-
1
-
-
0029051439
-
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
-
doi:10.1073/pnas.92.12.5510. PubMed: 7539918
-
Wang GL, Jiang BH, Rue EA, Semenza GL (1995) Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci U S A 92: 5510-5514. doi:10.1073/pnas.92.12.5510. PubMed: 7539918.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 5510-5514
-
-
Wang, G.L.1
Jiang, B.H.2
Rue, E.A.3
Semenza, G.L.4
-
2
-
-
0035347260
-
Induction of HIF-1alpha in response to hypoxia is instantaneous
-
PubMed: 11344124
-
Jewell UR, Kvietikova I, Scheid A, Bauer C, Wenger RH et al. (2001) Induction of HIF-1alpha in response to hypoxia is instantaneous. FASEB J 15: 1312-1314. PubMed: 11344124.
-
(2001)
FASEB J
, vol.15
, pp. 1312-1314
-
-
Jewell, U.R.1
Kvietikova, I.2
Scheid, A.3
Bauer, C.4
Wenger, R.H.5
-
3
-
-
0032493368
-
Regulation of hypoxiainducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway
-
doi:10.1073/pnas.95.14.7987. PubMed: 9653127
-
Huang LE, Gu J, Schau M, Bunn HF (1998) Regulation of hypoxiainducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci U S A 95: 7987-7992. doi:10.1073/pnas.95.14.7987. PubMed: 9653127.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 7987-7992
-
-
Huang, L.E.1
Gu, J.2
Schau, M.3
Bunn, H.F.4
-
4
-
-
0030961006
-
Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redoxinduced changes
-
doi:10.1074/jbc.272.36.22642. PubMed: 9278421
-
Salceda S, Caro J (1997) Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redoxinduced changes. J Biol Chem 272: 22642-22647. doi:10.1074/jbc.272.36.22642. PubMed: 9278421.
-
(1997)
J Biol Chem
, vol.272
, pp. 22642-22647
-
-
Salceda, S.1
Caro, J.2
-
5
-
-
40949142209
-
The role of hypoxia-inducible factors in tumorigenesis
-
doi:10.1038/cdd.2008.21. PubMed: 18259193
-
Rankin EB, Giaccia AJ (2008) The role of hypoxia-inducible factors in tumorigenesis. Cell Death Differ 15: 678-685. doi:10.1038/cdd.2008.21. PubMed: 18259193.
-
(2008)
Cell Death Differ
, vol.15
, pp. 678-685
-
-
Rankin, E.B.1
Giaccia, A.J.2
-
6
-
-
0034050050
-
Loss of PTEN facilitates HIF-1-mediated gene expression
-
PubMed: 10691731
-
Zundel W, Schindler C, Haas-Kogan D, Koong A, Kaper F et al. (2000) Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev 14: 391-396. PubMed: 10691731.
-
(2000)
Genes Dev
, vol.14
, pp. 391-396
-
-
Zundel, W.1
Schindler, C.2
Haas-Kogan, D.3
Koong, A.4
Kaper, F.5
-
7
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
-
PubMed: 10582706
-
Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA et al. (1999) Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res 59: 5830-5835. PubMed: 10582706.
-
(1999)
Cancer Res
, vol.59
, pp. 5830-5835
-
-
Zhong, H.1
De Marzo, A.M.2
Laughner, E.3
Lim, M.4
Hilton, D.A.5
-
8
-
-
43449116075
-
Hypoxia inducible factor-alpha activation in lymphoma and relationship to the thioredoxin family
-
doi:10.1111/j.1365-2141.2008.07093.x. PubMed: 18422776
-
Evens AM, Schumacker PT, Helenowski IB, Singh AT, Dokic D et al. (2008) Hypoxia inducible factor-alpha activation in lymphoma and relationship to the thioredoxin family. Br J Haematol 141: 676-680. doi:10.1111/j.1365-2141.2008. 07093.x. PubMed: 18422776.
-
(2008)
Br J Haematol
, vol.141
, pp. 676-680
-
-
Evens, A.M.1
Schumacker, P.T.2
Helenowski, I.B.3
Singh, A.T.4
Dokic, D.5
-
9
-
-
38649131327
-
The importance of angiogenesis markers in the outcome of patients with diffuse large B cell lymphoma: A retrospective study of 97 patients
-
doi:10.1007/s00432-007-0294-x. PubMed: 17694324
-
Ganjoo KN, Moore AM, Orazi A, Sen JA, Johnson CS et al. (2008) The importance of angiogenesis markers in the outcome of patients with diffuse large B cell lymphoma: a retrospective study of 97 patients. J Cancer Res Clin Oncol 134: 381-387. doi:10.1007/s00432-007-0294-x. PubMed: 17694324.
-
(2008)
J Cancer Res Clin Oncol
, vol.134
, pp. 381-387
-
-
Ganjoo, K.N.1
Moore, A.M.2
Orazi, A.3
Sen, J.A.4
Johnson, C.S.5
-
10
-
-
79959944338
-
High microvessel density determines a poor outcome in patients with diffuse large B-cell lymphoma treated with rituximab plus chemotherapy
-
doi:10.3324/haematol.2010.037408. PubMed: 21546504
-
Cardesa-Salzmann TM, Colomo L, Gutierrez G, Chan WC, Weisenburger D et al. (2011) High microvessel density determines a poor outcome in patients with diffuse large B-cell lymphoma treated with rituximab plus chemotherapy. Haematologica 96: 996-1001. doi:10.3324/haematol.2010.037408. PubMed: 21546504.
-
(2011)
Haematologica
, vol.96
, pp. 996-1001
-
-
Cardesa-Salzmann, T.M.1
Colomo, L.2
Gutierrez, G.3
Chan, W.C.4
Weisenburger, D.5
-
11
-
-
84859726033
-
VEGFA and VEGFR2 genetic polymorphisms and survival in patients with diffuse large B cell lymphoma
-
doi:10.1111/j.1349-7006.2011.02168.x. PubMed: 22129133
-
Kim MK, Suh C, Chi HS, Cho HS, Bae YK et al. (2012) VEGFA and VEGFR2 genetic polymorphisms and survival in patients with diffuse large B cell lymphoma. Cancer Sci 103: 497-503. doi:10.1111/j.1349-7006.2011.02168.x. PubMed: 22129133.
-
(2012)
Cancer Sci
, vol.103
, pp. 497-503
-
-
Kim, M.K.1
Suh, C.2
Chi, H.S.3
Cho, H.S.4
Bae, Y.K.5
-
12
-
-
77951629048
-
Lymphoma recurrence 5 years or later following diffuse large B-cell lymphoma: Clinical characteristics and outcome
-
doi:10.1200/JCO.2009.24.5860. PubMed: 20308668
-
Larouche JF, Berger F, Chassagne-Clément C, Ffrench M, Callet-Bauchu E et al. (2010) Lymphoma recurrence 5 years or later following diffuse large B-cell lymphoma: clinical characteristics and outcome. J Clin Oncol 28: 2094-2100. doi:10.1200/JCO.2009.24.5860. PubMed: 20308668.
-
(2010)
J Clin Oncol
, vol.28
, pp. 2094-2100
-
-
Larouche, J.F.1
Berger, F.2
Chassagne-Clément, C.3
Ffrench, M.4
Callet-Bauchu, E.5
-
13
-
-
26244438912
-
Hypoxia inducible factor-1: A novel target for cancer therapy
-
doi:10.1097/01.cad.0000180116.85912.69. PubMed: 16162966
-
Belozerov VE, Van Meir EG (2005) Hypoxia inducible factor-1: a novel target for cancer therapy. Anticancer Drugs 16: 901-909. doi:10.1097/01.cad. 0000180116.85912.69. PubMed: 16162966.
-
(2005)
Anticancer Drugs
, vol.16
, pp. 901-909
-
-
Belozerov, V.E.1
Van Meir, E.G.2
-
14
-
-
33749362031
-
Inhibiting hypoxia-inducible factor 1 for cancer therapy
-
doi:10.1158/1541-7786.MCR-06-0235. PubMed: 16940159
-
Melillo G (2006) Inhibiting hypoxia-inducible factor 1 for cancer therapy. Mol Cancer Res 4: 601-605. doi:10.1158/1541-7786.MCR-06-0235. PubMed: 16940159.
-
(2006)
Mol Cancer Res
, vol.4
, pp. 601-605
-
-
Melillo, G.1
-
15
-
-
35048875691
-
Evaluation of HIF-1 inhibitors as anticancer agents
-
doi:10.1016/j.drudis.2007.08.006. PubMed: 17933687
-
Semenza GL (2007) Evaluation of HIF-1 inhibitors as anticancer agents. Drug Discov Today 12: 853-859. doi:10.1016/j.drudis.2007.08.006. PubMed: 17933687.
-
(2007)
Drug Discov Today
, vol.12
, pp. 853-859
-
-
Semenza, G.L.1
-
16
-
-
4644364508
-
The histone deacetylase inhibitor NVP-LAQ824 inhibits angiogenesis and has a greater antitumor effect in combination with the vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584
-
doi:10.1158/0008-5472.CAN-04-0540. PubMed: 15374977
-
Qian DZ, Wang X, Kachhap SK, Kato Y, Wei Y et al. (2004) The histone deacetylase inhibitor NVP-LAQ824 inhibits angiogenesis and has a greater antitumor effect in combination with the vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584. Cancer Res 64: 6626-6634. doi:10.1158/0008-5472.CAN-04-0540. PubMed: 15374977.
-
(2004)
Cancer Res
, vol.64
, pp. 6626-6634
-
-
Qian, D.Z.1
Wang, X.2
Kachhap, S.K.3
Kato, Y.4
Wei, Y.5
-
17
-
-
33749006252
-
Class II histone deacetylases are associated with VHLindependent regulation of hypoxia-inducible factor 1 alpha
-
doi:10.1158/0008-5472.CAN-05-4598. PubMed: 16951198
-
Qian DZ, Kachhap SK, Collis SJ, Verheul HM, Carducci MA et al. (2006) Class II histone deacetylases are associated with VHLindependent regulation of hypoxia-inducible factor 1 alpha. Cancer Res 66: 8814-8821. doi:10.1158/0008- 5472.CAN-05-4598. PubMed: 16951198.
-
(2006)
Cancer Res
, vol.66
, pp. 8814-8821
-
-
Qian, D.Z.1
Kachhap, S.K.2
Collis, S.J.3
Verheul, H.M.4
Carducci, M.A.5
-
18
-
-
43249095919
-
Tumor angiogenesis
-
doi:10.1056/NEJMra0706596. PubMed: 18463380
-
Kerbel RS (2008) Tumor angiogenesis. N Engl J Med 358: 2039-2049. doi:10.1056/NEJMra0706596. PubMed: 18463380.
-
(2008)
N Engl J Med
, vol.358
, pp. 2039-2049
-
-
Kerbel, R.S.1
-
19
-
-
84887593197
-
Sirtuin and pan-class I/II deacetylase (DAC) inhibition is synergistic in preclinical models and clinical studies of lymphoma
-
doi:10.1182/blood-2013-02-485441. PubMed: 23913470
-
Amengual JE, Clark-Garvey S, Kalac M, Scotto L, Marchi E et al. (2013) Sirtuin and pan-class I/II deacetylase (DAC) inhibition is synergistic in preclinical models and clinical studies of lymphoma. Blood 122: 2104-2113. doi:10.1182/blood-2013-02-485441. PubMed: 23913470.
-
(2013)
Blood
, vol.122
, pp. 2104-2113
-
-
Amengual, J.E.1
Clark-Garvey, S.2
Kalac, M.3
Scotto, L.4
Marchi, E.5
-
20
-
-
74549173443
-
Romidepsin and belinostat synergize the antineoplastic effect of bortezomib in mantle cell lymphoma
-
doi:10.1158/1078-0432.CCR-09-1937. PubMed: 20068080
-
Paoluzzi L, Scotto L, Marchi E, Zain J, Seshan VE et al. (2010) Romidepsin and belinostat synergize the antineoplastic effect of bortezomib in mantle cell lymphoma. Clin Cancer Res 16: 554-565. doi:10.1158/1078-0432.CCR-09- 1937. PubMed: 20068080.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 554-565
-
-
Paoluzzi, L.1
Scotto, L.2
Marchi, E.3
Zain, J.4
Seshan, V.E.5
-
21
-
-
33748451151
-
Anticancer activities of histone deacetylase inhibitors
-
doi:10.1038/nrd2133. PubMed: 16955068
-
Bolden JE, Peart MJ, Johnstone RW (2006) Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov 5: 769-784. doi:10.1038/nrd2133. PubMed: 16955068.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 769-784
-
-
Bolden, J.E.1
Peart, M.J.2
Johnstone, R.W.3
-
22
-
-
79952270884
-
HDACs link the DNA damage response, processing of double-strand breaks and autophagy
-
doi:10.1038/nature09803. PubMed: 21368826
-
Robert T, Vanoli F, Chiolo I, Shubassi G, Bernstein KA et al. (2011) HDACs link the DNA damage response, processing of double-strand breaks and autophagy. Nature 471: 74-79. doi:10.1038/nature09803. PubMed: 21368826.
-
(2011)
Nature
, vol.471
, pp. 74-79
-
-
Robert, T.1
Vanoli, F.2
Chiolo, I.3
Shubassi, G.4
Bernstein, K.A.5
-
23
-
-
25444440875
-
The role of autophagy in cancer development and response to therapy
-
doi:10.1038/nrc1692. PubMed: 16148885
-
Kondo Y, Kanzawa T, Sawaya R, Kondo S (2005) The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 5: 726-734. doi:10.1038/nrc1692. PubMed: 16148885.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 726-734
-
-
Kondo, Y.1
Kanzawa, T.2
Sawaya, R.3
Kondo, S.4
-
24
-
-
38949119423
-
Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3
-
PubMed: 18059169
-
Azad MB, Chen Y, Henson ES, Cizeau J, McMillan-Ward E et al. (2008) Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3. Autophagy 4: 195-204. PubMed: 18059169.
-
(2008)
Autophagy
, vol.4
, pp. 195-204
-
-
Azad, M.B.1
Chen, Y.2
Henson, E.S.3
Cizeau, J.4
McMillan-Ward, E.5
-
25
-
-
35848930800
-
Regulation of mitochondrial integrity, autophagy and cell survival by BNIP3
-
PubMed: 17786027
-
Tracy K, Macleod KF (2007) Regulation of mitochondrial integrity, autophagy and cell survival by BNIP3. Autophagy 3: 616-619. PubMed: 17786027.
-
(2007)
Autophagy
, vol.3
, pp. 616-619
-
-
Tracy, K.1
Macleod, K.F.2
-
26
-
-
79959344464
-
Autophagic and apoptotic effects of HDAC inhibitors on cancer cells
-
Rikiishi H (2011) Autophagic and apoptotic effects of HDAC inhibitors on cancer cells. J Biomed Biotechnol 2011: 830260
-
(2011)
J Biomed Biotechnol
, vol.2011
, pp. 830260
-
-
Rikiishi, H.1
-
27
-
-
79251576774
-
Histone deacetylase inhibitors: The epigenetic therapeutics that repress hypoxia-inducible factors
-
Chen S, Sang N (2011) Histone deacetylase inhibitors: the epigenetic therapeutics that repress hypoxia-inducible factors. J Biomed Biotechnol 2011: 197946.
-
(2011)
J Biomed Biotechnol
, vol.2011
, pp. 197946
-
-
Chen, S.1
Sang, N.2
-
28
-
-
0035863399
-
A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles
-
PubMed: 11212227
-
Paglin S, Hollister T, Delohery T, Hackett N, McMahill M et al. (2001) A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res 61: 439-444. PubMed: 11212227.
-
(2001)
Cancer Res
, vol.61
, pp. 439-444
-
-
Paglin, S.1
Hollister, T.2
Delohery, T.3
Hackett, N.4
McMahill, M.5
-
29
-
-
77949893848
-
Hypoxia-inducible factor-1 {alpha} expression predicts superior survival in patients with diffuse large B-cell lymphoma treated with R-CHOP
-
doi:10.1200/JCO.2009.24.1893. PubMed: 20048181
-
Evens AM, Sehn LH, Farinha P, Nelson BP, Raji A et al. (2010) Hypoxia-inducible factor-1 {alpha} expression predicts superior survival in patients with diffuse large B-cell lymphoma treated with R-CHOP. J Clin Oncol 28: 1017-1024. doi:10.1200/JCO.2009.24.1893. PubMed: 20048181.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1017-1024
-
-
Evens, A.M.1
Sehn, L.H.2
Farinha, P.3
Nelson, B.P.4
Raji, A.5
-
30
-
-
84859775933
-
PX-478, a Novel Small Molecule Inhibitor of Hypoxia Inducible Factor-1 (HIF-1) Downregulates HIF and Induces Cytotoxicity in Diffuse Large B Cell Lymphoma Cells
-
Bhalla S, Gordon LI, Singh A, Ahmed S, Dokic D et al. (2009) PX-478, a Novel Small Molecule Inhibitor of Hypoxia Inducible Factor-1 (HIF-1) Downregulates HIF and Induces Cytotoxicity in Diffuse Large B Cell Lymphoma Cells. Blood 114: 1062-1063.
-
(2009)
Blood
, vol.114
, pp. 1062-1063
-
-
Bhalla, S.1
Gordon, L.I.2
Singh, A.3
Ahmed, S.4
Dokic, D.5
-
31
-
-
82055185047
-
A novel approach to cancer therapy using PX-478 as a HIF-1alpha inhibitor
-
doi:10.1007/s12272-011-1021-3. PubMed: 22076756
-
Lee K, Kim HM (2011) A novel approach to cancer therapy using PX-478 as a HIF-1alpha inhibitor. Arch Pharm Res 34: 1583-1585. doi:10.1007/s12272-011- 1021-3. PubMed: 22076756.
-
(2011)
Arch Pharm Res
, vol.34
, pp. 1583-1585
-
-
Lee, K.1
Kim, H.M.2
-
32
-
-
53449096820
-
PX-478, an inhibitor of hypoxia-inducible factor-1alpha, enhances radiosensitivity of prostate carcinoma cells
-
doi:10.1002/ijc.23807. PubMed: 18729192
-
Palayoor ST, Mitchell JB, Cerna D, Degraff W, John-Aryankalayil M et al. (2008) PX-478, an inhibitor of hypoxia-inducible factor-1alpha, enhances radiosensitivity of prostate carcinoma cells. Int J Cancer 123: 2430-2437. doi:10.1002/ijc.23807. PubMed: 18729192.
-
(2008)
Int J Cancer
, vol.123
, pp. 2430-2437
-
-
Palayoor, S.T.1
Mitchell, J.B.2
Cerna, D.3
Degraff, W.4
John-Aryankalayil, M.5
-
33
-
-
66449118481
-
The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects
-
doi:10.1158/1535-7163.MCT-08-0981. PubMed: 19372568
-
Schwartz DL, Powis G, Thitai-Kumar A, He Y, Bankson J et al. (2009) The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects. Mol Cancer Ther 8: 947-958. doi:10.1158/1535-7163.MCT-08-0981. PubMed: 19372568.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 947-958
-
-
Schwartz, D.L.1
Powis, G.2
Thitai-Kumar, A.3
He, Y.4
Bankson, J.5
-
34
-
-
4444369682
-
Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha
-
PubMed: 15026543
-
Welsh S, Williams R, Kirkpatrick L, Paine-Murrieta G, Powis G (2004) Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha. Mol Cancer Ther 3: 233-244. PubMed: 15026543.
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 233-244
-
-
Welsh, S.1
Williams, R.2
Kirkpatrick, L.3
Paine-Murrieta, G.4
Powis, G.5
-
35
-
-
67349201377
-
Targeting tumor angiogenesis with histone deacetylase inhibitors
-
doi:10.1016/j.canlet.2008.11.012. PubMed: 19111391
-
Ellis L, Hammers H, Pili R (2009) Targeting tumor angiogenesis with histone deacetylase inhibitors. Cancer Lett 280: 145-153. doi:10.1016/j.canlet. 2008.11.012. PubMed: 19111391.
-
(2009)
Cancer Lett
, vol.280
, pp. 145-153
-
-
Ellis, L.1
Hammers, H.2
Pili, R.3
-
36
-
-
66249124267
-
PCI-24781 induces caspase and reactive oxygen species-dependent apoptosis through NF-kappaB mechanisms and is synergistic with bortezomib in lymphoma cells
-
doi:10.1158/1078-0432.CCR-08-2365. PubMed: 19417023
-
Bhalla S, Balasubramanian S, David K, Sirisawad M, Buggy J et al. (2009) PCI-24781 induces caspase and reactive oxygen species-dependent apoptosis through NF-kappaB mechanisms and is synergistic with bortezomib in lymphoma cells. Clin Cancer Res 15: 3354-3365. doi:10.1158/1078-0432.CCR-08-2365. PubMed: 19417023.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 3354-3365
-
-
Bhalla, S.1
Balasubramanian, S.2
David, K.3
Sirisawad, M.4
Buggy, J.5
-
37
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
doi:10.1038/20459. PubMed: 10353251
-
Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC et al. (1999) The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399: 271-275. doi:10.1038/20459. PubMed: 10353251.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
-
38
-
-
11244341098
-
Rasdependent induction of HIF-1alpha785 via the Raf/MEK/ERK pathway: A novel mechanism of Ras-mediated tumor promotion
-
doi:10.1038/sj.onc.1208003. PubMed: 15543236
-
Lim JH, Lee ES, You HJ, Lee JW, Park JW et al. (2004) Rasdependent induction of HIF-1alpha785 via the Raf/MEK/ERK pathway: a novel mechanism of Ras-mediated tumor promotion. Oncogene 23: 9427-9431. doi:10.1038/sj.onc. 1208003. PubMed: 15543236.
-
(2004)
Oncogene
, vol.23
, pp. 9427-9431
-
-
Lim, J.H.1
Lee, E.S.2
You, H.J.3
Lee, J.W.4
Park, J.W.5
-
39
-
-
64149112403
-
The Akt/mTOR pathway assures the synthesis of HIF-1alpha protein in a glucose- and reoxygenation-dependent manner in irradiated tumors
-
PubMed: 19098000
-
Harada H, Itasaka S, Kizaka-Kondoh S, Shibuya K, Morinibu A et al. (2009) The Akt/mTOR pathway assures the synthesis of HIF-1alpha protein in a glucose- and reoxygenation-dependent manner in irradiated tumors. J Biol Chem 284: 5332-5342. PubMed: 19098000.
-
(2009)
J Biol Chem
, vol.284
, pp. 5332-5342
-
-
Harada, H.1
Itasaka, S.2
Kizaka-Kondoh, S.3
Shibuya, K.4
Morinibu, A.5
-
40
-
-
70450278715
-
Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1alpha gene transcription via phosphatidylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway
-
doi:10.1074/jbc.M109.054221. PubMed: 19801684
-
Koshikawa N, Hayashi J, Nakagawara A, Takenaga K (2009) Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1alpha gene transcription via phosphatidylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway. J Biol Chem 284: 33185-33194. doi:10.1074/jbc.M109.054221. PubMed: 19801684.
-
(2009)
J Biol Chem
, vol.284
, pp. 33185-33194
-
-
Koshikawa, N.1
Hayashi, J.2
Nakagawara, A.3
Takenaga, K.4
-
41
-
-
33745303045
-
Hypoxia signalling in cancer and approaches to enforce tumour regression
-
doi:10.1038/nature04871. PubMed: 16724055
-
Pouysségur J, Dayan F, Mazure NM (2006) Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 441: 437-443. doi:10.1038/nature04871. PubMed: 16724055.
-
(2006)
Nature
, vol.441
, pp. 437-443
-
-
Pouysségur, J.1
Dayan, F.2
Mazure, N.M.3
-
42
-
-
84865757807
-
Tumor cell autophagy as an adaptive response mediating resistance to treatments such as antiangiogenic therapy
-
doi:10.1158/0008-5472.CAN-12-1076. PubMed: 22915758
-
Hu YL, Jahangiri A, Delay M, Aghi MK (2012) Tumor cell autophagy as an adaptive response mediating resistance to treatments such as antiangiogenic therapy. Cancer Res 72: 4294-4299. doi:10.1158/0008-5472.CAN-12-1076. PubMed: 22915758.
-
(2012)
Cancer Res
, vol.72
, pp. 4294-4299
-
-
Hu, Y.L.1
Jahangiri, A.2
Delay, M.3
Aghi, M.K.4
-
43
-
-
33947250696
-
The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis
-
doi:10.1038/ncb1537. PubMed: 17237771
-
Liang J, Shao SH, Xu ZX, Hennessy B, Ding Z et al. (2007) The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol 9: 218-224. doi:10.1038/ncb1537. PubMed: 17237771.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 218-224
-
-
Liang, J.1
Shao, S.H.2
Xu, Z.X.3
Hennessy, B.4
Ding, Z.5
-
44
-
-
0242331755
-
HIF-1 as a target for drug development
-
doi:10.1038/nrd1199. PubMed: 14526383
-
Giaccia A, Siim BG, Johnson RS (2003) HIF-1 as a target for drug development. Nat Rev Drug Discov 2: 803-811. doi:10.1038/nrd1199. PubMed: 14526383.
-
(2003)
Nat Rev Drug Discov
, vol.2
, pp. 803-811
-
-
Giaccia, A.1
Siim, B.G.2
Johnson, R.S.3
-
45
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
doi:10.1038/nri1181. PubMed: 13130303
-
Semenza GL (2003) Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3: 721-732. doi:10.1038/nri1181. PubMed: 13130303.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
46
-
-
54349118907
-
Oxygen-independent stabilization of hypoxia inducible factor (HIF)-1 during RSV infection
-
doi:10.1371/journal.pone.0003352. PubMed: 18839041
-
Haeberle HA, Durrstein C, Rosenberger P, Hosakote YM, Kuhlicke J et al. (2008) Oxygen-independent stabilization of hypoxia inducible factor (HIF)-1 during RSV infection. PLOS ONE 3: e3352. doi:10.1371/journal.pone.0003352. PubMed: 18839041.
-
(2008)
PLOS ONE
, vol.3
-
-
Haeberle, H.A.1
Durrstein, C.2
Rosenberger, P.3
Hosakote, Y.M.4
Kuhlicke, J.5
-
47
-
-
84867381718
-
Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
-
doi:10.1073/pnas.1018866109. PubMed: 22988108
-
Clambey ET, McNamee EN, Westrich JA, Glover LE, Campbell EL et al. (2012) Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa. Proc Natl Acad Sci U S A 109: E2784-E2793. doi:10.1073/pnas.1018866109. PubMed: 22988108.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
-
-
Clambey, E.T.1
McNamee, E.N.2
Westrich, J.A.3
Glover, L.E.4
Campbell, E.L.5
-
48
-
-
79951829343
-
Hypoxia and inflammation
-
doi:10.1056/NEJMra0910283. PubMed: 21323543
-
Eltzschig HK, Carmeliet P (2011) Hypoxia and inflammation. N Engl J Med 364: 656-665. doi:10.1056/NEJMra0910283. PubMed: 21323543.
-
(2011)
N Engl J Med
, vol.364
, pp. 656-665
-
-
Eltzschig, H.K.1
Carmeliet, P.2
-
49
-
-
44449174536
-
Hypoxia inducible factor (HIF)-1 coordinates induction of Tolllike receptors TLR2 and TLR6 during hypoxia
-
doi:10.1371/journal.pone.0001364. PubMed: 18159247
-
Kuhlicke J, Frick JS, Morote-Garcia JC, Rosenberger P, Eltzschig HK (2007) Hypoxia inducible factor (HIF)-1 coordinates induction of Tolllike receptors TLR2 and TLR6 during hypoxia. PLOS ONE 2: e1364. doi:10.1371/journal. pone.0001364. PubMed: 18159247.
-
(2007)
PLOS ONE
, vol.2
-
-
Kuhlicke, J.1
Frick, J.S.2
Morote-Garcia, J.C.3
Rosenberger, P.4
Eltzschig, H.K.5
-
50
-
-
76049100577
-
HIF-1: Upstream and downstream of cancer metabolism
-
doi:10.1016/j.gde.2009.10.009. PubMed: 19942427
-
Semenza GL (2010) HIF-1: upstream and downstream of cancer metabolism. Curr Opin Genet Dev 20: 51-56. doi:10.1016/j.gde.2009.10.009. PubMed: 19942427.
-
(2010)
Curr Opin Genet Dev
, vol.20
, pp. 51-56
-
-
Semenza, G.L.1
-
51
-
-
45449110185
-
Hypoxia upregulates the histone demethylase JMJD1A via HIF-1
-
doi:10.1016/j.bbrc.2008.05.150. PubMed: 18538129
-
Wellmann S, Bettkober M, Zelmer A, Seeger K, Faigle M et al. (2008) Hypoxia upregulates the histone demethylase JMJD1A via HIF-1. Biochem Biophys Res Commun 372: 892-897. doi:10.1016/j.bbrc.2008.05.150. PubMed: 18538129.
-
(2008)
Biochem Biophys Res Commun
, vol.372
, pp. 892-897
-
-
Wellmann, S.1
Bettkober, M.2
Zelmer, A.3
Seeger, K.4
Faigle, M.5
-
52
-
-
1842426907
-
Upregulation of hypoxia-inducible factor 1alpha is an early event in prostate carcinogenesis
-
doi:10.1016/j.cdp.2003.12.009. PubMed: 15068831
-
Zhong H, Semenza GL, Simons JW, De Marzo AM (2004) Upregulation of hypoxia-inducible factor 1alpha is an early event in prostate carcinogenesis. Cancer Detect Prev 28: 88-93. doi:10.1016/j.cdp.2003.12.009. PubMed: 15068831.
-
(2004)
Cancer Detect Prev
, vol.28
, pp. 88-93
-
-
Zhong, H.1
Semenza, G.L.2
Simons, J.W.3
De Marzo, A.M.4
-
53
-
-
2342611976
-
Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: Role of reoxygenation, free radicals, and stress granules
-
doi:10.1016/S1535-6108(04)00115-1. PubMed: 15144951
-
Moeller BJ, Cao Y, Li CY, Dewhirst MW (2004) Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. Cancer Cell 5: 429-441. doi:10.1016/S1535- 6108(04)00115-1. PubMed: 15144951.
-
(2004)
Cancer Cell
, vol.5
, pp. 429-441
-
-
Moeller, B.J.1
Cao, Y.2
Li, C.Y.3
Dewhirst, M.W.4
-
54
-
-
2942724235
-
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
-
doi:10.1038/nm1052. PubMed: 15156201
-
Majumder PK, Febbo PG, Bikoff R, Berger R, Xue Q et al. (2004) mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat Med 10: 594-601. doi:10.1038/nm1052. PubMed: 15156201.
-
(2004)
Nat Med
, vol.10
, pp. 594-601
-
-
Majumder, P.K.1
Febbo, P.G.2
Bikoff, R.3
Berger, R.4
Xue, Q.5
-
55
-
-
84855471990
-
HDAC inhibitors in cancer biology: Emerging mechanisms and clinical applications
-
doi:10.1038/icb.2011.100. PubMed: 22124371
-
Khan O, La Thangue NB (2012) HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications. Immunol Cell Biol 90: 85-94. doi:10.1038/icb.2011.100. PubMed: 22124371.
-
(2012)
Immunol Cell Biol
, vol.90
, pp. 85-94
-
-
Khan, O.1
La Thangue, N.B.2
-
56
-
-
79956056274
-
HDAC inhibitors potentiate the activity of the BCR/ABL kinase inhibitor KW-2449 in imatinib-sensitive or -resistant BCR/ABL+ leukemia cells in vitro and in vivo
-
doi:10.1158/1078-0432.CCR-11-0234. PubMed: 21474579
-
Nguyen T, Dai Y, Attkisson E, Kramer L, Jordan N et al. (2011) HDAC inhibitors potentiate the activity of the BCR/ABL kinase inhibitor KW-2449 in imatinib-sensitive or -resistant BCR/ABL+ leukemia cells in vitro and in vivo. Clin Cancer Res 17: 3219-3232. doi:10.1158/1078-0432.CCR-11-0234. PubMed: 21474579.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 3219-3232
-
-
Nguyen, T.1
Dai, Y.2
Attkisson, E.3
Kramer, L.4
Jordan, N.5
-
57
-
-
34247187576
-
Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB site
-
doi:10.1161/01.ATV.0000258979.92828.bc. PubMed: 17272744
-
Bonello S, Zähringer C, BelAiba RS, Djordjevic T, Hess J et al. (2007) Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB site. Arterioscler Thromb Vasc Biol 27: 755-761. doi:10.1161/01.ATV. 0000258979.92828.bc. PubMed: 17272744.
-
(2007)
Arterioscler Thromb Vasc Biol
, vol.27
, pp. 755-761
-
-
Bonello, S.1
Zähringer, C.2
BelAiba, R.S.3
Djordjevic, T.4
Hess, J.5
-
58
-
-
79952523493
-
SIRT3 controls cancer metabolic reprogramming by regulating ROS and HIF
-
doi:10.1016/j.ccr.2011.03.001. PubMed: 21397853
-
Schumacker PT (2011) SIRT3 controls cancer metabolic reprogramming by regulating ROS and HIF. Cancer Cell 19: 299-300. doi:10.1016/j.ccr.2011.03.001. PubMed: 21397853.
-
(2011)
Cancer Cell
, vol.19
, pp. 299-300
-
-
Schumacker, P.T.1
-
59
-
-
0034654174
-
Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
-
PubMed: 10749120
-
Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C et al. (2000) Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 60: 1541-1545. PubMed: 10749120.
-
(2000)
Cancer Res
, vol.60
, pp. 1541-1545
-
-
Zhong, H.1
Chiles, K.2
Feldser, D.3
Laughner, E.4
Hanrahan, C.5
-
60
-
-
0043234256
-
Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells
-
doi:10.1074/jbc.M300763200. PubMed: 12764143
-
Mottet D, Dumont V, Deccache Y, Demazy C, Ninane N et al. (2003) Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells. J Biol Chem 278: 31277-31285. doi:10.1074/jbc. M300763200. PubMed: 12764143.
-
(2003)
J Biol Chem
, vol.278
, pp. 31277-31285
-
-
Mottet, D.1
Dumont, V.2
Deccache, Y.3
Demazy, C.4
Ninane, N.5
-
61
-
-
84863254048
-
PI3K/Akt contributes to increased expression of Toll-like receptor 4 in macrophages exposed to hypoxic stress
-
doi:10.1016/j.bbrc.2012.02.015. PubMed: 22424098
-
Kim SY, Jeong E, Joung SM, Lee JY (2012) PI3K/Akt contributes to increased expression of Toll-like receptor 4 in macrophages exposed to hypoxic stress. Biochem Biophys Res Commun 419: 466-471. doi:10.1016/j.bbrc.2012.02.015. PubMed: 22424098.
-
(2012)
Biochem Biophys Res Commun
, vol.419
, pp. 466-471
-
-
Kim, S.Y.1
Jeong, E.2
Joung, S.M.3
Lee, J.Y.4
-
62
-
-
12944303650
-
Growth factor regulation of autophagy and cell survival in the absence of apoptosis
-
doi:10.1016/j.cell.2004.11.046. PubMed: 15680329
-
Lum JJ, Bauer DE, Kong M, Harris MH, Li C et al. (2005) Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120: 237-248. doi:10.1016/j.cell.2004.11.046. PubMed: 15680329.
-
(2005)
Cell
, vol.120
, pp. 237-248
-
-
Lum, J.J.1
Bauer, D.E.2
Kong, M.3
Harris, M.H.4
Li, C.5
-
63
-
-
81155126200
-
Antiangiogenic therapies in non-Hodgkin's lymphoma
-
doi:10.2174/156800911798073014. PubMed: 21933106
-
Ruan J (2011) Antiangiogenic therapies in non-Hodgkin's lymphoma. Curr Cancer Drug Targets 11: 1030-1043. doi:10.2174/156800911798073014. PubMed: 21933106.
-
(2011)
Curr Cancer Drug Targets
, vol.11
, pp. 1030-1043
-
-
Ruan, J.1
-
64
-
-
25444524850
-
Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity
-
doi:10.1074/jbc.M502876200. PubMed: 16027121
-
Hahn-Windgassen A, Nogueira V, Chen CC, Skeen JE, Sonenberg N et al. (2005) Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. J Biol Chem 280: 32081-32089. doi:10.1074/jbc. M502876200. PubMed: 16027121.
-
(2005)
J Biol Chem
, vol.280
, pp. 32081-32089
-
-
Hahn-Windgassen, A.1
Nogueira, V.2
Chen, C.C.3
Skeen, J.E.4
Sonenberg, N.5
-
65
-
-
0141925771
-
Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart
-
doi:10.1074/jbc.M305371200. PubMed: 12890675
-
Kovacic S, Soltys CL, Barr AJ, Shiojima I, Walsh K et al. (2003) Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart. J Biol Chem 278: 39422-39427. doi:10.1074/jbc.M305371200. PubMed: 12890675.
-
(2003)
J Biol Chem
, vol.278
, pp. 39422-39427
-
-
Kovacic, S.1
Soltys, C.L.2
Barr, A.J.3
Shiojima, I.4
Walsh, K.5
|