The risk of heart failure and cardiometabolic complications in obesity may be masked by an apparent healthy status of normal blood glucose

Oxidative Medicine and Cellular Longevity

Volumn , Issue , 2013, Pages

  Tiwari, Shuchita ^a   Mishra, Manish ^a   Jadhav, Ashok ^a   Gerger, Courtney ^b   Lee, Paul ^a   Weber, Lynn ^b   Ndisang, Joseph Fomusi ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

8 EPI PROSTAGLANDIN F2ALPHA; 8-EPI-PROSTAGLANDIN F2ALPHA; ADIPONECTIN; ATRIAL NATRIURETIC FACTOR; CCL2 PROTEIN, RAT; DRUG DERIVATIVE; ENDOTHELIN 1; HEME OXYGENASE; HEMIN; INSULIN; MACROPHAGE INFLAMMATORY PROTEIN; METALLOPORPHYRIN; MONOCYTE CHEMOTACTIC PROTEIN 1; PROSTAGLANDIN F2 ALPHA; STANNSOPORFIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; ARTICLE; DRUG EFFECT; ECHOGRAPHY; ENZYMOLOGY; GLUCOSE BLOOD LEVEL; HEART FAILURE; HEART FUNCTION TEST; HEART MUSCLE CELL; HEART VENTRICLE; HEMODYNAMICS; INFLAMMATION; INSULIN RESISTANCE; MACROPHAGE; METABOLISM; OBESITY; PATHOLOGY; PATHOPHYSIOLOGY; RAT; RISK FACTOR; UPREGULATION; ZUCKER RAT;

ADIPONECTIN; ANIMALS; ATRIAL NATRIURETIC FACTOR; BLOOD GLUCOSE; CHEMOKINE CCL2; DINOPROST; ENDOTHELIN-1; HEART FAILURE; HEART FUNCTION TESTS; HEART VENTRICLES; HEME OXYGENASE (DECYCLIZING); HEMIN; HEMODYNAMICS; INFLAMMATION; INSULIN; INSULIN RESISTANCE; MACROPHAGE INFLAMMATORY PROTEINS; MACROPHAGES; METALLOPORPHYRINS; MYOCYTES, CARDIAC; OBESITY; RATS; RATS, ZUCKER; RISK FACTORS; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84893831897     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2013/253657     Document Type: Article

References (67)

1. Malik V. S., Willett W. C., Hu F. B., Global obesity: trends, risk factors and policy implications. Nature Reviews Endocrinology 2013 9 1 13 27
2. Han J. C., Lawlor D. A., Kimm S. Y., Childhood obesity. The Lancet 2010 375 9727 1737 1748 2-s2.0-77952323536 10.1016/S0140-6736(10)60171-7
3. Tiwari S., Ndisang J. F., The role of obesity in cardiomyopathy and nephropathy. Current Pharmaceutical Design. In press
4. Mittendorfer B., Peterson L. R., Cardiovascular consequences of obesity and targets for treatment. Drug Discovery Today 2008 5 1 53 61 2-s2.0-57249094367 10.1016/j.ddstr.2008.07.001
5. Ndisang J. F., Wang R., Novel therapeutic strategies for impaired endothelium-dependent vascular relaxation. Expert Opinion on Therapeutic Patents 2002 12 8 1237 1247 2-s2.0-0036679158 10.1517/13543776.12.8.1237 (Pubitemid 34919203)
6. Bluher M., Are there still healthy obese patients? Current Opinion in Endocrinology, Diabetes and Obesity 2012 19 5 341 346
7. den Engelsen C., Gorter K. J., Salomé P. L., Rutten G. E., Development of metabolic syndrome components in adults with a healthy obese phenotype: a three year follow-up. Obesity 2013 21 5 1025 1030 10.1002/oby.20049
8. Hirata Y., Tabata M., Kurobe H., Motoki T., Akaike M., Nishio C., Higashida M., Mikasa H., Nakaya Y., Takanashi S., Igarashi T., Kitagawa T., Sata M., Coronary atherosclerosis is associated with macrophage polarization in epicardial adipose tissue. Journal of the American College of Cardiology 2011 58 3 248 255 2-s2.0-79960065980 10.1016/j.jacc.2011.01.048
9. Gordon S., Alternative activation of macrophages. Nature Reviews Immunology 2003 3 1 23 35 (Pubitemid 37328697)
10. Lallukka S., Sevastianova K., Perttila J., Adipose tissue is inflamed in NAFLD due to obesity but not in NAFLD due to genetic variation in PNPLA3. Diabetologia 2013 56 4 886 892 10.1007/s00125-013-2829-9
11. Neumeier M., Bauer S., Brühl H., Eisinger K., Kopp A., Abke S., Walter R., Schäffler A., Buechler C., Adiponectin stimulates release of CCL2, -3, -4 and -5 while the surface abundance of CCR2 and -5 is simultaneously reduced in primary human monocytes. Cytokine 2011 56 3 573 580 2-s2.0-81455141356 10.1016/j.cyto.2011.08.017
12. Ndisang J. F., Role of heme oxygenase in inflammation, insulin-signalling, diabetes and obesity. Mediators of Inflammation 2010 2010 18 2-s2.0-77953527349 10.1155/2010/359732 359732
13. Jadhav A., Tiwari S., Lee P., Ndisang J. F., The heme oxygenase system selectively enhances the anti-inflammatory macrophage-m2 phenotype, reduces pericardial adiposity, and ameliorated cardiac injury in diabetic cardiomyopathy in zucker diabetic Fatty rats. Journal of Pharmacology and Experimental Therapeutics 2013 345 2 239 249
14. Rosenberg M., Zugck C., Nelles M., Juenger C., Frank D., Remppis A., Giannitsis E., Katus H. A., Frey N., Osteopontin, a new prognostic biomarker in patients with chronic heart failure. Circulation 2008 1 1 43 49 2-s2.0-55149122485
15. Ueland T., Dahl C. P., Kjekshus J., Hulthe J., Böhm M., Mach F., Goudev A., Lindberg M., Wikstrand J., Aukrust P., Gullestad L., Osteoprotegerin predicts progression of chronic heart failure: results from CORONA. Circulation 2011 4 2 145 152 2-s2.0-79955929820 10.1161/CIRCHEARTFAILURE.110.957332
16. Zeyda M., Gollinger K., Todoric J., Kiefer F. W., Keck M., Aszmann O., Prager G., Zlabinger G. J., Petzelbauer P., Stulnig T. M., Osteopontin is an activator of human adipose tissue macrophages and directly affects adipocyte function. Endocrinology 2011 152 6 2219 2227 2-s2.0-79956324407 10.1210/en.2010-1328
17. Oh E. S., Rhee E.-J., Oh K. W., Lee W. Y., Baek K. H., Yoon K. H., Kang M. I., Yun E. J., Park C. Y., Choi M. G., Yoo H. J., Park S. W., Circulating osteoprotegerin levels are associated with age, waist-to-hip ratio, serum total cholesterol, and low-density lipoprotein cholesterol levels in healthy Korean women. Metabolism 2005 54 1 49 54 2-s2.0-9644284520 10.1016/j.metabol.2004.08. 005 (Pubitemid 39572456)
18. Keophiphath M., Achard V., Henegar C., Rouault C., Clément K., Lacasa D. L., Macrophage-secreted factors promote a profibrotic phenotype in human preadipocytes. Molecular Endocrinology 2009 23 1 11 24 2-s2.0-58149269456 10.1210/me.2008-0183
19. Duckers H. J., Boehm M., True A. L., Yet S.-F., San H., Park J. L., Clinton Webb R., Lee M.-E., Nabel G. J., Nabel E. G., Heme oxygenase-1 protects against vascular constriction and proliferation. Nature Medicine 2001 7 6 693 698 2-s2.0-0034959256 10.1038/89068 (Pubitemid 32588025)
20. Mishra M., Ndisang J. F., A critical and comprehensive insight on heme oxygenase and related products including carbon monoxide, bilirubin, biliverdin and ferritin in type-1 and type-2 diabetes. Current Pharmaceutical Design. In press
21. Tiwari S., Ndisang J. F., The Heme oxygenase system and type-1 diabetes. Current Pharmaceutical Design. In press
22. Tiwari S., Ndisang J. F., Heme oxygenase system and hypertension: a comprehensive insight. Current Pharmaceutical Design. In press
23. Ndisang J. F., Lane N., Syed N., Jadhav A., Up-regulating the heme oxygenase system with hemin improves insulin sensitivity and glucose metabolism in adult spontaneously hypertensive rats. Endocrinology 2010 151 2 549 560 2-s2.0-74949102157 10.1210/en.2009-0471
24. Ndisang J. F., The Heme oxygenase system selectively modulates proteins implicated in metabolism, oxidative stress and inflammation in spontaneously hypertensive rats. Current Pharmaceutical Design. In press
25. Ndisang J. F., Jadhav A., Upregulating the Heme oxygenase system suppresses left ventricular hypertrophy in adult spontaneously hypertensive rats for 3 months. Journal of Cardiac Failure 2009 15 7 616 628 2-s2.0-68849093674 10.1016/j.cardfail.2009.02.003
26. Ndisang J. F., Lane N., Jadhav A., Upregulation of the heme oxygenase system ameliorates postprandial and fasting hyperglycemia in type 2 diabetes. The American Journal of Physiology 2009 296 5 E1029 E1041 2-s2.0-66149135526 10.1152/ajpendo.90241.2008
27. Ndisang J. F., Wang R., Age-related alterations in soluble guanylyl cyclase and cGMP pathway in spontaneously hypertensive rats. Journal of Hypertension 2003 21 6 1117 1124 2-s2.0-0037865221 10.1097/00004872-200306000- 00011 (Pubitemid 36667865)
28. Ndisang J. F., Tabien H. E. N., Wang R., Carbon monoxide and hypertension. Journal of Hypertension 2004 22 6 1057 1074 2-s2.0-2642537616 10.1097/00004872-200406000-00002 (Pubitemid 38720993)
29. Poornima I. G., Parikh P., Shannon R. P., Diabetic cardiomyopathy: the search for a unifying hypothesis. Circulation Research 2006 98 5 596 605 2-s2.0-33645280925 10.1161/01.RES.0000207406.94146.c2
30. Ndisang J. F., Lane N., Jadhav A., The heme oxygenase system abates hyperglycemia in zucker diabetic fatty rats by potentiating insulin-sensitizing pathways. Endocrinology 2009 150 5 2098 2108 2-s2.0-66449100734 10.1210/en.2008-0239
31. Ndisang J. F., Jadhav A., Hemin therapy suppresses inflammation and retroperitoneal adipocyte hypertrophy to improve glucose metabolism in obese rats co-morbid with insulin resistant type-2 diabetes. Diabetes, Obesity and Metabolism 2013 15 11 1029 1039 10.1111/dom.12130
32. Jadhav A., Torlakovic E., Ndisang J. F., Interaction among heme oxygenase, nuclear factor- B, and transcription activating factors in cardiac hypertrophy in hypertension. Hypertension 2008 52 5 910 917 2-s2.0-55949136575 10.1161/HYPERTENSIONAHA.108.114801
33. Ndisang J. F., Mishra M., The Heme oxygenase system selectively suppresses the proinflammatory macrophage M1 phenotype and potentiates insulin signaling in spontaneously hypertensive rats. The American Journal of Hypertension 2013 26 9 1123 1131 10.1093/ajh/hpt082
34. Ndisang J. F., Jadhav A., Hemin therapy improves kidney function in male streptozotocin-induced diabetic rats: role of the heme oxygenase/atrial- natriuretic peptide/adiponectin axis. Endocrinology. In press
35. Jadhav A., Ndisang J. F., Treatment with heme arginate alleviates adipose tissue inflammation and improves insulin sensitivity and glucose metabolism in a rat model of Human primary aldosteronism. Free Radical Biology and Medicine 2012 53 12 2277 2286
36. Jadhav A., Torlakovic E., Ndisang J. F., Hemin therapy attenuates kidney injury in deoxycorticosterone acetate-salt hypertensive rats. The American Journal of Physiology 2009 296 3 F521 F534 2-s2.0-66049154851 10.1152/ajprenal.00510.2007
37. Mosén H., Salehi A., Alm P., Henningsson R., Jimenez- Feltström J., Östenson C.-G., Efendic S., Lundquist I., Defective glucose-stimulated insulin release in the diabetic Goto-Kakizaki (GK) rat coincides with reduced activity of the islet carbon monoxide signaling pathway. Endocrinology 2005 146 3 1553 1558 2-s2.0-14244268391 10.1210/en.2004-0851 (Pubitemid 40289346)
38. Muiesan M. L., Salvetti M., Monteduro C., Bonzi B., Paini A., Viola S., Poisa P., Rizzoni D., Castellano M., Agabiti-Rosei E., Left ventricular concentric geometry during treatment adversely affects cardiovascular prognosis in hypertensive patients. Hypertension 2004 43 4 731 738 2-s2.0-12144289732 10.1161/01.HYP.0000121223.44837.de (Pubitemid 38405579)
39. Fukunaga M., Yura T., Badr K. F., Stimulatory effect of 8-Epi-PGF(2 α), an F2-isoprostane, on endothelin-1 release. Journal of Cardiovascular Pharmacology 1995 26 supplement 3 S51 S52 2-s2.0-0028806671
40. Delanty N., Reilly M. P., Pratico D., Lawson J. A., McCarthy J. F., Wood A. E., Ohnishi S. T., Fitzgerald D. J., FitzGerald G. A., 8-epi PGF(2 α) generation during coronary reperfusion: a potential quantitative marker of oxidant stress in vivo. Circulation 1997 95 11 2492 2499 2-s2.0-0030610106 (Pubitemid 27233114)
41. Piechota M., Banach M., Irzmański R., Misztal M., Rysz J., Barylski M., Piechota-Urbańska M., Kowalski J., Pawlicki L., N-terminal brain natriuretic propeptide levels correlate with procalcitonin and C-reactive protein levels in septic patients. Cellular and Molecular Biology Letters 2007 12 2 162 175 2-s2.0-34249089552 10.2478/s11658-006-0062-y (Pubitemid 46786625)
42. Aki K., Shimizu A., Masuda Y., Kuwahara N., Arai T., Ishikawa A., Fujita E., Mii A., Natori Y., Fukunaga Y., Fukuda Y., ANG II receptor blockade enhances anti-inflammatory macrophages in anti-glomerular basement membrane glomerulonephritis. The American Journal of Physiology 2010 298 4 F870 F882 2-s2.0-77950855431 10.1152/ajprenal.00374.2009
43. Anzai A., Anzai T., Nagai S., Maekawa Y., Naito K., Kaneko H., Sugano Y., Takahashi T., Abe H., Mochizuki S., Sano M., Yoshikawa T., Okada Y., Koyasu S., Ogawa S., Fukuda K., Regulatory role of dendritic cells in postinfarction healing and left ventricular remodeling. Circulation 2012 125 10 1234 1245 2-s2.0-84858382289 10.1161/CIRCULATIONAHA.111.052126
44. Heusinkveld M., de vos van Steenwijk P. J., Goedemans R., Ramwadhdoebe T. H., Gorter A., Welters M. J. P., Van Hall T., Van Der Burg S. H., M2 macrophages induced by prostaglandin E2 and IL-6 from cervical carcinoma are switched to activated M1 macrophages by CD4+ Th1 cells. Journal of Immunology 2011 187 3 1157 1165 2-s2.0-80051627660 10.4049/jimmunol.1100889
45. Bhattacharjee A., Pal S., Feldman G. M., Cathcart M. K., Hck is a key regulator of gene expression in alternatively activated human monocytes. Journal of Biological Chemistry 2011 286 42 36709 36723 2-s2.0-80054710649 10.1074/jbc.M111.291492
46. Gibbings S., Elkins N. D., Fitzgerald H., Tiao J., Weyman M. E., Shibao G., Fini M. A., Wright R. M., Xanthine oxidoreductase promotes the inflammatory state of mononuclear phagocytes through effects on chemokine expression, peroxisome proliferator-activated receptor- γ sumoylation, and HIF-1 α Journal of Biological Chemistry 2011 286 2 961 975 2-s2.0-78651409652 10.1074/jbc.M110.150847
47. Rosito G. A., Massaro J. M., Hoffmann U., Ruberg F. L., Mahabadi A. A., Vasan R. S., O'Donnell C. J., Fox C. S., Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample the framingham heart study. Circulation 2008 117 5 605 613 2-s2.0-40149093610 10.1161/CIRCULATIONAHA.107.743062
48. Sell H., Habich C., Eckel J., Adaptive immunity in obesity and insulin resistance. Nature Reviews 2012 8 12 709 716 10.1038/nrendo.2012.114
49. Li P., Wang D., Lucas J., Oparil S., Xing D., Cao X., Novak L., Renfrow M. B., Chen Y.-F., Atrial natriuretic peptide inhibits transforming growth factor β -induced Smad signaling and myofibroblast transformation in mouse cardiac fibroblasts. Circulation Research 2008 102 2 185 192 2-s2.0-41149122223 10.1161/CIRCRESAHA.107.157677 (Pubitemid 351651122)
50. Fang F., Liu L., Yang Y., Tamaki Z., Wei J., Marangoni R. G., Bhattacharyya S., Summer R. S., Ye B., Varga J., The adipokine adiponectin has potent anti-fibrotic effects mediated via adenosine monophosphate-activated protein kinase: novel target for fibrosis therapy. Arthritis Research and Therapy 2012 14 5, article R229
51. Dobaczewski M., Gonzalez-Quesada C., Frangogiannis N. G., The extracellular matrix as a modulator of the inflammatory and reparative response following myocardial infarction. Journal of Molecular and Cellular Cardiology 2010 48 3 504 511 2-s2.0-77649276038 10.1016/j.yjmcc.2009.07.015
52. Folco E. J., Rocha V. Z., López-Ilasaca M., Libby P., Adiponectin inhibits pro-inflammatory signaling in human macrophages independent of interleukin-10. Journal of Biological Chemistry 2009 284 38 25569 25575 2-s2.0-70350036010 10.1074/jbc.M109.019786
53. Robinson K., Prins J., Venkatesh B., Clinical review: adiponectin biology and its role in inflammation and critical illness. Critical Care 2011 15 2 article 221
54. McKinsey T. A., Olson E. N., Toward transcriptional therapies for the failing heart: chemical screens to modulate genes. Journal of Clinical Investigation 2005 115 3 538 546 2-s2.0-14644431730 10.1172/JCI200524144 (Pubitemid 40322223)
55. Konishi M., Sugiyama S., Sato Y., Oshima S., Sugamura K., Nozaki T., Ohba K., Matsubara J., Sumida H., Nagayoshi Y., Sakamoto K., Utsunomiya D., Awai K., Jinnouchi H., Matsuzawa Y., Yamashita Y., Asada Y., Kimura K., Umemura S., Ogawa H., Pericardial fat inflammation correlates with coronary artery disease. Atherosclerosis 2010 213 2 649 655 2-s2.0-78649754760 10.1016/j.atherosclerosis. 2010.10.007
56. Al Chekakie M. O., Welles C. C., Metoyer R., Ibrahim A., Shapira A. R., Cytron J., Santucci P., Wilber D. J., Akar J. G., Pericardial fat is independently associated with human atrial fibrillation. Journal of the American College of Cardiology 2010 56 10 784 788 2-s2.0-77956149911 10.1016/j.jacc.2010.03.071
57. Ren J., Yang M., Qi G., Zheng J., Jia L., Cheng J., Tian C., Li H., Lin X., Du J., Proinflammatory protein CARD9 is essential for infiltration of monocytic fibroblast precursors and cardiac fibrosis caused by angiotensin II infusion. The American Journal of Hypertension 2011 24 6 701 707 2-s2.0-79956062791 10.1038/ajh.2011.42
58. Shi-Wen X., Kennedy L., Renzoni E. A., Bou-Gharios G., Du Bois R. M., Black C. M., Denton C. P., Abraham D. J., Leask A., Endothelin is a downstream mediator of profibrotic responses to transforming growth factor β in human lung fibroblasts. Arthritis and Rheumatism 2007 56 12 4189 4194 2-s2.0-37149016368 10.1002/art.23134 (Pubitemid 350262347)
59. Moro C., Klimcakova E., Lolmède K., Berlan M., Lafontan M., Stich V., Bouloumié A., Galitzky J., Arner P., Langin D., Atrial natriuretic peptide inhibits the production of adipokines and cytokines linked to inflammation and insulin resistance in human subcutaneous adipose tissue. Diabetologia 2007 50 5 1038 1047 2-s2.0-34147154839 10.1007/s00125-007-0614-3 (Pubitemid 46559252)
60. Chien Y., Lai Y.-H., Kwok C. F., Ho L.-T., Endothelin-1 suppresses long-chain fatty acid uptake and glucose uptake via distinct mechanisms in 3T3-L1 adipocytes. Obesity 2011 19 1 6 12 2-s2.0-78650678400 10.1038/oby.2010.124
61. Tsukamoto O., Fujita M., Kato M., Yamazaki S., Asano Y., Ogai A., Okazaki H., Asai M., Nagamachi Y., Maeda N., Shintani Y., Minamino T., Asakura M., Kishimoto I., Funahashi T., Tomoike H., Kitakaze M., Natriuretic peptides enhance the production of adiponectin in human adipocytes and in patients with chronic heart failure. Journal of the American College of Cardiology 2009 53 22 2070 2077 2-s2.0-65649088262 10.1016/j.jacc.2009.02.038
62. Pandey K. N., Biology of natriuretic peptides and their receptors. Peptides 2005 26 6 901 932 2-s2.0-19444363531 10.1016/j.peptides.2004.09.024 (Pubitemid 40725366)
63. Riba R., Patel B., Aburima A., Naseem K. M., Globular adiponectin increases cGMP formation in blood platelets independently of nitric oxide. Journal of Thrombosis and Haemostasis 2008 6 12 2121 2131 2-s2.0-56749096780 10.1111/j.1538-7836.2008.03179.x
64. Kiemer A. K., Bildner N., Weber N. C., Vollmar A. M., Characterization of heme oxygenase 1 (heat shock protein 32) induction by atrial natriuretic peptide in human endothelial cells. Endocrinology 2003 144 3 802 812 2-s2.0-0037370554 10.1210/en.2002-220610 (Pubitemid 36262847)
65. Polte T., Hemmerle A., Berndt G., Grosser N., Abate A., Schröder H., Atrial natriuretic peptide reduces cyclosporin toxicity in renal cells: role of cGMP and heme oxygenase-1. Free Radical Biology and Medicine 2002 32 1 56 63 2-s2.0-0036139813 10.1016/S0891-5849(01)00761-4 (Pubitemid 34045137)
66. Ndisang J. F., Jadhav A., Heme arginate therapy enhanced adiponectin and atrial natriuretic peptide, but abated endothelin-1 with attenuation of kidney histopathological lesions in mineralocorticoid-induced hypertension. Journal of Pharmacology and Experimental Therapeutics 2010 334 1 87 98 2-s2.0-77953730770 10.1124/jpet.109.164871
67. Liu J., Fox C. S., Hickson D. A., May W. L., Ding J., Carr J. J., Taylor H. A., Pericardial fat and echocardiographic measures of cardiac abnormalities: the jackson heart study. Diabetes Care 2011 34 2 341 346 2-s2.0-79951685704 10.2337/dc10-1312