TNFSF15 transcripts from risk haplotype for Crohn's disease are overexpressed in stimulated T cells

Human Molecular Genetics

Volumn 18, Issue 6, 2009, Pages 1089-1098

  Kakuta, Yoichi ^a   Ueki, Nobuo ^a   Kinouchi, Yoshitaka ^a   Negoro, Kenichi ^a   Endo, Katsuya ^a   Nomura, Eiki ^a   Takagi, Sho ^a   Takahashi, Seiichi ^a   Shimosegawa, Tooru ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

IONOMYCIN; LUCIFERASE; MESSENGER RNA; PHORBOL 13 ACETATE 12 MYRISTATE; PHYTOHEMAGGLUTININ; VASCULAR ENDOTHELIAL GROWTH INHIBITOR;

ALLELE; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; CROHN DISEASE; DISEASE PREDISPOSITION; GENE ACTIVITY; GENE DELETION; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC RISK; GENETIC TRANSCRIPTION; HAPLOTYPE; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD MONONUCLEAR CELL; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; SINGLE NUCLEOTIDE POLYMORPHISM; T LYMPHOCYTE ACTIVATION;

ALLELES; ALLELIC IMBALANCE; CALIBRATION; CELL LINE, TUMOR; CROHN DISEASE; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; LUCIFERASES; LYMPHOCYTE ACTIVATION; NUCLEAR PROTEINS; PLASMIDS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RNA, MESSENGER; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 15;

EID: 61849167054     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddp005     Document Type: Article

References (21)

1. Cho, J.H. (2008) The genetics and immunopathogenesis of inflammatory bowel disease. Nat. Rev. Immunol., 8, 458-466.
2. Mathew, C.G. (2008) New links to the pathogenesis of Crohn disease provided by genome-wide association scans. Nat. Rev. Genet., 9 9-14.
3. Ogura, Y., Bonen, D.K., Inohara, N., Nicolae, D.L., Chen, F.F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R.H. et al. (2001) A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature, 411, 603-606.
4. Hugot, J.P., Chamaillard, M., Zouali, H., Lesage, S., Cezard, J.P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C.A., Gassull, M. et al. (2001) Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature, 411, 599-603.
5. Barrett, J.C., Hansoul, S., Nicolae, D.L., Cho, J.H., Duerr, R.H., Rioux, J.D., Brant, S.R., Silverberg, M.S., Taylor, K.D., Barmada, M.M. et al. (2008) Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat. Genet., 40, 955-962.
6. Yamazaki, K., McGovern, D., Ragoussis, J., Paolucci, M., Butler, H., Jewell, D., Cardon, L., Takazoe, M., Tanaka, T., Ichimori, T. et al. (2005) Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease. Hum. Mol. Genet., 14, 3499-3506.
7. Kakuta, Y., Kinouchi, Y., Negoro, K., Takahashi, S. and Shimosegawa, T. (2006) Association study of TNFSF15 polymorphisms in Japanese patients with inflammatory bowel disease. Gut, 55, 1527-1528.
8. Migone, T.S., Zhang, J., Luo, X., Zhuang, L., Chen, C., Hu, B., Hong, J.S., Perry, J.W., Chen, S.F., Zhou, J.X. et al. (2002) TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. Immunity, 16, 479-492.
9. Bamias, G., Martin, C. 3rd, Marini, M., Hoang, S., Mishina, M., Ross, W.G., Sachedina, M.A., Friel, C.M., Mize, J., Bickston, S.J. et al. (2003) Expression, localization, and functional activity of TL1A, a novel Th1-polarizing cytokine in inflammatory bowel disease. J. Immunol., 171, 4868-4874.
10. Prehn, J.L., Mehdizadeh, S., Landers, C.J., Luo, X., Cha, S.C., Wei, P. and Targan, S.R. (2004) Potential role for TL1A, the new TNF-family member and potent costimulator of IFN-gamma, in mucosal inflammation. Clin. Immunol., 112, 66-77.
11. Papadakis, K.A., Zhu, D., Prehn, J.L., Landers, C., Avanesyan, A., Lafkas, G. and Targan, S.R. (2005) Dominant role forTL1A/DR3 pathway in IL-12 plus IL-18-induced IFN-gamma production by peripheral blood and mucosal CCR9+ T lymphocytes. J. Immunol., 174, 4985-4990.
12. Takedatsu, H., Michelsen, K.S., Wei, B., Landers, C.J., Thomas, L.S., Dhall, D., Braun, J. and Targan, S.R. (2008) TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation. Gastroenterology, 135, 552-567.
13. Milani, L., Gupta, M., Andersen, M., Dhar, S., Fryknas, M., Isaksson, A., Larsson, R. and Syvanen, A.C. (2007) Allelic imbalance in gene expression as a guide to cis-acting regulatory single nucleotide polymorphisms in cancer cells. Nucleic Acids Res., 35, e34.
14. Heinemeyer, T., Wingender, E., Reuter, I., Hermjakob, H., Kel, A.E., Kel, O.V., Ignatieva, E.V., Ananko, E.A., Podkolodnaya, O.A., Kolpakov, F.A. et al. (1998) Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL. Nucleic Acids Res., 26, 362-367.
15. Williams, N.M., Glaser, B., Norton, N., Williams, H., Pierce, T., Moskvina, V., Monks, S., Del Favero, J., Goossens, D., Rujescu, D. et al. (2008) Strong evidence that GNB1L is associated with schizophrenia. Hum. Mol. Genet., 17, 555-566.
16. Snelling, S., Ferreira, A. and Loughlin, J. (2007) Allelic expression analysis suggests that cis-acting polymorphism of FRZB expression does not contribute to osteoarthritis susceptibility. Osteoarthritis Cartilage, 15, 90-92.
17. Southam, L., Rodriguez-Lopez, J., Wilkins, J.M., Pombo-Suarez, M., Snelling, S., Gomez-Reino, J.J., Chapman, K., Gonzalez, A. and Loughlin, J. (2007) An SNP in the 5′-UTR of GDF5 is associated with osteoarthritis susceptibility in Europeans and with in vivo differences in allelic expression in articular cartilage. Hum. Mol. Genet., 16, 2226-2232.
18. Cirulli, E.T. and Goldstein, D.B. (2007) In vitro assays fail to predict in vivo effects of regulatory polymorphisms. Hum. Mol. Genet., 16, 1931-1939.
19. Bamias, G., Mishina, M., Nyce, M., Ross, W.G., Kollias, G., Rivera-Nieves, J., Pizarro, T.T. and Cominelli, F. (2006) Role of TL1A and its receptor DR3 in two models of chronic murine ileitis. Proc. Natl. Acad. Sci. U. S. A., 103, 8441-8446.
20. Norton, N., Williams, N.M., Williams, H.J., Spurlock, G., Kirov, G., Morris, D.W., Hoogendoorn, B., Owen, M.J. and O'Donovan, M.C. (2002) Universal, robust, highly quantitative SNP allele frequency measurement in DNA pools. Hum. Genet., 110, 471-478.
21. Fukuda, Y., Koga, M., Arai, M., Noguchi, E., Ohtsuki, T., Horiuchi, Y., Ishiguro, H., Niizato, K., Iritani, S., Itokawa, M. et al. (2006) Monoallelic and unequal allelic expression of the HTR2A gene in human brain and peripheral lymphocytes. Biol. Psychiatry, 60, 1331-1335.