Multivariate analysis in the identification of biological targets for designed molecular structures: The BIOTA protocol

European Journal of Medicinal Chemistry

Volumn 75, Issue , 2014, Pages 106-110

  Lauria, Antonino ^a   Tutone, Marco ^a   Barone, Giampaolo ^a   Almerico, Anna Maria ^a  

^a UNIVERSITY OF PALERMO   (Italy)

Author keywords

Biological target; BIOTA protocol; Drugs repurposing; Inhibitors; PCA

Indexed keywords

ACETYLCHOLINESTERASE; ADENOSINE A1 RECEPTOR; ALDEHYDE REDUCTASE; ALDOSTERONE SYNTHASE; ANDROGEN RECEPTOR; ANGIOTENSIN CONVERTING ENZYME 2; AROMATASE; AURORA A KINASE; CANNABINOID 1 RECEPTOR; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CASPASE 3; CATHEPSIN D; CATHEPSIN K; COLLAGENASE; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; DELTA OPIATE RECEPTOR; DIHYDROFOLATE REDUCTASE; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL PEPTIDASE IV; DOPAMINE TRANSPORTER; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; LEGUMAIN; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; UNINDEXED DRUG;

ARTICLE; BINDING AFFINITY; BIOLOGICAL TARGET ASSIGNATION; CHEMICAL STRUCTURE; DRUG PROTEIN BINDING; DRUG TARGETING; IC 50; METHODOLOGY; MULTIVARIATE ANALYSIS; PRINCIPAL COMPONENT ANALYSIS;

BIOLOGICAL TARGET; BIOTA PROTOCOL; DRUGS REPURPOSING; INHIBITORS; PCA;

DRUG REPOSITIONING; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MOLECULAR TARGETED THERAPY; MULTIVARIATE ANALYSIS; PRINCIPAL COMPONENT ANALYSIS;

EID: 84893916821     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.01.025     Document Type: Article

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