Lens epithelial cells synthesize and secrete ceruloplasmin: Effects of ceruloplasmin and transferrin on iron efflux and intracellular iron dynamics

Experimental Eye Research

Volumn 83, Issue 4, 2006, Pages 721-727

  Harned, J ^a   Fleisher, L N ^a   McGahan, M C ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

ceruloplasmin; ferritin; iron; labile iron pool; lens; transferrin

Indexed keywords

CERULOPLASMIN; FERRITIN; IRON; TRANSFERRIN;

ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CHELATION; CONTROLLED STUDY; IRON OVERLOAD; LENS EPITHELIUM; NONHUMAN; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; SYNTHESIS;

ANIMALS; CERULOPLASMIN; CULTURE MEDIA, CONDITIONED; CYTOSOL; DOGS; EPITHELIAL CELLS; FERRITINS; IRON; LENS CAPSULE, CRYSTALLINE; TISSUE CULTURE TECHNIQUES; TRANSFERRIN;

EID: 33747890368     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2006.01.018     Document Type: Article

References (26)

1. Attieh Z.K., Mukhopadhyay C.K., Seshadri V., Tripoulas N.A., and Fox P.L. Ceruloplasmin ferroxidase activity stimulates cellular iron uptake by a trivalent cation-specific transport mechanism. J. Biol. Chem. 274 (1999) 1116-1123
2. Chen L., Dentchev T., Wong R., Hahn P., Wen R., Bennett J., and Dunaief J.L. Increased expression of ceruloplasmin in the retina following photic injury. Mol. Vis. 9 (2003) 151-158
3. Davis A.A., and Hunt R.C. Transferrin is made and bound by photoreceptor cells. J. Cell. Physiol. 156 (1993) 280-285
4. Drozdowska S., and Lipnicki B. Oxidative activity of ceruloplasmin in blood serum and aqueous humor in physiological and pathological conditions. Klin Oczna 42 (1972) 989-992
5. Dunaief J.L., Richa C., Franks E.P., Schultze R.L., Aleman T.S., Schenck J.F., Zimmerman E.A., and Brooks D.G. Macular degeneration in a patient with aceruloplasminemia, a disease associated with retinal iron overload. Ophthalmology 112 (2005) 1062-1065
6. Epsztejn S., Kakhlon O., Glickstein H., Breuer W., and Cabantchik Z.I. Fluorescence analysis of the labile iron pool of mammalian cells. Anal. Biochem. 248 (1997) 31-40
7. Goralska M., Harned J., Fleisher L.N., and McGahan M.C. The effect of ascorbic acid and ferric ammonium citrate on iron uptake and storage in lens epithelial cells. Exp. Eye Res. 66 (1998) 687-697
8. Goralska M., Holley B.L., and McGahan M.C. Identification of a mechanism by which lens epithelial cells limit accumulation of overexpressed H-chain ferritin. J. Biol. Chem. 278 (2003) 42920-42926
9. Hahn P., Qian Y., Dentchev T., Chen L., Beard J., Harris Z.L., and Dunaief J.L. Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration. Proc. Natl. Acad. Sci. USA 101 (2004) 13850-13855
10. Harris Z.L. Aceruloplasminemia. J. Neurol. Sci. 207 (2003) 108-109
11. Harris Z.L., Takahashi Y., and Miyajima H. Aceruloplasminemia: molecular characterization of this disorder of iron metabolism. Proc. Natl. Acad. Sci. USA 92 (1995) 2539-2543
12. Harris Z.L., Durley A.P., Man T.K., and Gitlin J.D. Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux. Proc. Natl. Acad. Sci. USA 96 (1999) 10812-10817
13. McGahan M.C. Does the lens serve as a 'sink' for iron during ocular inflammation?. Exp. Eye Res. 54 (1992) 525-530
14. McGahan M.C., Grimes A.M., and Fleisher L.N. Ferroxidase activity increases dramatically in the aqueous humor during the ocular inflammatory response. Ophthal. Res. 21 (1989) 221-225
15. McGahan M.C., Grimes A.M., Nasisse M.P., and Fleisher L.N. Iron uptake by cultured lens epithelial cells. Graefe's Arch. Clin. Exp. Ophthalmol. 233 (1995) 354-359
16. McGahan M.C., Harned J., Goralska M., Sherry B., and Fleisher L.N. Transferrin secretion by lens epithelial cells in culture. Exp. Eye Res. 60 (1995) 667-673
17. Mukhopadhyay C.K., Attieh Z.K., and Fox P.L. Role of ceruloplasmin in cellular iron uptake. Science 279 (1998) 714-717
18. Osaki S., Johnson D.A., and Frieden E. The possible significance of ferrous oxidase activity of ceruloplasmin in normal human serum. J. Biol. Chem. 241 (1966) 2746-2751
19. Osaki S., Johnson D.A., and Freiden E. Mobilization of iron from the perfused mammalian liver by a serum copper enzyme, ferroxidase I. J. Biol. Chem. 246 (1971) 3018-3023
20. Patel B.N., Dunn R.J., and David S. Alternative RNA splicing generates a glycosylphosphatidylinositol-anchored form of ceruloplasmin in mammalian brain. J. Biol. Chem. 275 (2000) 4305-4310
21. Patel B.N., Dunn R.J., Jeong S.Y., Zhu Q., Julien J.-P., and David S. Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury. J. Neurosci. 22 (2002) 6578-6586
22. Petrak J., and Vyoral D. Hephaestin-a ferroxidase of cellular iron export. Int. J. Biochem. Cell Biol. 37 (2005) 1173-1178
23. Richardson D.R. Role of ceruloplasmin and ascorbate in cellular iron release. J. Lab. Clin. Med. 134 (1999) 454-465
24. Sarkar J., Seshadri V., Tripoulas N.A., Ketterer M.E., and Fox P.L. Role of ceruloplasmin in macrophage iron efflux during hypoxia. J. Biol. Chem. 278 (2003) 44018-44024
25. Young S.P., Fahmy M., and Golding S. Ceruloplasmin, transferrin and apotransferrin facilitate iron release from human liver cells. FEBS Lett. 411 (1997) 93-96
26. Yu T.C., and Okamura R. Comparative study of native proteins in aqueous humor and serum-detection of characteristic aqueous humor proteins. Jpn. J. Ophthalmol. 31 (1987) 235-248