Development and implementation of a high-throughput compound screening assay for targeting disrupted ER calcium homeostasis in Alzheimer's disease

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Honarnejad, Kamran ^a,b,f   Daschner, Alexander ^a,b   Giese, Armin ^b   Zall, Andrea ^c   Schmidt, Boris ^c   Szybinska, Aleksandra ^d   Kuznicki, Jacek ^d   Herms, Jochen ^a,b,e  

^a GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c DARMSTADT UNIVERSITY OF TECHNOLOGY   (Germany)

^d INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Poland)

^e Munich Cluster for Systems Neurology ^*  (Germany)

^f UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; CALCIUM; CALCIUM CHANNELS; CARBACHOL; CELL LINE; DRUG DISCOVERY; ENDOPLASMIC RETICULUM; HIGH-THROUGHPUT SCREENING ASSAYS; HOMEOSTASIS; HUMANS; MOLECULAR IMAGING; MUTATION; PRESENILIN-1; PRESENILIN-2; REPRODUCIBILITY OF RESULTS; SMALL MOLECULE LIBRARIES;

EID: 84894057879     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0080645     Document Type: Article

References (43)

1. Holtzman DM, Morris JC, Goate AM (2011) Alzheimer's disease: the challenge of the second century. Sci Transl Med 3: 77sr71.
2. Camandola S, Mattson MP (2011) Aberrant subcellular neuronal calcium regulation in aging and Alzheimer's disease. Biochim Biophys Acta 1813: 965-973.
3. Thibault O, Gant JC, Landfield PW (2007) Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store. Aging Cell 6: 307-317. (Pubitemid 46785136)
4. Honarnejad K, Herms J (2012) Presenilins: Role in calcium homeostasis. Int J Biochem Cell Biol 44: 1983-1986.
5. Nelson O, Supnet C, Liu H, Bezprozvanny I (2010) Familial Alzheimer's disease mutations in presenilins: effects on endoplasmic reticulum calcium homeostasis and correlation with clinical phenotypes. J Alzheimers Dis 21: 781-793.
6. Stutzmann GE (2007) The pathogenesis of Alzheimers disease is it a lifelong "calciumopathy"? Neuroscientist 13: 546-559.
7. 2+ handling in excitable cells in health and disease. Pharmacol Rev 63: 700-727.
8. Green KN (2009) Calcium in the initiation, progression and as an effector of Alzheimer's disease pathology. J Cell Mol Med 13: 2787-2799.
9. Green KN, LaFerla FM (2008) Linking calcium to Abeta and Alzheimer's disease. Neuron 59: 190-194. (Pubitemid 352033693)
10. Mattson MP, Engle MG, Rychlik B (1991) Effects of elevated intracellular calcium levels on the cytoskeleton and tau in cultured human cortical neurons. Mol Chem Neuropathol 15: 117-142.
11. Patzke H, Tsai LH (2002) Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29. J Biol Chem 277: 8054-8060. (Pubitemid 34968258)
12. Pierrot N, Santos SF, Feyt C, Morel M, Brion JP, et al. (2006) Calcium-mediated transient phosphorylation of tau and amyloid precursor protein followed by intraneuronal amyloid-beta accumulation. J Biol Chem 281: 39907-39914. (Pubitemid 46041794)
13. Coleman PD, Yao PJ (2003) Synaptic slaughter in Alzheimer's disease. Neurobiol Aging 24: 1023-1027. (Pubitemid 37487880)
14. Gomez-Isla T, Price JL, McKeel DW Jr, Morris JC, Growdon JH, et al. (1996) Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease. J Neurosci 16: 4491-4500. (Pubitemid 26243044)
15. Scheff SW, Price DA, Schmitt FA, Mufson EJ (2006) Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment. Neurobiol Aging 27: 1372-1384. (Pubitemid 44279897)
16. Ripova D, Platilova V, Strunecka A, Jirak R, Hoschl C (2004) Alterations in calcium homeostasis as biological marker for mild Alzheimer's disease? Physiol Res 53: 449-452. (Pubitemid 39094833)
17. Jaworska A, Dzbek J, Styczynska M, Kuznicki J (2013) Analysis of calcium homeostasis in fresh lymphocytes from patients with sporadic Alzheimer's disease or mild cognitive impairment. Biochim Biophys Acta.
18. Bullock R (2006) Efficacy and safety of memantine in moderate-to-severe Alzheimer disease: the evidence to date. Alzheimer Dis Assoc Disord 20: 23-29.
19. Honarnejad K, Jung CK, Lammich S, Arzberger T, Kretzschmar H, et al. (2013) Involvement of presenilin holoprotein upregulation in calcium dyshomeostasis of Alzheimer's disease. J Cell Mol Med 17: 293-302.
20. 2+ by circularly permuted yellow fluorescent proteins. Proc Natl Acad Sci U S A 101: 10554-10559.
21. Mitterreiter S, Page RM, Kamp F, Hopson J, Winkler E, et al. (2010) Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms. J Neurosci 30: 8974-8983.
22. Page RM, Baumann K, Tomioka M, Perez-Revuelta BI, Fukumori A, et al. (2008) Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation. J Biol Chem 283: 677-683.
23. Lipinski CA, Lombardo F, Dominy BW, Feeney PJ (2001) Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 46: 3-26. (Pubitemid 33653411)
24. Carmichael J, DeGraff WG, Gazdar AF, Minna JD, Mitchell JB (1987) Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res 47: 936-942. (Pubitemid 17027905)
25. Zhang JH, Chung TD, Oldenburg KR (1999) A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. J Biomol Screen 4: 67-73. (Pubitemid 29278954)
26. 3 receptor modal gating by familial Alzheimer's disease-linked presenilin mutants in human cells and mouse neurons. Sci Signal 3: ra22.
27. 3 receptor channel gating. Neuron 58: 871-883.
28. Guo Q, Furukawa K, Sopher BL, Pham DG, Xie J, et al. (1996) Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide. Neuroreport 8: 379-383. (Pubitemid 126785592)
29. Mangialasche F, Solomon A, Winblad B, Mecocci P, Kivipelto M (2010) Alzheimer's disease: clinical trials and drug development. Lancet Neurol 9: 702-716.
30. 2+ - back to basics. Trends Pharmacol Sci 26: 218-223.
31. Ho A, Shen J (2011) Presenilins in synaptic function and disease. Trends Mol Med 17: 617-624.
32. Kelliher M, Fastbom J, Cowburn RF, Bonkale W, Ohm TG, et al. (1999) Alterations in the ryanodine receptor calcium release channel correlate with Alzheimer's disease neurofibrillary and beta-amyloid pathologies. Neuroscience 92: 499-513. (Pubitemid 29268039)
33. Landfield PW, Thibault O, Mazzanti ML, Porter NM, Kerr DS (1992) Mechanisms of neuronal death in brain aging and Alzheimer's disease: role of endocrine-mediated calcium dyshomeostasis. J Neurobiol 23: 1247-1260.
34. Bezprozvanny I (2009) Calcium signaling and neurodegenerative diseases. Trends Mol Med 15: 89-100.
35. Toescu EC, Verkhratsky A (2007) The importance of being subtle: small changes in calcium homeostasis control cognitive decline in normal aging. Aging Cell 6: 267-273. (Pubitemid 46785132)
36. Herrup K (2010) Reimagining Alzheimer's disease - an age-based hypothesis. J Neurosci 30: 16755-16762.
37. Li D, Parks SB, Kushner JD, Nauman D, Burgess D, et al. (2006) Mutations of presenilin genes in dilated cardiomyopathy and heart failure. Am J Hum Genet 79: 1030-1039. (Pubitemid 44853474)
38. Chadwick W, Mitchell N, Martin B, Maudsley S (2012) Therapeutic targeting of the endoplasmic reticulum in Alzheimer's disease. Curr Alzheimer Res 9: 110-119.
39. Ho M, Hoke DE, Chua YJ, Li QX, Culvenor JG, et al. (2011) Effect of Metal Chelators on gamma-Secretase Indicates That Calcium and Magnesium Ions Facilitate Cleavage of Alzheimer Amyloid Precursor Substrate. Int J Alzheimers Dis 2011: 950932.
40. Hayley M, Perspicace S, Schulthess T, Seelig J (2009) Calcium enhances the proteolytic activity of BACE1: An in vitro biophysical and biochemical characterization of the BACE1-calcium interaction. Biochim Biophys Acta 1788: 1933-1938.
41. 2+ disruptions in young, adult, and aged Alzheimer's disease mice. J Neurosci 26: 5180-5189.
42. Oules B, Del Prete D, Greco B, Zhang X, Lauritzen I, et al. (2012) Ryanodine Receptor Blockade Reduces Amyloid-beta Load and Memory Impairments in Tg2576 Mouse Model of Alzheimer Disease. J Neurosci 32: 11820-11834.
43. 2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell 126: 981-993.