Point-to-point ligand-receptor interactions across the subunit interface modulate the induction and stabilization of conformational states of alpha7 nAChR by benzylidene anabaseines

Biochemical Pharmacology

Volumn 85, Issue 6, 2013, Pages 817-828

  Isaacson, Matthew D ^a   Horenstein, Nicole A ^b   Stokes, Clare ^a   Kem, William R ^a   Papke, Roger L ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b University of Florida   (United States)

Author keywords

Conformational states; Homology modeling; Receptor desensitization; Site directed mutation

Indexed keywords

3 (2,4 DIMETHOXYBENZYLIDENE)ANABASEINE; BENZYLIDENE ANABASEINE; BENZYLIDENE DERIVATIVE; BUNGAROTOXIN RECEPTOR; HYDROXYL GROUP; LIGAND; MUTANT PROTEIN; SERINE; SERINE 36; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; COMPUTER PREDICTION; CONTROLLED STUDY; DESENSITIZATION; FEMALE; HUMAN; HUMAN CELL; HYDROGEN BOND; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN SUBUNIT; WILD TYPE; XENOPUS LAEVIS;

ANABASINE; ANIMALS; BENZYLIDENE COMPOUNDS; DNA, COMPLEMENTARY; HUMANS; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, NICOTINIC; XENOPUS LAEVIS;

EID: 84874105584     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.01.010     Document Type: Article

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