Microbial induction of inflammatory bowel disease associated gene TL1A (TNFSF15) in antigen presenting cells

European Journal of Immunology

Volumn 39, Issue 11, 2009, Pages 3239-3250

  Shih, David Q ^a,b   Kwan, Lola Y ^a   Chavez, Valerie ^a   Cohavy, Offer ^a   Gonsky, Rivkah ^a   Chang, Elmer Y ^b   Chang, Christopher ^a   Elson, Charles O ^c   Targan, Stephan R ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c University of Alabama   (United States)

Author keywords

APC; Inflammation; Innate immunity; Monocytes; TNF

Indexed keywords

FC RECEPTOR; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN TL1A; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANAEROBIC BACTERIUM; ANTIGEN PRESENTING CELL; ARTICLE; BACTERIAL STRAIN; BACTEROIDES THETAIOTAOMICRON; BIFIDOBACTERIUM BREVE; CAMPYLOBACTER JEJUNI; CD4+ T LYMPHOCYTE; CLOSTRIDIUM; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; ENTERITIS; ENZYME ACTIVATION; ENZYME INHIBITION; ESCHERICHIA COLI; GENE EXPRESSION; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LISTERIA MONOCYTOGENES; LYMPHOCYTE FUNCTION; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SALMONELLA TYPHIMURIUM; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS EPIDERMIDIS;

ANTIGEN PRESENTATION; ANTIGEN-PRESENTING CELLS; BACTERIA; BLOTTING, WESTERN; CD4-POSITIVE T-LYMPHOCYTES; CELL SEPARATION; COCULTURE TECHNIQUES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMANS; INFLAMMATORY BOWEL DISEASES; LYMPHOCYTE ACTIVATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 15;

EID: 70449417564     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200839087     Document Type: Article

References (46)

1. Migone, T. S., Zhang, J., Luo, X., Zhuang, L., Chen, C., Hu, B., Hong, J. S. et al., TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. Immunity 2002. 16: 479-492. (Pubitemid 34260924)
2. Prehn, J. L., Mehdizadeh, S., Landers, C. J., Luo, X., Cha, S. C., Wei, P. and Targan, S. R., Potential role for TL1A, the new TNF-family member and potent costimulator of IFN-gamma, in mucosal inflammation. Clin. Immunol. 2004. 112: 66-77.
3. Papadakis, K. A., Prehn, J. L., Landers, C., Han, Q., Luo, X., Cha, S. C., Wei, P. and Targan, S. R., TL1A synergizes with IL-12 and IL-18 to enhance IFN-gamma production in human T cells and NK cells. J. Immunol. 2004. 172: 7002-7007. (Pubitemid 38669141)
4. Kunkel, E. J., Campbell, J. J., Haraldsen, G., Pan, J., Boisvert, J., Roberts, A. I., Ebert, E. C. et al., Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity. J. Exp. Med. 2000. 192: 761-768.
5. Papadakis, K. A., Zhu, D., Prehn, J. L., Landers, C., Avanesyan, A., Lafkas, G. and Targan, S. R., Dominant role for TL1A/DR3 pathway in IL-12 plus IL-18-induced IFN-gamma production by peripheral blood and mucosal CCR9+T lymphocytes. J. Immunol. 2005. 174: 4985-4990. (Pubitemid 40504583)
6. Fang, L., Adkins, B., Deyev, V. and Podack, E. R., Essential role of TNF receptor superfamily 25 (TNFRSF25) in the development of allergic lung inflammation. J. Exp. Med. 2008. 205: 1037-1048.
7. Pappu, B. P., Borodovsky, A., Zheng, T. S., Yang, X., Wu, P., Dong, X., Weng, S. et al., TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease. J. Exp. Med. 2008. 205: 1049-1062.
8. Meylan, F., Davidson, T. S., Kahle, E., Kinder, M., Acharya, K., Jankovic, D., Bundoc, V. et al., The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases. Immunity 2008. 29: 79-89.
9. Bamias, G., Martin 3rd. C., Marini, M., Hoang, S., Mishina, M., Ross, W. G., Sachedina, M. A. et al., Expression, localization, and functional activity of TL1A, a novel Th1-polarizing cytokine in inflammatory bowel disease. J. Immunol. 2003. 171: 4868-4874.
10. Bamias, G., Mishina, M., Nyce, M., Ross, W. G., Kollias, G., Rivera-Nieves, J., Pizarro, T. T. and Cominelli, F., Role of TL1A and its receptor DR3 in two models of chronic murine ileitis. [see comment]. Proc. Nat. Acad. Sci. USA 2006. 103: 8441-8446. (Pubitemid 43838474)
11. Wei, B., Velazquez, P., Turovskaya, O., Spricher, K., Aranda, R., Kronenberg, M., Birnbaumer, L. and Braun, J., Mesenteric B cells centrally inhibit CD4+T cell colitis through interaction with regulatory T cell subsets. Proc. Nat. Acad. Sci. USA 2005. 102: 2010-2015.
12. Brewer, S., McPherson, M., Fujiwara, D., Turovskaya, O., Ziring, D., Chen, L., Takedatsu, H. et al., Molecular imaging of murine intestinal inflammation with 2-deoxy-2-[18F]fluoro-D-glucose and positron emission tomography. Gastroenterology 2008. 135: 744-755.
13. Takedatsu, H., Michelsen, K. S., Wei, B., Landers, C. J., Thomas, L. S., Dhall, D., Braun, J. and Targan, S. R., TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation. Gastroenterology 2008. 135: 552-567.
14. Barrett, J. C., Hansoul, S., Nicolae, D. L., Cho, J. H., Duerr, R. H., Rioux, J. D., Brant, S. R. et al., Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat. Genet. 2008. 40: 955-962.
15. Yamazaki, K., McGovern, D., Ragoussis, J., Paolucci, M., Butler, H., Jewell, D., Cardon, L. et al., Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease. Hum. Mol. Genet. 2005. 14: 3499-3506.
16. Kakuta, Y., Kinouchi, Y., Negoro, K., Takahashi, S. and Shimosegawa, T., Association study of TNFSF15 polymorphisms in Japanese patients with inflammatory bowel disease. Gut 2006. 55: 1527-1528. (Pubitemid 44476808)
17. Tremelling, M., Berzuini, C., Massey, D., Bredin, F., Price, C., Dawson, C., Bingham, S. A. and Parkes, M., Contribution of TNFSF15 gene variants to Crohn's disease susceptibility confirmed in UK population. Inflamm. Bowel Dis. 2008. 14: 733-737.
18. Picornell, Y., Mei, L., Taylor, K., Yang, H., Targan, S. R. and Rotter, J. I., TNFSF15 is an ethnic-specific IBD gene. Inflamm. Bowel Dis. 2007. 13: 1333-1338.
19. Kugathasan, S., Baldassano, R. N., Bradfield, J. P., Sleiman, P. M., Imielinski, M., Guthery, S. L., Cucchiara, S. et al., Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease. Nat. Genet. 2008. 40: 1211-1215.
20. Shih, D. Q. and Targan, S. R., Immunopathogenesis of inflammatory bowel disease. World J. Gastroenterol. 2008. 14: 390-400.
21. Kim, S. C., Tonkonogy, S. L., Albright, C. A., Tsang, J., Balish, E. J., Braun, J., Huycke, M. M. and Sartor, R. B., Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria.[see comment]. Gastroenterology 2005. 128: 891-906.
22. Kim, S. C., Tonkonogy, S. L., Karrasch, T., Jobin, C. and Sartor, R. B., Dual-association of gnotobiotic IL-10-/- mice with 2 nonpathogenic commensal bacteria induces aggressive pancolitis. Inflamm. Bowel Dis. 2007. 13: 1457-1466.
23. Bohn, E., Bechtold, O., Zahir, N., Frick, J. S., Reimann, J., Jilge, B. and Autenrieth, I. B., Host gene expression in the colon of gnotobiotic interleukin-2-deficient mice colonized with commensal colitogenic or noncolitogenic bacterial strains: common patterns and bacteria strain specific signatures. Inflamm. Bowel Dis. 2006. 12: 853-862.
24. Dieleman, L. A., Goerres, M. S., Arends, A., Sprengers, D., Torrice, C., Hoentjen, F., Grenther, W. B. and Sartor, R. B., Lactobacillus GG prevents recurrence of colitis in HLA-B27 transgenic rats after antibiotic treatment.[see comment]. Gut 2003. 52: 370-376.
25. Schultz, M., Tonkonogy, S. L., Sellon, R. K., Veltkamp, C., Godfrey, V. L., Kwon, J., Grenther, W. B. et al., IL-2-deficient mice raised under germfree conditions develop delayed mild focal intestinal inflammation. Am. J. Physiol. 1999. 276: G1461-1472.
26. Sartor, R. B., Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics. Gastroenterology 2004. 126: 1620-1633.
27. Cong, Y., Weaver, C. T., Lazenby, A. and Elson, C. O., Colitis induced by enteric bacterial antigen-specific CD4+T cells requires CD40-CD40 ligand interactions for a sustained increase in mucosal IL-12. J. Immunol. 2000. 165: 2173-2182. (Pubitemid 30643167)
28. Prehn, J. L., Thomas, L. S., Landers, C. J., Yu, Q. T., Michelsen, K. S. and Targan, S. R., The T cell costimulator TL1A is induced by FcgammaR signaling in human monocytes and dendritic cells. J. Immunol. 2007. 178: 4033-4038.
29. Inohara, N., Ogura, Y., Fontalba, A., Gutierrez, O., Pons, F., Crespo, J., Fukase, K. et al., Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J. Biol. Chem. 2003. 278: 5509-5512.
30. Cuenda, A., Rouse, J., Doza, Y. N., Meier, R., Cohen, P., Gallagher, T. F., Young, P. R. and Lee, J. C., SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 1995. 364: 229-233.
31. Barone, F. C., Irving, E. A., Ray, A. M., Lee, J. C., Kassis, S., Kumar, S., Badger, A. M. et al., SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemia. J. Pharmacol. Exp. Ther. 2001. 296: 312-321.
32. Grisham, M. B., Palombella, V. J., Elliott, P. J., Conner, E. M., Brand, S., Wong, H. L., Pien, C. et al., Inhibition of NF-kappa B activation in vitro and in vivo: role of 26S proteasome. Meth. Enzymol. 1999. 300: 345-363.
33. Snyder, J. G., Prewitt, R., Campsen, J. and Britt, L. D., PDTC and Mg132, inhibitors of NF-kappaB, block endotoxin induced vasodilation of isolated rat skeletal muscle arterioles. Shock 2002. 17: 304-307.
34. Tobe, M., Isobe, Y., Tomizawa, H., Nagasaki, T., Takahashi, H. and Hayashi, H., A novel structural class of potent inhibitors of NF-kappa B activation: structure-activity relationships and biological effects of 6-aminoquinazoline derivatives. Bioorg. Med. Chem. 2003. 11: 3869-3878.
35. May, M. J., D'Acquisto, F., Madge, L. A., Glockner, J., Pober, J. S. and Ghosh, S., Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex. Science 2000. 289: 1550-1554. (Pubitemid 30677473)
36. Lodes, M. J., Cong, Y., Elson, C. O., Mohamath, R., Landers, C. J., Targan, S. R., Fort, M. and Hershberg, R. M., Bacterial flagellin is a dominant antigen in Crohn disease. J. Clin. Invest. 2004. 113: 1296-1306.
37. Duck, L. W., Walter, M. R., Novak, J., Kelly, D., Tomasi, M., Cong, Y. and Elson, C. O., Isolation of flagellated bacteria implicated in Crohn's disease. Inflamm. Bowel Dis. 2007. 13: 1191-1201.
38. Papadakis, K. A., Landers, C., Prehn, J., Kouroumalis, E. A., Moreno, S. T., Gutierrez-Ramos, J. C., Hodge, M. R. and Targan, S. R., CC chemokine receptor 9 expression defines a subset of peripheral blood lymphocytes with mucosal T cell phenotype and Th1 or T-regulatory 1 cytokine profile. J. Immunol. 2003. 171: 159-165. (Pubitemid 36745284)
39. Papadakis, K. A., Prehn, J., Nelson, V., Cheng, L., Binder, S. W., Ponath, P. D., Andrew, D. P. and Targan, S. R., The role of thymus-expressed chemokine and its receptor CCR9 on lymphocytes in the regional specialization of the mucosal immune system. J. Immunol. 2000. 165: 5069-5076. (Pubitemid 30809436)
40. Papadakis, K. A., Prehn, J., Moreno, S. T., Cheng, L., Kouroumalis, E. A., Deem, R., Breaverman, T. et al., CCR9-positive lymphocytes and thymus-expressed chemokine distinguish small bowel from colonic Crohn's disease. Gastroenterology 2001. 121: 246-254. (Pubitemid 32729371)
41. Smythies, L. E., Sellers, M., Clements, R. H., Mosteller-Barnum, M., Meng, G., Benjamin, W. H., Orenstein, J. M. and Smith, P. D., Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity. J. Clin. Invest. 2005. 115: 66-75.
42. Flores-Langarica, A., Meza-Perez, S., Calderon-Amador, J., Estrada-Garcia, T., Macpherson, G., Lebecque, S., Saeland, S. et al., Network of dendritic cells within the muscular layer of the mouse intestine. Proc. Natl. Acad. Sci. USA 2005. 102: 19039-19044.
43. Chapuis, F., Rosenzwajg, M., Yagello, M., Ekman, M., Biberfeld, P. and Gluckman, J. C., Differentiation of human dendritic cells frommonocytes in vitro. Eur. J. Immunol. 1997. 27: 431-441.
44. Raffatellu, M., Santos, R. L., Verhoeven, D. E., George, M. D., Wilson, R. P., Winter, S. E., Godinez, I. et al., Simian immunodeficiency virus-induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut. Nat. Med. 2008. 14: 421-428.
45. Zenewicz, L. A. and Shen, H., Innate and adaptive immune responses to Listeria monocytogenes: a short overview. Microbes Infect. 2007. 9: 1208-1215. (Pubitemid 47375148)
46. Autieri, S. M., Lins, J. J., Leatham, M. P., Laux, D. C., Conway, T. and Cohen, P. S., L-fucose stimulates utilization of D-ribose by Escherichia coli MG1655 DeltafucAO and E. coli Nissle 1917 DeltafucAO mutants in the mouse intestine and in M9 minimal medium. Infect. Immun. 2007. 75: 5465-5475.