Changes in ferritin H- and L-chains in canine lenses with age-related nuclear cataract

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 1, 2009, Pages 305-310

  Goralska, Malgorzata ^a   Nagar, Steven ^a   Colitz, Carmen M H ^a,b,c   Fleisher, Lloyd N ^a   McGahan, M Christine ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b Animal Eye Specialty Clinic   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; APOFERRITIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATARACT; CELL FREE SYSTEM; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOG; ENZYME LINKED IMMUNOSORBENT ASSAY; FERRITIN BLOOD LEVEL; HEAVY CHAIN; HISTOLOGY; IMMUNODETECTION; IMMUNOHISTOCHEMISTRY; IRON STORAGE; LENS; LENS FIBER; LIGHT CHAIN; LIVER; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; AGING; ANIMAL; ANIMAL DISEASE; DOG DISEASE; FLUORESCENCE MICROSCOPY; FLUORESCENT ANTIBODY TECHNIQUE; METABOLISM;

AGING; ANIMALS; APOFERRITINS; CATARACT; DOG DISEASES; DOGS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; LENS, CRYSTALLINE; MICROSCOPY, FLUORESCENCE;

EID: 58249088844     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-2230     Document Type: Article

References (21)

1. Harding JJ. Viewing molecular mechanisms of ageing through a lens. Ageing Res Rev. 2002;1(3):465- 479.
2. Bron AJ, Vrensen GF, Koretz J, Maraini G, Harding JJ. The ageing lens. Ophthalmologica. 2000;214(1):86 -104.
3. Nakamura M, Russell P, Carper DA, Inana G, Kinoshita JH. Alteration of a developmentally regulated, heat-stable polypeptide in the lens of the Philly mouse: implications for cataract formation. J Biol Chem. 1988;263(35):19218-19221.
4. Girelli D, Corrocher R, Bisceglia L, et al Molecular basis for the recently described hereditary hyperferritinemia-cataract syndrome: a mutation in the iron-responsive element of ferritin L-subunit gene (the "Verona mutation"). Blood. 1995;86(11):4050-4053.
5. Brooks DG, Manova-Todorova K, Farmer J, et al. Ferritin crystal cataracts in hereditary hyperferritinemia cataract syndrome. Invest Ophthalmol Vis Sci. 2002;43(4):1121-1126.
6. Sweeney MH, Truscott RJ. An impediment to glutathione diffusion in older normal human lenses: a possible precondition for nuclear cataract. Exp Eye Res. 1998;67(5):587-595.
7. Spector A. Oxidative stress-induced cataract: mechanism of action. FASEB J. 1995;9(12):1173-1182.
8. Truscott RJ. Age-related nuclear cataract-oxidation is the key. Exp Eye Res. 2005;80(5):709 -725.
9. Stadtman ER. Metal ion-catalyzed oxidation of proteins: biochemical mechanism and biological consequences. Free Radic Biol Med. 1990;9(4):315-325.
10. Picard V, Epsztejn S, Santambrogio P, Cabantchik ZI, Beaumont C. Role of ferritin in the control of the labile iron pool in murine erythroleukemia cells. J Biol Chem. 1998;273(25):15382-15386.
11. Garner B, Roberg K, Qian M, Eaton JW, Truscott RJ. Distribution of ferritin and redox-active transition metals in normal and cataractous human lenses. Exp Eye Res. 2000;71(6):599-607.
12. Goralska M, Fleisher LN, McGahan MC. Ferritin H- and L-chains in fiber cell canine and human lenses of different ages. Invest Ophthalmol Vis Sci. 2007;48(9):3968-3975.
13. Balla G, Jacob HS, Balla J, et al. Ferritin: a cytoprotective antioxidant stratagem of endothelium. J Biol Chem. 1992;267(25): 18148-18153.
14. Goralska M, Holley BL, McGahan MC. Identification of a mechanism by which lens epithelial cells limit accumulation of overexpressed ferritin H-chain. J Biol Chem. 2003;278(44):42920-42926.
15. Cham BE, Roeser HP, Nikles A, Ridgway K. A procedure for the purification of ferritin from human liver by heating a methanoltreated homogenate. Anal Biochem. 1985;151:561-565.
16. McGahan MC, Harned J, Grimes AM, Fleisher LN. Regulation of ferritin levels in cultured lens epithelial cells. Exp Eye Res. 1994; 59(5):551-555.
17. Harrison PM, Arosio P. The ferritins: molecular properties, iron storage function and cellular regulation. Biochim Biophys Acta. 1996;1275(3):161-203.
18. Zheng H, Bhavsar D, Dugast I, Zappone E, Drysdale J. Conserved mutations in human ferritin H pseudogenes: a second functional sequence or an evolutionary quirk? Biochim Biophys Acta. 1997; 1351(1-2):150-156.
19. Quaresima B, Tiano MT, Porcellini A, et al. PCR analysis of the H ferritin multigene family reveals the existence of two classes of processed pseudogenes. PCR Methods Appl. 1994;4(2):85-88.
20. Shestopalov VI, Bassnett S. Expression of autofluorescent proteins reveals a novel protein permeable pathway between cells in the lens core. J Cell Sci. 2000;113(pt 11):1913-1921.
21. Fu S, Dean R, Southan M, Truscott R. The hydroxyl radical in lens nuclear cataractogenesis. J Biol Chem. 1998;273(44):28603-28609.