Anticlastogenic and anticarcinogenic potential of Thai bitter: Gourd fruits

Asian Pacific Journal of Cancer Prevention

Volumn 12, Issue 5, 2011, Pages 1299-1305

  Kupradinun, Piengchai ^a   Tepsuwan, Anong ^a   Tantasi, Nopsaran ^a   Meesiripun, Nuntana ^a   Rungsipipat, Anudep ^a   Kusamran, Wannee R ^a  

^a CHULALONGKORN UNIVERSITY   (Thailand)

Author keywords

AOM rodent model; Colon cancer; Micronucleus; Momordica charantia; Thai bitter gourd

Indexed keywords

EID: 84857929059     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Bourinbaiar AS, Lee-Huang S (1996). The activity of plantderived antiretroviral proteins MAP 30 and GAP 31 against herpes simplex virus in vitro. Biochem Biophys Res Comm, 219, 923-9.
2. Bieri LG, Stoewsand GS, Briggs GM, et al (1997). Report of the American Institute of Nutrition Ad Hoc Committee on Standards for Nutritional Studies. J Nutr, 10, 1340-8.
3. Block G, Patterson B, Subar A (1992). Fruits, vegetables and cancer prevention: a review of the epidemiologic evidence. Nutr. Cancer, 18, 1-29.
4. Brown JP (1980). A review of genetic effects of naturally occurring flavonoids, anthraquinones and related compounds. Mutat Res, 75, 243-77.
5. Chiampanichayakul S, Kataoka K, Arimochi H, et al (2001). Inhibitory effects of bitter melon (Momordica charantia Linn.) on bacterial mutagenesis and aberrant crypt focus formation in the rat colon. J Med Invest, 48, 88-96.
6. Deschner EE, Ruperto J, Wong J, et al (1991). Quercetin and rutin as inhibitor of azoxymethane-induced colonic neoplasia. Carcinogenesis, 12, 1193-6.
7. Dragsted LO, Strube M, Larsen JC (1993). Cancer-protective factors in fruits and vegetables: biochemical and biological background. Pharmacol Toxicol, 72, 116-35.
8. Food and Nutrition and the Prevention of Cancer: a global perspective (1997). World Cancer Research Fund/American Institute for Cancer Research. pp. 437.
9. Greenwald P, Nixon DW, Malone WF, et al (1990). Concepts in cancer chemoprevention research. Cancer, 65, 1483-90.
10. Guo D, Horio DT, Grove JS, et al (1995). Inhibition by chlorophyllin of 2-amino-3-methyl-6-phenylimidazo[4,5-f] quinoline- induced tumorigenesis in the male F344 rat. Cancer Lett, 95, 161-5.
11. Guo D, Schut HAJ, Davis CD, et al (1995). Protection by chlorophyllin and indole-3-carbinol against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced DNA adducts and colonic aberrant crypts on F344 rat. Carcinogenesis, 16, 2931-7.
12. Hayashi M, Morita T, Kodama Y, et al (1990). The micronucleus assay with mouse peripheral blood reticulocytes using acridine orange-coated slides. Mutat. Res, 245, 245-9.
13. Hong WK, Sporn MB (1997). Recent advances in chemoprevention of cancer. Science, 278, 1073-7.
14. Jiratchariyakul W, Wiwat C, Vongsakul M, et al (2001). HIV inhibitor from Thai bitter gourd. Planta Med, 67, 350-3.
15. Kim JH, Ju EM, Lee DK, et al (2002). Induction of apoptosis by momordin I in promyelocytic leukemia (HL-60) cells. Anticancer Res, 22, 1885-9.
16. Kobori M, Ohnishi-Kameyama M, Akimoto Y, et al (2008). Alpha-eleostearic acid and its dihydroxy derivative are major apoptosis-inducing components of bitter gourd. J. Agric Food Chem, 56, 10515-20.
17. Kohno H, Yasui Y, Suzuki R, et al. (2004). Dietary seed oil rich in conjugated linoleic acid from bitter melon inhibits azoxymethane-induced rat colon carcinogenesis through elevation of colonic PPARgamma expression and alteration of lipid composition. Int J Cancer, 110, 896-901.
18. Kupradinun P, Tepsuwan A, Kusamran WR (1997). Clastogenic and anticlastogenic potentials of neem flowers in erythrocytes micronucleus assay in the mouse. Thai Cancer J, 23, 34-45.
19. Kupradinun, P (2008). Anticlastogenic potentials of ivy gourd, sesbania, lemon grass and Chinese kale in the mouse. Thai J Toxicology, 23, 15-26.
20. Kupradinun P, Tepsuwan A, Kusamran WR (2011a). Anticlastogenic effect of Asiatic pennywort and Indian mulberry using rodent erythrocyte micronucleus assay. ThaiJ. Vet. Med, 41, 87-94.
21. Kupradinun P, Tepsuwan A, Kusamran WR (2011b). Anticlastogenic potential of Thai vegetable, Siamese cassia, using mouse erythrocytes micronucleus assay. Asian Biomed, (in press).
22. Kusamran WR, Ratanavila A, Tepsuwan A (1998a). Effects of neem flowers, Thai and Chinese bitter gourd fruits and sweet basil leaves on hepatic monooxygenases and glutathione S-transferase activities, and in vitro metabolic activation of chemical carcinogens in rats. Fd Chem Toxicol, 36, 475-84.
23. Kusamran WR, Tepsuwan A, Kupradinun P (1998b). Antimutagenic and anticarcinogenic potentials of some Thai vegetables. Mutat Res, 402, 247-58.
24. Lee-Huang S, Huang PL, Sun Y, et al (2000). Inhibition of MDA-MB-231 human breast tumor xenografts and HER2 expression by anti-tumor agents GAP31 and MAP30. Anticancer Res, 20, 215-35.
25. MacGregor JT, Jurd L (1978). Mutagenicity of plant flavonoids; structural requirements for mutagenic activity in Salmonella typhimurium. Mutat Res, 54, 297-309.
26. Nagasawa H, Watanabe K, Inatomi H (2002). Effects of bitter melon (Momordica charantia l.) or ginger rhizome (Zingiber offifinale rosc) on spontaneous mammary tumorigenesis in SHN mice. Am J Clin Med, 30, 195-205.
27. Nelson RL (1992). Chlorophyllin, an antimutagen, acts as a tumor promoter in the rat-dimethylhydrazine colon carcinogenesis model. Anticancer Res, 12, 737-9.
28. Nerurkar P, Ray RB (2010). Bitter melon: Antagonist to cancer. Pharm Res, 27, 1049-53.
29. Pence BC, Buddingh F, Yang SP (1986). Multiple dietary factors in the enhancement of dimethylhydrazine carcinogenesis: main effect of indole-3-carbinol. J Natl Cancer Inst, 77, 269-76.
30. Peto R, Pike MC, Day NE, et al (1980). Guidelines for simple, sensitive significance tests for carcinogenic effects in long-term animal experiments. IARC Monographs on the evaluation of the carcinogenic risk of chemicals to humans, Supplement 2, Long-term and short-term screening assays for carcinogens: a critical appraisal, International Agency for Research on Cancer, Lyon, pp. 311-426.
31. Phillips RL, Snowdon DA (1985). Dietary relationship with fatal colorectal cancer among Seventh-Day Adventists. J Natl Cancer Inst, 74, 307-17.
32. Pereira MA, Grubbs CJ, Barnes LH, et al (1996). Effects of the phytochemicals, curcumin and quercetin, upon azoxymethane-induced colon cancer and 7,12-dimethylbez(a) anthracene-induced mammary cancer in rats. Carcinogenesis, 17, 1305-11.
33. Potterat O, Hamburger M (2007). Morinda citrifolia (Noni) fruit-phytochemistry, pharmacology, safety. Planta Med, 73, 191-9.
34. Reeves PG, Nielsen FH, Fahay Jr GC (1993). AIN-93 purified diet for laboratory rodents: Final report of the American Institute of Nutrition Ad Hoc Writing Committee on the reformulation of the AIN-76 rodent diet. J Nutr, 123, 1939-51.
35. Rojanapo W, Tepsuwan A (1992). Mutagenic and antimutagenic activities of some vegetables. Bull Dept Med Serv,17, 461-9.
36. Rojanapo W, Tepsuwan A (1993). Antimutagenic and mutagenic potentials of Chinese radish. Environmental Health Perspective, 101, 247-52.
37. Rojanapo W, Tepsuwan A, Siripong P (1990). Mutagenicity and antimutagenicity constituents from Thai medicinal plants. Basic Life Sci, 52, 447-52.
38. Rojanapo W, Tepsuwan A (1993). Antimutagenic and mutagenic potentials of Chinese radish. Environ Health Perspect, 101, 247-52.
39. Steinmetz KA, Potter JD (1991). Vegetables, fruits and cancer prevention. Cancer Cause Control, 2, 427-42.
40. Sun Y, Huang PL, Li JJ, et al (2001). Anti-HIV agent MAP30 modulates the expression profile of viral and cellular genes for proliferation and apoptosis in AIDS-related lymphoma cells infected with Kaposi's sarcoma-associated virus. Biochem Biophys Res Comm, 287, 983-94.
41. Surh YJ (2003). Cancer chemoprevention with dietary phytochemicals. Nature Rev, 3, 768-80.
42. Tajima K, Tominga S (1985). Dietary habits and gastro-intestinal cancers: A comparature case-control study of stomach and large intestinal cancer in Nagoya Japan. Jpn J Cancer Res,76, 705-16.
43. Takemoto DJ, Dunford C, Vaughn D, et al (1982). Guanylate cyclase activity in human leukemic and normal lymphocytes. Enzyme inhibition and cytotoxicity of plant extracts. Enzyme, 27, 179-88.
44. Talalay P (1992). The role of enzyme induction in protection against carcinogenesis. In: Wattenberg, L.W., Lipkin, M., Boone, C.W., Kelloff, G.J., editors. Cancer Chemoprevention. CRC Press, Inc. Boca Raton, Florida. p. 469-78.
45. Tazzari PL, de Totero D, Bolognesi A, et al (1999). An Epstein-Barr virus-infected lymphoblastoid cell line (D430B) that grows in SCID-mice with the morphologic features of a CD30+ anaplastic large cell lymphoma, and is sensitive to anti-CD30 immunotoxins. Haematologica, 84, 988-95.
46. Tepsuwan A, Kusamran WR (1997). Effect of leaves of Siamese cassia, Indian mulberry and Asiatic pennywort on the metabolizing enzymes of chemical carcinogens in rat liver. Bull Dept Med Serv, 22, 425-37.
47. Tepsuwan A, Kupradinun P, Kusamran WR (1999). Effect of Siamese cassia leaves on the activities of chemical carcinogen metabolizing enzymes and on mammary gland carcinogenesis in the rat. Mutat Res, 428, 363-73.
48. Tepsuwan A, Kupradinun P, Kusamran WR (2002). Chemopreventive potential of neem flowers on carcinogeninduced rat mammary and liver carcinogenesis. Asian Pac. J. Cancer Prev, 3, 231-8.
49. Tsuzuki T, Tokuyama Y, Igarashi M, et al (2004). Tumor growth suppression by α-eleostearic acid, a linolenic acid isomer with conjugated triene system, via lipid peroxidation. Carcinogenesis, 25, 1417-25.
50. Vander BJ, Harris AC, Ellis RS (1963). Reticulocyte counts by means of fluorescence microscopy. J. Lab. Clin. Med, 62, 132-40.
51. Verma AK, Johnson JA, Gould MN, et al (1988). Inhibition of 7,12-DMBA and MNU-induced rat mammary cancer by dietary flavonol, quercetin. Cancer Res, 48, S754-8.
52. Wattenberg LW (1983). Inhibition of neoplasia by minor dietary constituents. Cancer Res, 43, 2448S-53S.
53. Wattenberg LW (1985). Chemoprevention of cancer. Cancer Res, 45, 1-8.
54. Wattenberg LW (1997). Inhibition of carcinogenic effects of polycyclic hydrocarbons by benzyl isothiocyanate and related compounds. J. Natl. Cancer Inst, 58, 395-8.
55. Weisburger JH (1991). Causes, relevant mechanisms, and prevention of large bowel cancer. Semin Oncol, 18, 316-36.
56. Xu M, Bailey AC, Hernaez JF, et al (1996). Protection by green tea, black tea and indole-3-carbinol against 2-amino-3-methylimidazo[4,5-f]quinoline-induced DNA adduct and colonic aberrant crypts in the F344 rat. Carcinogenesis, 17, 1429-34.
57. Xu M, Orner GA, Bailey GS, et al (2001). Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5 f] quinoline. Carcinogenesis, 22, 309-14.
58. Yoshida MA, Sasaki M, Sugimura K, et al (1980). Cytogenetics effects of quercetin on cultured mammalian cells. Proc Jpn Acad Serv B, 56, 443-7.