Biomarkers of oxidative stress and cataract. novel drug delivery therapeutic strategies targeting telomere reduction and the expression of telomerase activity in the lens epithelial cells with N-acetylcarnosine lubricant eye drops: Anti-cataract which helps to prevent and treat cataracts in the eyes of dogs and other animals

Current Drug Delivery

Volumn 11, Issue 1, 2014, Pages 24-61

  Babizhayev, Mark A ^a,b   Yegorov, Yegor E ^c  

^a Innovative Vision Products Incorporated   (United States)

^b MOSCOW HELMHOLTZ RESEARCH INSTITUTE OF EYE DISEASES   (Russian Federation)

^c ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

Author keywords

Aging and cataract; Biological marker; Carnosine; Cataract treatment in canines; Ferritin; Ferroxidase activity; L carnosine as universal antioxidant; Lens epithelial cells; Lifespan; N acetylcarnosine ophthalmic prodrug; Oxidative stress; Small animals; Telomerase activity; Telomere shortening; Telomere dependent senescent phenotype; Transition metal (ferrous) ions

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ALDEHYDE REDUCTASE; ALPHA CRYSTALLIN; ANTIOXIDANT; BLEOMYCIN; CARNOSINE; CERULOPLASMIN; DEHYDROASCORBIC ACID; ETOPOSIDE; EYE DROPS; FIBROBLAST GROWTH FACTOR; FIBRONECTIN; GLUTATHIONE; GLUTATHIONE REDUCTASE; GLYCOSPHINGOLIPID; HYDROGEN PEROXIDE; HYDROXYETHYLCELLULOSE; HYDROXYETHYLMETHYLCELLULOSE; HYDROXYPROPYLCELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE; LIPID PEROXIDE; LUBRICATING AGENT; N ACETYLCARNOSINE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SMAD3 PROTEIN; TELOMERASE; THIOREDOXIN; TRANSFORMING GROWTH FACTOR BETA; TRANSITION ELEMENT; UNCLASSIFIED DRUG;

ANTERIOR LENS CAPSULE; AQUEOUS HUMOR; ARTICLE; CATARACT; CATARACTOGENESIS; CELL AGING; CELL DEATH; CELL KILLING; CELL PROLIFERATION; CELL VIABILITY; DNA DAMAGE; DNA FRAGMENTATION; DNA METHYLATION; DNA SYNTHESIS; DOG; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SOLUBILITY; ENZYME ACTIVITY; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HYDROLYSIS; INTRAOCULAR DRUG ADMINISTRATION; LENS CAPSULE; LENS EPITHELIUM; LIPID PEROXIDATION; MEDICATION COMPLIANCE; MEMBRANE DAMAGE; METABOLIC STRESS; MITOSIS RATE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SMOOTH MUSCLE; TELOMERE SHORTENING; ULTRAVIOLET RADIATION; VISUAL IMPAIRMENT;

ADMINISTRATION, OPHTHALMIC; ANIMALS; ANTIOXIDANTS; BIOLOGICAL MARKERS; CARNOSINE; CATARACT; CELL AGING; CELL MEMBRANE; CERULOPLASMIN; CHEMISTRY, PHARMACEUTICAL; DOGS; DRUG CARRIERS; EPITHELIAL CELLS; LENS, CRYSTALLINE; OPHTHALMIC SOLUTIONS; OXIDATIVE STRESS; PRODRUGS; TECHNOLOGY, PHARMACEUTICAL; TELOMERASE; TELOMERE;

EID: 84894082388     PISSN: 15672018     EISSN: 18755704     Source Type: Journal    
DOI: 10.2174/15672018113106660062     Document Type: Article

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