Characterisation of human tubular cell monolayers as a model of proximal tubular xenobiotic handling

Toxicology and Applied Pharmacology

Volumn 233, Issue 3, 2008, Pages 428-438

  Brown, Colin D A ^a   Sayer, Rachel ^a   Windass, Amy S ^a   Haslam, Iain S ^a   De Broe, Marc E ^b   D'Haese, Patrick C ^b   Verhulst, Anja ^b  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

ABC transporters; Organic anion transporters; Organic cation transporters; Proximal tubule; Renal xenobiotic secretion

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; CALCEIN; CREATININE; HOE 33342; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 4; OCTAMER TRANSCRIPTION FACTOR 2; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 3; ORGANIC ANION TRANSPORTER 4; ORGANIC CATION TRANSPORT PROTEIN OCTN2; ORGANIC CATION TRANSPORTER; POLYCYCLIC AROMATIC HYDROCARBON; PROBENECID; SODIUM GLUCOSE COTRANSPORTER 1; SODIUM GLUCOSE COTRANSPORTER 2; UNCLASSIFIED DRUG; VERLUKAST; XENOBIOTIC AGENT;

APICAL MEMBRANE; ARTICLE; BASOLATERAL MEMBRANE; CELL DIFFERENTIATION; CONTROLLED STUDY; CULTURE MEDIUM; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; KIDNEY TUBULE EXCRETION; MEMBRANE MODEL; MEMBRANE TRANSPORT; MONOLAYER CULTURE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; TRANSPORT KINETICS;

ATP-BINDING CASSETTE TRANSPORTERS; CELLS, CULTURED; CREATININE; EPITHELIAL CELLS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; KIDNEY TUBULES, PROXIMAL; MODELS, BIOLOGICAL; ORGANIC ANION TRANSPORTERS; PROTEIN TRANSPORT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; XENOBIOTICS;

EID: 56249098350     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.09.018     Document Type: Article

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