Medicinal plants of the genus Gelsemium (Gelsemiaceae, Gentianales) - A review of their phytochemistry, pharmacology, toxicology and traditional use

Journal of Ethnopharmacology

Volumn 152, Issue 1, 2014, Pages 33-52

  Jin, Gui Lin ^a   Su, Yan Ping ^a   Liu, Ming ^a   Xu, Ying ^a   Yang, Jian ^a   Liao, Kai Jun ^a   Yu, Chang Xi ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

Alkaloids; Gelsemium; Iridoids; Pharmacology; Phytochemistry; Toxicology

Indexed keywords

ALKALOIDS; GELSEMIUM; IRIDOIDS; PHARMACOLOGY; PHYTOCHEMISTRY; TOXICOLOGY;

ANIMALS; ETHNOPHARMACOLOGY; GELSEMIUM; HUMANS; MEDICINE, CHINESE TRADITIONAL; MEDICINE, TRADITIONAL; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL;

EID: 84893871561     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2014.01.003     Document Type: Review

References (132)

1. W.K. Abdul, F.B. Ahmad, L.B. Din, H.C. Swee, and L.M. Shiueh A study of the in vitro cytotoxic activity of Gelsemium elegans using human ovarian and breast cancer cell lines Trop. Biomed. 21 2004 139 144
2. Y.F. An, C.M. Chen, and W.J. Lian Effect of B2 component of Gelsemium elegans Benth. on Hela cells proliferation and cell cycle J. Hunan Norm. Univ. (Med. Sci.) 5 2008 20 23
3. P. Bellavite, A. Conforti, M. Marzotto, P. Magnani, M. Cristofoletti, D. Olioso, and M.E. Zanolin Testing homeopathy in mouse emotional response models: pooled data analysis of two series of studies Evid.-Based Complement. Altern. Med. 2012 2012 954374
4. P. Bellavite Gelsemium sempervirens and animal behavioral models Front. Neurol. 2 2011 56
5. P. Bellavite, P. Magnani, M. Marzotto, and A. Conforti Assays of homeopathic remedies in rodent behavioural and psychopathological models Homeopath.: J. Fac. Homeopath. 98 2009 208 227
6. P. Bellavite, P. Magnani, E. Zanolin, and A. Conforti Homeopathic doses of Gelsemium sempervirens improve the behavior of mice in response to novel environments Evid.-Based Complement. Altern. Med. 2011 2011 362517
7. G. Bentham Notes on Loganiaceae J. Proc. Linnean Soc. Botany 1 1857 52 114
8. S.S. Bhattacharyya, S.K. Mandal, R. Biswas, S. Paul, S. Pathak, N. Boujedaini, P. Belon, and A.R. Khuda-Bukhsh In vitro studies demonstrate anticancer activity of an alkaloid of the plant Gelsemium sempervirens Exp. Biol. Med. (Maywood) 233 2008 1591 1601
9. S.S. Bhattacharyya et al. A synthetic coumarin (4-Methyl-7 hydroxy coumarin) has anti-cancer potentials against DMBA-induced skin cancer in mice Eur. J. Pharmacol. 614 2009 128 136
10. S.S. Bhattacharyya, S. Paul, N. Boujedaini, and A.R. Khuda-Bukhsh Anti-oncogenic potentials of a plant coumarin (7-hydroxy-6-methoxy coumarin) against 7, 12-dimethylbenz[α]anthracene-induced skin papilloma in mice: the possible role of several key signal proteins Zhongxiyi Jiehe Xuebao 8 2010 645 654
11. D. Bousta, R. Soulimani, I. Jarmouni, P. Belon, J. Falla, N. Froment, and C. Younos Neurotropic, immunological and gastric effects of low doses of Atropa belladonna L.; Gelsemium sempervirens L. and Poumon histamine in stressed mice J. Ethnopharmacol. 74 2001 205 215 (Pubitemid 32215448)
12. A. Brossi The Alkaloids: Chemistry and Pharmacology V33: Chemistry and Pharmacology 1988 Academic Press San Diego pp. 135.
13. L.É. Bureau De la Famille des Loganiacées et des Plantes Qu'elle Fournít a la Médecine: Thése 1856 Rignoux, Imprimeur de la Faculté de Médecine Paris pp. 27.
14. G.F. Butler A Text-book of Materia Medica, Pharmacology and Therapeutics 1900 W.B. Saunders Philadelphia (pp. 521-523)
15. J. Cai, L.S. Lei, and D.B. Chi Antineoplastic effect of koumine in mice bearing H22 solid tumor J. South. Med. Univ. 29 2009 1851 1852
16. J. Cai, W.S. Wang, and L.S. Lei An experimental study on anti-stress effect of koumine on mice J. Guangzhou Univ. Tradit. Chin. Med. 24 2007 317 319
17. C. Calarasu Pharmaceuticals containing diphenhydramine and Echinacea and Eupatorium and Gelsemium and Lachesis extracts for the treatment of psoriasis and neurodermatitis Fed. Repub. Ger. 1988 4
18. K.Y. Chen, S. Zhen, and Z.Y. Wu Zhong Guo You Du Zhi Wu 1987 Science Press Beijing pp. 371-375.
19. D. Chi, L. Lei, H. Yang, and L. Sun General pharmacology of koumine parenteral solution Acad. J. First Med. Coll. PLA 24 2004 32 34
20. H.M. Club Gelsemium sempervirens: A Monograph 1883 Otis Clapp Boston pp. 16.
21. J. Cullen The European garden flora: a manual for the identification of plants cultivated in Europe, both out-of-doors and under glass. Dicotyledons (Part 4) 2000 Cambridge University Press Cambridge pp. 17-18.
22. W. Dewey Homeopathy in influenza-a chorus of fifty in harmony J. Am. Inst. Homeopath. 13 1921 1028 1043
23. V. Dutt, V.J. Dhar, and A. Sharma Antianxiety activity of Gelsemium sempervirens Pharm. Biol. 48 2010 1091 1096
24. V. Dutt, S. Thakur, V.J. Dhar, and A. Sharma The genus Gelsemium: an update Pharmacogn. Rev. 4 2010 185 194
25. Editorial Committee of Zhonghua Bencao National Traditional Chinese Herb Administration Zhonghua Bencao (Chinese Herbal Medicine) 1999 Shanghai Science and Technology Publishing House Shanghai (pp. 213-215)
26. F.Z. Fang, C.W. Shan, and P.Y. Chen Effect of koumine on platelet aggregation in rabbit Pharmacol. Clin. Chin. Mater. Med. 14 1998 21 24
27. M.Y. Gao, W.Z. Shen, Y.H. Wu, C.S. Cao, D.M. Zhang, and J.H. Gao Study on anti-proliferation activity and the mechanisms of alkaloid monomers from Gelsemium elegans on HepG2 cell in vitro J. Chin. Med. Mater. 35 2012 438 442
28. G. Garland Gelsemium sempervirens Boston Med. Surg. J. 119 1888 243 245
29. A. Ghorbani, G. Langenberger, L. Feng, and J. Sauerborn Ethnobotanical study of medicinal plants utilised by Hani ethnicity in Naban River Watershed National Nature Reserve, Yunnan, China J. Ethnopharmacol. 134 2011 651 667
30. M. Grieve A Modern Herbal: The Medicinal, Culinary, Cosmetic and Economic Properties, Cultivation and Folk-Lore of Herbs, Grasses, Fungi, Shrubs, & Trees with all their Modern Scientific Uses 1971 Dover Publications New York pp. 345-347.
31. W. Gutman Gelsemium Br. Homoeopath. J. 61 1972 83 86
32. W. Hua, T. Guo, L. Zhang, L. Wu, and Q. Zhao Chemical constituents of Gelsemium elegans Benth Zhongguo Yaowu Huaxue Zazhi 17 2007 108 110
33. W. Hua, Q.C. Zhao, J. Yang, G.B. Shi, L.J. Wu, and T. Guo Two new benzofuran lignan glycosides from Gelsemium elegans Chin. Chem. Lett. 19 2008 1327 1329
34. J. Huang, Y.P. Su, C.X. Yu, Y. Xu, and J. Yang Cytotoxic effect s of alkaloidal compounds from Gelsemium elegans Benth. on the tumor cells of digestive system in vitro Strait Pharm. J. 22 2010 197 200
35. S.R. Jensen, O. Kirk, B.J. Nielsen, and R. Norrestam 9-Hydroxy substituted iridoids from Gelsemium sempervirens Phytochemistry 26 1987 1725 1731
36. Z. Jiao, and J. Li Phylogeny of intercontinental disjunct gelsemiaceae inferred from chloroplast and nuclear DNA sequences Syst. Bot. 32 2007 617 627 (Pubitemid 350057079)
37. H. Jin, and R. Xu Studies on the alkaloids of Gelsemium elegans Benth. - the structure of koumidine Huaxue Xuebao 40 1982 1129 1135
38. I.A. Khan, and E.A. Abourashed Leung's Encyclopedia of Common Natural Ingredients: Used in Food, Drugs, and Cosmetics 2009 Wiley (pp. 312-314)
39. F. Khuong-Huu, A. Chiaroni, and C. Riche Structure of koumine, an alkaloid from Gelsemium elegans Benth Tetrahedron Lett. 22 1981 733 734
40. Kimura, T.; Unesco, 1998. International collation of traditional and folk medicine. In: Sung, C.K.; Guo, J.X.; But, P.P.H.; Kimura, T.; Han, B.H. (Eds.), Northeast Asia: Part3. World Scientific, Sigapore, pp. 110-112.
41. J. King, H.W. Felter, and J.U. Lloyd King's American dispensatory 1900 Ohio Valley Co Cincinnati pp. 916-923.
42. M. Kitajima, Y. Arai, H. Takayama, and N. Aimi A chemical study on "Yakatsu" stored in Shosoin repository: Isolation and characterization of four indole alkaloids from a 1250 year-old sample of the Chinese toxic medicine Proc. Jpn. Acad.; Ser. B 74 1998 159 163 (Pubitemid 128736244)
43. M. Kitajima, H. Kobayashi, N. Kogure, and H. Takayama New oxindole and indole alkaloids from Gelsemium rankinii Tetrahedron 66 2010 5987 5992
44. M. Kitajima, N. Kogure, K. Yamaguchi, H. Takayama, and N. Aimi Structure reinvestigation of gelsemoxonine, a constituent of Gelsemium elegans, reveals a novel, azetidine-containing indole alkaloid Org. Lett. 5 2003 2075 2078 (Pubitemid 37140930)
45. M. Kitajima, T. Nakamura, N. Kogure, M. Ogawa, Y. Mitsuno, K. Ono, S. Yano, N. Aimi, and H. Takayama Isolation of gelsedine-type indole alkaloids from Gelsemium elegans and evaluation of the cytotoxic activity of gelsemium alkaloids for A431 epidermoid carcinoma cells J. Nat. Prod. 69 2006 715 718 (Pubitemid 43798138)
46. M. Kitajima, A. Urano, N. Kogure, H. Takayama, and N. Aimi New oxindole alkaloids and iridoid from Carolina jasmine (Gelsemium sempervirens Ait. f.) Chem. Pharm. Bull. 51 2003 1211 1214 (Pubitemid 41663086)
47. W. Klett Umfang und Inhalt der Familie der Loganiaceen Bot. Arch. 5 1924 312 338
48. N. Kogure, N. Ishii, M. Kitajima, S. Wongseripipatana, and H. Takayama Four novel gelsenicine-related oxindole alkaloids from the leaves of Gelsemium elegans Benth Org. Lett. 8 2006 3085 3088 (Pubitemid 44154436)
49. N. Kogure, N. Ishii, H. Kobayashi, M. Kitajima, S. Wongseripipatana, and H. Takayama New iridoids from Gelsemium species Chem. Pharm. Bull. 56 2008 870 872 (Pubitemid 351872263)
50. N. Kogure, H. Kobayashi, N. Ishii, M. Kitajima, S. Wongseripipatana, and H. Takayama New humantenine-type indole alkaloids with iridoid unit from Gelsemium species Tetrahedron Lett. 49 2008 3638 3642 (Pubitemid 351609072)
51. N. Kogure, C. Nishiya, M. Kitajima, and H. Takayama Six new indole alkaloids from Gelsemium sempervirens Ait. f Tetrahedron Lett. 46 2005 5857 5861 (Pubitemid 41073429)
52. N. Kogure, A. Someya, A. Urano, M. Kitajima, and H. Takayama Total synthesis and full NMR assignment of ourouparine, a yohimbane-type indole alkaloid isolated from Gelsemium sempervirens J. Nat. Med. 61 2007 208 212
53. J.S. Lee, J. Kim, B.Y. Kim, H.S. Lee, J.S. Ahn, and Y.S. Chang Inhibition of phospholipase cgamma1 and cancer cell proliferation by triterpene esters from Uncaria rhynchophylla J. Nat. Prod. 63 2000 753 756 (Pubitemid 30452165)
54. L.M. Leege, and L.M. Wolfe Do floral herbivores respond to variation in flower characteristics in Gelsemium sempervirens (Loganiaceae), a distylous vine? Am. J. Bot. 89 2002 1270 1274 (Pubitemid 34915476)
55. L.S. Lei, L.S. Sun, S.Q. Yang, and F.Z. Fang Effect of Gelsemium alkaloids abstract on the proliferation of mice splenocytes in vitro Acad. J. First Med. Coll. PLA 16 1996 74 75
56. S. Li, C. Long, F. Liu, S. Lee, Q. Guo, R. Li, and Y. Liu Herbs for medicinal baths among the traditional Yao communities of China J. Ethnopharmacol. 108 2006 59 67 (Pubitemid 44523765)
57. L.Z. Lin, S.F. Hu, and G.A. Cordell 19α-Hydroxygelsamydine from Gelsemium elegans Phytochemistry 43 1996 723 726
58. L. Lin, G.A. Cordell, C. Ni, and J. Clardy Gelsamydine, an indole alkaloid from Gelsemium elegans with two monoterpene units J. Org. Chem. 54 1989 3199 3202 (Pubitemid 19169472)
59. L. Lin, G.A. Cordell, C. Ni, and J. Clardy Two oxindole alkaloids from Gelsemium elegans Phytochemistry 29 1990 3013 3017
60. L. Lin, G.A. Cordell, C. Ni, and J. Clardy Oxindole alkaloids from Gelsemium elegans Phytochemistry 30 1991 1311 1315
61. L.Z. Lin, G.A. Cordell, C.Z. Ni, and J. Clardy Gelsemamide and 11-methoxygelsemamide, two novel secoindole alkaloids from Gelsemium elegans Tetrahedron Lett. 30 1989 1177 1180
62. L.Z. Lin, G.A. Cordell, C.Z. Ni, and J. Clardy N- Methoxyanhydrovobasinediol from Gelsemium elegans Phytochemistry 28 1989 2827 2831
63. L.Z. Lin, G.A. Cordell, C.Z. Ni, and J. Clardy New humantenine-type alkaloids from Gelsemium elegans J. Nat. Prod. 52 1989 588 594
64. L.Z. Lin, G.A. Cordell, C.Z. Ni, and J. Clardy 19-(R)- and 19-(S)-hydroxydihydrokoumine from Gelsemium elegans Phytochemistry 29 1990 965 968
65. L.Z. Lin, S. Yeh, G.A. Cordell, C.Z. Ni, and J. Clardy Three oxindole alkaloids from Gelsemium species Phytochemistry 30 1991 679 683
66. M. Liu, H.-H. Huang, J. Yang, Y.-P. Su, H.-W. Lin, L.-Q. Lin, W.-J. Liao, and C.-X. Yu The active alkaloids of Gelsemium elegans Benth. are potent anxiolytics Psychopharmacology 4 2013 839 851
67. M. Liu, J. Shen, H. Liu, Y. Xu, Y.-P. Su, J. Yang, and C.-X. Yu Gelsenicine from Gelsemium elegans attenuates neuropathic and inflammatory pain in mice Biol. Pharm. Bull. 34 2011 1877 1880
68. J.M. Lu, G.L. Liu, Z.Y. Shen, K.C. Tu, and Z.R. Qi Effect of Gelsemium elegans Benth. Injection on proliferation of tumor cells Chin. J. Cancer 9 1990 472 477
69. P. Magnani, A. Conforti, E. Zanolin, M. Marzotto, and P. Bellavite Dose-effect study of Gelsemium sempervirens in high dilutions on anxiety-related responses in mice Psychopharmacology 210 2010 533 545
70. L. Meyer et al. Pharmacological effect of gelsemine on anxiety-like behavior in rat Behav. Brain Res. 253 2013 90 94
71. C.F. Millspaugh American Medicinal Plants: An Illustrated and Descriptive Guide to Plants Indigenous to and Naturalized in the United States which are Used in Medicine 1892 Dover Publications New York (pp. 518-519)
72. F. Miranda, and A. Sharp Characteristics of the vegetation in certain temperate regions of eastern Mexico Ecology 31 1950 313 333
73. R.J. Moore Cytotaxonomic studies in the Loganiaceae. I. chromosome numbers and phylogeny in the Loganiaceae Am. J. Bot. 34 1947 527 538
74. R. Ornduff The systematics and breeding system of Gelsemium (Loganiaceae) J. Arnold Arboretum 51 1970 1 17
75. S. Ouyang, L. Wang, Q.W. Zhang, G.C. Wang, Y. Wang, X.J. Huang, X.Q. Zhang, R.W. Jiang, X.S. Yao, C.T. Che, and W.C. Ye Six new monoterpenoid indole alkaloids from the aerial part of Gelsemium elegans Tetrahedron 67 2011 4807 4813
76. A. Paris, S. Schmidlin, S. Mouret, E. Hodaj, P. Marijnen, N. Boujedaini, M. Polosan, and J.L. Cracowski Effect of Gelsemium 5CH and 15CH on anticipatory anxiety: a phase III, single-centre, randomized, placebo-controlled study Fundam. Clin. Pharmacol. 26 2012 751 760
77. J.B. Pascarella Mechanisms of prezygotic reproductive isolation between two sympatric species, Gelsemium rankinii and G. sempervirens (Gelsemiaceae), in the southeastern United States Am. J. Bot. 94 2007 468 476 (Pubitemid 46955025)
78. D. Ponglux, S. Wongseripipatana, H. Takayama, K. Ogata, N. Aimi, and S. Sakai A new class of indole alkaloid, elegansamine, constructed from a monoterpenoid indole alkaloid and an iridoid Tetrahedron Lett. 29 1988 5395 5396 (Pubitemid 18260631)
79. D. Ponglux, S. Wonseripipatana, S. Subhadhirasakul, H. Takayama, M. Yokota, K. Ogata, C. Phisalaphong, N. Aimi, and S. Sakai Studies on the indole alkaloids of Gelsemium elegans (Thailand). Structure elucidation and proposal of a biogenetic route Tetrahedron 44 1988 5075 5094
80. W. Robert, and S.B. Broyles Systematic Relationships within Gelsemium (Loganiaceae): Evidence from Isozymes and Cladistics Syst. Bot. 18 1993 345 355
81. C. Rujjanawate, D. Kanjanapothi, and A. Panthong Pharmacological effect and toxicity of alkaloids from Gelsemium elegans Benth J. Ethnopharmacol. 89 2003 91 95 (Pubitemid 37163804)
82. S. Sakai, S. Wongseripipatana, D. Ponglux, M. Yokota, K. Ogata, H. Takayama, and N. Aimi Indole alkaloids isolated from Gelsemium elegans (Thailand): 19-(Z)-akuammidine, 16-epi-voacarpine, 19-hydroxydihydrogelsevirine, and the revised structure of koumidine Chem. Pharm. Bull. 35 1987 4668 4671
83. Y. Schun, and G.A. Cordell 14β-Hydroxygelsedine, a new oxindole alkaloid from Gelsemium sempervirens J. Nat. Prod. 48 1985 788 791 (Pubitemid 16185155)
84. Y. Schun, and G.A. Cordell Cytotoxic steroids of Gelsemium sempervirens J. Nat. Prod. 50 1987 195 198 (Pubitemid 17110602)
85. Y. Schun, G.A. Cordell, and M. Garland 21-oxogelsevirine, a new alkaloid from Gelsemium rankinii J. Nat. Prod. 49 1986 483 487 (Pubitemid 16045812)
86. K. Srithi, C. Trisonthi, P. Wangpakapattanawong, and H. Balslev Medicinal plants used in Hmong women's healthcare in northern Thailand J. Ethnopharmacol. 139 2012 119 135
87. L. Struwe, V.A. Albert, and B. Bremer Cladistics and family level classification of the Gentianales Cladistics 10 1994 175 206
88. Y.P. Su, J. Shen, Y. Xu, M. Zheng, and C.X. Yu Preparative separation of alkaloids from Gelsemium elegans Benth. using pH-zone-refining counter-current chromatography J. Chromatogr. A 1218 2011 3695 3698
89. F. Sun, Q.Y. Xing, and X.T. Liang Structures of (19R)-kouminol and (19 S)-kouminol from Gelsemium elegans J. Nat. Prod. 52 1989 1180 1182
90. L. Sun, L. Lei, F. Fang, S. Yang, and J. Wang Inhibitory effects of koumine on splenocyte proliferation and humoral immune response in mice Pharmacol. Clin. Chin. Mater. Med. 15 1999 10 12
91. M. Sun, X. Hou, H. Gao, J. Guo, and K. Xiao Two new koumine-type indole alkaloids from Gelsemium elegans Benth Molecules 18 2013 1819 1825
92. C.K. Sung, J.X. Guo, P.P.H. But, T. Kimura, and B.H. Han International collation of traditional and folk medicine Northeast Asia: Part 3 1998 (pp. 110-112)
93. H. Takayama, Y. Morohoshi, M. Kitajima, N. Aimi, S. Wongseripipatana, D. Ponglux, and S.i. Sakai Two new iridoids from the leaves of Gelsemium elegans Benth, in Thailand Nat. Prod. Lett. 5 1994 15 20 (Pubitemid 24298206)
94. H. Takayama, and S.-I. Sakai Gelsemium Alkaloids Alkaloids 49 1997 Academic Press San Diego 1 78
95. J. Tan, C. Qiu, L. Zhen, and S. Li Analgesic effect and no physical dependence of Gelsemium elegans Benth Pharmacol. Clin. Chin. Mater. Med. 4 1988 24 28
96. G. Tantaquidgeon, and P.H. Commission A Study of Delaware Indian Medicine Practice and Folk Beliefs 1942 Pennsylvania Historical Commission Philadelphia pp. 29, 76
97. C. Venard, N. Boujedaini, A.G. Mensah-Nyagan, and C. Patte-Mensah Comparative analysis of gelsemine and Gelsemium sempervirens activity on neurosteroid allopregnanolone formation in the spinal cord and limbic system Evid.-Based Complement. Altern. Med. 2011 2011 407617
98. Y. Wang, Y. Fang, W. Lin, M. Cheng, Y. Jiang, and M. Yin Inhibitory effect of gelsemium alkaloids extract on hepatic carcinoma HepG2 cells in vitro J. Chin. Med. Mater. 24 2001 579 581
99. Z.R. Wang, C.Q. Huang, Z.Y. Zhang, L.L. Zhang, and J.M. Lin Effect of koumine on proliferation of murine CD4+T cells purified by magnetic-activated cell sorting in vitro Acad. J. First Med. Coll. PLA 25 2005 562 564
100. D.R. Wu, R. Qin, J. Cai, and D.B. Chi Antitumor activity of koumine in vitro and vivo Pharmacol. Clin. Chin. Mater. Med. 22 2006 6 8
101. Z. Wu, P.H. Raven, and M.B. Garden Flora of China. Beijing, and Missouri 1996 Botanical Garden Press Beijing (pp. 329)
102. W.Z. Xie, C.S. Fan, and Z.Y. Zhu Quan Guo Zhong Cao Yao Hui Bian 1996 People's Medical Publishing House Beijing (pp. 423-424)
103. K.Y. Xu, J.Q. Tan, and F.M. Shen A study on anti-inflammatory effect of Gelsemium elegans Benth Pharmacol. Clin. Chin. Mater. Med. 7 1991 27 28
104. Y.K. Xu, S.P. Yang, S.G. Liao, H. Zhang, L.P. Lin, J. Ding, and J.M. Yue Alkaloids from Gelsemium elegans J. Nat. Prod. 69 2006 1347 1350 (Pubitemid 44568246)
105. Y. Xu, H.Q. Qiu, H. Liu, M. Liu, Z.Y. Huang, J. Yang, Y.P. Su, and C.X. Yu Effects of koumine, an alkaloid of Gelsemium elegans Benth.; on inflammatory and neuropathic pain models and possible mechanism with allopregnanolone Pharmacol.; Biochem.; Behav. 101 2012 504 514
106. Y.K. Xu, S.G. Liao, Z. Na, H.B. Hu, Y. Li, and H.R. Luo Gelsemium alkaloids, immunosuppressive agents from Gelsemium elegans Fitoterapia 83 2012 1120 1124
107. Y. Yamada, M. Kitajima, N. Kogure, and H. Takayama Four novel gelsedine-type oxindole alkaloids from Gelsemium elegans Tetrahedron 64 2008 7690 7694
108. Y. Yamada, M. Kitajima, N. Kogure, S. Wongseripipatana, and H. Takayama Spectroscopic analyses and chemical transformation for structure elucidation of two novel indole alkaloids from Gelsemium elegans Tetrahedron Lett. 50 2009 3341 3344
109. Y. Yamada, M. Kitajima, N. Kogure, S. Wongseripipatana, and H. Takayama Seven new monoterpenoid indole alkaloids from Gelsemium elegans Chem.; Asian J. 6 2011 166 173
110. F. Yang, Y. Lu, and Y. Li Experimental research on antineoplastic effect of extract from Gelsemium elegans Benth Guangxi J. Tradit. Chin. Med. 27 2004 51 53
111. J. Yang, and Y. Chen Structural elucidation of humantenine and humantenirine Acta Pharm. Sin. 19 1984 686 690
112. S. Yin, X.F. He, Y. Wu, and J.M. Yue Monoterpenoid indole alkaloids bearing an N4- Iridoid from Gelsemium elegans Chem.; Asian J. 3 2008 1824 1829
113. B.-F. Zhang, G.X. Chou, and Z.T. Wang Two new 11-Hydroxy-substituted gelsedine-type indole alkaloids from the stems of Gelsemium elegans Helv. Chim. Acta 92 2009 1889 1894
114. B. Zhang, G. Chou, and Z. Wang Non-alkaloid constituents of Gelsemium elegans China J. Chin. Mater. Med. 34 2009 2334 2337
115. B. Zhang, Q. Zhang, H. Liu, G. Chou, and Z. Wang Iridoids from leaves of Gelsemium elegans Phytochemistry 72 2011 916 922
116. J.Y. Zhang, N. Gong, J.L. Huang, L.C. Guo, and Y.X. Wang Gelsemine, a principle alkaloid from Gelsemium sempervirens Ait.; exhibits potent and specific antinociception in chronic pain by acting at spinal α3 glycine receptors Pain 11 2013 2452 2462
117. L. Zhang et al. Four new koumine metabolites in rat liver microsomes J. Asian Nat. Prod. Res. 15 2013 46 52
118. L.L. Zhang, C.Q. Huang, Z.Y. Zhang, Z.R. Wang, and J.M. Lin Therapeutic effects of koumine on psoriasis: an experimental study in mice Acad. J. First Med. Coll. PLA 25 2005 547 549
119. L. Zhang, Q.C. Zhao, and Y. Li Advances in studies on alkaloid constituents of Gelsemium elegans Benth Shenyang Yaoke Daxue Xuebao 24 2007 515 520
120. Q.P. Zhang, B.F. Zhang, G.X. Chou, and Z.T. Wang Two New Megastigmane Glycosides and a New Iridoid Glycoside from Gelsemium elegans Helv. Chim. Acta 94 2011 1130 1138
121. Q. Zhang, B. Zhang, G. Chou, and Z. Wang Chemical constituents of aerial parts of Gelsemium elegans China J. Chin. Mater. Med. 36 2011 1305 1310
122. Y.G. Zhang, and G.Z. Huang Poisoning by toxic plants in China. Report of 19 autopsy cases Am. J. Forensic Med. Pathol. 9 1988 313 319
123. Z. Zhang, Y.T. Di, Y.H. Wang, S.Z. Mu, X. Fang, Y. Zhang, C.J. Tan, Q. Zhang, X.H. Yan, J. Guo, C.S. Li, and X.J. Hao Gelegamines A-E: five new oxindole alkaloids from Gelsemium elegans Tetrahedron 65 2009 4551 4556
124. Z. Zhang, X. Liang, F. Sun, Y. Lu, J. Yang, and Q. Xing Studies on the indole alkaloids of Gelsemium elegans Chin. Chem. Lett. 2 1991 365 368
125. Z. Zhang, P. Wang, W. Yuan, and S. Li Steroids, alkaloids, and coumarins from Gelsemium sempervirens Planta Med. 74 2008 1818 1822
126. Z. Zhang, Y. Zhang, Y.H. Wang, Q. Zhang, X.H. Yan, Y.T. Di, H.P. He, and X.J. Hao Three novel β-carboline alkaloids from Gelsemium elegans Fitoterapia 83 2012 704 708
127. M. Zhao, T. Guo, M. Wang, and Q. Zhao Comparative study on the antineoplastic effect of non- alkaloid components from Gelsemium elegans Benth. in vitro and in vivo China Pharm. 23 2006 1776 1778
128. M. Zhao, T. Guo, M. Wang, Q. Zhao, Y. Liu, X. Sun, H. Wang, and Y. Hou The course of uncarinic acid E-induced apoptosis of HepG2 cells from damage to DNA and p53 activation to mitochondrial release of cytochrome c Biol. Pharm. Bull. 29 2006 1639 1644 (Pubitemid 44166366)
129. Q.C. Zhao, Y.H. Fu, Z.Q. Du, W. Hua, T. Guo, and L.J. Wu Isolation and identification of the non-alkaloid constituents from Gelsemium elegans Benth Shenyang Yaoke Daxue Xuebao 26 2009 694 696
130. Q.C. Zhao, W. Hua, Y.-h. Fu, Z.Q. Du, T. Guo, and L.J. Wu Isolation and identification of the non-alkaloid constituents from whole plant of Gelsemium elegans Benth. (III) Shenyang Yaoke Daxue Xuebao 27 2010 551 554
131. Q.C. Zhao, W. Hua, L. Zhang, T. Guo, M.H. Zhao, M. Yan, G.B. Shi, and L.J. Wu Antitumor activity of two gelsemine metabolites in rat liver microsomes J. Asian Nat. Prod. Res. 12 2010 731 739
132. Y. Zhou, W. Xu, and X. Chen Toxicity and respiratory inhibition of humantenmine Zhongguo Yaolixue Yu Dulixue Zazhi 9 1995 69 72