메뉴 건너뛰기




Volumn 3, Issue , 2014, Pages

DNA-PKcs activates the Chk2-Brca1 pathway during mitosis to ensure chromosomal stability

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; CHECKPOINT KINASE 2; DNA DEPENDENT PROTEIN KINASE; GAMMA TUBULIN;

EID: 84893830951     PISSN: None     EISSN: 21579024     Source Type: Journal    
DOI: 10.1038/oncsis.2013.49     Document Type: Article
Times cited : (38)

References (56)
  • 1
    • 84859726409 scopus 로고    scopus 로고
    • Chromosomal instability and cancer: A complex relationship with therapeutic potential
    • Bakhoum SF, Compton DA. Chromosomal instability and cancer: a complex relationship with therapeutic potential. J Clin Invest 2012; 122: 1138-1143.
    • J Clin Invest , vol.2012 , Issue.122 , pp. 1138-1143
    • Bakhoum, S.F.1    Compton, D.A.2
  • 3
    • 58149260746 scopus 로고    scopus 로고
    • The spindle checkpoint and chromosomal stability
    • Qi W, Yu H. The spindle checkpoint and chromosomal stability. Genome Dyn 2006; 1: 116-130.
    • (2006) Genome Dyn , vol.1 , pp. 116-130
    • Qi, W.1    Yu, H.2
  • 4
    • 0242287897 scopus 로고    scopus 로고
    • Merotelic kinetochore orientation occurs frequently during early mitosis in mammalian tissue cells and error correction is achieved by two different mechanisms
    • DOI 10.1242/jcs.00716
    • Cimini D, Moree B, Canman JC, Salmon ED. Merotelic kinetochore orientation occurs frequently during early mitosis in mammalian tissue cells and error correction is achieved by two different mechanisms. J Cell Sci 2003; 116: 4213-4225. (Pubitemid 37337094)
    • (2003) Journal of Cell Science , vol.116 , Issue.20 , pp. 4213-4225
    • Cimini, D.1    Moree, B.2    Canman, J.C.3    Salmon, E.D.4
  • 5
    • 70450176266 scopus 로고    scopus 로고
    • Deviant kinetochore microtubule dynamics underlie chromosomal instability
    • Bakhoum SF, Genovese G, Compton DA. Deviant kinetochore microtubule dynamics underlie chromosomal instability. Curr Biol 2009; 19: 1937-1942.
    • (2009) Curr Biol , vol.19 , pp. 1937-1942
    • Bakhoum, S.F.1    Genovese, G.2    Compton, D.A.3
  • 6
    • 67649467032 scopus 로고    scopus 로고
    • A mechanism linking extra centrosomes to chromosomal instability
    • Ganem NJ, Godinho SA, Pellman D. A mechanism linking extra centrosomes to chromosomal instability. Nature 2009; 460: 278-282.
    • (2009) Nature , vol.460 , pp. 278-282
    • Ganem, N.J.1    Godinho, S.A.2    Pellman, D.3
  • 8
    • 69249157465 scopus 로고    scopus 로고
    • The BRCA1-dependent ubiquitin ligase, gamma-tubulin, and centrosomes
    • Parvin JD. The BRCA1-dependent ubiquitin ligase, gamma-tubulin, and centrosomes. Environ Mol Mutagen 2009; 50: 649-653.
    • (2009) Environ Mol Mutagen , vol.50 , pp. 649-653
    • Parvin, J.D.1
  • 9
    • 54349102282 scopus 로고    scopus 로고
    • Regulation of centrosomes by the BRCA1-dependent ubiquitin ligase
    • Kais Z, Parvin JD. Regulation of centrosomes by the BRCA1-dependent ubiquitin ligase. Cancer Biol Ther 2008; 7: 1540-1543.
    • (2008) Cancer Biol Ther , vol.7 , pp. 1540-1543
    • Kais, Z.1    Parvin, J.D.2
  • 10
    • 33645003172 scopus 로고    scopus 로고
    • BRCA1: Cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution
    • Deng CX. BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution. Nucleic Acids Res 2006; 34: 1416-1426.
    • (2006) Nucleic Acids Res , vol.34 , pp. 1416-1426
    • Deng, C.X.1
  • 13
    • 33646243237 scopus 로고    scopus 로고
    • Identification of domains of BRCA1 critical for the ubiquitin-dependent inhibition of centrosome function
    • Sankaran S, Starita LM, Simons AM, Parvin JD. Identification of domains of BRCA1 critical for the ubiquitin-dependent inhibition of centrosome function. Cancer Res 2006; 66: 4100-4107.
    • (2006) Cancer Res , vol.66 , pp. 4100-4107
    • Sankaran, S.1    Starita, L.M.2    Simons, A.M.3    Parvin, J.D.4
  • 14
    • 25444455576 scopus 로고    scopus 로고
    • Centrosomal microtubule nucleation activity is inhibited by BRCA1-dependent ubiquitination
    • DOI 10.1128/MCB.25.19.8656-8668.2005
    • Sankaran S, Starita LM, Groen AC, Ko MJ, Parvin JD. Centrosomal microtubule nucleation activity is inhibited by BRCA1-dependent ubiquitination. Mol Cell Biol 2005; 25: 8656-8668. (Pubitemid 41369184)
    • (2005) Molecular and Cellular Biology , vol.25 , Issue.19 , pp. 8656-8668
    • Sankaran, S.1    Starita, L.M.2    Groen, A.C.3    Ko, M.J.4    Parvin, J.D.5
  • 15
    • 3242884449 scopus 로고    scopus 로고
    • The Chk2 protein kinase
    • DOI 10.1016/j.dnarep.2004.03.033, PII S1568786404001053
    • Ahn J, Urist M, Prives C. The Chk2 protein kinase. DNA Repair (Amst) 2004; 3: 1039-1047. (Pubitemid 38997946)
    • (2004) DNA Repair , vol.3 , Issue.8-9 , pp. 1039-1047
    • Ahn, J.1    Urist, M.2    Prives, C.3
  • 16
    • 0037424258 scopus 로고    scopus 로고
    • Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody
    • DOI 10.1074/jbc.M211202200
    • Tsvetkov L, Xu X, Li J, Stern DF. Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody. J Biol Chem 2003; 278: 8468-8475. (Pubitemid 36800598)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.10 , pp. 8468-8475
    • Tsvetkov, L.1    Xu, X.2    Li, J.3    Stern, D.F.4
  • 17
    • 77951971957 scopus 로고    scopus 로고
    • The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells
    • Stolz A, Ertych N, Kienitz A, Vogel C, Schneider V, Fritz B et al. The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells. Nat Cell Biol 2010; 12: 492-499.
    • (2010) Nat Cell Biol , vol.12 , pp. 492-499
    • Stolz, A.1    Ertych, N.2    Kienitz, A.3    Vogel, C.4    Schneider, V.5    Fritz, B.6
  • 18
    • 32944459979 scopus 로고    scopus 로고
    • Ataxia telangiectasia mutated and checkpoint kinase 2 regulate BRCA1 to promote the fidelity of DNA end-joining
    • Wang HC, Chou WC, Shieh SY, Shen CY. Ataxia telangiectasia mutated and checkpoint kinase 2 regulate BRCA1 to promote the fidelity of DNA end-joining. Cancer Res 2006; 66: 1391-1400.
    • (2006) Cancer Res , vol.66 , pp. 1391-1400
    • Wang, H.C.1    Chou, W.C.2    Shieh, S.Y.3    Shen, C.Y.4
  • 21
    • 0037106180 scopus 로고    scopus 로고
    • Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks
    • DOI 10.1101/gad.1015202
    • Chan DW, Chen BP, Prithivirajsingh S, Kurimasa A, Story MD, Qin J et al. Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. Genes Dev 2002; 16: 2333-2338. (Pubitemid 35034402)
    • (2002) Genes and Development , vol.16 , Issue.18 , pp. 2333-2338
    • Chan, D.W.1    Chen, B.P.-C.2    Prithivirajsingh, S.3    Kurimasa, A.4    Story, M.D.5    Qin, J.6    Chen, D.J.7
  • 23
    • 34247507469 scopus 로고    scopus 로고
    • Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break
    • Chen BP, Uematsu N, Kobayashi J, Lerenthal Y, Krempler A, Yajima H et al. Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break. J Biol Chem 2007; 282: 6582-
    • (2007) J Biol Chem , vol.282 , pp. 6582
    • Chen, B.P.1    Uematsu, N.2    Kobayashi, J.3    Lerenthal, Y.4    Krempler, A.5    Yajima, H.6
  • 24
    • 79953299693 scopus 로고    scopus 로고
    • Involvement of DNAdependent protein kinase in normal cell cycle progression through mitosis
    • Lee KJ, Lin YF, Chou HY, Yajima H, Fattah KR, Lee SC et al. Involvement of DNAdependent protein kinase in normal cell cycle progression through mitosis. J Biol Chem 2011; 286: 12796-12802.
    • (2011) J Biol Chem , vol.286 , pp. 12796-12802
    • Lee, K.J.1    Lin, Y.F.2    Chou, H.Y.3    Yajima, H.4    Fattah, K.R.5    Lee, S.C.6
  • 25
    • 77951705618 scopus 로고    scopus 로고
    • Inactivation of DNAdependent protein kinase leads to spindle disruption and mitotic catastrophe with attenuated checkpoint protein 2 Phosphorylation in response to DNA damage
    • Shang ZF, Huang B, Xu QZ, Zhang SM, Fan R, Liu XD et al. Inactivation of DNAdependent protein kinase leads to spindle disruption and mitotic catastrophe with attenuated checkpoint protein 2 Phosphorylation in response to DNA damage. Cancer Res 2010; 70: 3657-3666.
    • (2010) Cancer Res , vol.70 , pp. 3657-3666
    • Shang, Z.F.1    Huang, B.2    Xu, Q.Z.3    Zhang, S.M.4    Fan, R.5    Liu, X.D.6
  • 26
    • 77958498222 scopus 로고    scopus 로고
    • The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer
    • Smith J, Tho LM, Xu N, Gillespie DA. The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer. Adv Cancer Res 2010; 108: 73-112.
    • (2010) Adv Cancer Res , vol.108 , pp. 73-112
    • Smith, J.1    Tho, L.M.2    Xu, N.3    Gillespie, D.A.4
  • 27
    • 78649739186 scopus 로고    scopus 로고
    • Loss of the tumour-suppressor genes CHK2 and BRCA1 results in chromosomal instability
    • Stolz A, Ertych N, Bastians H. Loss of the tumour-suppressor genes CHK2 and BRCA1 results in chromosomal instability. Biochem Soc Trans 2010; 38: 1704-1708.
    • (2010) Biochem Soc Trans , vol.38 , pp. 1704-1708
    • Stolz, A.1    Ertych, N.2    Bastians, H.3
  • 28
    • 70249109233 scopus 로고    scopus 로고
    • Enhanced genomic instabilities caused by deregulated microtubule dynamics and chromosome segregation: A perspective from genetic studies in mice
    • Rao CV, Yamada HY, Yao Y, Dai W. Enhanced genomic instabilities caused by deregulated microtubule dynamics and chromosome segregation: a perspective from genetic studies in mice. Carcinogenesis 2009; 30: 1469-1474.
    • (2009) Carcinogenesis , vol.30 , pp. 1469-1474
    • Rao, C.V.1    Yamada, H.Y.2    Yao, Y.3    Dai, W.4
  • 33
    • 84875423827 scopus 로고    scopus 로고
    • The ATM protein kinase: Regulating the cellular response to genotoxic stress, and more
    • Shiloh Y, Ziv Y. The ATM protein kinase: regulating the cellular response to genotoxic stress, and more. Nat Rev Mol Cell Biol 2013; 14: 197-210.
    • (2013) Nat Rev Mol Cell Biol , vol.14 , pp. 197-210
    • Shiloh, Y.1    Ziv, Y.2
  • 36
    • 53749094913 scopus 로고    scopus 로고
    • The spindle assembly checkpoint is satisfied in the absence of interkinetochore tension during mitosis with unreplicated genomes
    • OConnell CB, Loncarek J, Hergert P, Kourtidis A, Conklin DS, Khodjakov A. The spindle assembly checkpoint is satisfied in the absence of interkinetochore tension during mitosis with unreplicated genomes. J Cell Biol 2008; 183: 29-36.
    • (2008) J Cell Biol , vol.183 , pp. 29-36
    • Oconnell, C.B.1    Loncarek, J.2    Hergert, P.3    Kourtidis, A.4    Conklin, D.S.5    Khodjakov, A.6
  • 37
    • 51649083703 scopus 로고    scopus 로고
    • Merotelic kinetochore orientation, aneuploidy, and cancer
    • Cimini D. Merotelic kinetochore orientation, aneuploidy, and cancer. Biochim Biophys Acta 2008; 1786: 32-40.
    • (2008) Biochim Biophys Acta , vol.1786 , pp. 32-40
    • Cimini, D.1
  • 38
    • 0033106326 scopus 로고    scopus 로고
    • 2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells
    • DOI 10.1016/S1097-2765(00)80466-9
    • Xu X, Weaver Z, Linke SP, Li C, Gotay J, Wang XW et al. Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol Cell 1999; 3: 389-395. (Pubitemid 29290679)
    • (1999) Molecular Cell , vol.3 , Issue.3 , pp. 389-395
    • Xu, X.1    Weaver, Z.2    Linke, S.P.3    Li, C.4    Gotay, J.5    Wang, X.-W.6    Harris, C.C.7    Ried, T.8    Deng, C.-X.9
  • 39
    • 33847776094 scopus 로고    scopus 로고
    • Microtubule-organizing centres: A re-evaluation
    • DOI 10.1038/nrm2100, PII NRM2100
    • Luders J, Stearns T. Microtubule-organizing centres: a re-evaluation. Nat Rev Mol Cell Biol 2007; 8: 161-167. (Pubitemid 46432528)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.2 , pp. 161-167
    • Luders, J.1    Stearns, T.2
  • 40
    • 33646409883 scopus 로고    scopus 로고
    • BRCA1 downregulation leads to premature inactivation of spindle checkpoint and confers paclitaxel resistance
    • Chabalier C, Lamare C, Racca C, Privat M, Valette A, Larminat F. BRCA1 downregulation leads to premature inactivation of spindle checkpoint and confers paclitaxel resistance. Cell Cycle 2006; 5: 1001-1007.
    • (2006) Cell Cycle , vol.5 , pp. 1001-1007
    • Chabalier, C.1    Lamare, C.2    Racca, C.3    Privat, M.4    Valette, A.5    Larminat, F.6
  • 41
    • 0038031592 scopus 로고    scopus 로고
    • Role of BRCA1 in cellular resistance to paclitaxel and ionizing radiation in an ovarian cancer cell line carrying a defective BRCA1
    • DOI 10.1038/sj.onc.1206319
    • Zhou C, Smith JL, Liu J. Role of BRCA1 in cellular resistance to paclitaxel and ionizing radiation in an ovarian cancer cell line carrying a defective BRCA1. Oncogene 2003; 22: 2396-2404. (Pubitemid 36560723)
    • (2003) Oncogene , vol.22 , Issue.16 , pp. 2396-2404
    • Zhou, C.1    Smith, J.L.2    Liu, J.3
  • 42
    • 0030020158 scopus 로고    scopus 로고
    • Mitotic block induced in HeLa cells by low concentrations of paclitaxel (taxol) results in abnormal mitotic exit and apoptotic cell death
    • Jordan MA, Wendell K, Gardiner S, Derry WB, Copp H, Wilson L. Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death. Cancer Res 1996; 56: 816-825. (Pubitemid 26055472)
    • (1996) Cancer Research , vol.56 , Issue.4 , pp. 816-825
    • Jordan, M.A.1    Wendell, K.2    Gardiner, S.3    Derry, W.B.4    Copp, H.5    Wilson, L.6
  • 43
    • 79952107079 scopus 로고    scopus 로고
    • Sensing centromere tension: Aurora B and the regulation of kinetochore function
    • Lampson MA, Cheeseman IM. Sensing centromere tension: Aurora B and the regulation of kinetochore function. Trends Cell Biol 2011; 21: 133-140.
    • (2011) Trends Cell Biol , vol.21 , pp. 133-140
    • Lampson, M.A.1    Cheeseman, I.M.2
  • 44
    • 60749135979 scopus 로고    scopus 로고
    • Correcting aberrant kinetochore microtubule attachments: An Aurora B-centric view
    • Kelly AE, Funabiki H. Correcting aberrant kinetochore microtubule attachments: an Aurora B-centric view. Curr Opin Cell Biol 2009; 21: 51-58.
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 51-58
    • Kelly, A.E.1    Funabiki, H.2
  • 45
    • 37049023673 scopus 로고    scopus 로고
    • Aurora-A kinase regulates breast cancer-associated gene 1 inhibition of centrosome-dependent microtubule nucleation
    • DOI 10.1158/0008-5472.CAN-07-2578
    • Sankaran S, Crone DE, Palazzo RE, Parvin JD. Aurora-A kinase regulates breast cancer associated gene 1 inhibition of centrosome-dependent microtubule nucleation. Cancer Res 2007; 67: 11186-11194. (Pubitemid 350248543)
    • (2007) Cancer Research , vol.67 , Issue.23 , pp. 11186-11194
    • Sankaran, S.1    Crone, D.E.2    Palazzo, R.E.3    Parvin, J.D.4
  • 47
    • 36448973875 scopus 로고    scopus 로고
    • CHK2 kinase: Cancer susceptibility and cancer therapy - Two sides of the same coin?
    • DOI 10.1038/nrc2251, PII NRC2251
    • Antoni L, Sodha N, Collins I, Garrett MD. CHK2 kinase: cancer susceptibility and cancer therapy-two sides of the same coin? Nat Rev Cancer 2007; 7: 925-936. (Pubitemid 350165855)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.12 , pp. 925-936
    • Antoni, L.1    Sodha, N.2    Collins, I.3    Garrett, M.D.4
  • 48
    • 4544374528 scopus 로고    scopus 로고
    • BRCA1 and BRCA2 1994 and beyond
    • Narod SA, Foulkes WD. BRCA1 and BRCA2: 1994 and beyond. Nat Rev Cancer 2004; 4: 665-676.
    • (2004) Nat Rev Cancer , vol.4 , pp. 665-676
    • Narod, S.A.1    Foulkes, W.D.2
  • 49
    • 84962662283 scopus 로고    scopus 로고
    • Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment
    • Hsu FM, Zhang S, Chen BP. Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment. Transl Cancer Res 2012; 1: 22-34.
    • (2012) Transl Cancer Res , vol.1 , pp. 22-34
    • Hsu, F.M.1    Zhang, S.2    Chen, B.P.3
  • 51
    • 35848954749 scopus 로고    scopus 로고
    • Altered expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) during gastric carcinogenesis and its clinical implications on gastric cancer
    • Lee HS, Choe G, Park KU, Park do J, Yang HK, Lee BL et al. Altered expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) during gastric carcinogenesis and its clinical implications on gastric cancer. Int J Oncol 2007; 31: 859-866.
    • (2007) Int J Oncol , vol.31 , pp. 859-866
    • Lee, H.S.1    Choe, G.2    Park, K.U.3    Park Do, J.4    Yang, H.K.5    Lee, B.L.6
  • 52
    • 79957611272 scopus 로고    scopus 로고
    • Loss of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) expression in gastric cancers
    • Lee HS, Yang HK, Kim WH, Choe G. Loss of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) expression in gastric cancers. Cancer Res Treat 2005; 37: 98-102.
    • (2005) Cancer Res Treat , vol.37 , pp. 98-102
    • Lee, H.S.1    Yang, H.K.2    Kim, W.H.3    Choe, G.4
  • 54
    • 79957603876 scopus 로고    scopus 로고
    • The association of DNA-dependent protein kinase activity of peripheral blood lymphocytes with prognosis of cancer
    • Someya M, Sakata KI, Matsumoto Y, Kamdar RP, Kai M, Toyota M et al. The association of DNA-dependent protein kinase activity of peripheral blood lymphocytes with prognosis of cancer. Br J Cancer 2011; 104: 1724-1729.
    • (2011) Br J Cancer , vol.104 , pp. 1724-1729
    • Someya, M.1    Sakata, K.I.2    Matsumoto, Y.3    Kamdar, R.P.4    Kai, M.5    Toyota, M.6
  • 55
    • 53549118024 scopus 로고    scopus 로고
    • DNA-PKcs regulates proliferation, telomere length and genomic stability in human somatic cells
    • Ruis BL, Fattah KR, Hendrickson EA. DNA-PKcs regulates proliferation, telomere length and genomic stability in human somatic cells. Mol Cell Biol 2008; 28: 6182-6195.
    • (2008) Mol Cell Biol , vol.28 , pp. 6182-6195
    • Ruis, B.L.1    Fattah, K.R.2    Hendrickson, E.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.