Mode of action of the positive modulator PNU-120596 on α7 nicotinic acetylcholine receptors

Neuropharmacology

Volumn 81, Issue , 2014, Pages 42-54

  Szabo, Anett K ^a,b   Pesti, Krisztina ^a,b   Mike, Arpad ^b   Vizi, E Sylvester ^b  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Choline; Mode of action; PNU 120596; Positive allosteric modulator; 7 nicotinic acetylcholine receptor

Indexed keywords

ACETYLCHOLINE; BUNGAROTOXIN RECEPTOR; CHOLINE; CHOLINERGIC RECEPTOR STIMULATING AGENT; PNU 120596; UNCLASSIFIED DRUG; 1-(5-CHLORO-2,4-DIMETHOXYPHENYL)-3-(5-METHYLISOXAZOL-3-YL)UREA; CARBANILAMIDE DERIVATIVE; ISOXAZOLE DERIVATIVE; NICOTINIC AGENT;

ACETYLCHOLINE RELEASE; ALLOSTERISM; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISSOCIATION; DRUG MECHANISM; NONHUMAN; PATCH CLAMP TECHNIQUE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; RAT; RECEPTOR BINDING; RECEPTOR DOWN REGULATION; ANIMAL; BIOLOGICAL MODEL; BIOPHYSICS; COMPUTER SIMULATION; DOSE RESPONSE; DRUG EFFECTS; DRUG INTERACTION; ELECTROSTIMULATION; GENETIC TRANSFECTION; GENETICS; HYPOPHYSIS TUMOR; MEMBRANE POTENTIAL; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ACETYLCHOLINE; ALLOSTERIC REGULATION; ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR; ANIMALS; BIOPHYSICS; CELL LINE, TUMOR; CHOLINE; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ELECTRIC STIMULATION; ISOXAZOLES; MEMBRANE POTENTIALS; MODELS, BIOLOGICAL; NICOTINIC AGONISTS; PATCH-CLAMP TECHNIQUES; PHENYLUREA COMPOUNDS; PITUITARY NEOPLASMS; RATS; TRANSFECTION;

EID: 84894159096     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2014.01.033     Document Type: Article

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