Effect of aqueous extract of neem (Azadirachta indica) leaves on offensive and diffensive gastric mucosal factors in rats

Indian Journal of Physiology and Pharmacology

Volumn 50, Issue 3, 2006, Pages 241-249

  Dorababu, M ^a   Joshi, M C ^a   Bhawani, G ^a   Kumar, M Mohan ^a   Chaturvedi, Aditi ^a   Goel, R K ^a  

^a BANARAS HINDU UNIVERSITY   (India)

Author keywords

Acid pepsin secretion; Azadirachta indica; Mucin secretion; Pentagastrin; Proton pump inhibition

Indexed keywords

AZADIRACHTA INDICA EXTRACT; MUCIN; OMEPRAZOLE; PENTAGASTRIN; PEPSIN A; PROTON PUMP; PROTON PUMP INHIBITOR; STOMACH SECRETION INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AZADIRACHTA INDICA; BODY WEIGHT; CONTROLLED STUDY; DIABETES MELLITUS; DRUG ACTIVITY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; ENZYME ACTIVITY; FEMALE; FLUID INTAKE; FOOD INTAKE; HEALING; KIDNEY FUNCTION; LIFESPAN; LIVER FUNCTION; MALE; MORTALITY; MOUSE; MUCOSA CELL; NONHUMAN; ORGAN WEIGHT; PEPSIN SECRETION; PLANT LEAF; PYLORUS LIGATION; RAT; STOMACH ACID SECRETION; STOMACH FUNCTION; STOMACH JUICE; STOMACH MUCOSA; STOMACH PROTECTION; STOMACH ULCER; TOXICITY;

ANIMALS; AZADIRACHTA; DIABETES MELLITUS, EXPERIMENTAL; GASTRIC ACID; GASTRIC MUCOSA; MUCINS; PENTAGASTRIN; PEPTIC ULCER; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; PROTON PUMPS; RATS;

EID: 33747149610     PISSN: 00195499     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Murty KS, Rao DN, Rao DK, Murty LBG. A preliminary study on hypoglycemic and anti hyperglycemic effect of Azadirachta indica. Indian J Pharmacol 1978; 10: 247-250.
2. Pillai NR, Santha Kumari G. Hypoglycemic activity of Melia Azadirachta indica. Indian J Med Res 1981; 74: 931-933.
3. Sen P, Mediratta PK, Ray A. Effects of Azadirachta indica A Juss on some biochemical, immunological and visceral parameters in normal and stressed rats. Indian J Exp Biol 1992; 30: 1170-1175.
4. Ray A, Banerjee BD, Sen P. Modulation of humoral and cell mediated immune responses by Azadirachta indica (Neem) in mice. Indian J Exp Biol 1996; 34: 698-701.
5. Pillai NR, Suganthan D. Seshadri C, Santha kumari G. Anti-gastric activity of nimbidin. Indian J Med Res 1978; 68: 169-175.
6. Balakrishnan V, Narendranathan M, Subair AS, Raji EK, Pillai NR, Santhakumari G. Nimbidin in duodenal ulcer. Tropical Gastroenterology 1985; 6: 23-25.
7. Schmutterer H. In The Neem Tree edited by Schmutterer H. (Weinheim, Federal Republic of Germany: VCH) 1995; pp. 1.
8. Kraus W. Biologically active ingredients, in The Neem Tree edited by Schunutterer H. (Weinheim, Federal Republic of Germany: VCH) 1995; pp. 35.
9. Devakumar C, Sukh Dev, Chemistry, in Sukh Dev Chemistry Neem edited by Randhawa NS and Parmar BS. (2nd edition) 1996; pp-77.
10. Kontureck S J, Redecki T, Brzozowski T, Drozdowicz D, Piastuki I, Muramatsu M, Tangka M & Aihara H, Antiulcer and gastroprotective effects of solon, a synthetic flavanoid derivative of sophoradine: Role of endogenous prostaglandins. Eur J Pharmacol 1986; 125: 185-192.
11. Sachs G, Maton PN, Wallmark B. Pharmacology of parietal cell, in Pharmacology of peptic ulcer disease, edited by Collin MJ and Benjamin SB. (Springer VErlag, New York) 1991; pp-1.
12. Goel RK, Bhattacharya SK. Gastroduodenal mucosal defense and mucosal protective agents. Indian J Exp Biol 1991; 29: 701-714.
13. Dorababu M, Prabha T, Priyambada S, Agrawal VK, Aryaa NC, Goel RK. Effect of Bacopa monniera and Azadirachta indica on gastric ulceration and healing in experimental NIDDM rats. Indian J Exp Biol 2004; 42: 389-397.
14. Debnath PK, Gode KD, Govinda Das D, Sanyal AK. Effect of propranolol on gastric secretion in albino rats. Br J Pharmacol 1974; 51: 213-216.
15. Lowry OH, Rosenborough NJ, Farr AL, Randal RJ. Protein measurement with folin phenol reagent. J Biol Chem 1951; 193: 265-275.
16. Sanyal AK, Mitra PK, Goel RK. A modified method to estimate dissolved mucosubstances in gastric juice. Indian J Exp Biol 1983; 21: 78-80.
17. Mukhopadhyaya K, Bhattacharya D, Chakrabarti A, Goel RK, Sanyal AK. Effect of banana powder (Musa sapientum var. paradisiaca) on gastric mucosal shedding. J Ethnopharmacol 1987; 21: 11-19.
18. 2α on basal and pentagastrin stimulated gastric secretion in anaesthetized albino rats. Indian J Exp Biol 1982; 20: 901-903.
19. +-ATPase. In: Methods in enzymology, edited by Fleischer S, Fleischer B, Vol. 157, Academic press. Harcourt Brace Jovanovich, 1988; pp. 649-654.
20. Taussky HH, Shorr EA. Micro colorimetric method for the determination of inorganic phosphorus. J Biol Chem 1953; 202: 675-685.
21. +-ATPase inhibition and scavenging of hydroxyl radical. Life Sci 2002; 71: 2845-2865.
22. Pillai NR, Santhakumari G. Effects of nimbidin on acute and chronic gastroduodenal ulcer models in experimental animals. Planta Medica 1984; 50: 143-146.
23. Pierson RN, Holt PR, Watson RM, Keatling RR. Aspirin and gastrointestinal bleeding: Chromate 51 blood loss studies. Am J Med 1961; 31: 259-265.
24. Rainsford KD. Microvascular injury during gastric mucosal damage by inflammatory drugs in pigs and rats. Agents Actions 1983; 13: 5-6.
25. Takeuchi K, Okada M, Ebara S, Osano H. Increased microvascular permeability and lesions formation during gastric hypermotility caused by indomethacin and 2-deoxy-D-glucose in the rat. J Clin Gastroenterol 1990; 12: S76-S84.
26. Muira S, Sueatsu M, Tanaka S, Nagata S, Nagata H, Houzawa S, Suzuki M. microcirculatory disturbance in indomethacin-induced intestinal ulcer. Am J Physiol 1991; 261: G213-G219.
27. Abdel-Galil AAM, Marshall PB. Phenylbutazone and histamine formation in rat glandular stomach: Its relationship to gastric ulceration. Br J Pharmacol 1968; 33: 1-14.
28. Nagashima R, Samloff IM. Aggressive factors II: pepsin. In: Peptic ulcer disease, edited by Brocks F. Churchill Livingstone, Edinburgh. 1985; pp. 181-214.
29. Leonard A, Allen A. Gastric mucosal damage by aspirin. Gut 1986; 27: A1236-A1237.
30. Baron H. Pathophysiology of gastric acid and pepsin secretion. In: Magen and magenkrankheiten, edited by Domschke W, Wormsley KG, Stuttgart, Thieme Verlag, 1981; pp. 131-149.
31. +-ATPase activity. J Biol Chem 1985; 260: 13681-13684.
32. Goel RK, Pandey VB, Dwivedi SPD, Rao YV. Anti-inflammatory and anti-ulcer effects of Kaempferol, a flavone isolate from Rhamnus procumbent. Indian J Exp Biol 1988; 26: 121-24.