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Volumn 60, Issue 3, 2014, Pages 931-948

Analysis and optimization of continuous organic solvent nanofiltration by membrane cascade for pharmaceutical separation

Author keywords

Membrane cascade; Multiobjective optimization; Organic solvent nanofiltration; Pharmaceuticals; Sensitivity analysis

Indexed keywords


EID: 84894028562     PISSN: 00011541     EISSN: 15475905     Source Type: Journal    
DOI: 10.1002/aic.14345     Document Type: Article
Times cited : (49)

References (68)
  • 2
    • 46049094400 scopus 로고    scopus 로고
    • Designing robust preparative purification processes with high performance
    • Degerman M, Jakobsson N, Nilsson B. Designing robust preparative purification processes with high performance. Chem Eng Technol. 2008;31:875-882.
    • (2008) Chem Eng Technol. , vol.31 , pp. 875-882
    • Degerman, M.1    Jakobsson, N.2    Nilsson, B.3
  • 3
    • 84867618150 scopus 로고    scopus 로고
    • Continuous solute fractionation with membrane cascades-a high productivity alternative to diafiltration
    • Siew WE, Livingston AG, Ates C, Merschaert A. Continuous solute fractionation with membrane cascades-a high productivity alternative to diafiltration. Sep Purif Technol. 2013;102:1-14.
    • (2013) Sep Purif Technol. , vol.102 , pp. 1-14
    • Siew, W.E.1    Livingston, A.G.2    Ates, C.3    Merschaert, A.4
  • 4
    • 84871795166 scopus 로고    scopus 로고
    • Environmental and economic analysis for selection and engineering sustainable API degenotoxification processes
    • Székely G, Gil M, Sellergren B, Heggie W, Ferreira FC. Environmental and economic analysis for selection and engineering sustainable API degenotoxification processes. Green Chem. 2003;15:210-225.
    • (2003) Green Chem. , vol.15 , pp. 210-225
    • Székely, G.1    Gil, M.2    Sellergren, B.3    Heggie, W.4    Ferreira, F.C.5
  • 5
    • 34248591731 scopus 로고    scopus 로고
    • Bioprocess membrane technology
    • van Reis R, Zydney A. Bioprocess membrane technology. J Membr Sci. 2007;297:16-50.
    • (2007) J Membr Sci. , vol.297 , pp. 16-50
    • van Reis, R.1    Zydney, A.2
  • 6
    • 79955043893 scopus 로고    scopus 로고
    • Integration of ultrafiltration unit operations in biotechnology process design
    • Grote F, Fröhlich H, Strube J. Integration of ultrafiltration unit operations in biotechnology process design. Chem Eng Technol. 2011;34:673-687.
    • (2011) Chem Eng Technol. , vol.34 , pp. 673-687
    • Grote, F.1    Fröhlich, H.2    Strube, J.3
  • 7
    • 80053639308 scopus 로고    scopus 로고
    • Recent developments in membrane-based separations in biotechnology processes: review
    • Rathore AS, Shirke A. Recent developments in membrane-based separations in biotechnology processes: review. Prep Biochem Biotechnol. 2011;41:398-421.
    • (2011) Prep Biochem Biotechnol. , vol.41 , pp. 398-421
    • Rathore, A.S.1    Shirke, A.2
  • 8
    • 84855182452 scopus 로고    scopus 로고
    • Integration of reverse-osmosis unit operations in biotechnology process design
    • Grote F, Fröhlich H, Strube J. Integration of reverse-osmosis unit operations in biotechnology process design. Chem Eng Technol. 2012;35:191-197.
    • (2012) Chem Eng Technol. , vol.35 , pp. 191-197
    • Grote, F.1    Fröhlich, H.2    Strube, J.3
  • 9
    • 33751181034 scopus 로고    scopus 로고
    • Development of large-scale applications in organic solvent nanofiltration and pervaporation for chemical and refining processes
    • White LS. Development of large-scale applications in organic solvent nanofiltration and pervaporation for chemical and refining processes. J Membr Sci. 2006;286:26-35.
    • (2006) J Membr Sci. , vol.286 , pp. 26-35
    • White, L.S.1
  • 10
    • 58149171584 scopus 로고    scopus 로고
    • Organic solvent nanofiltration and adsorbents: a hybrid approach to achieve ultra low palladium contamination of post coupling reaction products
    • Pink CJ, Wong HT, Ferreira FC, Livingston AG. Organic solvent nanofiltration and adsorbents: a hybrid approach to achieve ultra low palladium contamination of post coupling reaction products. Org Process Res Dev. 2008;12:589-595.
    • (2008) Org Process Res Dev. , vol.12 , pp. 589-595
    • Pink, C.J.1    Wong, H.T.2    Ferreira, F.C.3    Livingston, A.G.4
  • 12
    • 82355172765 scopus 로고    scopus 로고
    • Performance of solvent resistant nanofiltration membranes for purification of residual solvent in the pharmaceutical industry: experiments and simulation
    • Darvishmanesh S, Firoozpour L, Vanneste J, Luis P, Degrève J, van der Bruggen B. Performance of solvent resistant nanofiltration membranes for purification of residual solvent in the pharmaceutical industry: experiments and simulation. Green Chem. 2011;12:3476-3483.
    • (2011) Green Chem. , vol.12 , pp. 3476-3483
    • Darvishmanesh, S.1    Firoozpour, L.2    Vanneste, J.3    Luis, P.4    Degrève, J.5    van der Bruggen, B.6
  • 14
    • 84859440917 scopus 로고    scopus 로고
    • Simple purification of ionic liquid solvents by nanofiltration in biorefining of lignocellulosic substrates
    • Abels C, Redepenning C, Moll A, Melin T, Wessling M. Simple purification of ionic liquid solvents by nanofiltration in biorefining of lignocellulosic substrates. J Membr Sci. 2012;405-406:1-10.
    • (2012) J Membr Sci. , vol.405-406 , pp. 1-10
    • Abels, C.1    Redepenning, C.2    Moll, A.3    Melin, T.4    Wessling, M.5
  • 15
    • 84873248739 scopus 로고    scopus 로고
    • Molecular separation with an organic solvent nanofiltration cascade-augmenting membrane selectivity with process engineering
    • Siew WE, Livingston AG, Ates C, Merschaert A. Molecular separation with an organic solvent nanofiltration cascade-augmenting membrane selectivity with process engineering. Chem Eng Sci. 2013;90:299-310.
    • (2013) Chem Eng Sci. , vol.90 , pp. 299-310
    • Siew, W.E.1    Livingston, A.G.2    Ates, C.3    Merschaert, A.4
  • 17
    • 84868672980 scopus 로고    scopus 로고
    • Continuous processing in the manufacture of active pharmaceutical ingredients and finished dosage forms: an industry perspective
    • Poechlauer P, Manley J, Broxterman R, Gregertsen B, Ridemark M. Continuous processing in the manufacture of active pharmaceutical ingredients and finished dosage forms: an industry perspective. Org Process Res Dev. 2012;16:1586-1590.
    • (2012) Org Process Res Dev. , vol.16 , pp. 1586-1590
    • Poechlauer, P.1    Manley, J.2    Broxterman, R.3    Gregertsen, B.4    Ridemark, M.5
  • 18
    • 15444378958 scopus 로고    scopus 로고
    • Can membrane cascades replace chromatography? Adapting binary ideal cascade theory of systems of two solutes in a single solvent
    • Lightfoot EN. Can membrane cascades replace chromatography? Adapting binary ideal cascade theory of systems of two solutes in a single solvent. Sep Sci Technol. 2005;40:739-756.
    • (2005) Sep Sci Technol. , vol.40 , pp. 739-756
    • Lightfoot, E.N.1
  • 20
    • 45149095129 scopus 로고    scopus 로고
    • Emergence of ideal membrane cascades for downstream processing
    • Lightfoot EN, Root TW, O'Dell JL. Emergence of ideal membrane cascades for downstream processing. Biotechnol Prog. 2008;24:599-605.
    • (2008) Biotechnol Prog. , vol.24 , pp. 599-605
    • Lightfoot, E.N.1    Root, T.W.2    O'Dell, J.L.3
  • 22
    • 84868686681 scopus 로고    scopus 로고
    • Optimum design of reverse osmosis systems for hydrogen peroxide ultrapurification
    • Abejón R, Garea A, Irabien A. Optimum design of reverse osmosis systems for hydrogen peroxide ultrapurification. AIChE J. 2012;58:3718-3730.
    • (2012) AIChE J. , vol.58 , pp. 3718-3730
    • Abejón, R.1    Garea, A.2    Irabien, A.3
  • 23
  • 24
    • 0242575128 scopus 로고    scopus 로고
    • Novel cascade ultrafiltration configuration for continuous, high-resolution protein-protein fractionation: a simulation study
    • Ghosh R. Novel cascade ultrafiltration configuration for continuous, high-resolution protein-protein fractionation: a simulation study. J Membr Sci. 2003;226:85-99.
    • (2003) J Membr Sci. , vol.226 , pp. 85-99
    • Ghosh, R.1
  • 25
    • 1242270470 scopus 로고    scopus 로고
    • A two-stage ultrafiltration process for fractionation of whey protein isolate
    • Cheang B, Zydney AL. A two-stage ultrafiltration process for fractionation of whey protein isolate. J Membr Sci. 2004;231:159-167.
    • (2004) J Membr Sci. , vol.231 , pp. 159-167
    • Cheang, B.1    Zydney, A.L.2
  • 26
    • 34247606680 scopus 로고    scopus 로고
    • Recovery and purification of surfactin from fermentation broth by a two-step ultrafiltration process
    • Isa MHM, Coraglia DE, Frazier RA, Jauregi P. Recovery and purification of surfactin from fermentation broth by a two-step ultrafiltration process. J Membr Sci. 2007;296:51-57.
    • (2007) J Membr Sci. , vol.296 , pp. 51-57
    • Isa, M.H.M.1    Coraglia, D.E.2    Frazier, R.A.3    Jauregi, P.4
  • 27
    • 37149049412 scopus 로고    scopus 로고
    • Novel tangential-flow countercurrent cascade ultrafiltration configuration for continuous purification of humanized monoclonal antibody
    • Mohanty K, Ghosh R. Novel tangential-flow countercurrent cascade ultrafiltration configuration for continuous purification of humanized monoclonal antibody. J Membr Sci. 2008;307:117-125.
    • (2008) J Membr Sci. , vol.307 , pp. 117-125
    • Mohanty, K.1    Ghosh, R.2
  • 28
    • 71649114116 scopus 로고    scopus 로고
    • Continuous fractionation of plasma proteins HSA and HIgG using cascade ultrafiltration systems
    • Mayani M, Mohanty K, Filipe C, Ghosh R. Continuous fractionation of plasma proteins HSA and HIgG using cascade ultrafiltration systems. Sep Purif Technol. 2009;70:231-241.
    • (2009) Sep Purif Technol. , vol.70 , pp. 231-241
    • Mayani, M.1    Mohanty, K.2    Filipe, C.3    Ghosh, R.4
  • 29
    • 71249117816 scopus 로고    scopus 로고
    • Cascade ultrafiltration systems-integrated processes for purification and concentration of lysozyme
    • Mayani M, Filipe C, Ghosh R. Cascade ultrafiltration systems-integrated processes for purification and concentration of lysozyme. J Membr Sci. 2010;347:150-158.
    • (2010) J Membr Sci. , vol.347 , pp. 150-158
    • Mayani, M.1    Filipe, C.2    Ghosh, R.3
  • 30
    • 77549087055 scopus 로고    scopus 로고
    • Cascade ultrafiltration bioreactor-separator system for continuous production of F(ab')2 fragment from immunoglobulin G
    • Wang L, Khan T, Mohanty K, Ghosh R. Cascade ultrafiltration bioreactor-separator system for continuous production of F(ab')2 fragment from immunoglobulin G. J Membr Sci. 2010;351:96-103.
    • (2010) J Membr Sci. , vol.351 , pp. 96-103
    • Wang, L.1    Khan, T.2    Mohanty, K.3    Ghosh, R.4
  • 31
    • 79961028015 scopus 로고    scopus 로고
    • Techno-economic evaluation of membrane cascades relative to simulated moving bed chromatography for the purification of mono- and oligosaccharides
    • Vanneste J, de Ron S, Vandecruys S, Soare SA, Darvishmanesh S, van der Bruggen B. Techno-economic evaluation of membrane cascades relative to simulated moving bed chromatography for the purification of mono- and oligosaccharides. Sep Purif Technol. 2011;80:600-609.
    • (2011) Sep Purif Technol. , vol.80 , pp. 600-609
    • Vanneste, J.1    de Ron, S.2    Vandecruys, S.3    Soare, S.A.4    Darvishmanesh, S.5    van der Bruggen, B.6
  • 32
    • 84872700045 scopus 로고    scopus 로고
    • Fractionation of alfa-lactalbumin from beta-lactoglobulin using positively charged tangential flow ultrafiltration membranes
    • Arunkumar A, Etzel MR. Fractionation of alfa-lactalbumin from beta-lactoglobulin using positively charged tangential flow ultrafiltration membranes. Sep Purif Technol. 2013;105:121-128.
    • (2013) Sep Purif Technol. , vol.105 , pp. 121-128
    • Arunkumar, A.1    Etzel, M.R.2
  • 33
    • 66149103267 scopus 로고    scopus 로고
    • Integrated nanofiltration cascades with low salt rejection for complete removal of pesticides in drinking water production
    • Caus A, Braeken L, Bousus K, van der Bruggen B. Integrated nanofiltration cascades with low salt rejection for complete removal of pesticides in drinking water production. J Chem Technol Biotechnol. 2009;84:391-398.
    • (2009) J Chem Technol Biotechnol. , vol.84 , pp. 391-398
    • Caus, A.1    Braeken, L.2    Bousus, K.3    van der Bruggen, B.4
  • 34
    • 34247165491 scopus 로고    scopus 로고
    • Nanofiltration membrane cascade for continuous solvent exchange
    • Lin JC, Livingston AG. Nanofiltration membrane cascade for continuous solvent exchange. Chem Eng Sci. 2007;62:2728-2736.
    • (2007) Chem Eng Sci. , vol.62 , pp. 2728-2736
    • Lin, J.C.1    Livingston, A.G.2
  • 35
    • 84894077558 scopus 로고    scopus 로고
    • Multi-Stage Membrane System and Process. US Patent 5676832
    • Katraro R, Linder C, Nemas M. Multi-Stage Membrane System and Process. US Patent 5676832, 1997.
    • (1997)
    • Katraro, R.1    Linder, C.2    Nemas, M.3
  • 37
    • 84874020997 scopus 로고    scopus 로고
    • Process systems engineering tools in the pharmaceutical industry
    • Troup GM, Georgakis C. Process systems engineering tools in the pharmaceutical industry. Comput Chem Eng. 2013;51:157-171.
    • (2013) Comput Chem Eng. , vol.51 , pp. 157-171
    • Troup, G.M.1    Georgakis, C.2
  • 39
    • 84867864049 scopus 로고    scopus 로고
    • Active pharmaceutical ingredient (API) production involving continuous processes-a process systems engineering (PSE)-assisted design framework
    • Cervera-Padrell AE, Skovby T, Kiil S, Gani R, Gernaey KV. Active pharmaceutical ingredient (API) production involving continuous processes-a process systems engineering (PSE)-assisted design framework. Eur J Pharm Biopharm. 2012;82:437-456.
    • (2012) Eur J Pharm Biopharm. , vol.82 , pp. 437-456
    • Cervera-Padrell, A.E.1    Skovby, T.2    Kiil, S.3    Gani, R.4    Gernaey, K.V.5
  • 40
    • 84861623544 scopus 로고    scopus 로고
    • A perspective on PSE in pharmaceutical process development and innovation
    • Gernaey KV, Cervera-Padrell AE, Woodley JM. A perspective on PSE in pharmaceutical process development and innovation. Comput Chem Eng. 2012;42:15-29.
    • (2012) Comput Chem Eng. , vol.42 , pp. 15-29
    • Gernaey, K.V.1    Cervera-Padrell, A.E.2    Woodley, J.M.3
  • 41
    • 76749120397 scopus 로고    scopus 로고
    • Purification fingerprints for experimentally based systematic downstream process development
    • Winkelnkemper T, Schembecker G. Purification fingerprints for experimentally based systematic downstream process development. Sep Purif Technol. 2010;71:356-366.
    • (2010) Sep Purif Technol. , vol.71 , pp. 356-366
    • Winkelnkemper, T.1    Schembecker, G.2
  • 42
    • 77649269732 scopus 로고    scopus 로고
    • Purification performance index and separation cost indicator for experimentally based systematic downstream process development
    • Winkelnkemper T, Schembecker G. Purification performance index and separation cost indicator for experimentally based systematic downstream process development. Sep Purif Technol. 2010;72:34-39.
    • (2010) Sep Purif Technol. , vol.72 , pp. 34-39
    • Winkelnkemper, T.1    Schembecker, G.2
  • 43
    • 0343052717 scopus 로고    scopus 로고
    • Optimization diagram for membrane separations
    • van Reis R, Saksena S. Optimization diagram for membrane separations. J Membr Sci. 1997;129:19-29.
    • (1997) J Membr Sci. , vol.129 , pp. 19-29
    • van Reis, R.1    Saksena, S.2
  • 44
    • 77953023164 scopus 로고    scopus 로고
    • Process optimization diagrams for membrane microfiltration
    • Venkiteshwaran A, Belfort G. Process optimization diagrams for membrane microfiltration. J Membr Sci. 2010;357:105-108.
    • (2010) J Membr Sci. , vol.357 , pp. 105-108
    • Venkiteshwaran, A.1    Belfort, G.2
  • 45
    • 84861304881 scopus 로고    scopus 로고
    • Designing and synthesis of novel amidated fentanyl analogs
    • Haghighatnia Y, Balalaie S, Bijanzadeh, HR. Designing and synthesis of novel amidated fentanyl analogs. Helv Chim Acta. 2012;95:818-824.
    • (2012) Helv Chim Acta. , vol.95 , pp. 818-824
    • Haghighatnia, Y.1    Balalaie, S.2    Bijanzadeh, H.R.3
  • 46
    • 0022972078 scopus 로고
    • Synthetic 1,4-disubstituted-l,4-dihydro-5H-tetrazol-5-one derivatives of fentanyl: alfentanil (R 39209), a potent, extremely short-acting narcotic analgesic
    • Janssens F, Torremans J, Janseen AJ. Synthetic 1, 4-disubstituted-l, 4-dihydro-5H-tetrazol-5-one derivatives of fentanyl: alfentanil (R 39209), a potent, extremely short-acting narcotic analgesic. J Med Chem. 1986;29:2290-2297.
    • (1986) J Med Chem. , vol.29 , pp. 2290-2297
    • Janssens, F.1    Torremans, J.2    Janseen, A.J.3
  • 47
    • 84894081701 scopus 로고    scopus 로고
    • Methods for the Synthesis of Alfentanil, Sufentanil and Remifentanil. US Patent 7208604 B2
    • Mathew J, Killgore K. Methods for the Synthesis of Alfentanil, Sufentanil and Remifentanil. US Patent 7208604 B2, 2007.
    • (2007)
    • Mathew, J.1    Killgore, K.2
  • 48
    • 0030200316 scopus 로고    scopus 로고
    • Design and economics of RO seawater desalination
    • Malek A, Hawlader AMN, Ho JC. Design and economics of RO seawater desalination. Desalination. 1996;105:245-261.
    • (1996) Desalination. , vol.105 , pp. 245-261
    • Malek, A.1    Hawlader, A.M.N.2    Ho, J.C.3
  • 49
    • 0037985532 scopus 로고    scopus 로고
    • Design consideration of RO units: case studies
    • Al-Enezi G, Fawzi N. Design consideration of RO units: case studies. Desalination. 2003;153:281-286.
    • (2003) Desalination , vol.153 , pp. 281-286
    • Al-Enezi, G.1    Fawzi, N.2
  • 50
    • 0043267713 scopus 로고    scopus 로고
    • Boron removal from seawater using FILMTECTM high rejection SWRO membranes
    • Redondo J, Busch M, de Witte JP. Boron removal from seawater using FILMTECTM high rejection SWRO membranes. Desalination. 2003;156:229-238.
    • (2003) Desalination. , vol.156 , pp. 229-238
    • Redondo, J.1    Busch, M.2    de Witte, J.P.3
  • 52
    • 84857447743 scopus 로고    scopus 로고
    • Analysis, modelling and simulation of hydrogen peroxide ultrapurification by multistage reverse osmosis
    • Abejón R, Garea A, Irabien A. Analysis, modelling and simulation of hydrogen peroxide ultrapurification by multistage reverse osmosis. Chem Eng Res Des. 2012;90:442-452.
    • (2012) Chem Eng Res Des. , vol.90 , pp. 442-452
    • Abejón, R.1    Garea, A.2    Irabien, A.3
  • 53
  • 54
    • 84864296214 scopus 로고    scopus 로고
    • The solution-diffusion with imperfections model as a method to understand organic solvent nanofiltration of multicomponent systems
    • Fierro D, Boschetti-de-Fierro A, Abetz V. The solution-diffusion with imperfections model as a method to understand organic solvent nanofiltration of multicomponent systems. J Membr Sci. 2012;413-414:91-101.
    • (2012) J Membr Sci. , vol.413-414 , pp. 91-101
    • Fierro, D.1    Boschetti-de-Fierro, A.2    Abetz, V.3
  • 55
    • 62649084522 scopus 로고    scopus 로고
    • Modeling of amino acid nanofiltration by irreversible thermodynamics
    • Kovács Z, Discacciati M, Samhaber W. Modeling of amino acid nanofiltration by irreversible thermodynamics. J Membr Sci. 2009;332:38-49.
    • (2009) J Membr Sci. , vol.332 , pp. 38-49
    • Kovács, Z.1    Discacciati, M.2    Samhaber, W.3
  • 56
    • 38349013679 scopus 로고    scopus 로고
    • Novel approach combining physico-chemical characterizations and mass transfer modelling of nanofiltration and low pressure reverse osmosis membranes for brackish water desalination intensification
    • Pontié M, Dach H, Leparc J, Hafsi M, Lhassani A. Novel approach combining physico-chemical characterizations and mass transfer modelling of nanofiltration and low pressure reverse osmosis membranes for brackish water desalination intensification. Desalination. 2008;221:174-191.
    • (2008) Desalination. , vol.221 , pp. 174-191
    • Pontié, M.1    Dach, H.2    Leparc, J.3    Hafsi, M.4    Lhassani, A.5
  • 57
    • 78149282219 scopus 로고    scopus 로고
    • Ultrapurification of hydrogen peroxide solution from ionic metals impurities to semiconductor grade by reverse osmosis
    • Abejón R, Garea A, Irabien A. Ultrapurification of hydrogen peroxide solution from ionic metals impurities to semiconductor grade by reverse osmosis. Sep Purif Technol. 2010;76:44-51.
    • (2010) Sep Purif Technol. , vol.76 , pp. 44-51
    • Abejón, R.1    Garea, A.2    Irabien, A.3
  • 58
    • 0033980820 scopus 로고    scopus 로고
    • Effect of solvent properties on permeate flow through nanofiltration membranes Part II
    • Machado DR, Hasson D, Semiat R. Effect of solvent properties on permeate flow through nanofiltration membranes Part II. Transport model. J Membr Sci. 2000;166:63-69.
    • (2000) Transport model. J Membr Sci. , vol.166 , pp. 63-69
    • Machado, D.R.1    Hasson, D.2    Semiat, R.3
  • 59
    • 64049089974 scopus 로고    scopus 로고
    • General model for prediction of solvent permeation through organic and inorganic solvent resistant nanofiltration membranes
    • Darvishmanesh S, Buekenhoudt A, Degrève J, van der Bruggen B. General model for prediction of solvent permeation through organic and inorganic solvent resistant nanofiltration membranes. J Membr Sci. 2009;334:43-49.
    • (2009) J Membr Sci. , vol.334 , pp. 43-49
    • Darvishmanesh, S.1    Buekenhoudt, A.2    Degrève, J.3    van der Bruggen, B.4
  • 60
    • 84864763156 scopus 로고    scopus 로고
    • An improved phenomenological model for prediction of solvent permeation through ceramic NF and UF membranes
    • Marchetti P, Butté A, Livingston AG. An improved phenomenological model for prediction of solvent permeation through ceramic NF and UF membranes. J Membr Sci. 2012;415-416:444-458.
    • (2012) J Membr Sci. , vol.415-416 , pp. 444-458
    • Marchetti, P.1    Butté, A.2    Livingston, A.G.3
  • 61
    • 0001203753 scopus 로고
    • Permeability of composite membranes: 1-3
    • Kedem O, Katchalsky A. Permeability of composite membranes: 1-3. Trans Faraday Soc. 1963;59:1918-1953.
    • (1963) Trans Faraday Soc. , vol.59 , pp. 1918-1953
    • Kedem, O.1    Katchalsky, A.2
  • 65
    • 54049149435 scopus 로고    scopus 로고
    • An exact epsilon-constraint method for bi-objective combinatorial optimization problems: application to the traveling salesman problem with profits
    • Bérubé JF, Gendreau M, Potvin JY. An exact epsilon-constraint method for bi-objective combinatorial optimization problems: application to the traveling salesman problem with profits. Eur J Oper Res. 2009;194:39-50.
    • (2009) Eur J Oper Res. , vol.194 , pp. 39-50
    • Bérubé, J.F.1    Gendreau, M.2    Potvin, J.Y.3
  • 66
    • 84862869033 scopus 로고    scopus 로고
    • Multiobjective optimization of membrane processes for chemicals ultrapurification
    • Abejón R, Garea A, Irabien A. Multiobjective optimization of membrane processes for chemicals ultrapurification. Comput Aided Chem Eng. 2012;30:542-546.
    • (2012) Comput Aided Chem Eng. , vol.30 , pp. 542-546
    • Abejón, R.1    Garea, A.2    Irabien, A.3
  • 67
    • 84862167022 scopus 로고    scopus 로고
    • Multi-objective optimization of coal-fired electricity production with CO2 capture
    • Cristóbal J, Guillén-Gosálbez G, Jiménez L, Irabien A. Multi-objective optimization of coal-fired electricity production with CO2 capture. Appl Energy. 2012;98:266-272.
    • (2012) Appl Energy. , vol.98 , pp. 266-272
    • Cristóbal, J.1    Guillén-Gosálbez, G.2    Jiménez, L.3    Irabien, A.4
  • 68
    • 84860634133 scopus 로고    scopus 로고
    • Integrated countercurrent reverse osmosis cascades for hydrogen peroxide ultrapurification
    • Abejón R, Garea A, Irabien A. Integrated countercurrent reverse osmosis cascades for hydrogen peroxide ultrapurification. Comput Chem Eng. 2012;41:67-76.
    • (2012) Comput Chem Eng. , vol.41 , pp. 67-76
    • Abejón, R.1    Garea, A.2    Irabien, A.3


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