Cystatin C triggers neuronal degeneration in a model of multiple system atrophy

American Journal of Pathology

Volumn 184, Issue 3, 2014, Pages 790-799

  Suzuki, Yasuyo ^a   Jin, Chenghua ^a   Yazawa, Ikuru ^a  

^a NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; CYSTATIN C; SNCA PROTEIN, HUMAN;

ANIMAL; BRAIN; DISEASE MODEL; GENETICS; HUMAN; METABOLISM; MOUSE; NERVE CELL; OLIGODENDROGLIA; PATHOLOGY; SHY DRAGER SYNDROME; TRANSGENIC MOUSE; UPREGULATION;

ALPHA-SYNUCLEIN; ANIMALS; BRAIN; CYSTATIN C; DISEASE MODELS, ANIMAL; HUMANS; MICE; MICE, TRANSGENIC; MULTIPLE SYSTEM ATROPHY; NEURONS; OLIGODENDROGLIA; UP-REGULATION;

EID: 84894197966     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2013.11.018     Document Type: Article

References (41)

1. Y. Lee, B.M. Morrison, Y. Li, S. Lengacher, M.H. Farah, P.N. Hoffman, Y. Liu, A. Tsingalia, L. Jin, P.W. Zhang, L. Pellerin, P.J. Magistretti, and J.D. Rothstein Oligodendroglia metabolically support axons and contribute to neurodegeneration Nature 487 2012 443 448
2. J.G. Graham, and D.R. Oppenheimer Orthostatic hypotension and nicotine sensitivity in a case of multiple system atrophy J Neurol Neurosurg Psychiatry 32 1969 28 34
3. S. Gilman, G.K. Wenning, P.A. Low, D.J. Brooks, C.J. Mathias, J.Q. Trojanowski, N.W. Wood, C. Colosimo, A. Dürr, C.J. Fowler, H. Kaufmann, T. Klockgether, A. Lees, W. Poewe, N. Quinn, T. Revesz, D. Robertson, P. Sandroni, K. Seppi, and M. Vidailhet Second consensus statement on the diagnosis of multiple system atrophy Neurology 71 2008 670 676
4. G.K. Wenning, and N. Stefanova Recent developments in multiple system atrophy J Neurol 256 2009 1791 1808
5. M.I. Papp, J.E. Kahn, and P.L. Lantos Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome) J Neurol Sci 94 1989 79 100 (Pubitemid 20019446)
6. K. Arima, K. Uéda, N. Sunohara, K. Arakawa, S. Hirai, M. Nakamura, H. Tonozuka-Uehara, and M. Kawai NACP/α-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy Acta Neuropathol 96 1998 439 444 (Pubitemid 28474750)
7. P.H. Tu, J.E. Galvin, M. Baba, B. Giasson, T. Tomita, S. Leight, S. Nakajo, T. Iwatsubo, J.Q. Trojanowski, and V.M. Lee Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α-synuclein Ann Neurol 44 1998 415 422 (Pubitemid 28421453)
8. M.G. Spillantini, R.A. Crowther, R. Jakes, N.J. Cairns, P.L. Lantos, and M. Goedert Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies Neurosci Lett 251 1998 205 208 (Pubitemid 28381082)
9. M.G. Spillantini, and M. Goedert The α-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy Ann N Y Acad Sci 920 2000 16 27 (Pubitemid 32056547)
10. M. Goedert Alpha-synuclein and neurodegenerative diseases Nat Rev Neurosci 2 2001 492 501 (Pubitemid 33676584)
11. P.J. Kahle, M. Neumann, L. Ozmen, V. Muller, H. Jacobsen, W. Spooren, B. Fuss, B. Mallon, W.B. Macklin, H. Fujiwara, M. Hasegawa, T. Iwatsubo, H.A. Kretzschmar, and C. Haass Hyperphosphorylation and insolubility of α-synuclein in transgenic mouse oligodendrocytes EMBO Rep 3 2002 583 588 (Pubitemid 34752460)
12. C.W. Shults, E. Rockenstein, L. Crews, A. Adame, M. Mante, G. Larrea, M. Hashimoto, D. Song, T. Iwatsubo, K. Tsuboi, and E. Masliah Neurological and neurodegenerative alterations in a transgenic mouse model expressing human α-synuclein under oligodendrocyte promoter: implications for multiple system atrophy J Neurosci 25 2005 10689 10699 (Pubitemid 41681917)
13. I. Yazawa, B.I. Giasson, R. Sasaki, B. Zhang, S. Joyce, K. Uryu, J.Q. Trojanowski, and V.M. Lee Mouse model of multiple system atrophy: α-synuclein expression in oligodendrocytes causes glial and neuronal degeneration Neuron 45 2005 847 859 (Pubitemid 40395264)
14. H. Ito, K. Nakayama, C. Jin, Y. Suzuki, and I. Yazawa α-Synuclein accumulation reduces GABAergic inhibitory transmission in a model of multiple system atrophy Biochem Biophys Res Commun 428 2012 348 353
15. K. Nakayama, Y. Suzuki, and I. Yazawa Microtubule depolymerization suppresses α-synuclein accumulation in a mouse model of multiple system atrophy Am J Pathol 174 2009 1471 1480
16. K. Nakayama, Y. Suzuki, and I. Yazawa Binding of neuronal α-synuclein to β-III tubulin and accumulation in a model of multiple system atrophy Biochem Biophys Res Commun 417 2012 1170 1175
17. K.D. McCarthy, and J. de Vellis Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue J Cell Biol 85 1980 890 902 (Pubitemid 10007455)
18. J. Vandesompele, K. De Preter, F. Pattyn, B. Poppe, N. Van Roy, A. De Paepe, and F. Speleman Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes Genome Biol 3 2002 RESEARCH0034
19. Y. Suzuki, K. Nakayama, N. Hashimoto, and I. Yazawa Proteolytic processing regulates pathological accumulation in dentatorubral-pallidoluysian atrophy FEBS J 277 2010 4873 4887
20. I. Yazawa, H. Nakase, and H. Kurisaki Abnormal dentatorubral- pallidoluysian atrophy (DRPLA) protein complex is pathologically ubiquitinated in DRPLA brains Biochem Biophys Res Commun 260 1999 133 138 (Pubitemid 29351797)
21. O. Yasuhara, K. Hanai, I. Ohkubo, M. Sasaki, P.L. McGeer, and H. Kimura Expression of cystatin C in rat, monkey and human brains Brain Res 628 1993 85 92 (Pubitemid 23331595)
22. D.E. Palm, N.W. Knuckey, M.J. Primiano, A.G. Spangenberger, and C.E. Johanson Cystatin C, a protease inhibitor, in degenerating rat hippocampal neurons following transient forebrain ischemia Brain Res 691 1995 1 8
23. C. Nishio, K. Yoshida, K. Nishiyama, H. Hatanaka, and M. Yamada Involvement of cystatin C in oxidative stress-induced apoptosis of cultured rat CNS neurons Brain Res 873 2000 252 262 (Pubitemid 30619049)
24. L. Xu, J. Sheng, Z. Tang, X. Wu, Y. Yu, H. Guo, Y. Shen, C. Zhou, L. Paraoan, and J. Zhou Cystatin C prevents degeneration of rat nigral dopaminergic neurons: in vitro and in vivo studies Neurobiol Dis 18 2005 152 165 (Pubitemid 40092905)
25. T.J. Pirttilä, K. Lukasiuk, K. Håkansson, A. Grubb, M. Abrahamson, and A. Pitkänen Cystatin C modulates neurodegeneration and neurogenesis following status epilepticus in mouse Neurobiol Dis 20 2005 241 253 (Pubitemid 41476252)
26. B. Caughey Transmissible spongiform encephalopathies, amyloidoses and yeast prions: common threads? Nat Med 6 2000 751 754 (Pubitemid 30469422)
27. M.D. Kane, W.J. Lipinski, M.J. Callahan, F. Bian, R.A. Durham, R.D. Schwarz, A.E. Roher, and L.C. Walker Evidence for seeding of β-amyloid by intracerebral infusion of Alzheimer brain extracts in β-amyloid precursor protein-transgenic mice J Neurosci 20 2000 3606 3611 (Pubitemid 30266223)
28. M. Meyer-Luehmann, J. Coomaraswamy, T. Bolmont, S. Kaeser, C. Schaefer, E. Kilger, A. Neuenschwander, D. Abramowski, P. Frey, A.L. Jaton, J.M. Vigouret, P. Paganetti, D.M. Walsh, P.M. Mathews, J. Ghiso, M. Staufenbiel, L.C. Walker, and M. Jucker Exogenous induction of cerebral β-amyloidogenesis is governed by agent and host Science 313 2006 1781 1784 (Pubitemid 44454153)
29. F. Clavaguera, T. Bolmont, R.A. Crowther, D. Abramowski, S. Frank, A. Probst, G. Fraser, A.K. Stalder, M. Beibel, M. Staufenbiel, M. Jucker, M. Goedert, and M. Tolnay Transmission and spreading of tauopathy in transgenic mouse brain Nat Cell Biol 11 2009 909 913
30. A. de Calignon, M. Polydoro, M. Suárez-Calvet, C. William, D.H. Adamowicz, K.J. Kopeikina, R. Pitstick, N. Sahara, K.H. Ashe, G.A. Carlson, T.L. Spires-Jones, and B.T. Hyman Propagation of tau pathology in a model of early Alzheimer's disease Neuron 73 2012 685 697
31. P. Desplats, H.J. Lee, E.J. Bae, C. Patrick, E. Rockenstein, L. Crews, B. Spencer, E. Masliah, and S.J. Lee Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein Proc Natl Acad Sci U S A 106 2009 13010 13015
32. K.C. Luk, C. Song, P. O'Brien, A. Stieber, J.R. Branch, K.R. Brunden, J.Q. Trojanowski, and V.M. Lee Exogenous α-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells Proc Natl Acad Sci U S A 106 2009 20051 20056
33. K.C. Luk, V. Kehm, J. Carroll, B. Zhang, P. O'Brien, J.Q. Trojanowski, and V.M. Lee Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice Science 338 2012 949 953
34. K. Ubhi, E. Rockenstein, M. Mante, C. Inglis, A. Adame, C. Patrick, K. Whitney, and E. Masliah Neurodegeneration in a transgenic mouse model of multiple system atrophy is associated with altered expression of oligodendroglial-derived neurotrophic factors J Neurosci 30 2010 6236 6246
35. L.A. Bobek, and M.J. Levine Cystatins-inhibitors of cysteine proteinases Crit Rev Oral Biol Med 3 1992 307 332
36. K. Håkansson, C. Huh, A. Grubb, S. Karlsson, and M. Abrahamson Mouse and rat cystatin C: Escherichia coli production, characterization and tissue distribution Comp Biochem Physiol B Biochem Mol Biol 114 1996 303 311 (Pubitemid 26261186)
37. G. Gudmundsson, J. Hallgrímsson, T.A. Jónasson, and O. Bjarnason Hereditary cerebral hemorrhage with amyloidosis Brain 95 1972 387 404
38. I. Olafsson, L. Thorsteinsson, and O. Jensson The molecular pathology of hereditary cystatin C amyloid angiopathy causing brain hemorrhage Brain Pathol 6 1996 121 126 (Pubitemid 26161870)
39. S.A. Kaeser, M.C. Herzig, J. Coomaraswamy, E. Kilger, M.L. Selenica, D.T. Winkler, M. Staufenbiel, E. Levy, A. Grubb, and M. Jucker Cystatin C modulates cerebral β-amyloidosis Nat Genet 39 2007 1437 1439
40. W. Mi, M. Pawlik, M. Sastre, S.S. Jung, D.S. Radvinsky, A.M. Klein, J. Sommer, S.D. Schmidt, R.A. Nixon, P.M. Mathews, and E. Levy Cystatin C inhibits amyloid-β deposition in Alzheimer's disease mouse models Nat Genet 39 2007 1440 1442 (Pubitemid 350191347)
41. B. Sun, Y. Zhou, B. Halabisky, I. Lo, S.H. Cho, S. Mueller-Steiner, N. Devidze, X. Wang, A. Grubb, and L. Gan Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease Neuron 60 2008 247 257