In silico, spectroscopic, and biological insights on annelated pyrrolo[3,2-e]pyrimidines with antiproliferative activity

Letters in Drug Design and Discovery

Volumn 11, Issue 1, 2014, Pages 15-26

  Lauria, Antonino ^a   Terenzi, Alessio ^a   Gentile, Carla ^a   Martorana, Annamaria ^a   Gennaro, Giuseppe ^a   Barone, Giampaolo ^a   Almerico, Anna Maria ^a  

^a UNIVERSITY OF PALERMO   (Italy)

Author keywords

Annelated pyrrolo pyrimidines; Anticancer drugs; Cell Cycle; Circular Dichroism; COMPARE analysis; DNA interactive drugs; Ethidium bromide displacement assay; UV vis DNA titrations

Indexed keywords

8 [3 (PIPERIDINO)PROPYL] 4,10 DIMETHYL 9 PHENYL 6 (METHYLSULFANYL) 3,4 DIHYDROPYRIMIDO[1,2 C]PYRROLO[3,2 E]PYRIMIDIN 2(8H) ONE; ANTINEOPLASTIC AGENT; CHROMOMYCIN A3; DACTINOMYCIN; PYRROLOPYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; AQUEOUS SOLUTION; ARTICLE; BINDING AFFINITY; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CIRCULAR DICHROISM; COMPUTER MODEL; CONTROLLED STUDY; DNA BINDING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TITRIMETRY; TUMOR CELL LINE; ULTRAVIOLET SPECTROPHOTOMETRY;

EID: 84889608021     PISSN: 15701808     EISSN: 1875628X     Source Type: Journal    
DOI: 10.2174/15701808113109990058     Document Type: Article

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