메뉴 건너뛰기




Volumn 85, Issue 3, 2014, Pages 408-419

Phosphodiesterase 5 inhibitors enhance chemotherapy killing in gastrointestinal/genitourinary cancer cells

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; ANTIGENS, CD95; ANTINEOPLASTIC AGENTS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CELL LINE, TUMOR; CHECKPOINT KINASE 2; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; GASTROINTESTINAL NEOPLASMS; HISTONES; HUMANS; LYMPHOMA, B-CELL; MICE; PHOSPHODIESTERASE 5 INHIBITORS; PHOSPHORYLATION; RATS; UROGENITAL NEOPLASMS;

EID: 84894055948     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.113.090043     Document Type: Article
Times cited : (64)

References (54)
  • 1
    • 84880274453 scopus 로고    scopus 로고
    • Inhibition of hepatocyte autophagy increases tumor necrosis factor-dependent liver injury by promoting caspase-8 activation
    • Amir M, Zhao E, Fontana L, Rosenberg H, Tanaka K, Gao G, and Czaja MJ (2013) Inhibition of hepatocyte autophagy increases tumor necrosis factor-dependent liver injury by promoting caspase-8 activation. Cell Death Differ 20:878-887.
    • (2013) Cell Death Differ , vol.20 , pp. 878-887
    • Amir, M.1    Zhao, E.2    Fontana, L.3    Rosenberg, H.4    Tanaka, K.5    Gao, G.6    Czaja, M.J.7
  • 2
    • 36448973875 scopus 로고    scopus 로고
    • CHK2 kinase: Cancer susceptibility and cancer therapy-two sides of the same coin?
    • Antoni L, Sodha N, Collins I, and Garrett MD (2007) CHK2 kinase: Cancer susceptibility and cancer therapy-two sides of the same coin? Nat Rev Cancer 7:925-936.
    • (2007) Nat Rev Cancer , vol.7 , pp. 925-936
    • Antoni, L.1    Sodha, N.2    Collins, I.3    Garrett, M.D.4
  • 4
    • 33748686575 scopus 로고    scopus 로고
    • Cyclic nucleotide phosphodiesterases: Molecular regulation to clinical use
    • Bender AT and Beavo JA (2006) Cyclic nucleotide phosphodiesterases: Molecular regulation to clinical use. Pharmacol Rev 58:488-520.
    • (2006) Pharmacol Rev , vol.58 , pp. 488-520
    • Bender, A.T.1    Beavo, J.A.2
  • 5
    • 84877857730 scopus 로고    scopus 로고
    • PARP and CHK inhibitors interact to cause DNA damage and cell death in mammary carcinoma cells
    • Booth L, Cruickshanks N, Ridder T, Dai Y, Grant S, and Dent P (2013) PARP and CHK inhibitors interact to cause DNA damage and cell death in mammary carcinoma cells. Cancer Biol Ther 14:458-465.
    • (2013) Cancer Biol Ther , vol.14 , pp. 458-465
    • Booth, L.1    Cruickshanks, N.2    Ridder, T.3    Dai, Y.4    Grant, S.5    Dent, P.6
  • 6
    • 0023099858 scopus 로고
    • Risks and benefits of repeated courses of intravesical bacillus Calmette-Guerin therapy for superficial bladder cancer
    • Catalona WJ, Hudson MA, Gillen DP, Andriole GL, and Ratliff TL (1987) Risks and benefits of repeated courses of intravesical bacillus Calmette-Guerin therapy for superficial bladder cancer. J Urol 137:220-224.
    • (1987) J Urol , vol.137 , pp. 220-224
    • Catalona, W.J.1    Hudson, M.A.2    Gillen, D.P.3    Andriole, G.L.4    Ratliff, T.L.5
  • 7
    • 84864313244 scopus 로고    scopus 로고
    • PDE5 inhibitors, sildenafil and vardenafil, reverse multidrug resistance by inhibiting the efflux function of multidrug resistance protein 7 (ATP-binding Cassette C10) transporter
    • Chen JJ, Sun YL, Tiwari AK, Xiao ZJ, Sodani K, Yang DH, Vispute SG, Jiang WQ, Chen SD, and Chen ZS (2012) PDE5 inhibitors, sildenafil and vardenafil, reverse multidrug resistance by inhibiting the efflux function of multidrug resistance protein 7 (ATP-binding Cassette C10) transporter. Cancer Sci 103:1531-1537.
    • (2012) Cancer Sci , vol.103 , pp. 1531-1537
    • Chen, J.J.1    Sun, Y.L.2    Tiwari, A.K.3    Xiao, Z.J.4    Sodani, K.5    Yang, D.H.6    Vispute, S.G.7    Jiang, W.Q.8    Chen, S.D.9    Chen, Z.S.10
  • 8
    • 0021118703 scopus 로고
    • Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors
    • Chou TC and Talalay P (1984) Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 22: 27-55.
    • (1984) Adv Enzyme Regul , vol.22 , pp. 27-55
    • Chou, T.C.1    Talalay, P.2
  • 9
    • 84869757978 scopus 로고    scopus 로고
    • Lapatinib and obatoclax kill breast cancer cells through reactive oxygen species-dependent endoplasmic reticulum stress
    • Cruickshanks N, Tang Y, Booth L, Hamed H, Grant S, and Dent P (2012) Lapatinib and obatoclax kill breast cancer cells through reactive oxygen species-dependent endoplasmic reticulum stress. Mol Pharmacol 82:1217-1229.
    • (2012) Mol Pharmacol , vol.82 , pp. 1217-1229
    • Cruickshanks, N.1    Tang, Y.2    Booth, L.3    Hamed, H.4    Grant, S.5    Dent, P.6
  • 10
    • 66149148931 scopus 로고    scopus 로고
    • ERK phosphorylation mediates sildenafil-induced myocardial protection against ischemia-reperfusion injury in mice
    • Das A, Salloum FN, Xi L, Rao YJ, and Kukreja RC (2009) ERK phosphorylation mediates sildenafil-induced myocardial protection against ischemia-reperfusion injury in mice. Am J Physiol Heart Circ Physiol 296:H1236-H1243.
    • (2009) Am J Physiol Heart Circ Physiol , vol.296
    • Das, A.1    Salloum, F.N.2    Xi, L.3    Rao, Y.J.4    Kukreja, R.C.5
  • 11
    • 57649155045 scopus 로고    scopus 로고
    • Protein kinase G-dependent cardioprotective mechanism of phosphodiesterase-5 inhibition involves phosphorylation of ERK and GSK3beta
    • Das A, Xi L, and Kukreja RC (2008) Protein kinase G-dependent cardioprotective mechanism of phosphodiesterase-5 inhibition involves phosphorylation of ERK and GSK3beta. J Biol Chem 283:29572-29585.
    • (2008) J Biol Chem , vol.283 , pp. 29572-29585
    • Das, A.1    Xi, L.2    Kukreja, R.C.3
  • 13
    • 1642344354 scopus 로고    scopus 로고
    • Protein kinase C plays an essential role in sildenafil-induced cardioprotection in rabbits
    • Das A, Ockaili R, Salloum F, and Kukreja RC (2004) Protein kinase C plays an essential role in sildenafil-induced cardioprotection in rabbits. Am J Physiol Heart Circ Physiol 286:H1455-H1460.
    • (2004) Am J Physiol Heart Circ Physiol , vol.286
    • Das, A.1    Ockaili, R.2    Salloum, F.3    Kukreja, R.C.4
  • 14
    • 16844382827 scopus 로고    scopus 로고
    • Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signaling
    • Das A, Xi L, and Kukreja RC (2005) Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signaling. J Biol Chem 280:12944-12955.
    • (2005) J Biol Chem , vol.280 , pp. 12944-12955
    • Das, A.1    Xi, L.2    Kukreja, R.C.3
  • 16
    • 84865700852 scopus 로고    scopus 로고
    • Increased gene expression of the ABCC5 transporter without distinct changes in the expression of PDE5 in human cervical cancer cells during growth
    • Eggen T, Sager G, Berg T, Nergaard B, Moe BT, and Ørbo A (2012) Increased gene expression of the ABCC5 transporter without distinct changes in the expression of PDE5 in human cervical cancer cells during growth. Anticancer Res 32:3055-3061.
    • (2012) Anticancer Res , vol.32 , pp. 3055-3061
    • Eggen, T.1    Sager, G.2    Berg, T.3    Nergaard, B.4    Moe, B.T.5    Ørbo, A.6
  • 17
    • 4644353365 scopus 로고    scopus 로고
    • Bile acids induce mitochondrial ROS, which promote activation of receptor tyrosine kinases and signaling pathways in rat hepatocytes
    • Fang Y, Han SI, Mitchell C, Gupta S, Studer E, Grant S, Hylemon PB, and Dent P (2004) Bile acids induce mitochondrial ROS, which promote activation of receptor tyrosine kinases and signaling pathways in rat hepatocytes. Hepatology 40: 961-971.
    • (2004) Hepatology , vol.40 , pp. 961-971
    • Fang, Y.1    Han, S.I.2    Mitchell, C.3    Gupta, S.4    Studer, E.5    Grant, S.6    Hylemon, P.B.7    Dent, P.8
  • 18
    • 17144405644 scopus 로고    scopus 로고
    • Phosphodiesterase-5 inhibition with sildenafil attenuates cardiomyocyte apoptosis and left ventricular dysfunction in a chronic model of doxorubicin cardiotoxicity
    • Fisher PW, Salloum F, Das A, Hyder H, and Kukreja RC (2005) Phosphodiesterase-5 inhibition with sildenafil attenuates cardiomyocyte apoptosis and left ventricular dysfunction in a chronic model of doxorubicin cardiotoxicity. Circulation 111: 1601-1610.
    • (2005) Circulation , vol.111 , pp. 1601-1610
    • Fisher, P.W.1    Salloum, F.2    Das, A.3    Hyder, H.4    Kukreja, R.C.5
  • 19
    • 33847066413 scopus 로고    scopus 로고
    • Extracellular signal-related kinase positively regulates ataxia telangiectasia mutated, homologous recombination repair, and the DNA damage response
    • Golding SE, Rosenberg E, Neill S, Dent P, Povirk LF, and Valerie K (2007) Extracellular signal-related kinase positively regulates ataxia telangiectasia mutated, homologous recombination repair, and the DNA damage response. Cancer Res 67: 1046-1053.
    • (2007) Cancer Res , vol.67 , pp. 1046-1053
    • Golding, S.E.1    Rosenberg, E.2    Neill, S.3    Dent, P.4    Povirk, L.F.5    Valerie, K.6
  • 21
    • 0028816002 scopus 로고
    • Carcinoma in situ of the bladder
    • Hudson MA and Herr HW (1995) Carcinoma in situ of the bladder. J Urol 153: 564-572.
    • (1995) J Urol , vol.153 , pp. 564-572
    • Hudson, M.A.1    Herr, H.W.2
  • 24
    • 84867848083 scopus 로고    scopus 로고
    • Evaluation of PDE5 and PDE9 expression in benign and malignant breast tumors
    • Karami-Tehrani F, Moeinifard M, Aghaei M, and Atri M (2012) Evaluation of PDE5 and PDE9 expression in benign and malignant breast tumors. Arch Med Res 43: 470-475.
    • (2012) Arch Med Res , vol.43 , pp. 470-475
    • Karami-Tehrani, F.1    Moeinifard, M.2    Aghaei, M.3    Atri, M.4
  • 25
    • 0029768723 scopus 로고    scopus 로고
    • Overexpression of p53 protein in a high-risk population of patients with superficial bladder cancer before and after bacillus Calmette-Guérin therapy: Correlation to clinical outcome
    • Lacombe L, Dalbagni G, Zhang ZF, Cordon-Cardo C, Fair WR, Herr HW, and Reuter VE (1996) Overexpression of p53 protein in a high-risk population of patients with superficial bladder cancer before and after bacillus Calmette-Guérin therapy: Correlation to clinical outcome. J Clin Oncol 14:2646-2652.
    • (1996) J Clin Oncol , vol.14 , pp. 2646-2652
    • Lacombe, L.1    Dalbagni, G.2    Zhang, Z.F.3    Cordon-Cardo, C.4    Fair, W.R.5    Herr, H.W.6    Reuter, V.E.7
  • 27
    • 34247483506 scopus 로고    scopus 로고
    • ATM activation and DNA damage response
    • Lavin MF and Kozlov S (2007) ATM activation and DNA damage response. Cell Cycle 6:931-942.
    • (2007) Cell Cycle , vol.6 , pp. 931-942
    • Lavin, M.F.1    Kozlov, S.2
  • 29
    • 18844405191 scopus 로고    scopus 로고
    • PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints
    • Lu X, Nannenga B, and Donehower LA (2005) PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints. Genes Dev 19:1162-1174.
    • (2005) Genes Dev , vol.19 , pp. 1162-1174
    • Lu, X.1    Nannenga, B.2    Donehower, L.A.3
  • 30
    • 0032836499 scopus 로고    scopus 로고
    • 5-year followup of a randomized prospective study comparing mitomycin C and bacillus Calmette-Guerin in patients with superficial bladder carcinoma
    • Swedish-Norwegian Bladder Cancer Study Group
    • Malmström PU, Wijkström H, Lundholm C, Wester K, Busch C, and Norlén BJ; Swedish-Norwegian Bladder Cancer Study Group (1999) 5-year followup of a randomized prospective study comparing mitomycin C and bacillus Calmette-Guerin in patients with superficial bladder carcinoma. J Urol 161:1124-1127.
    • (1999) J Urol , vol.161 , pp. 1124-1127
    • Malmström, P.U.1    Wijkström, H.2    Lundholm, C.3    Wester, K.4    Busch, C.5    Norlén, B.J.6
  • 32
    • 0036124906 scopus 로고    scopus 로고
    • A population pharmacokinetic analysis of sildenafil citrate in patients with erectile dysfunction
    • Milligan PA, Marshall SF, and Karlsson MO (2002) A population pharmacokinetic analysis of sildenafil citrate in patients with erectile dysfunction. Br J Clin Pharmacol 53 (Suppl 1):45S-52S.
    • (2002) Br J Clin Pharmacol , vol.53 , Issue.SUPPL. 1
    • Milligan, P.A.1    Marshall, S.F.2    Karlsson, M.O.3
  • 33
    • 0036350615 scopus 로고    scopus 로고
    • Sildenafil (Viagra) induces powerful cardioprotective effect via opening of mitochondrial K(ATP) channels in rabbits
    • Ockaili R, Salloum F, Hawkins J, and Kukreja RC (2002) Sildenafil (Viagra) induces powerful cardioprotective effect via opening of mitochondrial K(ATP) channels in rabbits. Am J Physiol Heart Circ Physiol 283:H1263-H1269.
    • (2002) Am J Physiol Heart Circ Physiol , vol.283
    • Ockaili, R.1    Salloum, F.2    Hawkins, J.3    Kukreja, R.C.4
  • 37
    • 0141786835 scopus 로고    scopus 로고
    • Liposomal anthracyclines in metastatic breast cancer: Clinical update
    • Rivera E (2003) Liposomal anthracyclines in metastatic breast cancer: Clinical update. Oncologist 8 (Suppl 2):3-9.
    • (2003) Oncologist , vol.8 , Issue.SUPPL. 2 , pp. 3-9
    • Rivera, E.1
  • 38
    • 33747884339 scopus 로고    scopus 로고
    • DNA damage-induced cell death by apoptosis
    • Roos WP and Kaina B (2006) DNA damage-induced cell death by apoptosis. Trends Mol Med 12:440-450.
    • (2006) Trends Mol Med , vol.12 , pp. 440-450
    • Roos, W.P.1    Kaina, B.2
  • 40
    • 0037418950 scopus 로고    scopus 로고
    • Sildenafil induces delayed preconditioning through inducible nitric oxide synthase-dependent pathway in mouse heart
    • Salloum F, Yin C, Xi L, and Kukreja RC (2003) Sildenafil induces delayed preconditioning through inducible nitric oxide synthase-dependent pathway in mouse heart. Circ Res 92:595-597.
    • (2003) Circ Res , vol.92 , pp. 595-597
    • Salloum, F.1    Yin, C.2    Xi, L.3    Kukreja, R.C.4
  • 42
    • 33244461488 scopus 로고    scopus 로고
    • Vardenafil: A novel type 5 phosphodiesterase inhibitor reduces myocardial infarct size following ischemia/reperfusion injury via opening of mitochondrial K(ATP) channels in rabbits
    • Salloum FN, Ockaili RA, Wittkamp M, Marwaha VR, and Kukreja RC (2006) Vardenafil: A novel type 5 phosphodiesterase inhibitor reduces myocardial infarct size following ischemia/reperfusion injury via opening of mitochondrial K(ATP) channels in rabbits. J Mol Cell Cardiol 40:405-411.
    • (2006) J Mol Cell Cardiol , vol.40 , pp. 405-411
    • Salloum, F.N.1    Ockaili, R.A.2    Wittkamp, M.3    Marwaha, V.R.4    Kukreja, R.C.5
  • 43
    • 0037222292 scopus 로고    scopus 로고
    • Sildenafil and vardenafil, types 5 and 6 phosphodiesterase inhibitors, induce caspase-dependent apoptosis of B-chronic lymphocytic leukemia cells
    • Sarfati M, Mateo V, Baudet S, Rubio M, Fernandez C, Davi F, Binet JL, Delic J, and Merle-Beral H (2003) Sildenafil and vardenafil, types 5 and 6 phosphodiesterase inhibitors, induce caspase-dependent apoptosis of B-chronic lymphocytic leukemia cells. Blood 101:265-269.
    • (2003) Blood , vol.101 , pp. 265-269
    • Sarfati, M.1    Mateo, V.2    Baudet, S.3    Rubio, M.4    Fernandez, C.5    Davi, F.6    Binet, J.L.7    Delic, J.8    Merle-Beral, H.9
  • 44
    • 84877853877 scopus 로고    scopus 로고
    • The co-repressor SMRT delays DNA damage-induced caspase activation by repressing pro-apoptotic genes and modulating the dynamics of checkpoint kinase 2 activation
    • Scafoglio C, Smolka M, Zhou H, Perissi V, and Rosenfeld MG. (2013) The co-repressor SMRT delays DNA damage-induced caspase activation by repressing pro-apoptotic genes and modulating the dynamics of checkpoint kinase 2 activation. PLoS One 8: E59986.
    • (2013) PLoS One , vol.8
    • Scafoglio, C.1    Smolka, M.2    Zhou, H.3    Perissi, V.4    Rosenfeld, M.G.5
  • 48
    • 79551698938 scopus 로고    scopus 로고
    • Tumor suppressor CHK2: Regulator of DNA damage response and mediator of chromosomal stability
    • Stolz A, Ertych N, and Bastians H (2011) Tumor suppressor CHK2: Regulator of DNA damage response and mediator of chromosomal stability. Clin Cancer Res 17: 401-405.
    • (2011) Clin Cancer Res , vol.17 , pp. 401-405
    • Stolz, A.1    Ertych, N.2    Bastians, H.3
  • 49
    • 17644402851 scopus 로고    scopus 로고
    • Requirement of Tyr-992 and Tyr-1173 in phosphorylation of the epidermal growth factor receptor by ionizing radiation and modulation by SHP2
    • Sturla LM, Amorino G, Alexander MS, Mikkelsen RB, Valerie K, and Schmidt-Ullrichr RK (2005) Requirement of Tyr-992 and Tyr-1173 in phosphorylation of the epidermal growth factor receptor by ionizing radiation and modulation by SHP2. J Biol Chem 280:14597-14604.
    • (2005) J Biol Chem , vol.280 , pp. 14597-14604
    • Sturla, L.M.1    Amorino, G.2    Alexander, M.S.3    Mikkelsen, R.B.4    Valerie, K.5    Schmidt-Ullrichr, R.K.6
  • 50
    • 0027238122 scopus 로고
    • Current management of invasive and metastatic transitional cell carcinoma of the bladder
    • Thrasher JB and Crawford ED (1993) Current management of invasive and metastatic transitional cell carcinoma of the bladder. J Urol 149:957-972.
    • (1993) J Urol , vol.149 , pp. 957-972
    • Thrasher, J.B.1    Crawford, E.D.2
  • 51
    • 0021237051 scopus 로고
    • The biology and treatment of superficial bladder cancer
    • Torti FM and Lum BL (1984) The biology and treatment of superficial bladder cancer. J Clin Oncol 2:505-531.
    • (1984) J Clin Oncol , vol.2 , pp. 505-531
    • Torti, F.M.1    Lum, B.L.2
  • 52
    • 0009989827 scopus 로고    scopus 로고
    • Results of a randomized phase III trial of sequential intravesical therapy with mitomycin C and bacillus Calmette-Guerin versus mitomycin C alone in patients with superficial bladder cancer
    • discussion 1671-1672
    • Witjes JA, Caris CT, Mungan NA, Debruyne FM, and Witjes WP (1998) Results of a randomized phase III trial of sequential intravesical therapy with mitomycin C and bacillus Calmette-Guerin versus mitomycin C alone in patients with superficial bladder cancer. J Urol 160:1668-1671, discussion 1671-1672.
    • (1998) J Urol , vol.160 , pp. 1668-1671
    • Witjes, J.A.1    Caris, C.T.2    Mungan, N.A.3    Debruyne, F.M.4    Witjes, W.P.5
  • 54
    • 84862514301 scopus 로고    scopus 로고
    • PDE5 inhibitor promotes melanin synthesis through the PKG pathway in B16 melanoma cells
    • Zhang X, Yan G, Ji J, Wu J, Sun X, Shen J, Jiang H, and Wang H (2012) PDE5 inhibitor promotes melanin synthesis through the PKG pathway in B16 melanoma cells. J Cell Biochem 113:2738-2743.
    • (2012) J Cell Biochem , vol.113 , pp. 2738-2743
    • Zhang, X.1    Yan, G.2    Ji, J.3    Wu, J.4    Sun, X.5    Shen, J.6    Jiang, H.7    Wang, H.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.