The potential role of Azadirachta indica treatment on cisplatin-induced hepatotoxicity and oxidative stress in female rats

Oxidative Medicine and Cellular Longevity

Volumn , Issue , 2013, Pages

  Dkhil, Mohamed A ^a,b   Al Quraishy, Saleh ^a   Aref, Ahmed M ^c   Othman, Mohamed S ^d   El Deib, Kamal M ^e   Abdel Moneim, Ahmed E ^b,f  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b Helwan University   (Egypt)

^c 6th October City   (Egypt)

^d October University for Modern Sciences and Arts   (Egypt)

^e NATIONAL ORGANIZATION FOR DRUG CONTROL AND RESEARCH NODCAR   (Egypt)

^f UNIVERSITY OF OVIEDO   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CASPASE 3; CASPASE 9; CATALASE; CISPLATIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; PLANT EXTRACT; PROTECTIVE AGENT; PROTEIN BAX; SUPEROXIDE DISMUTASE;

ANIMAL; ARTICLE; AZADIRACHTA INDICA; CHEMISTRY; DRUG EFFECT; ENZYMOLOGY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; LIPID PEROXIDATION; LIVER; METABOLISM; OXIDATIVE STRESS; PATHOLOGY; PHYTOTHERAPY; PLANT LEAF; RAT; TOXIC HEPATITIS; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; AZADIRACHTA; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASE 9; CATALASE; CISPLATIN; DRUG-INDUCED LIVER INJURY; FEMALE; GENE EXPRESSION REGULATION; LIPID PEROXIDATION; LIVER; NF-KAPPA B; OXIDATIVE STRESS; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; PROTECTIVE AGENTS; RATS; RATS, WISTAR; RNA, MESSENGER; SUPEROXIDE DISMUTASE;

EID: 84893839663     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2013/741817     Document Type: Article

References (60)

1. Fuertes M. A., Castilla J., Alonso C., Pérez J. M., Novel concepts in the development of platinum antitumor drugs. Current Medicinal Chemistry 2002 2 4 539 551 2-s2.0-0036086248 10.2174/1568011023353958 (Pubitemid 34649888)
2. Türk G., Ateşşahin A., Sönmez M., Çeribaşi A. O., Yüce A., Improvement of cisplatin-induced injuries to sperm quality, the oxidant-antioxidant system, and the histologic structure of the rat testis by ellagic acid. Fertility and Sterility 2008 89 5, supplement 1474 1481 2-s2.0-43549105129 10.1016/j.fertnstert.2007.04.059 (Pubitemid 351680100)
3. Lippard S. J., New chemistry of an old molecule: cis-[Pt(NH3)2Cl2]. Science 1982 218 4577 1075 1082 2-s2.0-0020457216
4. Wang D., Lippard S. J., Cellular processing of platinum anticancer drugs. Nature Reviews Drug Discovery 2005 4 4 307 320 2-s2.0-18244379333 10.1038/nrd1691 (Pubitemid 41130944)
5. Pratibha R., Sameer R., Rataboli P. V., Bhiwgade D. A., Dhume C. Y., Enzymatic studies of cisplatin induced oxidative stress in hepatic tissue of rats. European Journal of Pharmacology 2006 532 3 290 293 2-s2.0-33644499774 10.1016/j.ejphar.2006.01.007
6. Lu Y., Cederbaum A. I., Cisplatin-induced hepatotoxicity is enhanced by elevated expression of cytochrome P450 2E1. Toxicological Sciences 2006 89 2 515 523 2-s2.0-31144468764 10.1093/toxsci/kfj031 (Pubitemid 43126011)
7. Chirino Y. I., Pedraza-Chaverri J., Role of oxidative and nitrosative stress in cisplatin-induced nephrotoxicity. Experimental and Toxicologic Pathology 2009 61 3 223 242 2-s2.0-67349112401 10.1016/j.etp.2008.09.003
8. Sadzuka Y., Shimizu Y., Takino Y., Role of glutathione S-transferase isoenzymes in cisplatin-induced nephrotoxicity in the rat. Toxicology Letters 1994 70 2 211 222 2-s2.0-0028039073 10.1016/0378-4274(94)90165-1 (Pubitemid 24040834)
9. Kawai Y., Nakao T., Kunimura N., Kohda Y., Gemba M., Relationship of intracellular calcium and oxygen radicals to cisplatin-related renal cell injury. Journal of Pharmacological Sciences 2006 100 1 65 72 2-s2.0-31544452785 10.1254/jphs.FP0050661 (Pubitemid 43161616)
10. Arakaki J., Suzui M., Morioka T., Kinjo T., Kaneshiro T., Inamine M., Sunagawa N., Nishimaki T., Yoshimi N., Antioxidative and modifying effects of a tropical plant Azadirachta indica (Neem) on azoxymethane-induced preneoplastic lesions in the rat colon. Asian Pacific Journal of Cancer Prevention 2006 7 3 467 471 2-s2.0-39049195859
11. National Research Council (U.S.), Board on Science and Technology for International Development: Neem: A Tree for Solving global Problems: Report of an Ad Hoc Panel of the Board on Science and Technology for International Development, National Research Council 1992 Washington, DC, USA National Academy Press
12. Biswas K., Chattopadhyay I., Banerjee R. K., Bandyopadhyay U., Biological activities and medicinal properties of neem (Azadirachta indica). Current Science 2002 82 11 1336 1345 2-s2.0-0002925047 (Pubitemid 135695234)
13. Dkhil M. A., Al-Quraishy S., Abdel Moneim A. E., Delic D., Protective effect of Azadirachta indica extract against Eimeria papillata-induced coccidiosis. Parasitology Research 2013 112 1 101 106
14. Reitman S., Frankel S., A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. American Journal of Clinical Pathology 1957 28 1 56 63 2-s2.0-66349129125
15. Szasz G., A kinetic photometric method for serum gamma-glutamyl transpeptidase. Clinical Chemistry 1969 15 2 124 136 2-s2.0-0014467815
16. Belfield A., Goldberg D. M., Revised assay for serum phenyl phosphatase activity using 4-amino-antipyrine. Enzyme 1971 12 5 561 573 2-s2.0-0015195627
17. King E. J., Coxon R. V., Determination of bilirubin with precipitation of the plasma proteins. Journal of Clinical Pathology 1950 3 248 259
18. Ohkawa H., Ohishi N., Yagi K., Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry 1979 95 2 351 358 2-s2.0-0018384650 (Pubitemid 9194347)
19. Green L. C., Wagner D. A., Glogowski J., Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Analytical Biochemistry 1982 126 1 131 138 2-s2.0-0020448709 (Pubitemid 13203451)
20. Ellman G. L., Tissue sulfhydryl groups. Archives of Biochemistry and Biophysics 1959 82 1 70 77 2-s2.0-3042934967
21. Nishikimi M., Appaji Rao N., Yagi K., The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen. Biochemical and Biophysical Research Communications 1972 46 2 849 854 2-s2.0-0015530358
22. Aebi H., Catalase in vitro. Methods in Enzymology 1984 105 121 126 2-s2.0-0021318441 10.1016/S0076-6879(84)05016-3
23. Paglia D. E., Valentine W. N., Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. The Journal of Laboratory and Clinical Medicine 1967 70 1 158 169 2-s2.0-0014108436
24. Factor V. M., Kiss A., Woitach J. T., Wirth P. J., Thorgeirsson S. S., Disruption of redox homeostasis in the transforming growth factor- α /c-myc transgenic mouse model of accelerated hepatocarcinogenesis. Journal of Biological Chemistry 1998 273 25 15846 15853 2-s2.0-0032546792 10.1074/jbc.273.25.15846 (Pubitemid 28298207)
25. Del Rio D., Stewart A. J., Pellegrini N., A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. Nutrition, Metabolism and Cardiovascular Diseases 2005 15 4 316 328 2-s2.0-23944478990 10.1016/j.numecd.2005.05.003 (Pubitemid 41190990)
26. D'Angio C. T., Finkelstein J. N., Oxygen regulation of gene expression: a study in opposites. Molecular Genetics and Metabolism 2000 71 1-2 371 380 2-s2.0-0033808725 10.1006/mgme.2000.3074
27. Saleh S., El-Demerdash E., Protective effects of L-arginine against cisplatin-induced renal oxidative stress and toxicity: role of nitric oxide. Basic and Clinical Pharmacology and Toxicology 2005 97 2 91 97 2-s2.0-22544470879 10.1111/j.1742-7843.2005.pto-114.x (Pubitemid 41021108)
28. Silici S., Ekmekcioglu O., Kanbur M., Deniz K., The protective effect of royal jelly against cisplatin-induced renal oxidative stress in rats. World Journal of Urology 2011 29 1 127 132 2-s2.0-78751642648 10.1007/s00345-010-0543- 5
29. Takaki-Doi S., Hashimoto K., Yamamura M., Kamei C., Antihypertensive activities of royal jelly protein hydrolysate and its fractions in spontaneously hypertensive rats. Acta Medica Okayama 2009 63 1 57 64 2-s2.0-62249172972
30. Sithisarn P., Supabphol R., Gritsanapan W., Antioxidant activity of Siamese neem tree (VP1209). Journal of Ethnopharmacology 2005 99 1 109 112 2-s2.0-17644421819 10.1016/j.jep.2005.02.008 (Pubitemid 40569407)
31. Chattopadhyay R. R., Possible mechanism of hepatoprotective activity of Azadirachta indica leaf extract: part II. Journal of Ethnopharmacology 2003 89 2-3 217 219 2-s2.0-0242468790 10.1016/j.jep.2003.08.006 (Pubitemid 37378196)
32. Chattopadhyay R. R., Sarkar S. K., Ganguly S., Banerjee R. N., Basu T. K., Mukherjee A., Hepatoprotective activity of Azadirachta indica leaves on paracetamol induced hepatic damage in rats. Indian Journal of Experimental Biology 1992 30 8 738 740 2-s2.0-0026661151
33. Bhanwra S., Singh J., Khosla P., Effect of Azadirachta indica (Neem) leaf aqueous extract on paracetamol-induced liver damage in rats. Indian Journal of Physiology and Pharmacology 2000 44 1 64 68 2-s2.0-0033960418 (Pubitemid 30090035)
34. Mallick A., Ghosh S., Banerjee S., Neem leaf glycoprotein is nontoxic to physiological functions of Swiss mice and Sprague Dawley rats: histological, biochemical and immunological perspectives. International Immunopharmacology 2013 15 1 73 83
35. Liao Y., Lu X., Lu C., Li G., Jin Y., Tang H., Selection of agents for prevention of cisplatin-induced hepatotoxicity. Pharmacological Research 2008 57 2 125 131 2-s2.0-40349101931 10.1016/j.phrs.2008.01.001
36. Tarladacalisir Y. T., Kanter M., Uygun M., Protective effects of vitamin C on cisplatin-induced renal damage: a light and electron microscopic study. Renal Failure 2008 30 1 1 8 2-s2.0-38148999548 10.1080/08860220701742070
37. Ateşşahin A., Karahan I., Türk G., Gür S., Yilmaz S., Çeribaşi A. O., Protective role of lycopene on cisplatin-induced changes in sperm characteristics, testicular damage and oxidative stress in rats. Reproductive Toxicology 2006 21 1 42 47 2-s2.0-30044444945 10.1016/j.reprotox.2005.05.003 (Pubitemid 43048773)
38. El-Sayyad H. I., Ismail M. F., Shalaby F. M., Abou-El-Magd R. F., Gaur R. L., Fernando A., Raj M. H. G., Ouhtit A., Histopathological effects of cisplatin, doxorubicin and 5-flurouracil (5-FU) on the liver of male albino rats. International Journal of Biological Sciences 2009 5 5 466 473 2-s2.0-70249146563
39. Kart A., Cigremis Y., Karaman M., Ozen H., Caffeic acid phenethyl ester (CAPE) ameliorates cisplatin-induced hepatotoxicity in rabbit. Experimental and Toxicologic Pathology 2010 62 1 45 52 2-s2.0-71849119847 10.1016/j.etp.2009.02. 066
40. Kupradinun P., Tepsuwan A., Tantasi N., Meesiripun N., Rungsipipat A., Kusamran W. R., Anticlastogenic and anticarcinogenic potential of Thai bitter: gourd fruits. Asian Pacific Journal of Cancer Prevention 2011 12 5 1299 1305 2-s2.0-84857929059
41. Dorababu M., Joshi M. C., Bhawani G., Kumar M. M., Chaturvedi A., Goel R. K., Effect of aqueous extract of neem (Azadirachta indica) leaves on offensive and diffensive gastric mucosal factors in rats. Indian Journal of Physiology and Pharmacology 2006 50 3 241 249 2-s2.0-33747149610 (Pubitemid 44221166)
42. Srivastava R. C., Farookh A., Ahmad N., Misra M., Hasan S. K., Husain M. M., Evidence for the involvement of nitric oxide in cisplatin-induced toxicity in rats. BioMetals 1996 9 2 139 142 2-s2.0-0029915572 (Pubitemid 26144593)
43. Lu Y., Cederbaum A. I., Cisplatin-induced hepatotoxicity is enhanced by elevated expression of cytochrome P450 2E1. Toxicological Sciences 2006 89 2 515 523 2-s2.0-31144468764 10.1093/toxsci/kfj031 (Pubitemid 43126011)
44. Iraz M., Ozerol E., Gulec M., Tasdemir S., Idiz N., Fadillioglu E., Naziroglu M., Akyol O., Protective effect of caffeic acid phenethyl ester (CAPE) administration on cisplatin-induced oxidative damage to liver in rat. Cell Biochemistry and Function 2006 24 4 357 361 2-s2.0-33746025372 10.1002/cbf.1232 (Pubitemid 44065240)
45. Mansour H. H., Hafez F., Fahmy N. M., Silymarin modulates cisplatin-induced oxidative stress and hepatotoxicity in rats. Journal of Biochemistry and Molecular Biology 2006 39 6 656 661 2-s2.0-33845406305 (Pubitemid 44892889)
46. Santos N. A. G., Bezerra C. S. C., Martins N. M., Curti C., Bianchi M. L. P., Santos A. C., Hydroxyl radical scavenger ameliorates cisplatin-induced nephrotoxicity by preventing oxidative stress, redox state unbalance, impairment of energetic metabolism and apoptosis in rat kidney mitochondria. Cancer Chemotherapy and Pharmacology 2008 61 1 145 155 2-s2.0-34848832075 10.1007/s00280-007-0459-y (Pubitemid 47512636)
47. Lobo V., Patil A., Phatak A., Chandra N., Free radicals, antioxidants and functional foods: impact on human health. Pharmacognosy Reviews 2010 4 8 118 126 2-s2.0-78651391894 10.4103/0973-7847.70902
48. Weijl N. I., Elsendoorn T. J., Lentjes E. G. W. M., Hopman G. D., Wipkink-Bakker A., Zwinderman A. H., Cleton F. J., Osanto S., Supplementation with antioxidant micronutrients and chemotherapy-induced toxicity in cancer patients treated with cisplatin-based chemotherapy: a randomised, double-blind, placebo-controlled study. European Journal of Cancer 2004 40 11 1713 1723 2-s2.0-3142610921 10.1016/j.ejca.2004.02.029 (Pubitemid 38902907)
49. Karadeniz A., Simsek N., Karakus E., Yildirim S., Kara A., Can I., Kisa F., Emre H., Turkeli M., Royal jelly modulates oxidative stress and apoptosis in liver and kidneys of rats treated with cisplatin. Oxidative Medicine and Cellular Longevity 2012 2012 10 2-s2.0-80053508411 10.1155/2011/981793 981793
50. Bhattacharyya S., Mehta P., The hepatoprotective potential of Spirulina and vitamin C supplemention in cisplatin toxicity. Food and Function 2012 3 2 164 169 2-s2.0-84857275697 10.1039/c1fo10172b
51. Hightower R. D., Sevin B.-U., Perras J. P., Untch M., Angioli R., Ramos R., Averette H., Comparison of U-73,975 and cisplatin cytotoxicity in fresh cervical and ovarian carcinoma specimens with the ATP-chemosensitivity assay. Gynecologic Oncology 1992 47 2 186 190 2-s2.0-0026621457 10.1016/0090-8258(92) 90104-Q (Pubitemid 23001326)
52. Hassan I., Chibber S., Naseem I., Ameliorative effect of riboflavin on the cisplatin induced nephrotoxicity and hepatotoxicity under photoillumination. Food and Chemical Toxicology 2010 48 8-9 2052 2058 2-s2.0-77955049140 10.1016/j.fct.2010.05.004
53. Curran R. D., Ferrari F. K., Kispert P. H., Stadler J., Stuehr D. J., Simmons R. L., Billiar T. R., Nitric oxide and nitric oxide-generating compounds inhibit hepatocyte protein synthesis. The FASEB Journal 1991 5 7 2085 2092 2-s2.0-0025845606 (Pubitemid 121000173)
54. Chirino Y. I., Trujillo J., Sánchez-González D. J., Martínez-Martínez C. M., Cruz C., Bobadilla N. A., Pedraza-Chaverri J., Selective iNOS inhibition reduces renal damage induced by cisplatin. Toxicology Letters 2008 176 1 48 57 2-s2.0-37049025204 10.1016/j.toxlet.2007.10.006 (Pubitemid 50008205)
55. Gangar S. C., Koul A., Azadirachta indica modulates carcinogen biotransformation and reduced glutathione at peri-initiation phase of benzo(a)pyrene induced murine forestomach tumorigenesis. Phytotherapy Research 2008 22 9 1229 1238 2-s2.0-52649128348 10.1002/ptr.2453
56. Martins N. M., Santos N. A. G., Curti C., Bianchi M. L. P., Dos Santos A. C., Cisplatin induces mitochondrial oxidative stress with resultant energetic metabolism impairment, membrane rigidification and apoptosis in rat liver. Journal of Applied Toxicology 2008 28 3 337 344 2-s2.0-42049086080 10.1002/jat.1284 (Pubitemid 351518121)
57. Ezz-Din D., Gabry M. S., Farrag A. R. H., Abdel Moneim A. E., Physiological and histological impact of Azadirachta indica (neem) leaves extract in a rat model of cisplatin-induced hepato and nephrotoxicity. Journal of Medicinal Plant Research 2011 5 23 5499 5506 2-s2.0-80755125324
58. Jana S., Mandlekar S., Role of phase II drug metabolizing enzymes in cancer chemoprevention. Current Drug Metabolism 2009 10 6 595 616 2-s2.0-70450142649 10.2174/138920009789375379
59. Manikandan P., Ramalingam S. M., Vinothini G., Investigation of the chemopreventive potential of neem leaf subfractions in the hamster buccal pouch model and phytochemical characterization. European Journal of Medicinal Chemistry 2012 56 271 281
60. Bedri S., Khalil E. A., Khalid S. A., Azadirachta indica ethanolic extract protects neurons from apoptosis and mitigates brain swelling in experimental cerebral malaria. Malaria Journal 2013 12 1, article 298