Mucosal CXCR4+ IgG plasma cells contribute to the pathogenesis of human ulcerative colitis through FcγR-mediated CD14 macrophage activation

Gut

Volumn 62, Issue 12, 2013, Pages 1734-1744

  Uo, Michihide ^a,b   Hisamatsu, Tadakazu ^a   Miyoshi, Jun ^a   Kaito, Daiki ^a   Yoneno, Kazuaki ^a   Kitazume, Mina T ^a   Mori, Maiko ^a,b   Sugita, Akira ^c   Koganei, Kazutaka ^c   Matsuoka, Katsuyoshi ^a   Kanai, Takanori ^a   Hibi, Toshifumi ^a  

^a KEIO UNIVERSITY   (Japan)

^b AJINOMOTO CO INC   (Japan)

^c YOKOHAMA MUNICIPAL CITIZEN'S HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CD19 ANTIGEN; CD27 ANTIGEN; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR10; CHEMOKINE RECEPTOR CXCR4; FC RECEPTOR; FC RECEPTOR II; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; INTERLEUKIN 1BETA; INTERLEUKIN 23; TOLL LIKE RECEPTOR 1; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANTIGEN ANTIBODY COMPLEX; ARTICLE; CELL COUNT; CELL FUNCTION; CELL INFILTRATION; CELL ISOLATION; COMMENSAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; ENTERITIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOSTIMULATION; IN VITRO STUDY; INTESTINE MUCOSA; INTRACELLULAR SIGNALING; LAMINA PROPRIA; MACROPHAGE ACTIVATION; MONONUCLEAR CELL; MUCOSA INFLAMMATION; PATHOGENESIS; PLASMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; ULCERATIVE COLITIS; UPREGULATION;

B CELL; IBD BASIC RESEARCH; INFLAMMATION; MACROPHAGES; ULCERATIVE COLITIS;

ANTIGENS, CD14; COLITIS, ULCERATIVE; CYTOKINES; HUMANS; IMMUNOGLOBULIN G; INTESTINAL MUCOSA; MACROPHAGE ACTIVATION; PLASMA CELLS; RECEPTORS, CXCR4; RECEPTORS, IGG; SIGNAL TRANSDUCTION; TRANSCRIPTOME;

EID: 84887501363     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2012-303063     Document Type: Article

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