Continuous fractionation of plasma proteins HSA and HIgG using cascade ultrafiltration systems

Separation and Purification Technology

Volumn 70, Issue 2, 2009, Pages 231-241

  Mayani, Mukesh ^a   Mohanty, Kaustubha ^a   Filipe, Carlos ^a   Ghosh, Raja ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Bioseparation; Cascade ultrafiltration; Membrane; Protein; Protein protein interactions

Indexed keywords

BIO-SEPARATION; COUNTER CURRENT; FRACTIONATION PROCESS; FUNCTION OF TIME; HIGH PURITY; HUMAN IMMUNOGLOBULIN; HUMAN SERUM ALBUMINS; HYDRAULIC PERMEABILITY; MODEL PROTEINS; MOLAR RATIO; MULTI-STAGE; OPTIMIZED CONDITIONS; PLASMA PROTEIN; PROTEIN-PROTEIN INTERACTIONS; SAMPLE INJECTION; SIEVING COEFFICIENT; SIMULATED RESULTS; ULTRA-FILTRATION MEMBRANES;

ULTRAFILTRATION;

PROTEINS;

EID: 71649114116     PISSN: 13835866     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.seppur.2009.10.002     Document Type: Article

References (31)

1. The therapeutic proteins outlook to 2007: an analysis of leading products and late-stage pipeline developments, Source: Business Insights, 2007, www.globalbusinessinsights.com/content/rbhc0103t.pdf (February 28, 2009).
2. Low D., O'Leary R., and Pujar N.S. Future of antibody purification. J. Chromatogr. B 848 1 (2007) 48-63
3. Jain E., and Kumar A. Upstream processes in antibody production: evaluation of critical parameters. Biotechnol. Adv. 26 (2008) 46-72
4. Birch J.R., and Racher J.A. Antibody production. Adv. Drug Deliv. Rev. 58 (2006) 671-685
5. Przybycien T.M., Pujar N.S., and Steele L.M. Alternative bioseparations operations: life beyond packed-bed chromatography. Curr. Opin. Biotechnol. 15 (2004) 469-478
6. Farid S.S. Process economics of industrial monoclonal antibody manufacture. J. Chromatogr. B 848 (2007) 8-18
7. Shukla A.A., Hubbard B., Tressel T., Guhan S., and Low D. Downstream processing of monoclonal antibodies-application of platform approaches. J. Chromatogr. B 848 1 (2007) 28-39
8. Belter P.A., Cussler E.L., and Hu W. Bioseparations Downstream Processing for Biotechnology (1998), John Wiley & Sons, Toronto, Canada
9. Chi E.Y., Krishnan S., Randolph T.W., and Carpenter J.F. Physical stability of proteins in aqueous solution: mechanism and driving forces in nonnative protein aggregation. Pharm. Res. 20 9 (2003) 1325-1336
10. Lightfoot E.N., Root T.W., and O'Dell J.L. Emergence of ideal membrane cascades for downstream processing. Biotechnol. Prog. 24 (2008) 599-605
11. Feins M., and Sirkar K.K. Highly selective membranes in protein ultrafiltration. Biotechnol. Bioeng. 86 6 (2004) 603-611
12. Ghosh R. Protein Bioseparation Using Ultrafiltration: Theory, Applications and New Developments (2003), Imperial College Press/World Scientific Publishing Pte Ltd., London, UK
13. Lightfoot E.N., and Moscariello J.S. Bioseparations. Biotechnol. Bioeng. 87 3 (2004) 259-273
14. van Reis R., and Zydney A.L. Bioprocess membrane technology. J. Membr. Sci. 297 (2007) 16-50
15. Saksena S., and Zydney A.L. Effect of solution pH and ionic strength on the separation of albumin from immunoglobulins (IgG) by selective filtration. Biotechnol. Bioeng. 43 (1994) 960-968
16. van Eijndhoven R.H.C.M., Saksena S., and Zydney A.L. Protein fractionation using electrostatic interactions in membrane filtration. Biotechnol. Bioeng. 48 (1995) 406-414
17. van Reis R., Brake J.M., Charkoudian J., Burns B.D., and Zydney A.L. High-performance tangential flow filtration using charged membranes. J. Membr. Sci. 159 (1999) 133-142
18. Wan Y., Ghosh R., and Cui Z.F. High-resolution plasma protein fractionation using ultrafiltration. Desalination 144 (2002) 301-306
19. Wan Y., Ghosh R., and Cui Z.F. Separation of human serum albumin and human immunoglobulin using carrier phase ultrafiltration. Biotechnol. Prog. 20 (2004) 1103-1112
20. Lightfoot E.N. Can membrane cascades replace chromatography? Adapting binary ideal cascade theory of systems of two solutes in a single solvent. Sep. Sci. Technol. 40 (2005) 739-756
21. Ghosh R. Novel cascade ultrafiltration configuration for continuous, high-resolution protein-protein fractionation: a simulation study. J. Membr. Sci. 226 (2003) 85-99
22. Mohanty K., and Ghosh R. Novel tangential-flow countercurrent cascade ultrafiltration configuration for continuous purification of humanized monoclonal antibody. J. Membr. Sci. 307 (2008) 117-125
23. Wang W. Protein aggregation and its inhibition in biopharmaceutics. Int. J. Pharm. 289 (2005) 1-30
24. Tutunjian R.S., Robert S., and Reti A.R. Molecular fractionation by staged ultrafiltration. AIChE Sym. Ser. 74 (1978) 210-214
25. Prazeres D.M.F. A theoretical analogy between multistage ultrafiltration and size-exclusion chromatography. Chem. Eng. Sci. 52 (1997) 953-960
26. Cheang B., and Zydney A.L. A two-stage ultrafiltration process for fractionation of whey protein isolate. J. Membr. Sci. 231 (2004) 159-167
27. Isa M.H.M., Coraglia D.E., Frazier R.A., and Jauregi P. Recovery and purification of surfactin from fermentation broth by two-step ultrafiltration process. J. Membr. Sci. 296 (2007) 51-57
28. Li Q.Y., Cui Z.F., and Pepper D.S. Fractionation of HSA and IgG by gas sparged ultrafiltration. J. Membr. Sci. 136 (1997) 181-190
29. Ghosh R., Wan Y., Cui Z.F., and Hale G. Parameter scanning ultrafiltration: rapid optimization of protein separation. Biotechnol. Bioeng. 81 (2003) 673-682
30. Ghosh R., and Cui Z.F. Analysis of protein transport and polarization through membranes using pulsed sample injection technique. J. Membr. Sci. 175 (2000) 75-84
31. Filipe C.D.M., and Ghosh R. Effects of protein-protein interaction in ultrafiltration based fractionation processes. Biotechnol. Bioeng. 91 (2005) 678-687