; CHAPERONIN CONTAINING TCP1 SUBUNIT ETA; CHAPERONIN CONTAINING TCP1 SUBUNIT GAMMA; CHAPERONIN CONTAINING TCP1 SUBUNIT THETA; COILED COIL DOMAIN CONTAINING PROTEIN 72; DIHYDROFOLATE REDUCTASE; DNA REPAIR PROTEIN DDB1; DOCKING PROTEIN; INITIATION FACTOR 4A; INITIATION FACTOR 4A3; MESSENGER RNA; METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MONOCLONAL ANTIBODY; NUCLEIC ACID BINDING PROTEIN; PROTEIN HOOK HOMOLOG 3; RECOMBINANT ANTIBODY; SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA; TRANSPORTIN 1; TROPOMODULIN; TROPOMODULIN 3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBODY PRODUCTION; ARTICLE; CALCIUM SIGNALING; CARBON METABOLISM; CELL CYCLE PROGRESSION; CELL DENSITY; CELL LINE PROFILING; CELL POLARITY; CELL PROLIFERATION; CELL SIZE; CELL VIABILITY; CHO CELL; CULTURE MEDIUM; DNA REPAIR; GENOMIC INSTABILITY; GROWTH RATE; HEAVY CHAIN; LIGHT CHAIN; LIQUID CHROMATOGRAPHY; MICROARRAY ANALYSIS; NONHUMAN; PHENOTYPE; PRINCIPAL COMPONENT ANALYSIS; PROCESS OPTIMIZATION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEOMICS; TANDEM MASS SPECTROMETRY; TRANSCRIPTOMICS;

CRICETULUS GRISEUS; MAMMALIA;

CHINESE HAMSTER OVARY CELLS; MONOCLONAL ANTIBODY PRODUCTION; PRODUCTIVITY; PROTEOMICS; SYSTEMS BIOLOGY; TRANSCRIPTOMICS;

ANIMALS; ANTIBODIES, MONOCLONAL; CELL LINE; CELL PROLIFERATION; CHO CELLS; CLUSTER ANALYSIS; CRICETINAE; CRICETULUS; GENE EXPRESSION PROFILING; PRINCIPAL COMPONENT ANALYSIS; PROTEOMICS; RECOMBINANT PROTEINS; SYSTEMS BIOLOGY;

EID: 84894258110     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.25141     Document Type: Article

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