Cell growth and size homeostasis in proliferating animal cells

Science

Volumn 325, Issue 5937, 2009, Pages 167-171

  Tzur, Amit ^a   Kafri, Ran ^a   LeBleu, Valerie S ^a   Lahav, Galit ^a   Kirschner, Marc W ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH RATE; HOMEOSTASIS; MAMMAL; NUMERICAL MODEL; SIZE DISTRIBUTION;

ARTICLE; CELL AGING; CELL CYCLE; CELL CYCLE G1 PHASE; CELL DIVISION; CELL GROWTH; CELL POPULATION; CELL PROLIFERATION; CELL SIZE; CELLULAR DISTRIBUTION; GROWTH INHIBITION; GROWTH RATE; HOMEOSTASIS; LYMPHOBLAST; MAMMAL CELL; MATHEMATICAL ANALYSIS; METAZOON; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CELL CYCLE; CELL DIVISION; CELL ENLARGEMENT; CELL PROLIFERATION; CELL SIZE; G1 PHASE; HOMEOSTASIS; LYMPHOCYTES; MATHEMATICAL CONCEPTS; MICE; MITOSIS; PROBABILITY; TIME FACTORS;

ANIMALIA; MAMMALIA; METAZOA;

EID: 67650430047     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1174294     Document Type: Article

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28. We thank C. Helmstetter and J. Horn for sharing plans and construction of the newborn cell device; S. Cooper for suggesting we consider that device for cell cycle studies; J. Levy for discussions and for advice with the mathematical analyses; J. Waters and the Nikon Imaging Centre for help with the microscopy; C. Mock for cell sorting; G. Charras and T. Balla for reagents; and S. Tal, J. Toettcher, P. Bordalo, R. Milo, T. Mitchison, P. Jorgensen, G. Charras, E. Zlotorynski, S. Dumont, N. Shoresh, and M. Springer for advice and critical reading. Supported by NIH grant GM083303 (G.L.), a Human Frontier Science Program fellowship (R.K.), and NIH grant GM026875.