The active alkaloids of Gelsemium elegans Benth. are potent anxiolytics

Psychopharmacology

Volumn 225, Issue 4, 2013, Pages 839-851

  Liu, Ming ^a   Huang, Hui Hui ^a   Yang, Jian ^a   Su, Yan Ping ^a   Lin, Hong Wei ^a   Lin, Li Qing ^a   Liao, Wei Jian ^a   Yu, Chang Xi ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

Anxiety; Depression; Elevated plus maze; Forced swim test; Gelsemium elegans alkaloids; Glycine receptor; Light dark transition model; Mice; Strychnine; Tail suspension test

Indexed keywords

ALKALOID DERIVATIVE; DIAZEPAM; FLUOXETINE; GELSEMINE; GELSEMIUM ELEGANS EXTRACT; GELSENICINE; GELSEVIRINE; GLYCINE RECEPTOR; KOUMINE; PLANT EXTRACT; STRYCHNINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDEPRESSANT ACTIVITY; ANXIETY DISORDER; ARTICLE; DEPRESSION; DRUG MECHANISM; DRUG STRUCTURE; FORCED SWIMMING TEST; GELSEMIUM; GELSEMIUM ELEGANS; LIGHT DARK CYCLE; MEDICINAL PLANT; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANQUILIZING ACTIVITY;

ALKALOIDS; ANIMALS; ANTI-ANXIETY AGENTS; ANXIETY; DOSE-RESPONSE RELATIONSHIP, DRUG; GELSEMIUM; INJECTIONS, INTRAVENTRICULAR; MALE; MAZE LEARNING; MICE; MICE, INBRED ICR; PLANT EXTRACTS;

EID: 84873727999     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-012-2867-x     Document Type: Article

References (35)

1. Belzung C, Griebel G (2001) Measuring normal and pathological anxiety-like behaviour in mice: a review. Behav Brain Res 125:141-149
2. Boyer P (2000) Do anxiety and depression have a common pathophysiological mechanism? Acta Psychiatr Scand Suppl 102:24-29
3. Braida D, Capurro V, Zani A, Rubino T, Vigano D, Parolaro D, Sala M (2009) Potential anxiolytic- and antidepressant-like effects of salvinorin A, the main active ingredient of Salvia divinorum, in rodents. Br J Pharmacol 157:844-853
4. Chen Y, Dai TJ, Zeng YM (2007) Strychnine-sensitive glycine receptors mediate the analgesic but not hypnotic effects of emulsified volatile anesthetics. Pharmacology 80:151-157
5. Clement Y, Joubert C, Kopp C, Lepicard EM, Venault P, Misslin R, Cadot M, Chapouthier G (2007) Anxiety in mice: a principal component analysis study. Neural Plast 2007
6. Costall B, Jones B, Kelly M, Naylor R, Tomkins D (1989) Exploration of mice in a black and white test box: validation as a model of anxiety. Pharmacol Biochem Behav 32:777-785
7. Dutt V, Dhar VJ, Sharma A (2010) Antianxiety activity of Gelsemium sempervirens. Pharm Biol 48:1091-1096
8. Eser D, Romeo E, Baghai TC, Di Michele F, Schule C, Pasini A, Zwanzger P, Padberg F, Rupprecht R (2006) Neuroactive steroids as modulators of depression and anxiety. Neuroscience 138:1041-1048
9. Griebel G, Belzung C, Misslin R, Vogel E (1993) The free-exploratory paradigm: an effective method for measuring neophobic behaviour in mice and testing potential neophobia-reducing drugs. Behav Pharmacol 4:637-644
10. Haller J, Alicki M (2012) Current animal models of anxiety, anxiety disorders, and anxiolytic drugs. Curr Opin Psychiatry 25:59-64
11. Hattesohl M, Feistel B, Sievers H, Lehnfeld R, Hegger M, Winterhoff H (2008) Extracts of Valeriana officinalis L. s.l. show anxiolytic and antidepressant effects but neither sedative nor myorelaxant properties. Phytomedicine 15:2-15
12. Holladay JW, Dewey MJ, Yoo SD (1998) Pharmacokinetics and antidepressant activity of fluoxetine in transgenic mice with elevated serum alpha-1-acid glycoprotein levels. Drug Metab Dispos 26:20-24
13. Huang ZY, Liu M, Shen J, Su YP, Xu Y, Yu CX (2010) The anti-chronic pain effect of gelsevirine. Chin Tradit Herb Drugs 41:2034-2037
14. Kothari S, Minda M, Tonpay SD (2010) Anxiolytic and antidepressant activities of methanol extract of Aegle marmelos leaves in mice. Indian J Physiol Pharmacol 54:318-328
15. Kraft K (2011) Phytotherapy for psychosomatic diseases. MMW Fortschr Med 153:35-37
16. Laursen SE, Belknap JK (1986) Intracerebroventricular injections in mice. Some methodological refinements. J Pharmacol Methods 16:355-357
17. Lister RG (1987) The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology 92:180-185
18. Liu M, Shen J, Liu H, Xu Y, Su YP, Yang J, Yu CX (2011) Gelsenicine from Gelsemium elegans attenuates neuropathic and inflammatory pain in mice. Biol Pharm Bull 34:1877-1880
19. Magnani P, Conforti A, Zanolin E, Marzotto M, Bellavite P (2010) Dose-effect study of Gelsemium sempervirens in high dilutions on anxiety-related responses in mice. Psychopharmacology 210:533-545
20. Majewska MD (1992) Neurosteroids: endogenous bimodal modulators of the GABAA receptor. Mechanism of action and physiological significance. Prog Neurobiol 38:379-395
21. Micale V, Cristino L, Tamburella A, Petrosino S, Leggio GM, Drago F, Di Marzo V (2009) Anxiolytic effects in mice of a dual blocker of fatty acid amide hydrolase and transient receptor potential vanilloid type-1 channels. Neuropsychopharmacology 34:593-606
22. Ossenkopp KP, Macrae LK, Teskey GC (1987) Automated multivariate measurement of spontaneous motor activity in mice: time course and reliabilities of the behavioral measures. Pharmacol Biochem Behav 27:565-568
23. Paul SM, Purdy RH (1992) Neuroactive steroids. FASEB J 6:2311-2322
24. Porsolt R, Le Pichon M, Jalfre M (1977) Depression: a new animal model sensitive to antidepressant treatments. Nature 266:730-732
25. Ramos A (2008) Animal models of anxiety: do I need multiple tests? Trends Pharmacol Sci 29:493-498
26. Rupprecht R, di Michele F, Hermann B, Ströhle A, Lancel M, Romeo E, Holsboer F (2001) Neuroactive steroids: molecular mechanisms of action and implications for neuropsychopharmacology. Brain Res Brain Res Rev 37:59-67
27. Shen J, Su YP, Xu Y, Liu H, Liu M, Yu CX (2009) Isolation and purification of gelsenicine and gelsevirine from Gelsemium elegans by high-speed counter-current chromatography. Chin Tradit Herb Drugs 40:1392-1395
28. Steru L, Chermat R, Thierry B, Simon P (1985) The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology 85:367-370
29. Su YP, Shen J, Xu Y, Zheng M, Yu CX (2011) Preparative separation of alkaloids from Gelsemium elegans Benth. using pH-zone-refining counter-current chromatography. J Chromatogr A 1218:3695-3698
30. Svenningsson P, Tzavara ET, Qi H, Carruthers R, Witkin JM, Nomikos GG, Greengard P (2007) Biochemical and behavioral evidence for antidepressant-like effects of 5-HT6 receptor stimulation. J Neurosci 27:4201-4209
31. Venard C, Boujedaini N, Belon P, Mensah-Nyagan AG, Patte-Mensah C (2008) Regulation of neurosteroid allopregnanolone biosynthesis in the rat spinal cord by glycine and the alkaloidal analogs strychnine and gelsemine. Neuroscience 153:154-161
32. Venard C, Boujedaini N, Mensah-Nyagan AG, Patte-Mensah C (2009) Comparative analysis of gelsemine and Gelsemium sempervirens activity on neurosteroid allopregnanolone formation in the spinal cord and limbic system. Evid Based Complement Altern Med. doi: 10.1093/ecam/nep083
33. Walf AA, Frye CA (2007) The use of the elevated plus maze as an assay of anxiety-related behavior in rodents. Nat Protoc 2:322-328
34. Xu Y, Qiu HQ, Liu H, Liu M, Huang ZY, Yang J, Su YP, Yu CX (2012) Effects of koumine, an alkaloid of Gelsemium elegans Benth., on inflammatory and neuropathic pain models and possible mechanism with allopregnanolone. Pharmacol Biochem Behav 101:504-514
35. Yan HC, Cao X, Das M, Zhu XH, Gao TM (2010) Behavioral animal models of depression. Neurosci Bull 26:327-337