메뉴 건너뛰기




Volumn 7, Issue 3, 2006, Pages 467-471

Antioxidative and Modifying Effects of a Tropical Plant Azadirachta indica (Neem) on Azoxymethane-induced Preneoplastic Lesions in the Rat Colon

Author keywords

Ell proliferation; Hemoprevention; Neem leaf; Olon carcinogenesis; Reneoplastic lesions

Indexed keywords

ANTIOXIDANT; AZOXYMETHANE; CARCINOGEN; PLANT EXTRACT;

EID: 39049195859     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (21)

References (35)
  • 1
    • 0033956132 scopus 로고    scopus 로고
    • Modulatory effects of garlic and neem leaf extracts on N-methyl-N'-nitro-Nnitrosoguanidine (MNNG)-induced oxidative stress in Wistar rats
    • Arivazhagan S, Balasenthil S, Nagini S (2000). Modulatory effects of garlic and neem leaf extracts on N-methyl-N'-nitro-Nnitrosoguanidine (MNNG)-induced oxidative stress in Wistar rats. Cell Biochem Funct, 18, 17-21.
    • (2000) Cell Biochem Funct , vol.18 , pp. 17-21
    • Arivazhagan, S.1    Balasenthil, S.2    Nagini, S.3
  • 2
    • 4644352351 scopus 로고    scopus 로고
    • Effects of aqueous extracts of garlic (Allium sativum) and neem (Azadirachta indica) leaf on hepatic and blood oxidantantioxidant status during experimental gastric carcinogenesis
    • Arivazhagan S, Velmurugan B, Bhuvaneswari V, et al (2004). Effects of aqueous extracts of garlic (Allium sativum) and neem (Azadirachta indica) leaf on hepatic and blood oxidantantioxidant status during experimental gastric carcinogenesis. J Med Food, 7, 334-9.
    • (2004) J Med Food , vol.7 , pp. 334-339
    • Arivazhagan, S.1    Velmurugan, B.2    Bhuvaneswari, V.3
  • 3
    • 0030000421 scopus 로고    scopus 로고
    • Inhibitory effect of dietary flavonol quercetin on 7 12-dimethylbenz[a]anthraceneinduced hamster buccal pouch carcinogenesis
    • Balasubramanian, S, Govindasamy, S (1996). Inhibitory effect of dietary flavonol quercetin on 7,12-dimethylbenz[a]anthraceneinduced hamster buccal pouch carcinogenesis. Carcinogenesis, 17, 877-9.
    • (1996) Carcinogenesis , vol.17 , pp. 877-879
    • Balasubramanian, S.1    Govindasamy, S.2
  • 4
    • 0014797584 scopus 로고
    • Antiinflammatory activity of saponins and other natural products
    • Bhargava KP, Gupta MB, Gupta GP, et al (1970). Antiinflammatory activity of saponins and other natural products. Ind J Med Res, 58, 724-30.
    • (1970) Ind J Med Res , vol.58 , pp. 724-730
    • Bhargava, K.P.1    Gupta, M.B.2    Gupta, G.P.3
  • 5
    • 0023629080 scopus 로고
    • Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings
    • Bird RP (1987). Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings. Cancer Lett, 37, 147-51.
    • (1987) Cancer Lett , vol.37 , pp. 147-151
    • Bird, R.P.1
  • 6
    • 0038181338 scopus 로고    scopus 로고
    • Identification of mucin-depleted foci in the unsectioned colon of azoxymethanetreated rats: correlation with carcinogenesis
    • Caderni G, Femia AP, Giannini A, et al (2003). Identification of mucin-depleted foci in the unsectioned colon of azoxymethanetreated rats: correlation with carcinogenesis. Cancer Res, 63, 2388-92.
    • (2003) Cancer Res , vol.63 , pp. 2388-2392
    • Caderni, G.1    Femia, A.P.2    Giannini, A.3
  • 7
    • 0024461716 scopus 로고
    • The effects of the bioflavonoid quercetin on squamous cell carcinoma of head and neck origin
    • Castillo MH, Perkins E, Campbell JH, et al (1989). The effects of the bioflavonoid quercetin on squamous cell carcinoma of head and neck origin. Am J Surg, 158, 351-5.
    • (1989) Am J Surg , vol.158 , pp. 351-355
    • Castillo, M.H.1    Perkins, E.2    Campbell, J.H.3
  • 8
    • 0026035117 scopus 로고
    • Inflammation and oxidative stress in carcinogenesis
    • Cerutti PA, Trump BF (1991). Inflammation and oxidative stress in carcinogenesis. Cancer Cells, 3, 1-7.
    • (1991) Cancer Cells , vol.3 , pp. 1-7
    • Cerutti, P.A.1    Trump, B.F.2
  • 9
    • 0032840096 scopus 로고    scopus 로고
    • Effects of roselle (Hibiscus sabdariffa Linn.), a Thai medicinal plant, on the mutagenicity of various known mutagens in Salmonella typhimurium and on formation of aberrant crypt foci induced by the colon carcinogens azoxymethane and 2-amino-1-methyl-6-phenylimidazo[4 5-b]pyridine in F344 rats
    • Chewonarin T, Kinouchi T, Kataoka K, et al (1999). Effects of roselle (Hibiscus sabdariffa Linn.), a Thai medicinal plant, on the mutagenicity of various known mutagens in Salmonella typhimurium and on formation of aberrant crypt foci induced by the colon carcinogens azoxymethane and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in F344 rats. Food Chem Toxicol, 37, 591-601.
    • (1999) Food Chem Toxicol , vol.37 , pp. 591-601
    • Chewonarin, T.1    Kinouchi, T.2    Kataoka, K.3
  • 10
    • 84873667729 scopus 로고    scopus 로고
    • NEEM: The Ultimate Herb. Lotus Brands, Wisconsin
    • Conrick J (2001). NEEM: The Ultimate Herb. Lotus Brands, Wisconsin.
    • (2001)
    • Conrick, J.1
  • 11
    • 1942424089 scopus 로고    scopus 로고
    • Chemopreventive potential of Azadirachta indica (Neem) leaf extract in murine carcinogenesis model systems
    • Dasgupta T, Banerjee S, Yadava PK, et al (2004). Chemopreventive potential of Azadirachta indica (Neem) leaf extract in murine carcinogenesis model systems. J Ethnopharmacol, 92, 23-36.
    • (2004) J Ethnopharmacol , vol.92 , pp. 23-36
    • Dasgupta, T.1    Banerjee, S.2    Yadava, P.K.3
  • 12
    • 33646108576 scopus 로고    scopus 로고
    • Distribution of preneoplastic lesions and tumors, and ®-catenin gene mutations in the colon carcinomas induced by 1 2-dimethlhydrazine plus dextran sulfate sodium
    • Kinjo T, Suzui M, Morioka T, et al (2006). Distribution of preneoplastic lesions and tumors, and ®-catenin gene mutations in the colon carcinomas induced by 1,2-dimethlhydrazine plus dextran sulfate sodium. J Exp Clin Cancer Res, 25, 89-95.
    • (2006) J Exp Clin Cancer Res , vol.25 , pp. 89-95
    • Kinjo, T.1    Suzui, M.2    Morioka, T.3
  • 13
    • 0032101097 scopus 로고    scopus 로고
    • Effects of neem flowers, Thai and Chinese bitter gourd fruits and sweet basil leaves on hepatic monooxygenases and glutathione Stransferase activities, and in vitro metabolic activation of chemical carcinogens in rats
    • Kusamran WR, Ratanavila A, Tepsuwan A (1998). Effects of neem flowers, Thai and Chinese bitter gourd fruits and sweet basil leaves on hepatic monooxygenases and glutathione Stransferase activities, and in vitro metabolic activation of chemical carcinogens in rats. Food Chem Toxicol, 36, 475-84.
    • (1998) Food Chem Toxicol , vol.36 , pp. 475-484
    • Kusamran, W.R.1    Ratanavila, A.2    Tepsuwan, A.3
  • 14
    • 0034202211 scopus 로고    scopus 로고
    • Antioxidants and cancer, part 3 quercetin
    • Lamson DW, Brignall MS (2000). Antioxidants and cancer, part 3: quercetin. Altern Med Rev, 5, 196-208.
    • (2000) Altern Med Rev , vol.5 , pp. 196-208
    • Lamson, D.W.1    Brignall, M.S.2
  • 15
    • 0026578044 scopus 로고
    • Inhibition of hamster buccal pouch carcinogenesis by limonin 17-beta-D-glucopyranoside
    • Miller EG, Gonzales-Sanders AP, Couvillon AM, et al (1992). Inhibition of hamster buccal pouch carcinogenesis by limonin 17-beta-D-glucopyranoside. Nutr Cancer, 17, 1-7.
    • (1992) Nutr Cancer , vol.17 , pp. 1-7
    • Miller, E.G.1    Gonzales-Sanders, A.P.2    Couvillon, A.M.3
  • 16
    • 0033917711 scopus 로고    scopus 로고
    • Inhibition of azoxymethane-induced colon cancer by orange juice
    • Miyagi Y, Om AS, Chee KM, et al (2000). Inhibition of azoxymethane-induced colon cancer by orange juice. Nutr Cancer, 36, 224-9.
    • (2000) Nutr Cancer , vol.36 , pp. 224-229
    • Miyagi, Y.1    Om, A.S.2    Chee, K.M.3
  • 17
    • 0029903225 scopus 로고    scopus 로고
    • Nitric oxide synthase activity and expression in human colorectal cancer
    • Moochhala S, Chhatwal VJ, Chan ST, et al (1996). Nitric oxide synthase activity and expression in human colorectal cancer. Carcinogenesis, 17, 1171-4.
    • (1996) Carcinogenesis , vol.17 , pp. 1171-1174
    • Moochhala, S.1    Chhatwal, V.J.2    Chan, S.T.3
  • 18
    • 0026092411 scopus 로고
    • The synergistic effect of 1-hydroxyanthraquinone on methylazoxymethanol acetateinduced carcinogenesis in rats
    • Mori Y, Yoshimi N, Iwata H, et al (1991). The synergistic effect of 1-hydroxyanthraquinone on methylazoxymethanol acetateinduced carcinogenesis in rats. Carcinogenesis, 12, 335-8.
    • (1991) Carcinogenesis , vol.12 , pp. 335-338
    • Mori, Y.1    Yoshimi, N.2    Iwata, H.3
  • 19
    • 1242271231 scopus 로고    scopus 로고
    • The modifying effect of Peucedanum japonicum, a herb in the Ryukyu Islands, on azoxymethane-induced colon preneoplastic lesions in male F344 rats
    • Morioka T, Suzui M, Nabandith V, et al (2004). The modifying effect of Peucedanum japonicum, a herb in the Ryukyu Islands, on azoxymethane-induced colon preneoplastic lesions in male F344 rats. Cancer Lett, 205, 133-41.
    • (2004) Cancer Lett , vol.205 , pp. 133-141
    • Morioka, T.1    Suzui, M.2    Nabandith, V.3
  • 20
    • 17144407588 scopus 로고    scopus 로고
    • Modifying effects of Terminalia catappa on azoxymethane-induced colon carcinogenesis in male F344 rats
    • Morioka T, Suzui M, Nabandith V, et al (2005). Modifying effects of Terminalia catappa on azoxymethane-induced colon carcinogenesis in male F344 rats. Eur J Cancer Prev, 14, 101-5.
    • (2005) Eur J Cancer Prev , vol.14 , pp. 101-105
    • Morioka, T.1    Suzui, M.2    Nabandith, V.3
  • 21
    • 0028092958 scopus 로고
    • Nitric oxide synthases: roles, tolls, and controls
    • Nathan C, Xie QW (1994). Nitric oxide synthases: roles, tolls, and controls. Cell, 78, 915-8.
    • (1994) Cell , vol.78 , pp. 915-918
    • Nathan, C.1    Xie, Q.W.2
  • 22
    • 0019378734 scopus 로고
    • Anti-inflammatory and antipyretic activities of Azadirachta indica
    • Okpanyi SN, Ezeukwu GC (1981). Anti-inflammatory and antipyretic activities of Azadirachta indica. Planta Med, 41, 34-9.
    • (1981) Planta Med , vol.41 , pp. 34-39
    • Okpanyi, S.N.1    Ezeukwu, G.C.2
  • 23
    • 0035467993 scopus 로고    scopus 로고
    • Global cancer statistics in the year 2000
    • Parkin, DM (2001). Global cancer statistics in the year 2000. Lancet Oncol, 2, 533-43.
    • (2001) Lancet Oncol , vol.2 , pp. 533-543
    • Parkin, D.M.1
  • 24
    • 0021257159 scopus 로고
    • Effects of nimbidin on acute and chronic gastro-duodenal ulcer models in experimental animals
    • Pillai NR, Santhakumari G (1984). Effects of nimbidin on acute and chronic gastro-duodenal ulcer models in experimental animals. Planta Med, 50, 143-6.
    • (1984) Planta Med , vol.50 , pp. 143-146
    • Pillai, N.R.1    Santhakumari, G.2
  • 25
    • 0025753555 scopus 로고
    • Aberrant crypts: putative preneoplastic foci in human colonic mucosa
    • Pretlow TP, Barrow BJ, Ashton WS, et al (1991). Aberrant crypts: putative preneoplastic foci in human colonic mucosa. Cancer Res, 51, 1564-7.
    • (1991) Cancer Res , vol.51 , pp. 1564-1567
    • Pretlow, T.P.1    Barrow, B.J.2    Ashton, W.S.3
  • 26
    • 0036209901 scopus 로고    scopus 로고
    • Aberrant crypt foci and colon cancer: comparison between a short- and medium-term bioassay for colon carcinogenesis using dimethylhydrazine in Wistar rats
    • Rodrigues MA, Silva LA, Salvadori DM, et al (2002). Aberrant crypt foci and colon cancer: comparison between a short- and medium-term bioassay for colon carcinogenesis using dimethylhydrazine in Wistar rats. Braz J Med Biol Res, 35, 351-5.
    • (2002) Braz J Med Biol Res , vol.35 , pp. 351-355
    • Rodrigues, M.A.1    Silva, L.A.2    Salvadori, D.M.3
  • 27
    • 0032198416 scopus 로고    scopus 로고
    • Immunopotentiating effects of Azadirachta indica (Neem) dry leaves powder in broilers, naturally infected with IBD virus
    • Sadekar RD, Kolte AY, Barmase BS, et al (1998). Immunopotentiating effects of Azadirachta indica (Neem) dry leaves powder in broilers, naturally infected with IBD virus. Ind J Exp Biol, 36, 1151-3.
    • (1998) Ind J Exp Biol , vol.36 , pp. 1151-1153
    • Sadekar, R.D.1    Kolte, A.Y.2    Barmase, B.S.3
  • 29
    • 0642371429 scopus 로고    scopus 로고
    • Ethanolic neem leaf extract protects against N-methyl -N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in Wistar rats
    • Subapriya R, Nagini S (2003). Ethanolic neem leaf extract protects against N-methyl -N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in Wistar rats. Asian Pac J Cancer Prev, 4, 215-23.
    • (2003) Asian Pac J Cancer Prev , vol.4 , pp. 215-223
    • Subapriya, R.1    Nagini, S.2
  • 31
    • 0030901206 scopus 로고    scopus 로고
    • Increased expression of inducible and endothelial constitutive nitric oxide synthases in rat colon tumors induced by azoxymethane
    • Takahashi M, Fukuda K, Ohata T, et al (1997). Increased expression of inducible and endothelial constitutive nitric oxide synthases in rat colon tumors induced by azoxymethane. Cancer Res, 57, 1233-7.
    • (1997) Cancer Res , vol.57 , pp. 1233-1237
    • Takahashi, M.1    Fukuda, K.2    Ohata, T.3
  • 32
    • 0034130822 scopus 로고    scopus 로고
    • Prevention of colonic aberrant crypt foci by dietary feeding of garcinol in male F344 rats
    • Tanaka T, Kohno H, Shimada R, et al (2000). Prevention of colonic aberrant crypt foci by dietary feeding of garcinol in male F344 rats. Carcinogenesis, 21, 1183-9.
    • (2000) Carcinogenesis , vol.21 , pp. 1183-1189
    • Tanaka, T.1    Kohno, H.2    Shimada, R.3
  • 33
    • 0027518874 scopus 로고
    • Superoxide radical scavenging activity of phenolic compounds
    • Tsujimoto Y, Hashizume H, Yamazaki M (1993). Superoxide radical scavenging activity of phenolic compounds. Int J Biochem, 25, 491-4.
    • (1993) Int J Biochem , vol.25 , pp. 491-494
    • Tsujimoto, Y.1    Hashizume, H.2    Yamazaki, M.3
  • 34
    • 0034235011 scopus 로고    scopus 로고
    • Frequent beta-catenin gene mutations and accumulations of the protein in the putative preneoplastic lesions lacking macroscopic aberrant crypt foci appearance, in rat colon carcinogenesis
    • Yamada Y, Yoshimi N, Hirose Y, et al (2000). Frequent beta-catenin gene mutations and accumulations of the protein in the putative preneoplastic lesions lacking macroscopic aberrant crypt foci appearance, in rat colon carcinogenesis. Cancer Res, 60, 3323-7.
    • (2000) Cancer Res , vol.60 , pp. 3323-3327
    • Yamada, Y.1    Yoshimi, N.2    Hirose, Y.3
  • 35
    • 9144249036 scopus 로고    scopus 로고
    • Histological and immunohistochemical observations of mucin-depleted foci (MDF) stained with Alcian blue, in rat colon carcinogenesis induced with 1 2-dimethylhydrazine dihydrochloride
    • Yoshimi N, Morioka T, Kinjo T, et al (2004). Histological and immunohistochemical observations of mucin-depleted foci (MDF) stained with Alcian blue, in rat colon carcinogenesis induced with 1,2-dimethylhydrazine dihydrochloride. Cancer Sci, 95, 792-7.
    • (2004) Cancer Sci , vol.95 , pp. 792-797
    • Yoshimi, N.1    Morioka, T.2    Kinjo, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.