-
1
-
-
35548995475
-
Budding yeast mitotic chromosomes have an intrinsic bias to biorient on the spindle
-
The authors demonstrate that budding yeast Sgo1 is not only required for the tension-sensitive SAC, but also for correction of erroneous kinetochore attachments. Since bipolar attachment is more severely affected in sgo1 mutants with unseparated spindle pole bodies (SPBs) than those with separated SPBs, the authors conclude that yeast chromosomes have an intrinsic geometrical bias to bi-orientation.
-
Indjeian V.B., and Murray A.W. Budding yeast mitotic chromosomes have an intrinsic bias to biorient on the spindle. Curr Biol 17 (2007) 1837-1846. The authors demonstrate that budding yeast Sgo1 is not only required for the tension-sensitive SAC, but also for correction of erroneous kinetochore attachments. Since bipolar attachment is more severely affected in sgo1 mutants with unseparated spindle pole bodies (SPBs) than those with separated SPBs, the authors conclude that yeast chromosomes have an intrinsic geometrical bias to bi-orientation.
-
(2007)
Curr Biol
, vol.17
, pp. 1837-1846
-
-
Indjeian, V.B.1
Murray, A.W.2
-
2
-
-
56149122155
-
Bi-orienting chromosomes: acrobatics on the mitotic spindle
-
Tanaka T.U. Bi-orienting chromosomes: acrobatics on the mitotic spindle. Chromosoma 117 (2008) 521-533
-
(2008)
Chromosoma
, vol.117
, pp. 521-533
-
-
Tanaka, T.U.1
-
3
-
-
24344439888
-
The spindle checkpoint: tension versus attachment
-
Pinsky B.A., and Biggins S. The spindle checkpoint: tension versus attachment. Trends Cell Biol 15 (2005) 486-493
-
(2005)
Trends Cell Biol
, vol.15
, pp. 486-493
-
-
Pinsky, B.A.1
Biggins, S.2
-
4
-
-
1542287231
-
Tension between two kinetochores suffices for their bi-orientation on the mitotic spindle
-
Dewar H., Tanaka K., Nasmyth K., and Tanaka T.U. Tension between two kinetochores suffices for their bi-orientation on the mitotic spindle. Nature 428 (2004) 93-97
-
(2004)
Nature
, vol.428
, pp. 93-97
-
-
Dewar, H.1
Tanaka, K.2
Nasmyth, K.3
Tanaka, T.U.4
-
5
-
-
0033677801
-
Tension on chromosomes increases the number of kinetochore microtubules but only within limits
-
King J.M., and Nicklas R.B. Tension on chromosomes increases the number of kinetochore microtubules but only within limits. J Cell Sci 113 Pt 21 (2000) 3815-3823
-
(2000)
J Cell Sci
, vol.113
, Issue.PART 21
, pp. 3815-3823
-
-
King, J.M.1
Nicklas, R.B.2
-
6
-
-
51649110069
-
Heterochromatin links to centromeric protection by recruiting shugoshin
-
Yamagishi Y., Sakuno T., Shimura M., and Watanabe Y. Heterochromatin links to centromeric protection by recruiting shugoshin. Nature 455 (2008) 251-255
-
(2008)
Nature
, vol.455
, pp. 251-255
-
-
Yamagishi, Y.1
Sakuno, T.2
Shimura, M.3
Watanabe, Y.4
-
7
-
-
33846949409
-
The enhancement of pericentromeric cohesin association by conserved kinetochore components promotes high-fidelity chromosome segregation and is sensitive to microtubule-based tension
-
Eckert C.A., Gravdahl D.J., and Megee P.C. The enhancement of pericentromeric cohesin association by conserved kinetochore components promotes high-fidelity chromosome segregation and is sensitive to microtubule-based tension. Genes Dev 21 (2007) 278-291
-
(2007)
Genes Dev
, vol.21
, pp. 278-291
-
-
Eckert, C.A.1
Gravdahl, D.J.2
Megee, P.C.3
-
8
-
-
0036178929
-
Evidence that the Ipl1-Sli15 (aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections
-
Tanaka T.U., Rachidi N., Janke C., Pereira G., Galova M., Schiebel E., Stark M.J., and Nasmyth K. Evidence that the Ipl1-Sli15 (aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections. Cell 108 (2002) 317-329
-
(2002)
Cell
, vol.108
, pp. 317-329
-
-
Tanaka, T.U.1
Rachidi, N.2
Janke, C.3
Pereira, G.4
Galova, M.5
Schiebel, E.6
Stark, M.J.7
Nasmyth, K.8
-
11
-
-
35348862523
-
Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together
-
The crystal structure of survivin, N-terminal INCENP, and N-terminal Borealin reveals a three-helix bundle. The authors show that this module can recruit the CPC to the midbody during anaphase, but not to the centromere during metaphase, suggesting that the C-terminus of Borealin contributes to centromere targeting.
-
Jeyaprakash A.A., Klein U.R., Lindner D., Ebert J., Nigg E.A., and Conti E. Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together. Cell 131 (2007) 271-285. The crystal structure of survivin, N-terminal INCENP, and N-terminal Borealin reveals a three-helix bundle. The authors show that this module can recruit the CPC to the midbody during anaphase, but not to the centromere during metaphase, suggesting that the C-terminus of Borealin contributes to centromere targeting.
-
(2007)
Cell
, vol.131
, pp. 271-285
-
-
Jeyaprakash, A.A.1
Klein, U.R.2
Lindner, D.3
Ebert, J.4
Nigg, E.A.5
Conti, E.6
-
12
-
-
4944250023
-
Survivin dynamics increases at centromeres during G2/M phase transition and is regulated by microtubule-attachment and Aurora B kinase activity
-
Beardmore V.A., Ahonen L.J., Gorbsky G.J., and Kallio M.J. Survivin dynamics increases at centromeres during G2/M phase transition and is regulated by microtubule-attachment and Aurora B kinase activity. J Cell Sci 117 (2004) 4033-4042
-
(2004)
J Cell Sci
, vol.117
, pp. 4033-4042
-
-
Beardmore, V.A.1
Ahonen, L.J.2
Gorbsky, G.J.3
Kallio, M.J.4
-
13
-
-
4444249610
-
Kinetochore localization of spindle checkpoint proteins: who controls whom?
-
Vigneron S., Prieto S., Bernis C., Labbe J.C., Castro A., and Lorca T. Kinetochore localization of spindle checkpoint proteins: who controls whom?. Mol Biol Cell 15 (2004) 4584-4596
-
(2004)
Mol Biol Cell
, vol.15
, pp. 4584-4596
-
-
Vigneron, S.1
Prieto, S.2
Bernis, C.3
Labbe, J.C.4
Castro, A.5
Lorca, T.6
-
14
-
-
0013057087
-
Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores
-
Ditchfield C., Johnson V.L., Tighe A., Ellston R., Haworth C., Johnson T., Mortlock A., Keen N., and Taylor S.S. Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J Cell Biol 161 (2003) 267-280
-
(2003)
J Cell Biol
, vol.161
, pp. 267-280
-
-
Ditchfield, C.1
Johnson, V.L.2
Tighe, A.3
Ellston, R.4
Haworth, C.5
Johnson, T.6
Mortlock, A.7
Keen, N.8
Taylor, S.S.9
-
15
-
-
0038376119
-
Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension
-
Lens S.M., Wolthuis R.M., Klompmaker R., Kauw J., Agami R., Brummelkamp T., Kops G., and Medema R.H. Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension. EMBO J 22 (2003) 2934-2947
-
(2003)
EMBO J
, vol.22
, pp. 2934-2947
-
-
Lens, S.M.1
Wolthuis, R.M.2
Klompmaker, R.3
Kauw, J.4
Agami, R.5
Brummelkamp, T.6
Kops, G.7
Medema, R.H.8
-
16
-
-
42449132216
-
Aurora B kinase and protein phosphatase 1 have opposing roles in modulating kinetochore assembly
-
Emanuele M.J., Lan W., Jwa M., Miller S.A., Chan C.S., and Stukenberg P.T. Aurora B kinase and protein phosphatase 1 have opposing roles in modulating kinetochore assembly. J Cell Biol 181 (2008) 241-254
-
(2008)
J Cell Biol
, vol.181
, pp. 241-254
-
-
Emanuele, M.J.1
Lan, W.2
Jwa, M.3
Miller, S.A.4
Chan, C.S.5
Stukenberg, P.T.6
-
17
-
-
1542290607
-
Aurora B phosphorylates centromeric MCAK and regulates its localization and microtubule depolymerization activity
-
Lan W., Zhang X., Kline-Smith S.L., Rosasco S.E., Barrett-Wilt G.A., Shabanowitz J., Hunt D.F., Walczak C.E., and Stukenberg P.T. Aurora B phosphorylates centromeric MCAK and regulates its localization and microtubule depolymerization activity. Curr Biol 14 (2004) 273-286
-
(2004)
Curr Biol
, vol.14
, pp. 273-286
-
-
Lan, W.1
Zhang, X.2
Kline-Smith, S.L.3
Rosasco, S.E.4
Barrett-Wilt, G.A.5
Shabanowitz, J.6
Hunt, D.F.7
Walczak, C.E.8
Stukenberg, P.T.9
-
18
-
-
0442294189
-
Aurora B regulates MCAK at the mitotic centromere
-
Andrews P.D., Ovechkina Y., Morrice N., Wagenbach M., Duncan K., Wordeman L., and Swedlow J.R. Aurora B regulates MCAK at the mitotic centromere. Dev Cell 6 (2004) 253-268
-
(2004)
Dev Cell
, vol.6
, pp. 253-268
-
-
Andrews, P.D.1
Ovechkina, Y.2
Morrice, N.3
Wagenbach, M.4
Duncan, K.5
Wordeman, L.6
Swedlow, J.R.7
-
19
-
-
2542495883
-
Differentiation of cytoplasmic and meiotic spindle assembly MCAK functions by Aurora B-dependent phosphorylation
-
Ohi R., Sapra T., Howard J., and Mitchison T.J. Differentiation of cytoplasmic and meiotic spindle assembly MCAK functions by Aurora B-dependent phosphorylation. Mol Biol Cell 15 (2004) 2895-2906
-
(2004)
Mol Biol Cell
, vol.15
, pp. 2895-2906
-
-
Ohi, R.1
Sapra, T.2
Howard, J.3
Mitchison, T.J.4
-
20
-
-
34548276583
-
Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1
-
Pouwels J., Kukkonen A.M., Lan W., Daum J.R., Gorbsky G.J., Stukenberg T., and Kallio M.J. Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1. Cell Cycle 6 (2007) 1579-1585
-
(2007)
Cell Cycle
, vol.6
, pp. 1579-1585
-
-
Pouwels, J.1
Kukkonen, A.M.2
Lan, W.3
Daum, J.R.4
Gorbsky, G.J.5
Stukenberg, T.6
Kallio, M.J.7
-
21
-
-
33244490241
-
Complex formation of Plk1 and INCENP required for metaphase-anaphase transition
-
Goto H., Kiyono T., Tomono Y., Kawajiri A., Urano T., Furukawa K., Nigg E.A., and Inagaki M. Complex formation of Plk1 and INCENP required for metaphase-anaphase transition. Nat Cell Biol 8 (2006) 180-187
-
(2006)
Nat Cell Biol
, vol.8
, pp. 180-187
-
-
Goto, H.1
Kiyono, T.2
Tomono, Y.3
Kawajiri, A.4
Urano, T.5
Furukawa, K.6
Nigg, E.A.7
Inagaki, M.8
-
22
-
-
34248177268
-
Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments
-
Huang H., Feng J., Famulski J., Rattner J.B., Liu S.T., Kao G.D., Muschel R., Chan G.K., and Yen T.J. Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments. J Cell Biol 177 (2007) 413-424
-
(2007)
J Cell Biol
, vol.177
, pp. 413-424
-
-
Huang, H.1
Feng, J.2
Famulski, J.3
Rattner, J.B.4
Liu, S.T.5
Kao, G.D.6
Muschel, R.7
Chan, G.K.8
Yen, T.J.9
-
23
-
-
33847219959
-
Shugoshin enables tension-generating attachment of kinetochores by loading Aurora to centromeres
-
This paper shows that fission yeast Sgo2 interacts with Survivin and recruits the CPC to pericentromeres. By artificially targeting the CPC to centromeres, the authors demonstrate that the Sgo2-mediated CPC localization of the centromere is important for correct microtubule attachment.
-
Kawashima S.A., Tsukahara T., Langegger M., Hauf S., Kitajima T.S., and Watanabe Y. Shugoshin enables tension-generating attachment of kinetochores by loading Aurora to centromeres. Genes Dev 21 (2007) 420-435. This paper shows that fission yeast Sgo2 interacts with Survivin and recruits the CPC to pericentromeres. By artificially targeting the CPC to centromeres, the authors demonstrate that the Sgo2-mediated CPC localization of the centromere is important for correct microtubule attachment.
-
(2007)
Genes Dev
, vol.21
, pp. 420-435
-
-
Kawashima, S.A.1
Tsukahara, T.2
Langegger, M.3
Hauf, S.4
Kitajima, T.S.5
Watanabe, Y.6
-
24
-
-
33750612373
-
Aurora kinase promotes turnover of kinetochore microtubules to reduce chromosome segregation errors
-
Cimini D., Wan X., Hirel C.B., and Salmon E.D. Aurora kinase promotes turnover of kinetochore microtubules to reduce chromosome segregation errors. Curr Biol 16 (2006) 1711-1718
-
(2006)
Curr Biol
, vol.16
, pp. 1711-1718
-
-
Cimini, D.1
Wan, X.2
Hirel, C.B.3
Salmon, E.D.4
-
25
-
-
0038746733
-
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint
-
Hauf S., Cole R.W., LaTerra S., Zimmer C., Schnapp G., Walter R., Heckel A., van Meel J., Rieder C.L., and Peters J.M. The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J Cell Biol 161 (2003) 281-294
-
(2003)
J Cell Biol
, vol.161
, pp. 281-294
-
-
Hauf, S.1
Cole, R.W.2
LaTerra, S.3
Zimmer, C.4
Schnapp, G.5
Walter, R.6
Heckel, A.7
van Meel, J.8
Rieder, C.L.9
Peters, J.M.10
-
26
-
-
33750609316
-
Aurora B is enriched at merotelic attachment sites, where it regulates MCAK
-
Knowlton A.L., Lan W., and Stukenberg P.T. Aurora B is enriched at merotelic attachment sites, where it regulates MCAK. Curr Biol 16 (2006) 1705-1710
-
(2006)
Curr Biol
, vol.16
, pp. 1705-1710
-
-
Knowlton, A.L.1
Lan, W.2
Stukenberg, P.T.3
-
27
-
-
0035084058
-
Differential regulation of CENP-A and histone H3 phosphorylation in G2/M
-
Zeitlin S.G., Barber C.M., Allis C.D., and Sullivan K.F. Differential regulation of CENP-A and histone H3 phosphorylation in G2/M. J Cell Sci 114 (2001) 653-661
-
(2001)
J Cell Sci
, vol.114
, pp. 653-661
-
-
Zeitlin, S.G.1
Barber, C.M.2
Allis, C.D.3
Sullivan, K.F.4
-
28
-
-
33751232957
-
The conserved KMN network constitutes the core microtubule-binding site of the kinetochore
-
Cheeseman I.M., Chappie J.S., Wilson-Kubalek E.M., and Desai A. The conserved KMN network constitutes the core microtubule-binding site of the kinetochore. Cell 127 (2006) 983-997
-
(2006)
Cell
, vol.127
, pp. 983-997
-
-
Cheeseman, I.M.1
Chappie, J.S.2
Wilson-Kubalek, E.M.3
Desai, A.4
-
29
-
-
33751227843
-
Kinetochore microtubule dynamics and attachment stability are regulated by Hec1
-
DeLuca J.G., Gall W.E., Ciferri C., Cimini D., Musacchio A., and Salmon E.D. Kinetochore microtubule dynamics and attachment stability are regulated by Hec1. Cell 127 (2006) 969-982
-
(2006)
Cell
, vol.127
, pp. 969-982
-
-
DeLuca, J.G.1
Gall, W.E.2
Ciferri, C.3
Cimini, D.4
Musacchio, A.5
Salmon, E.D.6
-
30
-
-
43149104627
-
Phosphoregulation and depolymerization-driven movement of the Dam1 complex do not require ring formation
-
Gestaut D.R., Graczyk B., Cooper J., Widlund P.O., Zelter A., Wordeman L., Asbury C.L., and Davis T.N. Phosphoregulation and depolymerization-driven movement of the Dam1 complex do not require ring formation. Nat Cell Biol 10 (2008) 407-414
-
(2008)
Nat Cell Biol
, vol.10
, pp. 407-414
-
-
Gestaut, D.R.1
Graczyk, B.2
Cooper, J.3
Widlund, P.O.4
Zelter, A.5
Wordeman, L.6
Asbury, C.L.7
Davis, T.N.8
-
31
-
-
36849029848
-
MCAK facilitates chromosome movement by promoting kinetochore microtubule turnover
-
Wordeman L., Wagenbach M., and von Dassow G. MCAK facilitates chromosome movement by promoting kinetochore microtubule turnover. J Cell Biol 179 (2007) 869-879
-
(2007)
J Cell Biol
, vol.179
, pp. 869-879
-
-
Wordeman, L.1
Wagenbach, M.2
von Dassow, G.3
-
32
-
-
20844436307
-
Mechanism of Aurora B activation by INCENP and inhibition by hesperadin
-
Sessa F., Mapelli M., Ciferri C., Tarricone C., Areces L.B., Schneider T.R., Stukenberg P.T., and Musacchio A. Mechanism of Aurora B activation by INCENP and inhibition by hesperadin. Mol Cell 18 (2005) 379-391
-
(2005)
Mol Cell
, vol.18
, pp. 379-391
-
-
Sessa, F.1
Mapelli, M.2
Ciferri, C.3
Tarricone, C.4
Areces, L.B.5
Schneider, T.R.6
Stukenberg, P.T.7
Musacchio, A.8
-
33
-
-
33845783921
-
Chromosomal enrichment and activation of the aurora B pathway are coupled to spatially regulate spindle assembly
-
This paper demonstrates that the Aurora B pathway is suppressed in the cytoplasm of metaphase Xenopus egg extracts by phosphatase activity, but that chromatin, stabilized microtubules, centrosomes and forced clustering of the CPC can stimulate kinase activation. The authors propose a model detailing how the Aurora B pathway mediates spindle assembly.
-
Kelly A.E., Sampath S.C., Maniar T.A., Woo E.M., Chait B.T., and Funabiki H. Chromosomal enrichment and activation of the aurora B pathway are coupled to spatially regulate spindle assembly. Dev Cell 12 (2007) 31-43. This paper demonstrates that the Aurora B pathway is suppressed in the cytoplasm of metaphase Xenopus egg extracts by phosphatase activity, but that chromatin, stabilized microtubules, centrosomes and forced clustering of the CPC can stimulate kinase activation. The authors propose a model detailing how the Aurora B pathway mediates spindle assembly.
-
(2007)
Dev Cell
, vol.12
, pp. 31-43
-
-
Kelly, A.E.1
Sampath, S.C.2
Maniar, T.A.3
Woo, E.M.4
Chait, B.T.5
Funabiki, H.6
-
34
-
-
33645231284
-
Aurora B is required for mitotic chromatin-induced phosphorylation of Op18/Stathmin
-
Gadea B.B., and Ruderman J.V. Aurora B is required for mitotic chromatin-induced phosphorylation of Op18/Stathmin. Proc Natl Acad Sci U S A 103 (2006) 4493-4498
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 4493-4498
-
-
Gadea, B.B.1
Ruderman, J.V.2
-
35
-
-
38549168381
-
Centromeric Aurora-B activation requires TD-60, microtubules, and substrate priming phosphorylation
-
Dephosphorylated CPC cannot be activated efficiently unless microtubules and TD-60 are present. The results suggest that Aurora B substrates can inhibit Aurora B activity, and that priming by centromeric kinases (Haspin or Plk1) could alleviate this, revealing a possible mechanism for regulation of Aurora B at the centromere.
-
Rosasco-Nitcher S.E., Lan W., Khorasanizadeh S., and Stukenberg P.T. Centromeric Aurora-B activation requires TD-60, microtubules, and substrate priming phosphorylation. Science 319 (2008) 469-472. Dephosphorylated CPC cannot be activated efficiently unless microtubules and TD-60 are present. The results suggest that Aurora B substrates can inhibit Aurora B activity, and that priming by centromeric kinases (Haspin or Plk1) could alleviate this, revealing a possible mechanism for regulation of Aurora B at the centromere.
-
(2008)
Science
, vol.319
, pp. 469-472
-
-
Rosasco-Nitcher, S.E.1
Lan, W.2
Khorasanizadeh, S.3
Stukenberg, P.T.4
-
36
-
-
33846636785
-
Chk1 is required for spindle checkpoint function
-
Using a conditional knockdown of Chk1 in chicken DT40 cells, the authors convincingly demonstrate that Chk1, which plays an important role in the DNA-damage checkpoint, can directly activate Aurora B, is required for Aurora B-mediated phosphorylation of Cenp-A and proper chromosome segregation.
-
Zachos G., Black E.J., Walker M., Scott M.T., Vagnarelli P., Earnshaw W.C., and Gillespie D.A. Chk1 is required for spindle checkpoint function. Dev Cell 12 (2007) 247-260. Using a conditional knockdown of Chk1 in chicken DT40 cells, the authors convincingly demonstrate that Chk1, which plays an important role in the DNA-damage checkpoint, can directly activate Aurora B, is required for Aurora B-mediated phosphorylation of Cenp-A and proper chromosome segregation.
-
(2007)
Dev Cell
, vol.12
, pp. 247-260
-
-
Zachos, G.1
Black, E.J.2
Walker, M.3
Scott, M.T.4
Vagnarelli, P.5
Earnshaw, W.C.6
Gillespie, D.A.7
-
37
-
-
36849091065
-
Mps1 kinase promotes sister-kinetochore bi-orientation by a tension-dependent mechanism
-
This paper clearly demonstrates that Mps1 is required for error correction process of microtubule attachment in budding yeast.
-
Maure J.F., Kitamura E., and Tanaka T.U. Mps1 kinase promotes sister-kinetochore bi-orientation by a tension-dependent mechanism. Curr Biol 17 (2007) 2175-2182. This paper clearly demonstrates that Mps1 is required for error correction process of microtubule attachment in budding yeast.
-
(2007)
Curr Biol
, vol.17
, pp. 2175-2182
-
-
Maure, J.F.1
Kitamura, E.2
Tanaka, T.U.3
-
38
-
-
38649133379
-
Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment
-
By RNAi-mediated knockdown of Mps1 in HeLa cells, the authors show that Mps1 is required for error correction process of microtubule attachment. Mps1 can phosphorylate Borealin and stimulate Aurora B activity in the CPC. Strikingly, a phospho-mimetic mutant of Borealin can rescue the chromosome misalignment but not spindle checkpoint defect of Mps1 knockdown.
-
Jelluma N., Brenkman A.B., van den Broek N.J., Cruijsen C.W., van Osch M.H., Lens S.M., Medema R.H., and Kops G.J. Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment. Cell 132 (2008) 233-246. By RNAi-mediated knockdown of Mps1 in HeLa cells, the authors show that Mps1 is required for error correction process of microtubule attachment. Mps1 can phosphorylate Borealin and stimulate Aurora B activity in the CPC. Strikingly, a phospho-mimetic mutant of Borealin can rescue the chromosome misalignment but not spindle checkpoint defect of Mps1 knockdown.
-
(2008)
Cell
, vol.132
, pp. 233-246
-
-
Jelluma, N.1
Brenkman, A.B.2
van den Broek, N.J.3
Cruijsen, C.W.4
van Osch, M.H.5
Lens, S.M.6
Medema, R.H.7
Kops, G.J.8
-
39
-
-
0028304675
-
Type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregation
-
Francisco L., Wang W., and Chan C.S. Type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregation. Mol Cell Biol 14 (1994) 4731-4740
-
(1994)
Mol Cell Biol
, vol.14
, pp. 4731-4740
-
-
Francisco, L.1
Wang, W.2
Chan, C.S.3
-
40
-
-
0034604354
-
Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes
-
Hsu J.Y., Sun Z.W., Li X., Reuben M., Tatchell K., Bishop D.K., Grushcow J.M., Brame C.J., Caldwell J.A., Hunt D.F., et al. Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes. Cell 102 (2000) 279-291
-
(2000)
Cell
, vol.102
, pp. 279-291
-
-
Hsu, J.Y.1
Sun, Z.W.2
Li, X.3
Reuben, M.4
Tatchell, K.5
Bishop, D.K.6
Grushcow, J.M.7
Brame, C.J.8
Caldwell, J.A.9
Hunt, D.F.10
-
41
-
-
33644524404
-
Repo-Man recruits PP1 gamma to chromatin and is essential for cell viability
-
Trinkle-Mulcahy L., Andersen J., Lam Y.W., Moorhead G., Mann M., and Lamond A.I. Repo-Man recruits PP1 gamma to chromatin and is essential for cell viability. J Cell Biol 172 (2006) 679-692
-
(2006)
J Cell Biol
, vol.172
, pp. 679-692
-
-
Trinkle-Mulcahy, L.1
Andersen, J.2
Lam, Y.W.3
Moorhead, G.4
Mann, M.5
Lamond, A.I.6
-
42
-
-
0037244295
-
Time-lapse imaging reveals dynamic relocalization of PP1gamma throughout the mammalian cell cycle
-
Trinkle-Mulcahy L., Andrews P.D., Wickramasinghe S., Sleeman J., Prescott A., Lam Y.W., Lyon C., Swedlow J.R., and Lamond A.I. Time-lapse imaging reveals dynamic relocalization of PP1gamma throughout the mammalian cell cycle. Mol Biol Cell 14 (2003) 107-117
-
(2003)
Mol Biol Cell
, vol.14
, pp. 107-117
-
-
Trinkle-Mulcahy, L.1
Andrews, P.D.2
Wickramasinghe, S.3
Sleeman, J.4
Prescott, A.5
Lam, Y.W.6
Lyon, C.7
Swedlow, J.R.8
Lamond, A.I.9
-
43
-
-
44949185572
-
The human spindle assembly checkpoint protein bub3 is required for the establishment of efficient kinetochore-microtubule attachments
-
Logarinho E., Resende T., Torres C., and Bousbaa H. The human spindle assembly checkpoint protein bub3 is required for the establishment of efficient kinetochore-microtubule attachments. Mol Biol Cell 19 (2008) 1798-1813
-
(2008)
Mol Biol Cell
, vol.19
, pp. 1798-1813
-
-
Logarinho, E.1
Resende, T.2
Torres, C.3
Bousbaa, H.4
-
44
-
-
12344266713
-
The human mitotic checkpoint protein BubR1 regulates chromosome-spindle attachments
-
Lampson M.A., and Kapoor T.M. The human mitotic checkpoint protein BubR1 regulates chromosome-spindle attachments. Nat Cell Biol 7 (2005) 93-98
-
(2005)
Nat Cell Biol
, vol.7
, pp. 93-98
-
-
Lampson, M.A.1
Kapoor, T.M.2
-
45
-
-
24944592549
-
Bub1 and aurora B cooperate to maintain BubR1-mediated inhibition of APC/CCdc20
-
Morrow C.J., Tighe A., Johnson V.L., Scott M.I., Ditchfield C., and Taylor S.S. Bub1 and aurora B cooperate to maintain BubR1-mediated inhibition of APC/CCdc20. J Cell Sci 118 (2005) 3639-3652
-
(2005)
J Cell Sci
, vol.118
, pp. 3639-3652
-
-
Morrow, C.J.1
Tighe, A.2
Johnson, V.L.3
Scott, M.I.4
Ditchfield, C.5
Taylor, S.S.6
-
46
-
-
0032101688
-
Localization of Mad2 to kinetochores depends on microtubule attachment, not tension
-
Waters J.C., Chen R.H., Murray A.W., and Salmon E.D. Localization of Mad2 to kinetochores depends on microtubule attachment, not tension. J Cell Biol 141 (1998) 1181-1191
-
(1998)
J Cell Biol
, vol.141
, pp. 1181-1191
-
-
Waters, J.C.1
Chen, R.H.2
Murray, A.W.3
Salmon, E.D.4
-
47
-
-
0036732808
-
Aurora B kinase exists in a complex with survivin and INCENP and its kinase activity is stimulated by survivin binding and phosphorylation
-
Bolton M.A., Lan W., Powers S.E., McCleland M.L., Kuang J., and Stukenberg P.T. Aurora B kinase exists in a complex with survivin and INCENP and its kinase activity is stimulated by survivin binding and phosphorylation. Mol Biol Cell 13 (2002) 3064-3077
-
(2002)
Mol Biol Cell
, vol.13
, pp. 3064-3077
-
-
Bolton, M.A.1
Lan, W.2
Powers, S.E.3
McCleland, M.L.4
Kuang, J.5
Stukenberg, P.T.6
-
48
-
-
0037078332
-
Both midzone and astral microtubules are involved in the delivery of cytokinesis signals: insights from the mobility of aurora B
-
Murata-Hori M., and Wang Y.L. Both midzone and astral microtubules are involved in the delivery of cytokinesis signals: insights from the mobility of aurora B. J Cell Biol 159 (2002) 45-53
-
(2002)
J Cell Biol
, vol.159
, pp. 45-53
-
-
Murata-Hori, M.1
Wang, Y.L.2
-
49
-
-
14644399115
-
Distinct dynamics of Aurora B and Survivin during mitosis
-
Delacour-Larose M., Molla A., Skoufias D.A., Margolis R.L., and Dimitrov S. Distinct dynamics of Aurora B and Survivin during mitosis. Cell Cycle 3 (2004) 1418-1426
-
(2004)
Cell Cycle
, vol.3
, pp. 1418-1426
-
-
Delacour-Larose, M.1
Molla, A.2
Skoufias, D.A.3
Margolis, R.L.4
Dimitrov, S.5
-
51
-
-
33745712591
-
A perikinetochoric ring defined by MCAK and Aurora-B as a novel centromere domain
-
Parra M.T., Gomez R., Viera A., Page J., Calvente A., Wordeman L., Rufas J.S., and Suja J.A. A perikinetochoric ring defined by MCAK and Aurora-B as a novel centromere domain. PLoS Genet 2 (2006) e84
-
(2006)
PLoS Genet
, vol.2
-
-
Parra, M.T.1
Gomez, R.2
Viera, A.3
Page, J.4
Calvente, A.5
Wordeman, L.6
Rufas, J.S.7
Suja, J.A.8
-
52
-
-
0037444577
-
Dynamic relocalization of the chromosomal passenger complex proteins inner centromere protein (INCENP) and aurora-B kinase during male mouse meiosis
-
Parra M.T., Viera A., Gomez R., Page J., Carmena M., Earnshaw W.C., Rufas J.S., and Suja J.A. Dynamic relocalization of the chromosomal passenger complex proteins inner centromere protein (INCENP) and aurora-B kinase during male mouse meiosis. J Cell Sci 116 (2003) 961-974
-
(2003)
J Cell Sci
, vol.116
, pp. 961-974
-
-
Parra, M.T.1
Viera, A.2
Gomez, R.3
Page, J.4
Carmena, M.5
Earnshaw, W.C.6
Rufas, J.S.7
Suja, J.A.8
-
53
-
-
55949106979
-
Deconstructing Survivin: comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line
-
Yue Z., Carvalho A., Xu Z., Yuan X., Cardinale S., Ribeiro S., Lai F., Ogawa H., Gudmundsdottir E., Gassmann R., et al. Deconstructing Survivin: comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line. J Cell Biol 183 (2008) 279-296
-
(2008)
J Cell Biol
, vol.183
, pp. 279-296
-
-
Yue, Z.1
Carvalho, A.2
Xu, Z.3
Yuan, X.4
Cardinale, S.5
Ribeiro, S.6
Lai, F.7
Ogawa, H.8
Gudmundsdottir, E.9
Gassmann, R.10
-
54
-
-
45749115811
-
Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient
-
The authors develop an Aurora B-phosphorylation sensitive FRET sensor, which reveals that Aurora B-mediated phosphorylation remains higher on chromosomes near the anaphase spindle midzone than on those near spindle poles.
-
Fuller B.G., Lampson M.A., Foley E.A., Rosasco-Nitcher S., Le K.V., Tobelmann P., Brautigan D.L., Stukenberg P.T., and Kapoor T.M. Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient. Nature 453 (2008) 1132-1136. The authors develop an Aurora B-phosphorylation sensitive FRET sensor, which reveals that Aurora B-mediated phosphorylation remains higher on chromosomes near the anaphase spindle midzone than on those near spindle poles.
-
(2008)
Nature
, vol.453
, pp. 1132-1136
-
-
Fuller, B.G.1
Lampson, M.A.2
Foley, E.A.3
Rosasco-Nitcher, S.4
Le, K.V.5
Tobelmann, P.6
Brautigan, D.L.7
Stukenberg, P.T.8
Kapoor, T.M.9
-
55
-
-
33845438713
-
A Bir1-Sli15 complex connects centromeres to microtubules and is required to sense kinetochore tension
-
Sandall S., Severin F., McLeod I.X., Yates III J.R., Oegema K., Hyman A., and Desai A. A Bir1-Sli15 complex connects centromeres to microtubules and is required to sense kinetochore tension. Cell 127 (2006) 1179-1191
-
(2006)
Cell
, vol.127
, pp. 1179-1191
-
-
Sandall, S.1
Severin, F.2
McLeod, I.X.3
Yates III, J.R.4
Oegema, K.5
Hyman, A.6
Desai, A.7
-
56
-
-
34548248276
-
Detection and correction of merotelic kinetochore orientation by Aurora B and its partners
-
Cimini D. Detection and correction of merotelic kinetochore orientation by Aurora B and its partners. Cell Cycle 6 (2007) 1558-1564
-
(2007)
Cell Cycle
, vol.6
, pp. 1558-1564
-
-
Cimini, D.1
-
57
-
-
35848971221
-
The chromosomal passenger complex controls spindle checkpoint function independent from its role in correcting microtubule kinetochore interactions
-
The authors demonstrate in human tissue culture cells that deletion of the putative coiled-coil domain of INCENP leads to inactivation of SAC function of the CPC without affecting its role in error correction.
-
Vader G., Cruijsen C.W., van Harn T., Vromans M.J., Medema R.H., and Lens S.M. The chromosomal passenger complex controls spindle checkpoint function independent from its role in correcting microtubule kinetochore interactions. Mol Biol Cell 18 (2007) 4553-4564. The authors demonstrate in human tissue culture cells that deletion of the putative coiled-coil domain of INCENP leads to inactivation of SAC function of the CPC without affecting its role in error correction.
-
(2007)
Mol Biol Cell
, vol.18
, pp. 4553-4564
-
-
Vader, G.1
Cruijsen, C.W.2
van Harn, T.3
Vromans, M.J.4
Medema, R.H.5
Lens, S.M.6
-
58
-
-
41149112015
-
Beyond the code: the mechanical properties of DNA as they relate to mitosis
-
Bloom K.S. Beyond the code: the mechanical properties of DNA as they relate to mitosis. Chromosoma 117 (2008) 103-110
-
(2008)
Chromosoma
, vol.117
, pp. 103-110
-
-
Bloom, K.S.1
-
59
-
-
50249129235
-
Dual role of topoisomerase II in centromere resolution and aurora B activity
-
This paper demonstrates that RNAi-mediated depletion or ICRF-187-mediated inhibition of topo II in Drosophila S2 cells leads to the accumulation of syntelic attachments and loss of Aurora B-dependent histone H3 phosphorylation. Treatment of HeLa cells with ICRF-187 also causes syntelic attachments and decreases Aurora B-dependent Cenp-A phosphorylation.
-
Coelho P.A., Queiroz-Machado J., Carmo A.M., Moutinho-Pereira S., Maiato H., and Sunkel C.E. Dual role of topoisomerase II in centromere resolution and aurora B activity. PLoS Biol 6 (2008) e207. This paper demonstrates that RNAi-mediated depletion or ICRF-187-mediated inhibition of topo II in Drosophila S2 cells leads to the accumulation of syntelic attachments and loss of Aurora B-dependent histone H3 phosphorylation. Treatment of HeLa cells with ICRF-187 also causes syntelic attachments and decreases Aurora B-dependent Cenp-A phosphorylation.
-
(2008)
PLoS Biol
, vol.6
-
-
Coelho, P.A.1
Queiroz-Machado, J.2
Carmo, A.M.3
Moutinho-Pereira, S.4
Maiato, H.5
Sunkel, C.E.6
-
60
-
-
41149168802
-
Persistence of DNA threads in human anaphase cells suggests late completion of sister chromatid decatenation
-
Wang L.H., Schwarzbraun T., Speicher M.R., and Nigg E.A. Persistence of DNA threads in human anaphase cells suggests late completion of sister chromatid decatenation. Chromosoma 117 (2008) 123-135
-
(2008)
Chromosoma
, vol.117
, pp. 123-135
-
-
Wang, L.H.1
Schwarzbraun, T.2
Speicher, M.R.3
Nigg, E.A.4
-
61
-
-
33845981777
-
PICH, a centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint
-
These two papers show that centromeric alphoid DNA remains connected in a thread-like structure between chromatids during anaphase. These threads are coated with a novel centromeric ATPase, PICH, and must be decatenated by topo II for completion of sister chromatid separation. PICH is also required for metaphase chromosome alignment and SAC activation.
-
Baumann C., Korner R., Hofmann K., and Nigg E.A. PICH, a centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint. Cell 128 (2007) 101-114. These two papers show that centromeric alphoid DNA remains connected in a thread-like structure between chromatids during anaphase. These threads are coated with a novel centromeric ATPase, PICH, and must be decatenated by topo II for completion of sister chromatid separation. PICH is also required for metaphase chromosome alignment and SAC activation.
-
(2007)
Cell
, vol.128
, pp. 101-114
-
-
Baumann, C.1
Korner, R.2
Hofmann, K.3
Nigg, E.A.4
-
62
-
-
34548436939
-
Tension-sensitive Plk1 phosphorylation on BubR1 regulates the stability of kinetochore microtubule interactions
-
Elowe S., Hummer S., Uldschmid A., Li X., and Nigg E.A. Tension-sensitive Plk1 phosphorylation on BubR1 regulates the stability of kinetochore microtubule interactions. Genes Dev 21 (2007) 2205-2219
-
(2007)
Genes Dev
, vol.21
, pp. 2205-2219
-
-
Elowe, S.1
Hummer, S.2
Uldschmid, A.3
Li, X.4
Nigg, E.A.5
-
63
-
-
24944452696
-
Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling
-
Mao Y., Desai A., and Cleveland D.W. Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling. J Cell Biol 170 (2005) 873-880
-
(2005)
J Cell Biol
, vol.170
, pp. 873-880
-
-
Mao, Y.1
Desai, A.2
Cleveland, D.W.3
-
64
-
-
62149111407
-
-
Liu D, Vader G, Vromans MJM, Lampson MA, Lens SMA: Sensing Chromosome Bi-Orientation by Spatial Separation of Aurora B Kinase from Kinetochore Substrates. Science 2009, doi:10.1126/science.1167000. Using a well characterized FRET sensor to measure phosphorylation of a model Aurora B substrate, Liu et al. show that substrate phosphorylation depends on the distance of the substrate from Aurora B at the inner centromere. Furthermore, they demonstrate that recruiting the CPC to the kinetochore prevented the stabilization of bi-oriented attachments and activated the SAC.
-
Liu D, Vader G, Vromans MJM, Lampson MA, Lens SMA: Sensing Chromosome Bi-Orientation by Spatial Separation of Aurora B Kinase from Kinetochore Substrates. Science 2009, doi:10.1126/science.1167000. Using a well characterized FRET sensor to measure phosphorylation of a model Aurora B substrate, Liu et al. show that substrate phosphorylation depends on the distance of the substrate from Aurora B at the inner centromere. Furthermore, they demonstrate that recruiting the CPC to the kinetochore prevented the stabilization of bi-oriented attachments and activated the SAC.
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