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Volumn 337, Issue 1-2, 2014, Pages 104-111

Cerebrolysin reduces amyloid-β deposits, apoptosis and autophagy in the thalamus and improves functional recovery after cortical infarction

Author keywords

Amyloid ; Apoptosis; Autophagy; Cerebral infarction; Cerebrolysin; Thalamus

Indexed keywords

AMYLOID-Β; APOPTOSIS; AUTOPHAGY; CEREBRAL INFARCTION; CEREBROLYSIN; THALAMUS;

EID: 84894049283     PISSN: 0022510X     EISSN: 18785883     Source Type: Journal    
DOI: 10.1016/j.jns.2013.11.028     Document Type: Article
Times cited : (43)

References (37)
  • 1
    • 0025838155 scopus 로고
    • Thalamic atrophy following cerebral infarction in the territory of the middle cerebral artery
    • A. Tamura, Y. Tahira, H. Nagashima, T. Kirino, O. Gotoh, and S. Hojo et al. Thalamic atrophy following cerebral infarction in the territory of the middle cerebral artery Stroke 22 1991 615 618
    • (1991) Stroke , vol.22 , pp. 615-618
    • Tamura, A.1    Tahira, Y.2    Nagashima, H.3    Kirino, T.4    Gotoh, O.5    Hojo, S.6
  • 2
    • 19544376505 scopus 로고    scopus 로고
    • Inflammation in areas of remote changes following focal brain lesion
    • F. Block, M. Dihne, and M. Loos Inflammation in areas of remote changes following focal brain lesion Prog Neurobiol 75 2005 342 365
    • (2005) Prog Neurobiol , vol.75 , pp. 342-365
    • Block, F.1    Dihne, M.2    Loos, M.3
  • 3
    • 33846063485 scopus 로고    scopus 로고
    • Long-term functional outcome following transient middle cerebral artery occlusion in the rat: Correlation between brain damage and behavioral impairment
    • T. Freret, L. Chazalviel, S. Roussel, M. Bernaudin, P. Schumann-Bard, and M. Boulouard Long-term functional outcome following transient middle cerebral artery occlusion in the rat: correlation between brain damage and behavioral impairment Behav Neurosci 120 2006 1285 1298
    • (2006) Behav Neurosci , vol.120 , pp. 1285-1298
    • Freret, T.1    Chazalviel, L.2    Roussel, S.3    Bernaudin, M.4    Schumann-Bard, P.5    Boulouard, M.6
  • 4
    • 22044439980 scopus 로고    scopus 로고
    • Transformation of diffuse beta-amyloid precursor protein and beta-amyloid deposits to plaques in the thalamus after transient occlusion of the middle cerebral artery in rats
    • T. van Groen, K. Puurunen, H.M. Maki, J. Sivenius, and J. Jolkkonen Transformation of diffuse beta-amyloid precursor protein and beta-amyloid deposits to plaques in the thalamus after transient occlusion of the middle cerebral artery in rats Stroke 36 2005 1551 1556
    • (2005) Stroke , vol.36 , pp. 1551-1556
    • Van Groen, T.1    Puurunen, K.2    Maki, H.M.3    Sivenius, J.4    Jolkkonen, J.5
  • 5
    • 38549147680 scopus 로고    scopus 로고
    • Coaccumulation of calcium and beta-amyloid in the thalamus after transient middle cerebral artery occlusion in rats
    • S. Makinen, T. van Groen, J. Clarke, A. Thornell, D. Corbett, and M. Hiltunen et al. Coaccumulation of calcium and beta-amyloid in the thalamus after transient middle cerebral artery occlusion in rats J Cereb Blood Flow Metab 28 2008 263 268
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 263-268
    • Makinen, S.1    Van Groen, T.2    Clarke, J.3    Thornell, A.4    Corbett, D.5    Hiltunen, M.6
  • 6
    • 67349143960 scopus 로고    scopus 로고
    • Focal cerebral ischemia in rats alters APP processing and expression of Abeta peptide degrading enzymes in the thalamus
    • M. Hiltunen, P. Makinen, S. Peraniemi, J. Sivenius, T. van Groen, and H. Soininen et al. Focal cerebral ischemia in rats alters APP processing and expression of Abeta peptide degrading enzymes in the thalamus Neurobiol Dis 35 2009 103 113
    • (2009) Neurobiol Dis , vol.35 , pp. 103-113
    • Hiltunen, M.1    Makinen, P.2    Peraniemi, S.3    Sivenius, J.4    Van Groen, T.5    Soininen, H.6
  • 7
    • 79551629454 scopus 로고    scopus 로고
    • Reduction of beta-amyloid deposits by gamma-secretase inhibitor is associated with the attenuation of secondary damage in the ipsilateral thalamus and sensory functional improvement after focal cortical infarction in hypertensive rats
    • Y. Zhang, S. Xing, J. Zhang, J. Li, C. Li, and Z. Pei et al. Reduction of beta-amyloid deposits by gamma-secretase inhibitor is associated with the attenuation of secondary damage in the ipsilateral thalamus and sensory functional improvement after focal cortical infarction in hypertensive rats J Cereb Blood Flow Metab 31 2011 572 579
    • (2011) J Cereb Blood Flow Metab , vol.31 , pp. 572-579
    • Zhang, Y.1    Xing, S.2    Zhang, J.3    Li, J.4    Li, C.5    Pei, Z.6
  • 8
    • 0029918952 scopus 로고    scopus 로고
    • Apoptosis and c-Jun in the thalamus of the rat following cortical infarction
    • M.A. Soriano, I. Ferrer, E. Rodriguez-Farre, and A.M. Planas Apoptosis and c-Jun in the thalamus of the rat following cortical infarction Neuroreport 7 1996 425 428
    • (1996) Neuroreport , vol.7 , pp. 425-428
    • Soriano, M.A.1    Ferrer, I.2    Rodriguez-Farre, E.3    Planas, A.M.4
  • 9
    • 0034024798 scopus 로고    scopus 로고
    • Cell death is prevented in thalamic fields but not in injured neocortical areas after permanent focal ischaemia in mice overexpressing the anti-apoptotic protein Bcl-2
    • F. De Bilbao, E. Guarin, P. Nef, P. Vallet, P. Giannakopoulos, and M. Dubois-Dauphin Cell death is prevented in thalamic fields but not in injured neocortical areas after permanent focal ischaemia in mice overexpressing the anti-apoptotic protein Bcl-2 Eur J Neurosci 12 2000 921 934
    • (2000) Eur J Neurosci , vol.12 , pp. 921-934
    • De Bilbao, F.1    Guarin, E.2    Nef, P.3    Vallet, P.4    Giannakopoulos, P.5    Dubois-Dauphin, M.6
  • 10
    • 84863011717 scopus 로고    scopus 로고
    • Beclin 1 knockdown inhibits autophagic activation and prevents the secondary neurodegenerative damage in the ipsilateral thalamus following focal cerebral infarction
    • S. Xing, Y. Zhang, J. Li, J. Zhang, Y. Li, and C. Dang et al. Beclin 1 knockdown inhibits autophagic activation and prevents the secondary neurodegenerative damage in the ipsilateral thalamus following focal cerebral infarction Autophagy 8 2012 63 76
    • (2012) Autophagy , vol.8 , pp. 63-76
    • Xing, S.1    Zhang, Y.2    Li, J.3    Zhang, J.4    Li, Y.5    Dang, C.6
  • 11
    • 34249336353 scopus 로고    scopus 로고
    • Trophic factors counteract elevated FGF-2-induced inhibition of adult neurogenesis
    • H. Chen, Y.C. Tung, B. Li, K. Iqbal, and I. Grundke-Iqbal Trophic factors counteract elevated FGF-2-induced inhibition of adult neurogenesis Neurobiol Aging 28 2007 1148 1162
    • (2007) Neurobiol Aging , vol.28 , pp. 1148-1162
    • Chen, H.1    Tung, Y.C.2    Li, B.3    Iqbal, K.4    Grundke-Iqbal, I.5
  • 12
    • 78650121248 scopus 로고    scopus 로고
    • Efficacy and safety of Cerebrolysin in moderate to moderately severe Alzheimer's disease: Results of a randomized, double-blind, controlled trial investigating three dosages of Cerebrolysin
    • X.A. Alvarez, R. Cacabelos, C. Sampedro, M. Aleixandre, C. Linares, and E. Granizo et al. Efficacy and safety of Cerebrolysin in moderate to moderately severe Alzheimer's disease: results of a randomized, double-blind, controlled trial investigating three dosages of Cerebrolysin Eur J Neurol 18 2011 59 68
    • (2011) Eur J Neurol , vol.18 , pp. 59-68
    • Alvarez, X.A.1    Cacabelos, R.2    Sampedro, C.3    Aleixandre, M.4    Linares, C.5    Granizo, E.6
  • 13
    • 84857642810 scopus 로고    scopus 로고
    • Cerebrolysin in patients with acute ischemic stroke in Asia results of a double-blind, placebo-controlled randomized trial
    • W.D. Heiss, M. Brainin, N.M. Bornstein, J. Tuomilehto, Z. Hong, and Acute S. Cerebrolysin Cerebrolysin in patients with acute ischemic stroke in Asia results of a double-blind, placebo-controlled randomized trial Stroke 43 2012 630 636
    • (2012) Stroke , vol.43 , pp. 630-636
    • Heiss, W.D.1    Brainin, M.2    Bornstein, N.M.3    Tuomilehto, J.4    Hong, Z.5    Cerebrolysin, A.S.6
  • 14
    • 0031596276 scopus 로고    scopus 로고
    • Brain-derived peptides reduce the size of cerebral infarction and loss of MAP2 immunoreactivity after focal ischemia in rats
    • M. Schwab, I. Antonow-Schlorke, U. Zwiener, and R. Bauer Brain-derived peptides reduce the size of cerebral infarction and loss of MAP2 immunoreactivity after focal ischemia in rats J Neural Transm Suppl 53 1998 299 311
    • (1998) J Neural Transm Suppl , vol.53 , pp. 299-311
    • Schwab, M.1    Antonow-Schlorke, I.2    Zwiener, U.3    Bauer, R.4
  • 15
    • 34247326556 scopus 로고    scopus 로고
    • Cerebrolysin enhances functional recovery following focal cerebral infarction in rats
    • J. Ren, D. Sietsma, S. Qiu, H. Moessler, and S.P. Finklestein Cerebrolysin enhances functional recovery following focal cerebral infarction in rats Restor Neurol Neurosci 25 2007 25 31
    • (2007) Restor Neurol Neurosci , vol.25 , pp. 25-31
    • Ren, J.1    Sietsma, D.2    Qiu, S.3    Moessler, H.4    Finklestein, S.P.5
  • 16
    • 0031596279 scopus 로고    scopus 로고
    • Antioxidant systemic effect of short-term Cerebrolysin administration
    • M.E. Gonzalez, L. Francis, and O. Castellano Antioxidant systemic effect of short-term Cerebrolysin administration J Neural Transm Suppl 53 1998 333 341
    • (1998) J Neural Transm Suppl , vol.53 , pp. 333-341
    • Gonzalez, M.E.1    Francis, L.2    Castellano, O.3
  • 17
  • 18
    • 33745675491 scopus 로고    scopus 로고
    • Neuroprotection of cerebrolysin in tissue culture models of brain ischemia: Post lesion application indicates a wide therapeutic window
    • E. Schauer, R. Wronski, J. Patockova, H. Moessler, E. Doppler, and B. Hutter-Paier et al. Neuroprotection of cerebrolysin in tissue culture models of brain ischemia: post lesion application indicates a wide therapeutic window J Neural Transm 113 2006 855 868
    • (2006) J Neural Transm , vol.113 , pp. 855-868
    • Schauer, E.1    Wronski, R.2    Patockova, J.3    Moessler, H.4    Doppler, E.5    Hutter-Paier, B.6
  • 19
    • 78649405553 scopus 로고    scopus 로고
    • Cerebrolysin enhances neurogenesis in the ischemic brain and improves functional outcome after stroke
    • C. Zhang, M. Chopp, Y. Cui, L. Wang, R. Zhang, and L. Zhang et al. Cerebrolysin enhances neurogenesis in the ischemic brain and improves functional outcome after stroke J Neurosci Res 88 2010 3275 3281
    • (2010) J Neurosci Res , vol.88 , pp. 3275-3281
    • Zhang, C.1    Chopp, M.2    Cui, Y.3    Wang, L.4    Zhang, R.5    Zhang, L.6
  • 20
    • 84879909069 scopus 로고    scopus 로고
    • Sonic hedgehog signaling pathway mediates cerebrolysin-improved neurological function after stroke
    • L. Zhang, M. Chopp, D.H. Meier, S. Winter, L. Wang, and A. Szalad et al. Sonic hedgehog signaling pathway mediates cerebrolysin-improved neurological function after stroke Stroke 44 2013 1965 1972
    • (2013) Stroke , vol.44 , pp. 1965-1972
    • Zhang, L.1    Chopp, M.2    Meier, D.H.3    Winter, S.4    Wang, L.5    Szalad, A.6
  • 21
    • 0031905357 scopus 로고    scopus 로고
    • Two-kidney, two clip renovascular hypertensive rats can be used as stroke-prone rats
    • J. Zeng, Y. Zhang, J. Mo, Z. Su, and R. Huang Two-kidney, two clip renovascular hypertensive rats can be used as stroke-prone rats Stroke 29 1998 1708 1713
    • (1998) Stroke , vol.29 , pp. 1708-1713
    • Zeng, J.1    Zhang, Y.2    Mo, J.3    Su, Z.4    Huang, R.5
  • 22
    • 0022483434 scopus 로고
    • Rat middle cerebral artery occlusion: Evaluation of the model and development of a neurologic examination
    • J.B. Bederson, L.H. Pitts, M. Tsuji, M.C. Nishimura, R.L. Davis, and H. Bartkowski Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination Stroke 17 1986 472 476
    • (1986) Stroke , vol.17 , pp. 472-476
    • Bederson, J.B.1    Pitts, L.H.2    Tsuji, M.3    Nishimura, M.C.4    Davis, R.L.5    Bartkowski, H.6
  • 23
    • 33646364811 scopus 로고    scopus 로고
    • Cerebrolysin decreases amyloid-beta production by regulating amyloid protein precursor maturation in a transgenic model of Alzheimer's disease
    • E. Rockenstein, M. Torrance, M. Mante, A. Adame, A. Paulino, and J.B. Rose et al. Cerebrolysin decreases amyloid-beta production by regulating amyloid protein precursor maturation in a transgenic model of Alzheimer's disease J Neurosci Res 83 2006 1252 1261
    • (2006) J Neurosci Res , vol.83 , pp. 1252-1261
    • Rockenstein, E.1    Torrance, M.2    Mante, M.3    Adame, A.4    Paulino, A.5    Rose, J.B.6
  • 24
    • 0020538899 scopus 로고
    • Posture-independent sensorimotor analysis of inter-hemispheric receptor asymmetries in neostriatum
    • T. Schallert, M. Upchurch, R.E. Wilcox, and D.M. Vaughn Posture-independent sensorimotor analysis of inter-hemispheric receptor asymmetries in neostriatum Pharmacol Biochem Behav 18 1983 753 759
    • (1983) Pharmacol Biochem Behav , vol.18 , pp. 753-759
    • Schallert, T.1    Upchurch, M.2    Wilcox, R.E.3    Vaughn, D.M.4
  • 25
    • 34147120073 scopus 로고    scopus 로고
    • Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: Implications for Alzheimer's disease pathogenesis
    • J. Zhao, Y. Fu, M. Yasvoina, P. Shao, B. Hitt, and T. O'Connor et al. Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis J Neurosci 27 2007 3639 3649
    • (2007) J Neurosci , vol.27 , pp. 3639-3649
    • Zhao, J.1    Fu, Y.2    Yasvoina, M.3    Shao, P.4    Hitt, B.5    O'Connor, T.6
  • 26
    • 77955863408 scopus 로고    scopus 로고
    • A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease
    • H. Fukumoto, H. Takahashi, N. Tarui, J. Matsui, T. Tomita, and M. Hirode et al. A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease J Neurosci 30 2010 11157 11166
    • (2010) J Neurosci , vol.30 , pp. 11157-11166
    • Fukumoto, H.1    Takahashi, H.2    Tarui, N.3    Matsui, J.4    Tomita, T.5    Hirode, M.6
  • 28
    • 40449087334 scopus 로고    scopus 로고
    • Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing
    • Y. Wen, E. Planel, M. Herman, H.Y. Figueroa, L. Wang, and L. Liu et al. Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing J Neurosci 28 2008 2624 2632
    • (2008) J Neurosci , vol.28 , pp. 2624-2632
    • Wen, Y.1    Planel, E.2    Herman, M.3    Figueroa, H.Y.4    Wang, L.5    Liu, L.6
  • 31
    • 27744447179 scopus 로고    scopus 로고
    • Amyloid-beta causes apoptosis of neuronal cells via caspase cascade, which can be prevented by amyloid-beta-derived short peptides
    • A. Awasthi, Y. Matsunaga, and T. Yamada Amyloid-beta causes apoptosis of neuronal cells via caspase cascade, which can be prevented by amyloid-beta-derived short peptides Exp Neurol 196 2005 282 289
    • (2005) Exp Neurol , vol.196 , pp. 282-289
    • Awasthi, A.1    Matsunaga, Y.2    Yamada, T.3
  • 32
    • 58449101589 scopus 로고    scopus 로고
    • Abeta42-induced neurodegeneration via an age-dependent autophagic-lysosomal injury in Drosophila
    • D. Ling, H.J. Song, D. Garza, T.P. Neufeld, and P.M. Salvaterra Abeta42-induced neurodegeneration via an age-dependent autophagic-lysosomal injury in Drosophila PLoS One 4 2009 e4201
    • (2009) PLoS One , vol.4 , pp. 4201
    • Ling, D.1    Song, H.J.2    Garza, D.3    Neufeld, T.P.4    Salvaterra, P.M.5
  • 33
    • 25144457455 scopus 로고    scopus 로고
    • Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
    • S. Pattingre, A. Tassa, X. Qu, R. Garuti, X.H. Liang, and N. Mizushima et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy Cell 122 2005 927 939
    • (2005) Cell , vol.122 , pp. 927-939
    • Pattingre, S.1    Tassa, A.2    Qu, X.3    Garuti, R.4    Liang, X.H.5    Mizushima, N.6
  • 34
    • 39549093998 scopus 로고    scopus 로고
    • Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury
    • M. Koike, M. Shibata, M. Tadakoshi, K. Gotoh, M. Komatsu, and S. Waguri et al. Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury Am J Pathol 172 2008 454 469
    • (2008) Am J Pathol , vol.172 , pp. 454-469
    • Koike, M.1    Shibata, M.2    Tadakoshi, M.3    Gotoh, K.4    Komatsu, M.5    Waguri, S.6
  • 35
    • 0034090892 scopus 로고    scopus 로고
    • Two peptidergic drugs increase the synaptophysin immunoreactivity in brains of 6-week-old rats
    • E. Windholz, A. Gschanes, M. Windisch, and G. Fachbach Two peptidergic drugs increase the synaptophysin immunoreactivity in brains of 6-week-old rats Histochem J 32 2000 79 84
    • (2000) Histochem J , vol.32 , pp. 79-84
    • Windholz, E.1    Gschanes, A.2    Windisch, M.3    Fachbach, G.4
  • 36
    • 0033747106 scopus 로고    scopus 로고
    • Neurotrophic effects of FPF-1070 (Cerebrolysin®) on cultured neurons from chicken embryo dorsal root ganglia, ciliary ganglia, and sympathetic trunks
    • T. Satou, T. Itoh, Y. Tamai, H. Ohde, A.J. Anderson, and S. Hashimoto Neurotrophic effects of FPF-1070 (Cerebrolysin®) on cultured neurons from chicken embryo dorsal root ganglia, ciliary ganglia, and sympathetic trunks J Neural Transm 107 2000 1253 1262
    • (2000) J Neural Transm , vol.107 , pp. 1253-1262
    • Satou, T.1    Itoh, T.2    Tamai, Y.3    Ohde, H.4    Anderson, A.J.5    Hashimoto, S.6
  • 37
    • 0033624431 scopus 로고    scopus 로고
    • Neurotrophic effects of Cerebrolysin in animal models of excitotoxicity
    • I. Veinbergs, M. Mante, M. Mallory, and E. Masliah Neurotrophic effects of Cerebrolysin in animal models of excitotoxicity J Neural Transm Suppl 59 2000 273 280
    • (2000) J Neural Transm Suppl , vol.59 , pp. 273-280
    • Veinbergs, I.1    Mante, M.2    Mallory, M.3    Masliah, E.4


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