-
1
-
-
84872257350
-
Renal transporters in drug development
-
Comprehensive review of renal transporters and respective substrates involved in renal elimination indicating their important role in drug development
-
Morrissey KM, Stocker SL, Wittwer MB, et al. Renal transporters in drug development. Annu Rev Pharmacol Toxicol 2013;53:503-29. Comprehensive review of renal transporters and respective substrates involved in renal elimination indicating their important role in drug development.
-
(2013)
Annu Rev Pharmacol Toxicol
, vol.53
, pp. 503-29
-
-
Morrissey, K.M.1
Stocker, S.L.2
Wittwer, M.B.3
-
2
-
-
84875123211
-
The ABCs of membrane transporters in health and disease (SLC series): Introduction
-
Hediger MA, Clemencon B, Burrier RE, et al. The ABCs of membrane transporters in health and disease (SLC series): Introduction. Mol Aspects Med 2013;34:95-107
-
(2013)
Mol Aspects Med
, vol.34
, pp. 95-107
-
-
Hediger, M.A.1
Clemencon, B.2
Burrier, R.E.3
-
3
-
-
0033849976
-
Cellular and molecular aspects of drug transport in the kidney
-
Inui KI, Masuda S, Saito H. Cellular and molecular aspects of drug transport in the kidney. Kidney Int 2000;58:944-58
-
(2000)
Kidney Int
, vol.58
, pp. 944-58
-
-
Inui, K.I.1
Masuda, S.2
Saito, H.3
-
4
-
-
0030892709
-
Interaction of anionic cephalosporins with the intestinal and renal peptide transporters PEPT 1 and PEPT 2
-
Ganapathy ME, Prasad PD, Mackenzie B, et al. Interaction of anionic cephalosporins with the intestinal and renal peptide transporters PEPT 1 and PEPT 2. Biochim Biophys Acta 1997;1324:296-308
-
(1997)
Biochim Biophys Acta
, vol.1324
, pp. 296-308
-
-
Ganapathy, M.E.1
Prasad, P.D.2
Mackenzie, B.3
-
5
-
-
0033659819
-
Physiological and pharmacological implications of peptide transporters, PEPT1 and PEPT2
-
Inui K, Terada T, Masuda S, et al. Physiological and pharmacological implications of peptide transporters, PEPT1 and PEPT2. Nephrol Dial Transplant 2000;15(Suppl 6):11-13
-
(2000)
Nephrol Dial Transplant
, vol.15
, Issue.SUPPL. 6
, pp. 11-13
-
-
Inui, K.1
Terada, T.2
Masuda, S.3
-
6
-
-
84873329542
-
Proton-coupled oligopeptide transporter family SLC15: Physiological, pharmacological and pathological implications
-
Smith DE, Clemencon B, Hediger MA. Proton-coupled oligopeptide transporter family SLC15: Physiological, pharmacological and pathological implications. Mol Aspects Med 2013;34:323-36
-
(2013)
Mol Aspects Med
, vol.34
, pp. 323-36
-
-
Smith, D.E.1
Clemencon, B.2
Hediger, M.A.3
-
7
-
-
78751687938
-
An integrative overview on the mechanisms underlying the renal tubular cytotoxicity of gentamicin
-
Quiros Y, Vicente-Vicente L, Morales AI, et al. An integrative overview on the mechanisms underlying the renal tubular cytotoxicity of gentamicin. Toxicol Sci 2011;119:245-56
-
(2011)
Toxicol Sci
, vol.119
, pp. 245-56
-
-
Quiros, Y.1
Vicente-Vicente, L.2
Morales, A.I.3
-
8
-
-
67649159093
-
Renal toxicity of therapeutic drugs
-
John R, Herzenberg AM. Renal toxicity of therapeutic drugs. J Clin Pathol 2009;62:505-15
-
(2009)
J Clin Pathol
, vol.62
, pp. 505-15
-
-
John, R.1
Herzenberg, A.M.2
-
9
-
-
0000784127
-
Changing demography of acute renal failure
-
Elasy TA, Anderson RJ. Changing demography of acute renal failure. Semin Dial 1996;9:438-43
-
(1996)
Semin Dial
, vol.9
, pp. 438-43
-
-
Elasy, T.A.1
Anderson, R.J.2
-
10
-
-
67549145035
-
Drug-induced nephrotoxicity
-
Naughton CA. Drug-induced nephrotoxicity. Am Fam Physician 2008;78:743-50
-
(2008)
Am Fam Physician
, vol.78
, pp. 743-50
-
-
Naughton, C.A.1
-
12
-
-
70349303831
-
Renal vulnerability to drug toxicity
-
Perazella MA. Renal vulnerability to drug toxicity. Clin J Am Soc Nephrol 2009;4:1275-83
-
(2009)
Clin J Am Soc Nephrol
, vol.4
, pp. 1275-83
-
-
Perazella, M.A.1
-
13
-
-
79952192991
-
Nephrotoxicity-what do we know and what don't we know?
-
Skinner R. Nephrotoxicity-what do we know and what don't we know? J Pediatr Hematol Oncol 2011;33:128-34
-
(2011)
J Pediatr Hematol Oncol
, vol.33
, pp. 128-34
-
-
Skinner, R.1
-
14
-
-
33644829720
-
Drug-associated renal dysfunction and injury
-
Comprehensive overview on different entities of drug-related nephrotoxicity including mechanistic explanations
-
Choudhury D, Ahmed Z. Drug-associated renal dysfunction and injury. Nat Clin Pract Nephrol 2006;2:80-91 . Comprehensive overview on different entities of drug-related nephrotoxicity including mechanistic explanations.
-
(2006)
Nat Clin Pract Nephrol
, vol.2
, pp. 80-91
-
-
Choudhury, D.1
Ahmed, Z.2
-
16
-
-
28244486151
-
Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2
-
Original article on cisplatin-related nephrotoxicity mediated by renal OCT2 and mechanistic evidence for OCT2 inhibition by cimetidine to overcome cisplatin nephrotoxicity
-
Ciarimboli G, Ludwig T, Lang D, et al. Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2. Am J Pathol 2005;167:1477-84. Original article on cisplatin-related nephrotoxicity mediated by renal OCT2 and mechanistic evidence for OCT2 inhibition by cimetidine to overcome cisplatin nephrotoxicity.
-
(2005)
Am J Pathol
, vol.167
, pp. 1477-84
-
-
Ciarimboli, G.1
Ludwig, T.2
Lang, D.3
-
17
-
-
69449098951
-
The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin
-
Tzvetkov MV, Vormfelde SV, Balen D, et al. The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin. Clin Pharmacol Ther 2009;86:299-306
-
(2009)
Clin Pharmacol Ther
, vol.86
, pp. 299-306
-
-
Tzvetkov, M.V.1
Vormfelde, S.V.2
Balen, D.3
-
18
-
-
26244449838
-
Roles of organic anion transporters (OATs) and a urate transporter (URAT1) in the pathophysiology of human disease
-
Enomoto A, Endou H. Roles of organic anion transporters (OATs) and a urate transporter (URAT1) in the pathophysiology of human disease. Clin Exp Nephrol 2005;9:195-205
-
(2005)
Clin Exp Nephrol
, vol.9
, pp. 195-205
-
-
Enomoto, A.1
Endou, H.2
-
19
-
-
26944486690
-
Regulating renal drug elimination?
-
Lang F. Regulating renal drug elimination? J Am Soc Nephrol 2005;16:1535-6
-
(2005)
J Am Soc Nephrol
, vol.16
, pp. 1535-6
-
-
Lang, F.1
-
20
-
-
84874514025
-
Renal drug transporters and nephrotoxicity
-
Anzai N, Endou H. Renal drug transporters and nephrotoxicity. AATEX 2007;14:447-52
-
(2007)
AATEX
, vol.14
, pp. 447-52
-
-
Anzai, N.1
Endou, H.2
-
21
-
-
0031897770
-
Hospital-acquired acute renal failure
-
Nolan CR, Anderson RJ. Hospital-acquired acute renal failure. J Am Soc Nephrol 1998;9:710-18
-
(1998)
J Am Soc Nephrol
, vol.9
, pp. 710-18
-
-
Nolan, C.R.1
Anderson, R.J.2
-
22
-
-
0033999391
-
Tubular cell damage in acute renal failure-apoptosis, necrosis, or both
-
Ueda N, Shah SV. Tubular cell damage in acute renal failure-apoptosis, necrosis, or both. Nephrol Dial Transplant 2000;15:318-23
-
(2000)
Nephrol Dial Transplant
, vol.15
, pp. 318-23
-
-
Ueda, N.1
Shah, S.V.2
-
23
-
-
20044381728
-
Tubular cell apoptosis and cidofovir-induced acute renal failure
-
Ortiz A, Justo P, Sanz A, et al. Tubular cell apoptosis and cidofovir-induced acute renal failure. Antivir Ther 2005;10:185-90
-
(2005)
Antivir Ther
, vol.10
, pp. 185-90
-
-
Ortiz, A.1
Justo, P.2
Sanz, A.3
-
24
-
-
38049139423
-
Renal cell apoptosis induced by nephrotoxic drugs: Cellular and molecular mechanisms and potential approaches to modulation
-
Servais H, Ortiz A, Devuyst O, et al. Renal cell apoptosis induced by nephrotoxic drugs: Cellular and molecular mechanisms and potential approaches to modulation. Apoptosis 2008;13:11-32
-
(2008)
Apoptosis
, vol.13
, pp. 11-32
-
-
Servais, H.1
Ortiz, A.2
Devuyst, O.3
-
25
-
-
79952095132
-
Assessment of the role of renal organic anion transporters in drug-induced nephrotoxicity
-
Hagos Y, Wolff NA. Assessment of the role of renal organic anion transporters in drug-induced nephrotoxicity. Toxins (Basel) 2010;2:2055-82
-
(2010)
Toxins (Basel)
, vol.2
, pp. 2055-82
-
-
Hagos, Y.1
Wolff, N.A.2
-
26
-
-
67651235787
-
Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin
-
Chen Y, Li S, Brown C, et al. Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin. Pharmacogenet Genomics 2009;19:497-504
-
(2009)
Pharmacogenet Genomics
, vol.19
, pp. 497-504
-
-
Chen, Y.1
Li, S.2
Brown, C.3
-
27
-
-
70349440952
-
Contribution of organic cation transporter 2 (OCT2) to cisplatin-induced nephrotoxicity
-
Filipski KK, Mathijssen RH, Mikkelsen TS, et al. Contribution of organic cation transporter 2 (OCT2) to cisplatin-induced nephrotoxicity. Clin Pharmacol Ther 2009;86:396-402
-
(2009)
Clin Pharmacol Ther
, vol.86
, pp. 396-402
-
-
Filipski, K.K.1
Mathijssen, R.H.2
Mikkelsen, T.S.3
-
28
-
-
0029000871
-
Clinical pharmacokinetics of cidofovir in human immunodeficiency virus-infected patients
-
Cundy KC, Petty BG, Flaherty J, et al. Clinical pharmacokinetics of cidofovir in human immunodeficiency virus-infected patients. Antimicrob Agents Chemother 1995;39:1247-52
-
(1995)
Antimicrob Agents Chemother
, vol.39
, pp. 1247-52
-
-
Cundy, K.C.1
Petty, B.G.2
Flaherty, J.3
-
29
-
-
0020325272
-
Effects of probenecid on the pharmacokinetics and elimination of acyclovir in humans
-
Laskin OL, de MP, King DH, et al. Effects of probenecid on the pharmacokinetics and elimination of acyclovir in humans. Antimicrob Agents Chemother 1982;21:804-7
-
(1982)
Antimicrob Agents Chemother
, vol.21
, pp. 804-7
-
-
Laskin, O.L.1
De, M.P.2
King, D.H.3
-
30
-
-
84884573410
-
DNA Methylation of the SLC16A3 promoter regulates expression of the human lactate transporter mct4 in renal cancer with consequences for clinical outcome
-
Fisel P, Kruck S, Winter S, et al. DNA Methylation of the SLC16A3 promoter regulates expression of the human lactate transporter mct4 in renal cancer with consequences for clinical outcome. Clin Cancer Res 2013;19:5170-81
-
(2013)
Clin Cancer Res
, vol.19
, pp. 5170-81
-
-
Fisel, P.1
Kruck, S.2
Winter, S.3
-
31
-
-
84857361302
-
A critical evaluation of in vitro cell culture models for high-throughput drug screening and toxicity
-
Extensive review on the impact of in vitro cell models in general for preclinical research in drug development with specific focus on drug toxicity issues
-
Astashkina A, Mann B, Grainger DW. A critical evaluation of in vitro cell culture models for high-throughput drug screening and toxicity. Pharmacol Ther 2012;134:82-106. Extensive review on the impact of in vitro cell models in general for preclinical research in drug development with specific focus on drug toxicity issues.
-
(2012)
Pharmacol Ther
, vol.134
, pp. 82-106
-
-
Astashkina, A.1
Mann, B.2
Grainger, D.W.3
-
32
-
-
84889303621
-
Overview on bioreactor design prototyping and in process controls for reproducible three dimensional tissue culture
-
Marx and Sandig editors Wiley-VCH Verlag GmbH&Co. KgaA, Weinheim
-
Pörtner R, Giese C. Overview on bioreactor design, prototyping and in process controls for reproducible three dimensional tissue culture. In: Marx and Sandig, editors. Drug testing in vitro - breakthroughs and trends in cell culture technology. Wiley-VCH Verlag GmbH &Co. KgaA, Weinheim; 2007. p. 53-78
-
(2007)
Drug Testing in Vitro - Breakthroughs and Trends in Cell Culture Technology.
, pp. 53-78
-
-
Pörtner, R.1
Giese, C.2
-
33
-
-
84894194436
-
-
Available from
-
Available from: Http://www bioparadigmsorg/slc/intro.htm
-
-
-
-
34
-
-
0033921479
-
Structure of renal organic anion and cation transporters
-
Burckhardt G, Wolff NA. Structure of renal organic anion and cation transporters. Am J Physiol Renal Physiol 2000;278:853-66
-
(2000)
Am J Physiol Renal Physiol
, vol.278
, pp. 853-66
-
-
Burckhardt, G.1
Wolff, N.A.2
-
35
-
-
0031410948
-
The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26
-
Koehler MR, Wissinger B, Gorboulev V, et al. The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26. Cytogenet Cell Genet 1997;79:198-200
-
(1997)
Cytogenet Cell Genet
, vol.79
, pp. 198-200
-
-
Koehler, M.R.1
Wissinger, B.2
Gorboulev, V.3
-
36
-
-
84875181483
-
The SLC22 family with transporters of organic cations, anions and zwitterions
-
Koepsell H. The SLC22 family with transporters of organic cations, anions and zwitterions. Mol Aspects Med 2013;34:413-35
-
(2013)
Mol Aspects Med
, vol.34
, pp. 413-35
-
-
Koepsell, H.1
-
37
-
-
78649646556
-
Organic cation transporters (OCTs MATEs) in vitro and in vivo evidence for the importance in drug therapy
-
Fromm MF Kim RB. editors. Drug transporters - importance for drug disposition and effects, Springer, Heidelberg
-
Nies AT, Koepsell H, Damme K, Schwab M. Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy. In: Fromm MF, Kim RB. editors. Drug transporters - importance for drug disposition and effects. Handb Exp Pharmacol. Springer, Heidelberg; 2011;201. p. 105-67
-
(2011)
Handb Exp Pharmacol.
, vol.201
, pp. 105-67
-
-
Nies, A.T.1
Koepsell, H.2
Damme, K.3
Schwab, M.4
-
38
-
-
70350075408
-
Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver
-
Nies AT, Koepsell H, Winter S, et al. Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver. Hepatology 2009;50:1227-40
-
(2009)
Hepatology
, vol.50
, pp. 1227-40
-
-
Nies, A.T.1
Koepsell, H.2
Winter, S.3
-
39
-
-
84155173299
-
DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma
-
Schaeffeler E, Hellerbrand C, Nies AT, et al. DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma. Genome Med 2011;3:82
-
(2011)
Genome Med
, vol.3
, pp. 82
-
-
Schaeffeler, E.1
Hellerbrand, C.2
Nies, A.T.3
-
40
-
-
0036205460
-
Gene expression levels and immunolocalization of organic ion transporters in the human kidney
-
Motohashi H, Sakurai Y, Saito H, et al. Gene expression levels and immunolocalization of organic ion transporters in the human kidney. J Am Soc Nephrol 2002;13:866-74
-
(2002)
J Am Soc Nephrol
, vol.13
, pp. 866-74
-
-
Motohashi, H.1
Sakurai, Y.2
Saito, H.3
-
41
-
-
79952124892
-
New clues for nephrotoxicity induced by ifosfamide: Preferential renal uptake via the human organic cation transporter 2
-
Ciarimboli G, Holle SK, Vollenbrocker B, et al. New clues for nephrotoxicity induced by ifosfamide: Preferential renal uptake via the human organic cation transporter 2. Mol Pharm 2011;8:270-9
-
(2011)
Mol Pharm
, vol.8
, pp. 270-9
-
-
Ciarimboli, G.1
Holle, S.K.2
Vollenbrocker, B.3
-
42
-
-
77951768942
-
Genetic loci influencing kidney function and chronic kidney disease
-
Chambers JC, Zhang W, Lord GM, et al. Genetic loci influencing kidney function and chronic kidney disease. Nat Genet 2010;42:373-5
-
(2010)
Nat Genet
, vol.42
, pp. 373-5
-
-
Chambers, J.C.1
Zhang, W.2
Lord, G.M.3
-
43
-
-
77956927105
-
Genome-wide association studies in nephrology research
-
Kottgen A. Genome-wide association studies in nephrology research. Am J Kidney Dis 2010;56:743-58
-
(2010)
Am J Kidney Dis
, vol.56
, pp. 743-58
-
-
Kottgen, A.1
-
44
-
-
80053483147
-
Genetic association for renal traits among participants of African ancestry reveals new loci for renal function
-
Liu CT, Garnaas MK, Tin A, et al. Genetic association for renal traits among participants of African ancestry reveals new loci for renal function. PLoS Genet 2011;7:e1002264
-
(2011)
PLoS Genet
, vol.7
-
-
Liu, C.T.1
Garnaas, M.K.2
Tin, A.3
-
45
-
-
84863177864
-
Proximal tubular secretion of creatinine by organic cation transporter OCT2 in cancer patients
-
Ciarimboli G, Lancaster CS, Schlatter E, et al. Proximal tubular secretion of creatinine by organic cation transporter OCT2 in cancer patients. Clin Cancer Res 2012;18:1101-8
-
(2012)
Clin Cancer Res
, vol.18
, pp. 1101-8
-
-
Ciarimboli, G.1
Lancaster, C.S.2
Schlatter, E.3
-
46
-
-
34249943356
-
Polyspecific organic cation transporters: Structure, function, physiological roles, and biopharmaceutical implications
-
Koepsell H, Lips K, Volk C. Polyspecific organic cation transporters: Structure, function, physiological roles, and biopharmaceutical implications. Pharm Res 2007;24:1227-51
-
(2007)
Pharm Res
, vol.24
, pp. 1227-51
-
-
Koepsell, H.1
Lips, K.2
Volk, C.3
-
47
-
-
0032569029
-
OCT (SLC22A) and OCTN Familiy (Chapter 8)
-
Kekuda R, Prasad PD, Wu X, et al. OCT (SLC22A) and OCTN Familiy (Chapter 8). J Biol Chem 1998;273:15971-9
-
(1998)
J Biol Chem
, vol.273
, pp. 15971-9
-
-
Kekuda, R.1
Prasad, P.D.2
Wu, X.3
-
48
-
-
0033829943
-
Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney
-
Wu X, Huang W, Ganapathy ME, et al. Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney. Am J Physiol Renal Physiol 2000;279:449-58
-
(2000)
Am J Physiol Renal Physiol
, vol.279
, pp. 449-58
-
-
Wu, X.1
Huang, W.2
Ganapathy, M.E.3
-
49
-
-
84886172147
-
OCT (SLC22A) and OCTN Familiy (Chapter 8)
-
Ishikawa T Kim RB König J editors. John Wiley & Sons, Inc., Hoboken
-
Stocker SL, Emami RA, Schwab M, Giacomini KM. OCT (SLC22A) and OCTN Familiy (Chapter 8). In: Ishikawa T, Kim RB, König J, editors. Pharmacogenomics of human drug transporters: Clinical impacts. John Wiley & Sons, Inc., Hoboken; 2013. p. 171-208
-
(2013)
Pharmacogenomics of Human Drug Transporters: Clinical Impacts
, pp. 171-208
-
-
Stocker, S.L.1
Emami, R.A.2
Schwab, M.3
Giacomini, K.M.4
-
50
-
-
0031434178
-
Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1
-
Tamai I, Yabuuchi H, Nezu J, et al. Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1. FEBS Lett 1997;419:107-11
-
(1997)
FEBS Lett
, vol.419
, pp. 107-11
-
-
Tamai, I.1
Yabuuchi, H.2
Nezu, J.3
-
51
-
-
0032493741
-
Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2
-
Tamai I, Ohashi R, Nezu J, et al. Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2. J Biol Chem 1998;273:20378-82
-
(1998)
J Biol Chem
, vol.273
, pp. 20378-82
-
-
Tamai, I.1
Ohashi, R.2
Nezu, J.3
-
52
-
-
39449103552
-
Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin
-
Urban TJ, Brown C, Castro RA, et al. Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin. Clin Pharmacol Ther 2008;83:416-21
-
(2008)
Clin Pharmacol Ther
, vol.83
, pp. 416-21
-
-
Urban, T.J.1
Brown, C.2
Castro, R.A.3
-
53
-
-
0034695673
-
Beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter
-
Ganapathy ME, Huang W, Rajan DP, et al. Beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. J Biol Chem 2000;275:1699-707
-
(2000)
J Biol Chem
, vol.275
, pp. 1699-707
-
-
Ganapathy, M.E.1
Huang, W.2
Rajan, D.P.3
-
54
-
-
1242295185
-
The SLC22 drug transporter family
-
Koepsell H, Endou H. The SLC22 drug transporter family. Pflugers Arch 2004;447:666-76
-
(2004)
Pflugers Arch
, vol.447
, pp. 666-76
-
-
Koepsell, H.1
Endou, H.2
-
55
-
-
84930483089
-
Organic anion transporters and their implications in pharmacotherapy
-
Emami RA, Nies AT, Schaeffeler E, et al. Organic anion transporters and their implications in pharmacotherapy. Pharmacol Rev 2012;64:421-49
-
(2012)
Pharmacol Rev
, vol.64
, pp. 421-49
-
-
Emami, R.A.1
Nies, A.T.2
Schaeffeler, E.3
-
56
-
-
1342287145
-
The molecular pharmacology of organic anion transporters: From DNA to FDA?
-
Eraly SA, Bush KT, Sampogna RV, et al. The molecular pharmacology of organic anion transporters: From DNA to FDA? Mol Pharmacol 2004;65:479-87
-
(2004)
Mol Pharmacol
, vol.65
, pp. 479-87
-
-
Eraly, S.A.1
Bush, K.T.2
Sampogna, R.V.3
-
57
-
-
33847139479
-
Organic anion transporters of the SLC22 family: Biopharmaceutical, physiological, and pathological roles
-
Rizwan AN, Burckhardt G. Organic anion transporters of the SLC22 family: Biopharmaceutical, physiological, and pathological roles. Pharm Res 2007;24:450-70
-
(2007)
Pharm Res
, vol.24
, pp. 450-70
-
-
Rizwan, A.N.1
Burckhardt, G.2
-
58
-
-
0034008388
-
Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1
-
Ho ES, Lin DC, Mendel DB, et al. Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1. J Am Soc Nephrol 2000;11:383-93
-
(2000)
J Am Soc Nephrol
, vol.11
, pp. 383-93
-
-
Ho, E.S.1
Lin, D.C.2
Mendel, D.B.3
-
59
-
-
84894194315
-
-
US Food Drug Administration. Highlights of Prescribing Information: Vistide- (cidofovir injection). US Food Drug Admin, Silver Spring, MD; 1999. Available from
-
US Food Drug Administration. Highlights of Prescribing Information: Vistide- (cidofovir injection). US Food Drug Admin, Silver Spring, MD; 1999. Available from: Http://www. accessdata.fda.gov/drugsatfda-docs/label/1999- 020638s003lbl.pdf
-
-
-
-
60
-
-
0032856603
-
The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1
-
Cihlar T, Lin DC, Pritchard JB, et al. The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1. Mol Pharmacol 1999;56:570-80
-
(1999)
Mol Pharmacol
, vol.56
, pp. 570-80
-
-
Cihlar, T.1
Lin, D.C.2
Pritchard, J.B.3
-
61
-
-
24344439264
-
Transporters and drug therapy: Implications for drug disposition and disease
-
Ho RH, Kim RB. Transporters and drug therapy: Implications for drug disposition and disease. Clin Pharmacol Ther 2005;78:260-77
-
(2005)
Clin Pharmacol Ther
, vol.78
, pp. 260-77
-
-
Ho, R.H.1
Kim, R.B.2
-
62
-
-
84865578333
-
Drug transport by organic anion transporters (OATs)
-
Burckhardt G. Drug transport by organic anion transporters (OATs). Pharmacol Ther 2012;136:106-30
-
(2012)
Pharmacol Ther
, vol.136
, pp. 106-30
-
-
Burckhardt, G.1
-
63
-
-
34247236764
-
Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein
-
Chu XY, Bleasby K, Yabut J, et al. Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein. J Pharmacol Exp Ther 2007;321:673-83
-
(2007)
J Pharmacol Exp Ther
, vol.321
, pp. 673-83
-
-
Chu, X.Y.1
Bleasby, K.2
Yabut, J.3
-
64
-
-
84859039113
-
In vitro and in vivo assessment of renal drug transporters in the disposition of mesna and dimesna
-
Cutler MJ, Urquhart BL, Velenosi TJ, et al. In vitro and in vivo assessment of renal drug transporters in the disposition of mesna and dimesna. J Clin Pharmacol 2012;52:530-42
-
(2012)
J Clin Pharmacol
, vol.52
, pp. 530-42
-
-
Cutler, M.J.1
Urquhart, B.L.2
Velenosi, T.J.3
-
65
-
-
47749112096
-
Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13)
-
Bahn A, Hagos Y, Reuter S, et al. Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13). J Biol Chem 2008;283:16332-41
-
(2008)
J Biol Chem
, vol.283
, pp. 16332-41
-
-
Bahn, A.1
Hagos, Y.2
Reuter, S.3
-
66
-
-
29144523534
-
A human transporter protein that mediates the final excretion step for toxic organic cations
-
Otsuka M, Matsumoto T, Morimoto R, et al. A human transporter protein that mediates the final excretion step for toxic organic cations. Proc Natl Acad Sci USA 2005;102:17923-8
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 17923-8
-
-
Otsuka, M.1
Matsumoto, T.2
Morimoto, R.3
-
67
-
-
80054935612
-
Mammalian MATE (SLC47A) transport proteins: Impact on efflux of endogenous substrates and xenobiotics
-
Damme K, Nies AT, Schaeffeler E, et al. Mammalian MATE (SLC47A) transport proteins: Impact on efflux of endogenous substrates and xenobiotics. Drug Metab Rev 2011;43:499-523
-
(2011)
Drug Metab Rev
, vol.43
, pp. 499-523
-
-
Damme, K.1
Nies, A.T.2
Schaeffeler, E.3
-
68
-
-
79551489546
-
Organic cation transporter OCT/SLC22A and H(+)/organic cation antiporter MATE/SLC47A are key molecules for nephrotoxicity of platinum agents
-
Yonezawa A, Inui K. Organic cation transporter OCT/SLC22A and H(+)/organic cation antiporter MATE/SLC47A are key molecules for nephrotoxicity of platinum agents. Biochem Pharmacol 2011;81:563-8
-
(2011)
Biochem Pharmacol
, vol.81
, pp. 563-8
-
-
Yonezawa, A.1
Inui, K.2
-
69
-
-
34547103001
-
Transport of paraquat by human organic cation transporters and multidrug and toxic compound extrusion family
-
Chen Y, Zhang S, Sorani M, et al. Transport of paraquat by human organic cation transporters and multidrug and toxic compound extrusion family. J Pharmacol Exp Ther 2007;322:695-700
-
(2007)
J Pharmacol Exp Ther
, vol.322
, pp. 695-700
-
-
Chen, Y.1
Zhang, S.2
Sorani, M.3
-
70
-
-
82955240616
-
Deficiency of multidrug and toxin extrusion 1 enhances renal accumulation of paraquat and deteriorates kidney injury in mice
-
Li Q, Peng X, Yang H, et al. Deficiency of multidrug and toxin extrusion 1 enhances renal accumulation of paraquat and deteriorates kidney injury in mice. Mol Pharm 2011;8:2476-83
-
(2011)
Mol Pharm
, vol.8
, pp. 2476-83
-
-
Li, Q.1
Peng, X.2
Yang, H.3
-
71
-
-
84875163715
-
The SLCO (former SLC21) superfamily of transporters
-
Hagenbuch B, Stieger B. The SLCO (former SLC21) superfamily of transporters. Mol Aspects Med 2013;34:396-412
-
(2013)
Mol Aspects Med
, vol.34
, pp. 396-412
-
-
Hagenbuch, B.1
Stieger, B.2
-
72
-
-
84857092984
-
OATPs OATs and OCTs: The organic anion and cation transporters of the SLCO and SLC22A gene superfamilies
-
Roth M, Obaidat A, Hagenbuch B. OATPs, OATs and OCTs: The organic anion and cation transporters of the SLCO and SLC22A gene superfamilies. Br J Pharmacol 2012;165:1260-87
-
(2012)
Br J Pharmacol
, vol.165
, pp. 1260-87
-
-
Roth, M.1
Obaidat, A.2
Hagenbuch, B.3
-
73
-
-
12144288563
-
Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney
-
Mikkaichi T, Suzuki T, Onogawa T, et al. Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc Natl Acad Sci USA 2004;101:3569-74
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 3569-74
-
-
Mikkaichi, T.1
Suzuki, T.2
Onogawa, T.3
-
74
-
-
33751578245
-
Expression profiles of 50 xenobiotic transporter genes in humans and preclinical species: A resource for investigations into drug disposition
-
Bleasby K, Castle JC, Roberts CJ, et al. Expression profiles of 50 xenobiotic transporter genes in humans and preclinical species: A resource for investigations into drug disposition. Xenobiotica 2006;36:963-88
-
(2006)
Xenobiotica
, vol.36
, pp. 963-88
-
-
Bleasby, K.1
Castle, J.C.2
Roberts, C.J.3
-
75
-
-
84879417097
-
In vitro methods to support transporter evaluation in drug discovery and development
-
Brouwer KL, Keppler D, Hoffmaster KA, et al. In vitro methods to support transporter evaluation in drug discovery and development. Clin Pharmacol Ther 2013;94:95-112
-
(2013)
Clin Pharmacol Ther
, vol.94
, pp. 95-112
-
-
Brouwer, K.L.1
Keppler, D.2
Hoffmaster, K.A.3
-
77
-
-
84879409509
-
Emerging transporters of clinical importance: An update from the international transporter consortium
-
Very recent update of the International Transporter Consortium on the emerging role of transporters for drug development with particular focus on pharmacokinetics, drug-drug interactions and clinical aspects
-
Hillgren KM, Keppler D, Zur AA, et al. Emerging transporters of clinical importance: An update from the International Transporter Consortium. Clin Pharmacol Ther 2013;94:52-63. Very recent update of the International Transporter Consortium on the emerging role of transporters for drug development with particular focus on pharmacokinetics, drug-drug interactions and clinical aspects.
-
(2013)
Clin Pharmacol Ther
, vol.94
, pp. 52-63
-
-
Hillgren, K.M.1
Keppler, D.2
Zur, A.A.3
-
78
-
-
33744508040
-
Human primary renal cells as a model for toxicity assessment of chemo-therapeutic drugs
-
Li W, Lam M, Choy D, et al. Human primary renal cells as a model for toxicity assessment of chemo-therapeutic drugs. Toxicol In Vitro 2006;20:669-76
-
(2006)
Toxicol In Vitro
, vol.20
, pp. 669-76
-
-
Li, W.1
Lam, M.2
Choy, D.3
-
79
-
-
0031834028
-
Nephrotoxicity testing in vitro-what we know and what we need to know
-
Pfaller W, Gstraunthaler G. Nephrotoxicity testing in vitro-what we know and what we need to know. Environ Health Perspect 1998;106(Suppl 2):559-69
-
(1998)
Environ Health Perspect
, vol.106
, Issue.SUPPL. 2
, pp. 559-69
-
-
Pfaller, W.1
Gstraunthaler, G.2
-
80
-
-
0021848486
-
Biochemical characterization of renal epithelial cell cultures (LLC-PK1 and MDCK)
-
Gstraunthaler G, Pfaller W, Kotanko P. Biochemical characterization of renal epithelial cell cultures (LLC-PK1 and MDCK). Am J Physiol 1985;248:536-44
-
(1985)
Am J Physiol
, vol.248
, pp. 536-44
-
-
Gstraunthaler, G.1
Pfaller, W.2
Kotanko, P.3
-
81
-
-
0018096851
-
Establishment and characterization of a cell line from the American opossum (Didelphys virginiana)
-
Koyama H, Goodpasture C, Miller MM, et al. Establishment and characterization of a cell line from the American opossum (Didelphys virginiana). In Vitro 1978;14:239-46
-
(1978)
Vitro
, vol.14
, pp. 239-46
-
-
Koyama, H.1
Goodpasture, C.2
Miller, M.M.3
-
82
-
-
0034607670
-
Carrier-mediated uptake of cisplatin by the OK renal epithelial cell line
-
Endo T, Kimura O, Sakata M. Carrier-mediated uptake of cisplatin by the OK renal epithelial cell line. Toxicology 2000;146:187-95
-
(2000)
Toxicology
, vol.146
, pp. 187-95
-
-
Endo, T.1
Kimura, O.2
Sakata, M.3
-
83
-
-
77952046959
-
Comparison of the novel HK-2 human renal proximal tubular cell line with the standard LLC-PK1 cell line in studying drug-induced nephrotoxicity
-
Gunness P, Aleksa K, Kosuge K, et al. Comparison of the novel HK-2 human renal proximal tubular cell line with the standard LLC-PK1 cell line in studying drug-induced nephrotoxicity. Can J Physiol Pharmacol 2010;88:448-55
-
(2010)
Can J Physiol Pharmacol
, vol.88
, pp. 448-55
-
-
Gunness, P.1
Aleksa, K.2
Kosuge, K.3
-
84
-
-
85027933239
-
The limitations of renal epithelial cell line HK-2 as a model of drug transporter expression and function in the proximal tubule
-
Jenkinson SE, Chung GW, van LE, et al. The limitations of renal epithelial cell line HK-2 as a model of drug transporter expression and function in the proximal tubule. Pflugers Arch 2012;464:601-11
-
(2012)
Pflugers Arch
, vol.464
, pp. 601-11
-
-
Jenkinson, S.E.1
Chung, G.W.2
Van, L.E.3
-
85
-
-
44349108972
-
Kidney injury molecule-1 in acute kidney injury and renal repair: A review
-
Ichimura T, Mou S. Kidney injury molecule-1 in acute kidney injury and renal repair: A review. Zhong Xi Yi Jie He Xue Bao 2008;6:533-8
-
(2008)
Zhong Xi Yi Jie He Xue Bao
, vol.6
, pp. 533-8
-
-
Ichimura, T.1
Mou, S.2
-
86
-
-
43349106270
-
Evaluation of putative biomarkers of nephrotoxicity after exposure to ochratoxin a in vivo and in vitro
-
Rached E, Hoffmann D, Blumbach K, et al. Evaluation of putative biomarkers of nephrotoxicity after exposure to ochratoxin a in vivo and in vitro. Toxicol Sci 2008;103:371-81
-
(2008)
Toxicol Sci
, vol.103
, pp. 371-81
-
-
Rached, E.1
Hoffmann, D.2
Blumbach, K.3
-
87
-
-
0029688557
-
Biotransformation and renal processing of nephrotoxic agents
-
Dekant W. Biotransformation and renal processing of nephrotoxic agents. Arch Toxicol Suppl 1996;18:163-72
-
(1996)
Arch Toxicol Suppl
, vol.18
, pp. 163-72
-
-
Dekant, W.1
-
88
-
-
0028913368
-
Improved culture conditions stimulate gluconeogenesis in primary cultures of renal proximal tubule cells
-
Nowak G, Schnellmann RG. Improved culture conditions stimulate gluconeogenesis in primary cultures of renal proximal tubule cells. Am J Physiol 1995;268:1053-61
-
(1995)
Am J Physiol
, vol.268
, pp. 1053-61
-
-
Nowak, G.1
Schnellmann, R.G.2
-
89
-
-
0030463882
-
L-ascorbic acid regulates growth and metabolism of renal cells: Improvements in cell culture
-
Nowak G, Schnellmann RG. L-ascorbic acid regulates growth and metabolism of renal cells: Improvements in cell culture. Am J Physiol 1996;271:2072-80
-
(1996)
Am J Physiol
, vol.271
, pp. 2072-80
-
-
Nowak, G.1
Schnellmann, R.G.2
-
90
-
-
77954177589
-
A high-throughput respirometric assay for mitochondrial biogenesis and toxicity
-
Beeson CC, Beeson GC, Schnellmann RG. A high-throughput respirometric assay for mitochondrial biogenesis and toxicity. Anal Biochem 2010;404:75-81
-
(2010)
Anal Biochem
, vol.404
, pp. 75-81
-
-
Beeson, C.C.1
Beeson, G.C.2
Schnellmann, R.G.3
-
91
-
-
56249098350
-
Characterisation of human tubular cell monolayers as a model of proximal tubular xenobiotic handling
-
Brown CD, Sayer R, Windass AS, et al. Characterisation of human tubular cell monolayers as a model of proximal tubular xenobiotic handling. Toxicol Appl Pharmacol 2008;233:428-38
-
(2008)
Toxicol Appl Pharmacol
, vol.233
, pp. 428-38
-
-
Brown, C.D.1
Sayer, R.2
Windass, A.S.3
-
92
-
-
84859734598
-
Cross talk between primary human renal tubular cells and endothelial cells in cocultures
-
Original research article indicating the high impact of cocultures of human proximal tubular cells and primary endothelial cells as powerful model for the analysis of cellular communication in renal disease and repair
-
Tasnim F, Zink D. Cross talk between primary human renal tubular cells and endothelial cells in cocultures. Am J Physiol Renal Physiol 2012;302:1055-62 . Original research article indicating the high impact of cocultures of human proximal tubular cells and primary endothelial cells as powerful model for the analysis of cellular communication in renal disease and repair.
-
(2012)
Am J Physiol Renal Physiol
, vol.302
, pp. 1055-62
-
-
Tasnim, F.1
Zink, D.2
-
93
-
-
84859839108
-
Comparing predictive drug nephrotoxicity biomarkers in kidney 3-D primary organoid culture and immortalized cell lines
-
Astashkina AI, Mann BK, Prestwich GD, et al. Comparing predictive drug nephrotoxicity biomarkers in kidney 3-D primary organoid culture and immortalized cell lines. Biomaterials 2012;33:4712-21
-
(2012)
Biomaterials
, vol.33
, pp. 4712-21
-
-
Astashkina, A.I.1
Mann, B.K.2
Prestwich, G.D.3
-
94
-
-
0025825990
-
Induction of epithelial tubular morphogenesis in vitro by fibroblastderived soluble factors
-
Montesano R, Schaller G, Orci L. Induction of epithelial tubular morphogenesis in vitro by fibroblastderived soluble factors. Cell 1991;66:697-711
-
(1991)
Cell
, vol.66
, pp. 697-711
-
-
Montesano, R.1
Schaller, G.2
Orci, L.3
-
95
-
-
0036990109
-
The organizing principle: Microenvironmental influences in the normal and malignant breast
-
Bissell MJ, Radisky DC, Rizki A, et al. The organizing principle: Microenvironmental influences in the normal and malignant breast. Differentiation 2002;70:537-46
-
(2002)
Differentiation
, vol.70
, pp. 537-46
-
-
Bissell, M.J.1
Radisky, D.C.2
Rizki, A.3
-
96
-
-
0035941075
-
Taking cell-matrix adhesions to the third dimension
-
Cukierman E, Pankov R, Stevens DR, et al. Taking cell-matrix adhesions to the third dimension. Science 2001;294:1708-12
-
(2001)
Science
, vol.294
, pp. 1708-12
-
-
Cukierman, E.1
Pankov, R.2
Stevens, D.R.3
-
97
-
-
44949166671
-
Three-dimensional cell culture matrices: State of the art
-
Lee J, Cuddihy MJ, Kotov NA. Three-dimensional cell culture matrices: State of the art. Tissue Eng Part B Rev 2008;14:61-86
-
(2008)
Tissue Eng Part B Rev
, vol.14
, pp. 61-86
-
-
Lee, J.1
Cuddihy, M.J.2
Kotov, N.A.3
-
98
-
-
38349143408
-
Evaluating drug efficacy and toxicology in three dimensions: Using synthetic extracellular matrices in drug discovery
-
Prestwich GD. Evaluating drug efficacy and toxicology in three dimensions: Using synthetic extracellular matrices in drug discovery. Acc Chem Res 2008;41:139-48
-
(2008)
Acc Chem Res
, vol.41
, pp. 139-48
-
-
Prestwich, G.D.1
-
99
-
-
84859812143
-
A 3-D organoid kidney culture model engineered for high-throughput nephrotoxicity assays
-
Astashkina AI, Mann BK, Prestwich GD, et al. A 3-D organoid kidney culture model engineered for high-throughput nephrotoxicity assays. Biomaterials 2012;33:4700-11
-
(2012)
Biomaterials
, vol.33
, pp. 4700-11
-
-
Astashkina, A.I.1
Mann, B.K.2
Prestwich, G.D.3
-
100
-
-
84875048928
-
Bioengineered 3D human kidney tissue, a platform for the determination of nephrotoxicity
-
Desrochers TM, Suter L, Roth A, et al. Bioengineered 3D human kidney tissue, a platform for the determination of nephrotoxicity. PLoS One 2013;8:e59219
-
(2013)
PLoS One
, vol.8
-
-
Desrochers, T.M.1
Suter, L.2
Roth, A.3
-
101
-
-
33644529130
-
Capturing complex 3D tissue physiology in vitro
-
Griffith LG, Swartz MA. Capturing complex 3D tissue physiology in vitro. Nat Rev Mol Cell Biol 2006;7:211-24
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 211-24
-
-
Griffith, L.G.1
Swartz, M.A.2
-
102
-
-
34648834682
-
The third dimension bridges the gap between cell culture and live tissue
-
Pampaloni F, Reynaud EG, Stelzer EH. The third dimension bridges the gap between cell culture and live tissue. Nat Rev Mol Cell Biol 2007;8:839-45
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 839-45
-
-
Pampaloni, F.1
Reynaud, E.G.2
Stelzer, E.H.3
-
103
-
-
78650746205
-
Shear stress-induced changes of membrane transporter localization and expression in mouse proximal tubule cells
-
Duan Y, Weinstein AM, Weinbaum S, et al. Shear stress-induced changes of membrane transporter localization and expression in mouse proximal tubule cells. Proc Natl Acad Sci USA 2010;107:21860-5
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 21860-5
-
-
Duan, Y.1
Weinstein, A.M.2
Weinbaum, S.3
-
104
-
-
84882590738
-
Human kidney proximal tubule-on-achip for drug transport and nephrotoxicity assessment
-
Jang KJ, Mehr AP, Hamilton GA, et al. Human kidney proximal tubule-on-achip for drug transport and nephrotoxicity assessment. Integr Biol (Camb) 2013;5:1119-29
-
(2013)
Integr Biol (Camb)
, vol.5
, pp. 1119-29
-
-
Jang, K.J.1
Mehr, A.P.2
Hamilton, G.A.3
-
105
-
-
84875736346
-
Human embryonic stem cells differentiate into functional renal proximal tubular-like cells
-
Narayanan K, Schumacher KM, Tasnim F, et al. Human embryonic stem cells differentiate into functional renal proximal tubular-like cells. Kidney Int 2013;83:593-603
-
(2013)
Kidney Int
, vol.83
, pp. 593-603
-
-
Narayanan, K.1
Schumacher, K.M.2
Tasnim, F.3
-
106
-
-
84894211523
-
-
Available from
-
Available from: Http://www.ncbi.nlm.nih. gov/pccompound
-
-
-
|