The role of TL1a and DR3 in autoimmune and inflammatory diseases

Mediators of Inflammation

Volumn 2013, Issue , 2013, Pages

  Aiba, Yoshihiro ^a   Nakamura, Minoru ^a,b  

^a NATIONAL HOSPITAL ORGANIZATION NAGASAKI MEDICAL CENTER   (Japan)

^b NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DEATH RECEPTOR 3; VASCULAR ENDOTHELIAL GROWTH INHIBITOR;

ANIMAL; AUTOIMMUNE DISEASE; GENETICS; HUMAN; IMMUNOLOGY; INFLAMMATION; INFLAMMATORY BOWEL DISEASE; PHYSIOLOGY; PSORIASIS; REGULATORY T LYMPHOCYTE; REVIEW; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; TH1 CELL; TH17 CELL; TH2 CELL;

ANIMALS; ARTHRITIS, RHEUMATOID; AUTOIMMUNE DISEASES; HUMANS; INFLAMMATION; INFLAMMATORY BOWEL DISEASES; PSORIASIS; RECEPTORS, TUMOR NECROSIS FACTOR, MEMBER 25; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, REGULATORY; TH1 CELLS; TH17 CELLS; TH2 CELLS; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 15;

EID: 84893838811     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2013/258164     Document Type: Review

References (95)

1. Migone T.-S., Zhang J., Luo X., Zhuang L., Chen C., Hu B., Hong J. S., Perry J. W., Chen S.-F., Zhou J. X. H., Cho Y. H., Ullrich S., Kanakaraj P., Carrell J., Boyd E., Olsen H. S., Hu G., Pukac L., Liu D., Ni J., Kim S., Gentz R., Feng P., Moore P. A., Ruben S. M., Wei P., TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. Immunity 2002 16 3 479 492 2-s2.0-18344385475 10.1016/S1074-7613(02)00283-2 (Pubitemid 34260924)
2. Zhan C., Yan Q., Patskovsky Y., Li Z., Toro R., Meyer A., Cheng H., Brenowitz M., Nathenson S. G., Almo S. C., Biochemical and structural characterization of the human TL1A ectodomain. Biochemistry 2009 48 32 7636 7645 2-s2.0-68849112042 10.1021/bi900031w
3. Mück C., Herndler-Brandstetter D., Micutkova L., Grubeck-Loebenstein B., Jansen-Dürr P., Two functionally distinct isoforms of TL1A (TNFSF15) generated by differential ectodomain shedding. The Journals of Gerontology A 2010 65 11 1165 1180 2-s2.0-77958069021 10.1093/gerona/glq129
4. Zhang J., Wang X., Fahmi H., Wojcik S., Fikes J., Yu Y., Wu J., Luo H., Role of TL1A in the pathogenesis of rheumatoid arthritis. Journal of Immunology 2009 183 8 5350 5357 2-s2.0-76649096907 10.4049/jimmunol.0802645
5. Prehn J. L., Thomas L. S., Landers C. J., Yu Q. T., Michelsen K. S., Targan S. R., The T cell costimulator TL1A is induced by Fc γ R signaling in human monocytes and dendritic cells. Journal of Immunology 2007 178 7 4033 4038 2-s2.0-33947637808 (Pubitemid 46492351)
6. Cassatella M. A., da Silva G. P., Tinazzi I., Facchetti F., Scapini P., Calzetti F., Tamassia N., Wei P., Nardelli B., Roschke V., Vecchi A., Mantovani A., Bambara L. M., Edwards S. W., Carletto A., Soluble TNF-like cytokine (TL1A) production by immune complexes stimulated monocytes in rheumatoid arthritis. Journal of Immunology 2007 178 11 7325 7333 2-s2.0-34249812070 (Pubitemid 46847460)
7. Shih D. Q., Kwan L. Y., Chavez V., Cohavy O., Gonsky R., Chang E. Y., Chang C., Elson C. O., Targan S. R., Microbial induction of inflammatory bowel disease associated gene TL1A (TNFSF15) in antigen presenting cells. European Journal of Immunology 2009 39 11 3239 3250 2-s2.0-70449417564 10.1002/eji.200839087
8. Screaton G. R., Xu X.-N., Olsen A. L., Cowper A. E., Tan R., Mcmichael A. J., Bell J. I., LARD: a new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing. Proceedings of the National Academy of Sciences of the United States of America 1997 94 9 4615 4619 2-s2.0-0030940538 10.1073/pnas.94.9.4615 (Pubitemid 27194291)
9. Tan K. B., Harrop J., Reddy M., Young P., Terrett J., Emery J., Moore G., Truneh A., Characterization of a novel TNF-like ligand and recently described TNF ligand and TNF receptor superfamily genes and their constitutive and inducible expression in hematopoietic and non-hematopoietic cells. Gene 1997 204 1-2 35 46 2-s2.0-0031578808 10.1016/S0378-1119(97)00509-X (Pubitemid 28022168)
10. Fang L., Adkins B., Deyev V., Podack E. R., Essential role of TNF receptor superfamily 25 (TNFRSF25) in the development of allergic lung inflammation. The Journal of Experimental Medicine 2008 205 5 1037 1048 2-s2.0-43549110073 10.1084/jem.20072528 (Pubitemid 351679680)
11. Jones G. W., Stumhofer J. S., Foster T., Twohig J. P., Hertzog P., Topley N., Williams A. S., Hunter C. A., Jenkins B. J., Wang E. C. Y., Jones S. A., Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation. The Journal of the Federation of American Societies for Experimental Biology 2011 25 1 409 419 2-s2.0-79251544547 10.1096/fj.10-166843
12. Schreiber T. H., Wolf D., Tsai M. S., Chirinos J., Deyev V. V., Gonzalez L., Malek T. R., Levy R. B., Podack E. R., Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation. The Journal of Clinical Investigation 2010 120 10 3629 3640 2-s2.0-77957828102 10.1172/JCI42933
13. Pappu B. P., Borodovsky A., Zheng T. S., Yang X., Wu P., Dong X., Weng S., Browning B., Scott M. L., Li M., Su L., Tian Q., Schneider P., Flavell R. A., Dong C., Burkly L. C., TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease. The Journal of Experimental Medicine 2008 205 5 1049 1062 2-s2.0-43549087629 10.1084/jem.20071364 (Pubitemid 351679681)
14. Cavallini C., Lovato O., Bertolaso A., The TNF-family cytokine TL1A inhibits proliferation of human activated B cells. PloS One 2013 8 4 e60136
15. Kitson J., Raven T., Jiang Y.-P., Goeddel D. V., Giles K. M., Pun K.-T., Grinham C. J., Brown R., Farrow S. N., A death-domain-containing receptor that mediates apoptosis. Nature 1996 384 6607 372 375 2-s2.0-0029969717 10.1038/384372a0 (Pubitemid 26408521)
16. Warzocha K., Ribeiro P., Charlot C., Renard N., Coiffier B., Salles G., New death receptor 3 isoform: expression in human lymphoid cell lines and non-Hodgkin's lymphomas. Biochemical and Biophysical Research Communications 1998 242 2 376 379 2-s2.0-0032515317 10.1006/bbrc.1997.7948 (Pubitemid 28412435)
17. Wang E. C. Y., Kitson J., Thern A., Williamson J., Farrow S. N., Owen M. J., Genomic structure, expression, and chromosome mapping of the mouse homologue for the WSL-1 (DR3, Apo3, TRAMP, LARD, TR3, TNFRSF12) gene. Immunogenetics 2001 53 1 59 63 2-s2.0-0035095008 10.1007/s002510000290 (Pubitemid 32209415)
18. Bodmer J.-L., Burns K., Schneider P., Hofmann K., Steiner V., Thome M., Bornand T., Hahne M., Schröter M., Becker K., Wilson A., French L. E., Browning J. L., Macdonald H. R., Tschopp J., TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95). Immunity 1997 6 1 79 88 2-s2.0-0030896087 10.1016/S1074- 7613(00)80244-7 (Pubitemid 27130217)
19. Chinnaiyan A. M., O'Rourke K., Yu G.-L., Lyons R. H., Garg M., Duan D. R., Xing L., Gentz R., Ni J., Dixit V. M., Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. Science 1996 274 5289 990 992 2-s2.0-10544236916 10.1126/science.274.5289.990 (Pubitemid 26398422)
20. Wen L., Zhuang L., Luo X., Wei P., TL1A-induced NF- B activation and c-IAP2 production prevent DR3-mediated apoptosis in TF-1 cells. The Journal of Biological Chemistry 2003 278 40 39251 39258 2-s2.0-0141531101 10.1074/jbc.M305833200 (Pubitemid 37221829)
21. Varfolomeev E. E., Schuchmann M., Luria V., Chiannilkulchai N., Beckmann J. S., Mett I. L., Rebrikov D., Brodianski V. M., Kemper O. C., Kollet O., Lapidot T., Soffer D., Sobe T., Avraham K. B., Goncharov T., Holtmann H., Lonai P., Wallach D., Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. Immunity 1998 9 2 267 276 2-s2.0-0032143986 (Pubitemid 28400040)
22. Yeh W.-C., de la Pompa J. L., McCurrach M. E., Shu H.-B., Elia A. J., Shahinian A., Ng M., Wakeham A., Khoo W., Mitchell K., El-Deiry W. S., Lowe S. W., Goeddel D. V., Mak T. W., FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis. Science 1998 279 5358 1954 1958 2-s2.0-7144263731 10.1126/science.279.5358.1954 (Pubitemid 28168653)
23. Wang E. C. Y., Thern A., Denzel A., Kitson J., Farrow S. N., Owen M. J., DR3 regulates negative selection during thymocyte development. Molecular and Cellular Biology 2001 21 10 3451 3461 2-s2.0-0035027854 10.1128/MCB.21.10.3451- 3461.2001 (Pubitemid 32381781)
24. Meylan F., Davidson T. S., Kahle E., Kinder M., Acharya K., Jankovic D., Bundoc V., Hodges M., Shevach E. M., Keane-Myers A., Wang E. C. Y., Siegel R. M., The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases. Immunity 2008 29 1 79 89 2-s2.0-46749097474 10.1016/j.immuni.2008.04.021
25. Bamias G., Mishina M., Nyce M., Ross W. G., Kollias G., Rivera-Nieves J., Pizarro T. T., Cominelli F., Role of TL1A and its receptor DR3 in two models of chronic murine ileitis. Proceedings of the National Academy of Sciences of the United States of America 2006 103 22 8441 8446 2-s2.0-33744791820 10.1073/pnas.0510903103 (Pubitemid 43838474)
26. Taraban V. Y., Slebioda T. J., Willoughby J. E., Buchan S. L., James S., Sheth B., Smyth N. R., Thomas G. J., Wang E. C. Y., Al-Shamkhani A., Sustained TL1A expression modulates effector and regulatory T-cell responses and drives intestinal goblet cell hyperplasia. Mucosal Immunology 2011 4 2 186 196 2-s2.0-79551556334 10.1038/mi.2010.70
27. Meylan F., Song Y.-J., Fuss I., Villarreal S., Kahle E., Malm I.-J., Acharya K., Ramos H. L., Lo L., Mentink-Kane M. M., Wynn T. A., Migone T.-S., Strober W., Siegel R. M., The TNF-family cytokine TL1A drives IL-13-dependent small intestinal inflammation. Mucosal Immunology 2011 4 2 172 185 2-s2.0-79551529001 10.1038/mi.2010.67
28. Papadakis K. A., Prehn J. L., Landers C., Han Q., Luo X., Cha S. C., Wei P., Targan S. R., TL1A synergizes with IL-12 and IL-18 to enhance IFN- γ production in human T cells and NK cells. Journal of Immunology 2004 172 11 7002 7007 2-s2.0-2442689136 (Pubitemid 38669141)
29. Twohig J. P., Marsden M., Cuff S. M., The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4(+) and CD8(+) T-cell immunity. The Journal of the Federation of American Societies For Experimental Biology 2012 26 8 3575 3586 10.1096/fj.11-200618
30. Laurence A., Tato C. M., Davidson T. S., Kanno Y., Chen Z., Yao Z., Blank R., Meylan F., Siegel R., Hennighausen L., Shevach E. M., O'Shea J., Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 2007 26 3 371 381 2-s2.0-33947162110 10.1016/j.immuni.2007.02.009 (Pubitemid 46413906)
31. Liu L., Okada S., Kong X. F., Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis. The Journal of Experimental Medicine 2011 208 8 1635 1648
32. Takedatsu H., Michelsen K. S., Wei B., Landers C. J., Thomas L. S., Dhall D., Braun J., Targan S. R., TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation. Gastroenterology 2008 135 2 552.e2 567.e2 2-s2.0-48549106477 10.1053/j.gastro.2008.04.037
33. Kayamuro H., Yoshioka Y., Abe Y., Katayama K., Yoshida T., Yamashita K., Yoshikawa T., Hiroi T., Itoh N., Kawai Y., Mayumi T., Kamada H., Tsunoda S.-I., Tsutsumi Y., TNF superfamily member, TL1A, is a potential mucosal vaccine adjuvant. Biochemical and Biophysical Research Communications 2009 384 3 296 300 2-s2.0-65649099412 10.1016/j.bbrc.2009.04.115
34. Shih D. Q., Barrett R., Zhang X., Yeager N., Koon H. W. K., Phaosawasdi P., Song Y., Ko B., Wong M. H., Michelsen K. S., Martins G., Pothoulakis C., Targan S. R., Constitutive TL1A (TNFSF15) expression on lymphoid or myeloid cells leads to mild intestinal inflammation and fibrosis. PLoS ONE 2011 6 1 2-s2.0-79251581032 10.1371/journal.pone.0016090 e16090
35. Khan S. Q., Tsai M. S., Schreiber T. H., Cloning, expression, and functional characterization of TL1A-Ig. Journal of Immunology 2013 190 4 1540 1550
36. Heidemann S. C., Chavez V., Landers C. J., Kucharzik T., Prehn J. L., Targan S. R., TL1A selectively enhances IL-12/IL-18-induced NK cell cytotoxicity against NK-resistant tumor targets. Journal of Clinical Immunology 2010 30 4 531 538 2-s2.0-77956268945 10.1007/s10875-010-9382-9
37. Yamazaki K., McGovern D., Ragoussis J., Paolucci M., Butler H., Jewell D., Cardon L., Takazoe M., Tanaka T., Ichimori T., Saito S., Sekine A., Iida A., Takahashi A., Tsunoda T., Lathrop M., Nakamura Y., Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease. Human Molecular Genetics 2005 14 22 3499 3506 2-s2.0-27944464550 10.1093/hmg/ddi379 (Pubitemid 41672132)
38. Tremelling M., Berzuini C., Massey D., Bredin F., Price C., Dawson C., Bingham S. A., Parkes M., Contribution of TNFSF15 gene variants to Crohn's disease susceptibility confirmed in UK population. Inflammatory Bowel Diseases 2008 14 6 733 737 2-s2.0-46049089270 10.1002/ibd.20399 (Pubitemid 351898055)
39. Kakuta Y., Kinouchi Y., Negoro K., Takahashi S., Shimosegawa T., Association study of TNFSF15 polymorphisms in Japanese patients with inflammatory bowel disease. Gut 2006 55 10 1527 1528 2-s2.0-33749182955 10.1136/gut.2006.100297 (Pubitemid 44476808)
40. Barrett J. C., Hansoul S., Nicolae D. L., Cho J. H., Duerr R. H., Rioux J. D., Brant S. R., Silverberg M. S., Taylor K. D., Barmada M. M., Bitton A., Dassopoulos T., Datta L. W., Green T., Griffiths A. M., Kistner E. O., Murtha M. T., Regueiro M. D., Rotter J. I., Schumm L. P., Steinhart A. H., Targan S. R., Xavier R. J., Libioulle C., Sandor C., Lathrop M., Belaiche J., Dewit O., Gut I., Heath S., Laukens D., Mni M., Rutgeerts P., van Gossum A., Zelenika D., Franchimont D., Hugot J.-P., De Vos M., Vermeire S., Louis E., Cardon L. R., Anderson C. A., Drummond H., Nimmo E., Ahmad T., Prescott N. J., Onnie C. M., Fisher S. A., Marchini J., Ghori J., Bumpstead S., Gwilliam R., Tremelling M., Deloukas P., Mansfield J., Jewell D., Satsangi J., Mathew C. G., Parkes M., Georges M., Daly M. J., Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nature Genetics 2008 40 8 955 962 2-s2.0-48349136889 10.1038/ng.175
41. Franke A., Balschun T., Karlsen T. H., Hedderich J., May S., Lu T., Schuldt D., Nikolaus S., Rosenstiel P., Krawczak M., Schreiber S., Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. Nature Genetics 2008 40 6 713 715 2-s2.0-44349173654 10.1038/ng.148 (Pubitemid 351748866)
42. Wang K., Baldassano R., Zhang H., Qu H.-Q., Imielinski M., Kugathasan S., Annese V., Dubinsky M., Rotter J. I., Russell R. K., Bradfield J. P., Sleiman P. M. A., Glessner J. T., Walters T., Hou C., Kim C., Frackelton E. C., Garris M., Doran J., Romano C., Catassi C., van Limbergen J., Guthery S. L., Denson L., Piccoli D., Silverberg M. S., Stanley C. A., Monos D., Wilson D. C., Griffiths A., Grant S. F. A., Satsangi J., Polychronakos C., Hakonarson H., Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects. Human Molecular Genetics 2010 19 10 2059 2067 2-s2.0-77952480892 10.1093/hmg/ddq078
43. Thiébaut R., Kotti S., Jung C., Merlin F., Colombel J. F., Lemann M., Almer S., Tysk C., O'Morain M., Gassull M., Binder V., Finkel Y., Pascoe L., Hugot J.-P., TNFSF15 polymorphisms are associated with susceptibility to inflammatory bowel disease in a new European cohort. The American Journal of Gastroenterology 2009 104 2 384 391 2-s2.0-59749094752 10.1038/ajg.2008.36
44. Yang S.-K., Lim J., Chang H.-S., Lee I., Li Y., Liu J., Song K., Association of TNFSF15 with Crohn's disease in Koreans. The American Journal of Gastroenterology 2008 103 6 1437 1442 2-s2.0-44949240320 10.1111/j.1572-0241. 2007.01752.x (Pubitemid 351813898)
45. Jostins L., Ripke S., Weersma R. K., Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 2012 491 7422 119 124
46. Hirano A., Yamazaki K., Umeno J., Association study of 71 European Crohn's disease susceptibility loci in a Japanese population. Inflammatory Bowel Diseases 2013 19 3 526 533
47. Cleynen I., Gonzalez J. R., Figueroa C., Genetic factors conferring an increased susceptibility to develop Crohn's disease also influence disease phenotype: results from the IBDchip European Project. Gut 2012 62 11 1556 1565
48. Haritunians T., Taylor K. D., Targan S. R., Dubinsky M., Ippoliti A., Kwon S., Guo X., Melmed G. Y., Berel D., Mengesha E., Psaty B. M., Glazer N. L., Vasiliauskas E. A., Rotter J. I., Fleshner P. R., McGovern D. P. B., Genetic predictors of medically refractory ulcerative colitis. Inflammatory Bowel Diseases 2010 16 11 1830 1840 2-s2.0-78249287838 10.1002/ibd.21293
49. Picornell Y., Mei L., Taylor K., Yang H., Targan S. R., Rotter J. I., TNFSF15 is an ethnic-specific IBD gene. Inflammatory Bowel Diseases 2007 13 11 1333 1338 2-s2.0-36749055773 10.1002/ibd.20223 (Pubitemid 350206842)
50. Michelsen K. S., Thomas L. S., Taylor K. D., Yu Q. T., Mei L., Landers C. J., Derkowski C., McGovern D. P. B., Rotter J. I., Targan S. R., IBD-associated TL1A gene (TNFSFI5) haplotypes determine increased expression of TL1A protein. PLoS ONE 2009 4 3 2-s2.0-61849115157 10.1371/journal.pone.0004719 e4719
51. Kakuta Y., Ueki N., Kinouchi Y., Negoro K., Endo K., Nomura E., Takagi S., Takahashi S., Shimosegawa T., TNFSF15 transcripts from risk haplotype for Crohn's disease are overexpressed in stimulated T cells. Human Molecular Genetics 2009 18 6 1089 1098 2-s2.0-61849167054 10.1093/hmg/ddp005
52. Zucchelli M., Camilleri M., Andreasson A. N., Bresso F., Dlugosz A., Halfvarson J., Törkvist L., Schmidt P. T., Karling P., Ohlsson B., Duerr R. H., Simren M., Lindberg G., Agreus L., Carlson P., Zinsmeister A. R., D'Amato M., Association of TNFSF15 polymorphism with irritable bowel syndrome. Gut 2011 60 12 1671 1677 2-s2.0-80052862553 10.1136/gut.2011.241877
53. Zinovieva E., Bourgain C., Kadi A., Letourneur F., Izac B., Said-Nahal R., Lebrun N., Cagnard N., Vigier A., Jacques S., Miceli-Richard C., Garchon H.-J., Heath S., Charon C., Bacq D., Boland A., Zelenika D., Chiocchia G., Breban M., Comprehensive linkage and association analyses identify haplotype, near to the TNFSF15 gene, significantly associated with spondyloarthritis. PLoS Genetics 2009 5 6 2-s2.0-67651214028 10.1371/journal.pgen.1000528 e1000528
54. Nakamura M., Nishida N., Kawashima M., Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population. American Journal of Human Genetics 2012 91 4 721 728
55. Franke A., McGovern D. P., Barrett J. C., Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nature Genetics 2010 42 12 1118 1125
56. Anderson C. A., Boucher G., Lees C. W., Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nature Genetics 2011 43 3 246 252
57. Juran B. D., Lazaridis K. N., Update on the genetics and genomics of PBC. Journal of Autoimmunity 2010 35 3 181 187 2-s2.0-77957760331 10.1016/j.jaut.2010.06.005
58. Zhang F. R., Huang W., Chen S. M., Genomewide association study of leprosy. The New England Journal of Medicine 2009 361 27 2609 2618
59. Zhang F., Liu H., Chen S., Low H., Sun L., Cui Y., Chu T., Li Y., Fu X., Yu Y., Yu G., Shi B., Tian H., Liu D., Yu X., Li J., Lu N., Bao F., Yuan C., Liu J., Liu H., Zhang L., Sun Y., Chen M., Yang Q., Yang H., Yang R., Zhang L., Wang Q., Zuo F., Zhang H., Khor C. C., Hibberd M. L., Yang S., Liu J., Zhang X., Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy. Nature Genetics 2011 43 12 1247 1251 2-s2.0-82255179222 10.1038/ng.973
60. Bamias G., Siakavellas S. I., Stamatelopoulos K. S., Chryssochoou E., Papamichael C., Sfikakis P. P., Circulating levels of TNF-like cytokine 1A (TL1A) and its decoy receptor 3 (DcR3) in rheumatoid arthritis. Clinical Immunology 2008 129 2 249 255 2-s2.0-53749090050 10.1016/j.clim.2008.07.014
61. Osawa K., Takami N., Shiozawa K., Hashiramoto A., Shiozawa S., Death receptor 3 (DR3) gene duplication in a chromosome region 1p36.3: gene duplication is more prevalent in rheumatoid arthritis. Genes and Immunity 2004 5 6 439 443 2-s2.0-4644359892 10.1038/sj.gene.6364097 (Pubitemid 39263880)
62. Kang Y.-J., Kim W.-J., Bae H.-U., Kim D.-I., Park Y. B., Park J.-E., Kwon B. S., Lee W.-H., Involvement of TL1A and DR3 in induction of pro-inflammatory cytokines and matrix metalloproteinase-9 in atherogenesis. Cytokine 2005 29 5 229 235 2-s2.0-14744279915 10.1016/j.cyto.2004.12.001 (Pubitemid 40326609)
63. Bull M. J., Williams A. S., Mecklenburgh Z., Calder C. J., Twohig J. P., Elford C., Evans B. A. J., Rowley T. F., Slebioda T. J., Taraban V. Y., Al-Shamkhani A., Wang E. C. Y., The death receptor 3-TNF-like protein 1A pathway drives adverse bone pathology in inflammatory arthritis. The Journal of Experimental Medicine 2008 205 11 2457 2464 2-s2.0-58149171978 10.1084/jem.20072378
64. Solomon D. H., Goodson N. J., Katz J. N., Weinblatt M. E., Avorn J., Setoguchi S., Canning C., Schneeweiss S., Patterns of cardiovascular risk in rheumatoid arthritis. Annals of the Rheumatic Diseases 2006 65 12 1608 1612 2-s2.0-33751291002 10.1136/ard.2005.050377 (Pubitemid 44799673)
65. McLaren J. E., Calder C. J., McSharry B. P., Sexton K., Salter R. C., Singh N. N., Wilkinson G. W. G., Wang E. C. Y., Ramji D. P., The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro. Journal of Immunology 2010 184 10 5827 5834 2-s2.0-77954752068 10.4049/jimmunol.0903782
66. Bamias G., Stamatelopoulos K., Zampeli E., Circulating levels of TNF-like cytokine 1A correlate with the progression of atheromatous lesions in patients with rheumatoid arthritis. Clinical Immunology 2013 147 2 144 150
67. Bamias G., Kaltsa G., Siakavellas S. I., Papaxoinis K., Zampeli E., Michopoulos S., Zouboulis-Vafiadis I., Ladas S. D., High intestinal and systemic levels of decoy receptor 3 (DcR3) and its ligand TL1A in active ulcerative colitis. Clinical Immunology 2010 137 2 242 249 2-s2.0-77957302227 10.1016/j.clim.2010.07.001
68. Bamias G., Martin C. III, Marini M., Hoang S., Mishina M., Ross W. G., Sachedina M. A., Friel C. M., Mize J., Bickston S. J., Pizarro T. T., Wei P., Cominelli F., Expression, localization, and functional activity of TL1A, a novel Th1-polarizing cytokine in inflammatory bowel disease. Journal of Immunology 2003 171 9 4868 4874 2-s2.0-10744225786 (Pubitemid 37310609)
69. Prehn J. L., Mehdizadeh S., Landers C. J., Luo X., Cha S. C., Wei P., Targan S. R., Potential role for TL1A, the new TNF-family member and potent costimulator of IFN- γ in mucosal inflammation. Clinical Immunology 2004 112 1 66 77 2-s2.0-2942652655 10.1016/j.clim.2004.02.007 (Pubitemid 38781059)
70. Kamada N., Hisamatsu T., Honda H., Kobayashi T., Chinen H., Takayama T., Kitazume M. T., Okamoto S., Koganei K., Sugita A., Kanai T., Hibi T., TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohn's disease. Inflammatory Bowel Diseases 2010 16 4 568 575 2-s2.0-77949514515 10.1002/ibd.21124
71. Uo M., Hisamatsu T., Miyoshi J., Mucosal CXCR4+ IgG plasma cells contribute to the pathogenesis of human ulcerative colitis through FcgammaR-mediated CD14 macrophage activation. Gut 2013 62 12 1734 1744
72. Saruta M., Yu Q. T., Avanesyan A., Fleshner P. R., Targan S. R., Papadakis K. A., Phenotype and effector function of CC chemokine receptor 9-expressing lymphocytes in small intestinal Crohn's disease. Journal of Immunology 2007 178 5 3293 3300 2-s2.0-33847390444 (Pubitemid 46333214)
73. Steenwinckel V., Louahed J., Lemaire M. M., Sommereyns C., Warnier G., McKenzie A., Brombacher F., van Snick J., Renauld J.-C., IL-9 promotes IL-13-dependent paneth cell hyperplasia and up-regulation of innate immunity mediators in intestinal mucosa. Journal of Immunology 2009 182 8 4737 4743 2-s2.0-65249123621 10.4049/jimmunol.0801941
74. Kim Y. S., Ho S. B., Intestinal goblet cells and mucins in health and disease: recent insights and progress. Current Gastroenterology Reports 2010 12 5 319 330 2-s2.0-77958170401 10.1007/s11894-010-0131-2
75. Fuss I. J., Is the Th1/Th2 paradigm of immune regulation applicable to IBD? Inflammatory Bowel Diseases 2008 14 supplement 2 S110 S112 2-s2.0-79958244691
76. Bamias G., Evangelou K., Vergou T., Tsimaratou K., Kaltsa G., Antoniou C., Kotsinas A., Kim S., Gorgoulis V., Stratigos A. J., Sfikakis P. P., Upregulation and nuclear localization of TNF-like Cytokine 1A (TL1A) and its receptors DR3 and DcR3 in psoriatic skin lesions. Experimental Dermatology 2011 20 9 725 731 2-s2.0-80051668846 10.1111/j.1600-0625.2011.01304.x
77. Aiba Y., Harada K., Komori A., Systemic and local expression levels of TNF-like ligand 1A and its decoy receptor 3 are increased in primary biliary cirrhosis. Liver International 2013 10.1111/liv.12296
78. Lee C.-S., Hu C.-Y., Tsai H.-F., Wu C.-S., Hsieh S.-L., Liu L.-C., Hsu P.-N., Elevated serum decoy receptor 3 with enhanced T cell activation in systemic lupus erythematosus. Clinical and Experimental Immunology 2008 151 3 383 390 2-s2.0-38549147922 10.1111/j.1365-2249.2007.03579.x (Pubitemid 351160729)
79. Zhang J., Salcedo T. W., Wan X., Ullrich S., Hu B., Gregorio T., Feng P., Qi S., Chen H., Cho Y. H., Li Y., Moore P. A., Wu J., Modulation of T-cell responses to alloantigens by TR6/DcR3. The Journal of Clinical Investigation 2001 107 11 1459 1468 2-s2.0-0034983086 (Pubitemid 32522040)
80. Yu K.-Y., Kwon B., Ni J., Zhai Y., Ebner R., Kwon B. S., A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis. The Journal of Biological Chemistry 1999 274 20 13733 13736 2-s2.0-0033553489 10.1074/jbc.274.20.13733 (Pubitemid 29228004)
81. Pitti R. M., Marsters S. A., Lawrence D. A., Roy M., Kischkel F. C., Dowd P., Huang A., Donahue C. J., Sherwood S. W., Baldwin D. T., Godowski P. J., Wood W. I., Gurney A. L., Hillan K. J., Cohen R. L., Goddard A. D., Botstein D., Ashkenazi A., Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer. Nature 1998 396 6712 699 703 2-s2.0-17444424930 10.1038/25387 (Pubitemid 29003951)
82. Kim S., McAuliffe W. J., Zaritskaya L. S., Moore P. A., Zhang L., Nardelli B., Selective induction of tumor necrosis receptor factor 6/decoy receptor 3 release by bacterial antigens in human monocytes and myeloid dendritic cells. Infection and Immunity 2004 72 1 89 93 2-s2.0-0346251047 10.1128/IAI.72.1.89-93.2004 (Pubitemid 38018165)
83. Kim S., Fotiadu A., Kotoula V., Increased expression of soluble decoy receptor 3 in acutely inflamed intestinal epithelia. Clinical Immunology 2005 115 3 286 294 2-s2.0-19044393886 10.1016/j.clim.2005.02.014 (Pubitemid 40712324)
84. Hsu T.-L., Chang Y.-C., Chen S.-J., Liu Y.-J., Chiu A. W., Chio C.-C., Chen L., Hsieh S.-L., Modulation of dendritic cell differentiation and maturation by decoy receptor 3. Journal of Immunology 2002 168 10 4846 4853 2-s2.0-0037093990 (Pubitemid 34495945)
85. Huang Z. M., Kang J. K., Chen C. Y., Decoy receptor 3 suppresses TLR2-mediated B cell activation by targeting NF-kappaB. Journal of Immunology 2012 188 12 5867 5876
86. Funke B., Autschbach F., Kim S., Lasitschka F., Strauch U., Rogler G., Gdynia G., Li L., Gretz N., Macher-Goeppinger S., Sido B., Schirmacher P., Meuer S. C., Roth W., Functional characterisation of decoy receptor 3 in Crohn's disease. Gut 2009 58 4 483 491 2-s2.0-63849290926 10.1136/gut.2008.148908
87. Otsuki T., Tomokuni A., Sakaguchi H., Aikoh T., Matsuki T., Isozaki Y., Hyodoh F., Ueki H., Kusaka M., Kita S., Ueki A., Over-expression of the decoy receptor 3 (DcR3) gene in peripheral blood mononuclear cells (PBMC) derived from silicosis patients. Clinical and Experimental Immunology 2000 119 2 323 327 2-s2.0-0033979307 10.1046/j.1365-2249.2000.01132.x (Pubitemid 30073037)
88. Chen J., Zhang L., Kim S., Quantification and detection of DcR3, a decoy receptor in TNFR family. Journal of Immunological Methods 2004 285 1 63 70 2-s2.0-0442323631 10.1016/j.jim.2003.11.004 (Pubitemid 38186586)
89. Chun Chen C., Hsu Yang Y., Tsan Lin Y., Liang Hsieh S., Chiang B.-L., Soluble decoy receptor 3: increased levels in atopic patients. The Journal of Allergy and Clinical Immunology 2004 114 1 195 197 2-s2.0-3442876400 10.1016/j.jaci.2004.02.048 (Pubitemid 39005139)
90. Wu Y., Han B., Sheng H., Lin M., Moore P. A., Zhang J., Wu J., Clinical significance of detecting elevated serum DcR3/TR6/M68 in malignant tumor patients. International Journal of Cancer 2003 105 5 724 732 2-s2.0-0038513479 10.1002/ijc.11138 (Pubitemid 36687744)
91. Wang Y.-L., Chou F.-C., Sung H.-H., Fan P.-L., Hsueh C.-W., Lin W.-C., Chen S.-J., Lin W.-W., Sytwu H.-K., Decoy receptor 3 protects non-obese diabetic mice from autoimmune diabetes by regulating dendritic cell maturation and function. Molecular Immunology 2010 47 16 2552 2562 2-s2.0-78649328400 10.1016/j.molimm.2010.07.001
92. Sung H.-H., Juang J.-H., Lin Y.-C., Kuo C.-H., Hung J.-T., Chen A., Chang D.-M., Chang S.-Y., Hsieh S.-L., Sytwu H.-K., Transgenic expression of decoy receptor 3 protects islets from spontaneous and chemical-induced autoimmune destruction in nonobese diabetic mice. The Journal of Experimental Medicine 2004 199 8 1143 1151 2-s2.0-2442536706 10.1084/jem.20031939 (Pubitemid 38619910)
93. Ka S.-M., Hsieh T.-T., Lin S.-H., Yang S.-S., Wu C.-C., Sytwu H.-K., Chen A., Decoy receptor 3 inhibits renal mononuclear leukocyte infiltration and apoptosis and prevents progression of IgA nephropathy in mice. American Journal of Physiology-Renal Physiology 2011 301 6 F1218 F1230 2-s2.0-82755192038 10.1152/ajprenal.00050.2011
94. Ka S.-M., Sytwu H.-K., Chang D.-M., Hsieh S.-L., Tsai P.-Y., Chen A., Decoy receptor 3 ameliorates an autoimmune crescentic glomerulonephritis model in mice. Journal of the American Society of Nephrology 2007 18 9 2473 2485 2-s2.0-34548505481 10.1681/ASN.2006111242 (Pubitemid 47378864)
95. Han B., Moore P. A., Wu J., Luo H., Overexpression of human decoy receptor 3 in mice results in a systemic lupus erythematosus-like syndrome. Arthritis and Rheumatism 2007 56 11 3748 3758 2-s2.0-36048940662 10.1002/art.22978 (Pubitemid 350100708)