Expression and characterization of the catalytic subunit of telomerase in normal and cataractous canine lens epithelial cells

Molecular Vision

Volumn 12, Issue , 2006, Pages 1067-1076

  Colitz, Carmen Maria Helena ^a   Barden, Curtis Andrew ^a   Pu, Ping ^a   Chandler, Heather Lynn ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN 90; MESSENGER RNA; PROTEIN P23; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CATARACT; CELL CULTURE; CELL NUCLEUS; CELL PROLIFERATION; CELL TYPE; CONTROLLED STUDY; CYTOPLASM; DOG; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME REGULATION; EPITHELIUM CELL; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; INHIBITION KINETICS; LENS CAPSULE; LENS EPITHELIUM; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOMATIC CELL; TELOMERIC REPEAT AMPLIFICATION PROTOCOL; TUMOR CELL; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CATALYTIC DOMAIN; CATARACT; CELLS, CULTURED; DOGS; EPITHELIAL CELLS; HSP90 HEAT-SHOCK PROTEINS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; LENS, CRYSTALLINE; RNA, MESSENGER; STAINING AND LABELING; SUBCELLULAR FRACTIONS; TELOMERASE; TISSUE DISTRIBUTION;

EID: 33748747133     PISSN: 10900535     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Harding CV, Reddan JR, Unakar NJ, Bagchi M. The control of cell division in the ocular lens. Int Rev Cytol 1971; 31:215-300.
2. Miller RC, Riley EF. Retention of labelled DNA precursor by murine cells after a single administration of tritium labelled thymidine. Cell Tissue Kinet 1986; 19:519-25.
3. Rakic JM, Galand A, Vrensen GF. Separation of fibres from the capsule enhances mitotic activity of human lens epithelium. Exp Eye Res 1997; 64:67-72.
4. Rafferty NS, Rafferty KA Jr. Cell population kinetics of the mouse lens epithelium. J Cell Physiol 1981; 107:309-15.
5. McAvoy JW, McDonald J. Proliferation of lens epithelial explants in culture increases with age of donor rat. Curr Eye Res 1984; 3:1151-3.
6. Paterson CA, Delamere NA. The Lens. In: Hart WM, editor. Adler's physiology of the eye: clinical application. 9ed. St. Louis: Mosby Year Book; 1992. p. 348-90.
7. Kuszak JR. A re-examination of primate lens epithelial cell size, density and structure as a function of development, growth and age. Nova Acta Leopold 1997; 75:45-66.
8. Beebe DC. The Lens. In: Kaufman PL, Alm A, editors. Adler's physiology of the eye: clinical application. 10th ed. St. Louis: Mosby; 2003. p. 117-58.
9. Duke-Elder S. The capsule and subcapsular epithelium. In: Duke-Elder S, editors. Systems of Ophthalmology. London: Henry Kimpton; 1969. p. 19-62.
10. Karim AK, Jacob TJ, Thompson GM. The human anterior lens capsule: cell density, morphology and mitotic index in normal and cataractous lenses. Exp Eye Res 1987; 45:865-74.
11. Colitz CM, Davidson MG, McGahan MC. Telornerase activity in lens epithelial cells of normal and cataractous lenses. Exp Eye Res 1999; 69:641-9.
12. Morin GB. The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell 1989; 59:521-9.
13. Blackburn E. The telomere and telomerase: how Do they interact? Mt Sinai J Med 1999; 66:292-300.
14. Fu W, Begley JG, Killen MW, Mattson MR Anti-apoptotic role of telomerase in pheochromocytoma cells. J Biol Chem 1999; 274:7264-71.
15. Ren JG, Yja HL, Tian YM, Just T, Cai GP, Dai YR. Expression of telomerase inhibits hydroxyl radical-induced apoptosis in normal telomerase negative human lung fibroblasts. FEBS Lett 2001; 488:133-8.
16. Akiyama M, Yamada O, Kanda N, Akita S, Kawano T, Ohno T, Mizoguchi H, Eto Y, Anderson KC, Yamada H. Telomerase overexpression in K562 leukemia cells protects against apoptosis by serum deprivation and double-stranded DNA break inducing agents, but not against DNA synthesis inhibitors. Cancer Lett 2002, 178:187-97.
17. Gorbunova V, Scluanov A, Pereira-Smith OM. Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis. J Biol Chem 2002; 277:38540-9.
18. Haendeler J, Hoffmann J, Rahman S, Zeiher AM, Dimmeler S. Regulation of telomerase activity and anti-apoptotic function by protein-protein interaction and phosphorylation. FEBS Lett 2003; 536:180-6.
19. Harle-Bachor C, Boukamp P. Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytes. Proc Natl Acad Sci U S A 1996; 93:6476-81.
20. Wright WE, Piatyszek MA, Rainey WE, Byrd W, Shay JW. Telomerase activity in human gerinline and embryonic tissues and cells. Dev Genet 1996; 18:173-9.
21. Banerjee PP, Banerjee S, ZiTkin BR, Brown TR. Telomerase activity in normal adult Brown Norway rat seminal vesicle: regional distribution and age-dependent changes. Endocrinology 1998; 139:1075-81.
22. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, Coviello GM, Wright WE, Weinrich SL, Shay JW. Specific association of human telomerase activity with immortal cells and cancer. Science 1994; 266:2011-5.
23. Greider CW. Telomerase activity, cell proliferation, and cancer. Proc Nad Acad Sci U S A 1998; 95:90-2.
24. Elmore LW, Holt SE. Cell proliferation, telomerase, and cancer. In: Mattson MP, Pandita TK, editors. Telomerase, aging and disease. 1st ed. Amsterdam: Elsevier; 2001. p. 89-102.
25. Bachor C, Bachor OA, Boukamp P. Telornerase is active in normal gastrointestinal mucosa and not up-regulated in precancerous lesions. J Cancer Res Clin Oncol 1999; 125:453-60.
26. Klapper W, Shin T, Mattson MP. Differential regulation of telomerase activity and TERT expression during brain development in mice. J Neurosci Res 2001; 64:252-60.
27. Klapper W, Parwaresch R, Krupp G. Assembly and function of the telomerase enzyme complex. In: Mattson MP, Pandita TK, editors. Telomerase, aging and disease. 1st ed. Amsterdam: Elsevier; 2001. p. 15-31.
28. Feng J, Funk WD, Wang SS, Weinrich SL, Avilion AA, Chiu CP, Adams RR, Chang E, Allsopp RC, Yu J, Le S, West MD, Harley CB, Andrews WH, Greider CW, Villeponteau B. The RNA component of human telomerase. Science 1995; 269:123641.
29. Dhaene K, Van Marck E, Parwaresch R. Telomeres, telomerase and cancer: an up-date. Virchows Arch 2000; 437:1-16.
30. Weinrich SL, Pruzan R, Ma L, Ouellette M, Tesmer VM, Holt SE, Bodnar AG, Lichtsteiner S, Kim NW, Trager JB, Taylor RD, Carlos R, Andrews WH, Wright WE, Shay JW, Harley CB, Morin GB. Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat Genet 1997; 17:498-502.
31. Beattie TL, Zhou W, Robinson MO, Harrington L. Reconstitution of human telomerase activity in vitro. Curr Biol 1998; 8:177-80.
32. Nakayama J, Tahara H, Tahara E, Saito M, Ito K, Nakamura H, Nakanishi T, Tahara E, Ide T, Ishikawa F. Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas. Nat Genet 1998; 18:65-8.
33. Bettendorf O, Heine B, Kneif S, Eltze E, Semjonow A, Herbst H, Stein H, Bocker W, Poremba C. Expression-patterns of the RNA component (hTR)and the catalytic subunit (hTERT) of human telomerase in nonneoplastic prostate tissue, prostatic intraepithelial neoplasia, and prostate cancer. Prostate 2003; 55:99-104.
34. Hiyama E, Hiyama K, Yokoyarna T, Shay JW. Inununohistochemical detection of telomerase (hTERT) protein in human cancer tissues and a subset of cells in normal tissues. Neoplasia 2001; 3:17-26.
35. Wada H, Enomoto T, Yoshino K, Ozaki K, Kurachi H, Nomura T, Murata Y, Kim N, Weinrich S, Lea-Chou E, Lopez-Uribe D, Shroyer KR. Immunohistocheinical localization of telomerase hTERT protein and analysis of clonality in multifocal vulvar intraepithelial neoplasia. Am J Clin Pathol 2000; 114:371-9.
36. Fu W, Killen M, Culmsee C, Dhar S, Pandita TK, Mattson MP. The catalytic subunit of telomerase is expressed in developing brain neurons and serves a cell survival-promoting function. J Mol Neurosci 2000; 14:3-15.
37. Ramakers C, Ruijter JM, Deprez RH, Moorman AR Assumption-free analysis of quantitative real-time polymerase chain reaction (PCR) data. Neurosci Lett 2003; 339:62-6.
38. Colitz CM, Malarkey D, Dykstra MJ, McGahan MC, Davidson MG. Histologic and immunohistochemical characterization of lens capsular plaques in dogs with cataracts. Am J Vet Res 2000; 61:139-43.
39. Zhou J, Menko AS. Coordinate signaling by Src and p38 kinases in the induction of cortical cataracts. Invest Ophthalmol Vis Sci 2004; 45:2314-23.
40. Cong YS, Wright WE, Shay JW. Human telomerase and its regulation. Microbiol Mol Biol Rev 2002; 66:407-25,tableofcontents.
41. Mattson MP, Fu W, Zhang P. Emerging roles for telomerase in regulating cell differentiation and survival: a neuroscientist's perspective. Mech Ageing Dev 2001; 122:659-71.
42. Akiyama M, Yamada O, Hideshima T, Yanagisawa T, Yokoi K, Fujisawa K, Eto Y, Yamada H, Anderson KC. TNFalpha induces rapid activation and nuclear translocation of telomerase in human lymphocytes. Biochem Biophys Res Commun 2004; 316:528-32.
43. Jagadeesh S, Kyo S, Baneijee PP. Genistein represses telomerase activity via both transcriptional and posttranslational mechanisms in human prostate cancer cells. Cancer Res 2006; 66:2107-15.
44. Wilkie DA, Gemensky-Metzler AJ, Colitz CM, Bras ID, Kuonen VJ, Norris KN, Basharn CR. Canine cataracts, diabetes mellitus and spontaneous lens capsule rupture: a retrospective study of 18 dogs. Vet Ophthalmol 2006; 9:328-34.
45. Bras ID, Colitz CM, Saville WJ, Gemensky-Metzler AJ, Wilkie DA. Posterior capsular opacification in diabetic and nondiabetic canine patients following cataract surgery. Vet Ophthalmol 2006; 9:317-27.
46. Bassnett S. Fiber cell denucleation in the primate lens. Invest Ophthalmol Vis Sci 1997; 38:1678-87.
47. Bassnett S, Mataic D. Chromatin degradation in differentiating fiber cells of the eye lens. J Cell Biol 1997; 137:37-49.
48. Sue Menko A. Lens epithelial cell differentiation. Exp Eye Res 2002; 75:485-90.
49. Nguyen MM, Potter SJ, Griep AE. Deregulated cell cycle control in lens epithelial cells by expression of inhibitors of tumor suppressor function. Mech Dev 2002; 112:101-13.
50. Foley JD, Rosenbaum H, Griep AE. Temporal regulation of VEID- 7-amino-4-trifluoromethylcoumarin cleavage activity and caspase-6 correlates with organelle loss during lens development. J Biol Chem 2004; 279:32142-50.
51. Holt SE, Aisner DL, Baur J, Tesmer VM, Dy M, Ouellette M, Trager JB, Morin GB, Toft DO, Shay JW, Wright WE, White MA. Functional requirement of p23 and Hsp90 in telomerase complexes. Genes Dev 1999; 13:817-26.
52. Colitz CMH, Barden CA, Chandler H, Lu P, Metzler AG, Wilkie DA, et al. Phosphorylation of telom6rase and estrogen receptor-alpha by Akt in cataracts. 35th Annual Meeting of the American College of Veterinary Ophthalmologists, Washington, DC, USA. October 21-23, 2004. p.445.