Effects of koumine, an alkaloid of Gelsemium elegans Benth., on inflammatory and neuropathic pain models and possible mechanism with allopregnanolone

Pharmacology Biochemistry and Behavior

Volumn 101, Issue 3, 2012, Pages 504-514

  Xu, Ying ^a   Qiu, Hong Qiang ^a   Liu, Hao ^a   Liu, Ming ^a   Huang, Zhi Yi ^a   Yang, Jian ^a   Su, Yan Ping ^a   Yu, Chang Xi ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

Analgesia; Gelsemium elegans Benth; Inflammatory pain; Koumine; Neuropathic pain; Neurosteroid

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; ACETYLSALICYLIC ACID; GABAPENTIN; INDOMETACIN; KOUMINE; MORPHINE; NEUROSTEROID;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC CONSTRICTION INJURY; CLONIC SEIZURE; CONSTIPATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG FATALITY; DRUG MECHANISM; DRUG STRUCTURE; FEMALE; GELSEMIUM; GELSEMIUM ELEGANS; HYPERALGESIA; INFLAMMATORY PAIN; LIQUID CHROMATOGRAPHY; MALE; MOUSE; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; SPINAL NERVE; TANDEM MASS SPECTROMETRY; UPREGULATION;

ANALGESICS; ANIMALS; DISEASE MODELS, ANIMAL; GELSEMIUM; HYPERALGESIA; INDOLE ALKALOIDS; INFLAMMATION; MALE; MICE; MICE, INBRED ICR; NEURALGIA; PAIN; PAIN MEASUREMENT; PREGNANOLONE; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; UP-REGULATION;

GELSEMIUM; GELSEMIUM ELEGANS; MUS; RATTUS; RODENTIA;

EID: 84862817694     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2012.02.009     Document Type: Article

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